Amino acid dipepetide frequency for Exophiala spinifera

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.938AlaAla: 8.938 ± 0.052	1.097AlaCys: 1.097 ± 0.014	4.349AlaAsp: 4.349 ± 0.028	5.079AlaGlu: 5.079 ± 0.031	3.259AlaPhe: 3.259 ± 0.025	5.892AlaGly: 5.892 ± 0.036	1.823AlaHis: 1.823 ± 0.02	4.286AlaIle: 4.286 ± 0.035	3.965AlaLys: 3.965 ± 0.028	7.844AlaLeu: 7.844 ± 0.041	1.981AlaMet: 1.981 ± 0.019	2.899AlaAsn: 2.899 ± 0.023	4.42AlaPro: 4.42 ± 0.033	3.473AlaGln: 3.473 ± 0.024	5.074AlaArg: 5.074 ± 0.03	7.298AlaSer: 7.298 ± 0.042	5.434AlaThr: 5.434 ± 0.033	5.505AlaVal: 5.505 ± 0.034	1.191AlaTrp: 1.191 ± 0.015	2.241AlaTyr: 2.241 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	0.964CysAla: 0.964 ± 0.014	0.234CysCys: 0.234 ± 0.007	0.637CysAsp: 0.637 ± 0.011	0.594CysGlu: 0.594 ± 0.01	0.552CysPhe: 0.552 ± 0.011	0.911CysGly: 0.911 ± 0.014	0.338CysHis: 0.338 ± 0.007	0.694CysIle: 0.694 ± 0.011	0.482CysLys: 0.482 ± 0.009	1.303CysLeu: 1.303 ± 0.017	0.278CysMet: 0.278 ± 0.007	0.404CysAsn: 0.404 ± 0.008	0.632CysPro: 0.632 ± 0.011	0.437CysGln: 0.437 ± 0.008	0.765CysArg: 0.765 ± 0.013	0.887CysSer: 0.887 ± 0.015	0.683CysThr: 0.683 ± 0.011	0.823CysVal: 0.823 ± 0.013	0.21CysTrp: 0.21 ± 0.007	0.363CysTyr: 0.363 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.706AspAla: 4.706 ± 0.032	0.604AspCys: 0.604 ± 0.011	4.485AspAsp: 4.485 ± 0.041	4.464AspGlu: 4.464 ± 0.036	2.305AspPhe: 2.305 ± 0.022	4.067AspGly: 4.067 ± 0.032	1.36AspHis: 1.36 ± 0.017	2.963AspIle: 2.963 ± 0.024	2.387AspLys: 2.387 ± 0.022	5.197AspLeu: 5.197 ± 0.034	1.27AspMet: 1.27 ± 0.016	1.863AspAsn: 1.863 ± 0.019	3.352AspPro: 3.352 ± 0.025	2.042AspGln: 2.042 ± 0.021	3.145AspArg: 3.145 ± 0.028	4.117AspSer: 4.117 ± 0.034	3.052AspThr: 3.052 ± 0.025	3.87AspVal: 3.87 ± 0.03	0.911AspTrp: 0.911 ± 0.014	1.569AspTyr: 1.569 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	5.284GluAla: 5.284 ± 0.032	0.607GluCys: 0.607 ± 0.011	4.151GluAsp: 4.151 ± 0.036	5.051GluGlu: 5.051 ± 0.044	1.863GluPhe: 1.863 ± 0.019	3.567GluGly: 3.567 ± 0.026	1.459GluHis: 1.459 ± 0.017	3.032GluIle: 3.032 ± 0.023	3.467GluLys: 3.467 ± 0.028	5.049GluLeu: 5.049 ± 0.038	1.402GluMet: 1.402 ± 0.016	2.185GluAsn: 2.185 ± 0.019	2.655GluPro: 2.655 ± 0.025	2.525GluGln: 2.525 ± 0.022	3.918GluArg: 3.918 ± 0.035	4.228GluSer: 4.228 ± 0.031	3.467GluThr: 3.467 ± 0.023	3.646GluVal: 3.646 ± 0.027	0.861GluTrp: 0.861 ± 0.012	1.622GluTyr: 1.622 ± 0.017	0.0GluXaa: 0.0 ± 0.0
Phe	3.14PheAla: 3.14 ± 0.026	0.583PheCys: 0.583 ± 0.01	2.371PheAsp: 2.371 ± 0.018	2.207PheGlu: 2.207 ± 0.02	1.673PhePhe: 1.673 ± 0.024	2.953PheGly: 2.953 ± 0.031	0.884PheHis: 0.884 ± 0.012	1.742PheIle: 1.742 ± 0.021	1.459PheLys: 1.459 ± 0.015	3.534PheLeu: 3.534 ± 0.031	0.804PheMet: 0.804 ± 0.013	1.388PheAsn: 1.388 ± 0.017	1.946PhePro: 1.946 ± 0.021	1.417PheGln: 1.417 ± 0.016	2.009PheArg: 2.009 ± 0.02	3.003PheSer: 3.003 ± 0.026	2.122PheThr: 2.122 ± 0.019	2.518PheVal: 2.518 ± 0.024	0.684PheTrp: 0.684 ± 0.011	1.112PheTyr: 1.112 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.353GlyAla: 5.353 ± 0.041	0.837GlyCys: 0.837 ± 0.013	3.598GlyAsp: 3.598 ± 0.029	3.468GlyGlu: 3.468 ± 0.027	2.882GlyPhe: 2.882 ± 0.025	5.873GlyGly: 5.873 ± 0.049	1.765GlyHis: 1.765 ± 0.02	3.517GlyIle: 3.517 ± 0.029	3.328GlyLys: 3.328 ± 0.028	6.238GlyLeu: 6.238 ± 0.036	1.627GlyMet: 1.627 ± 0.018	2.39GlyAsn: 2.39 ± 0.024	3.382GlyPro: 3.382 ± 0.029	2.655GlyGln: 2.655 ± 0.023	4.22GlyArg: 4.22 ± 0.032	5.616GlySer: 5.616 ± 0.04	4.085GlyThr: 4.085 ± 0.03	4.5GlyVal: 4.5 ± 0.033	1.186GlyTrp: 1.186 ± 0.016	2.156GlyTyr: 2.156 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	1.929HisAla: 1.929 ± 0.019	0.318HisCys: 0.318 ± 0.009	1.456HisAsp: 1.456 ± 0.016	1.427HisGlu: 1.427 ± 0.016	0.959HisPhe: 0.959 ± 0.013	1.792HisGly: 1.792 ± 0.016	0.885HisHis: 0.885 ± 0.013	1.19HisIle: 1.19 ± 0.014	0.949HisLys: 0.949 ± 0.013	2.331HisLeu: 2.331 ± 0.024	0.497HisMet: 0.497 ± 0.009	0.851HisAsn: 0.851 ± 0.012	1.642HisPro: 1.642 ± 0.016	1.021HisGln: 1.021 ± 0.012	1.591HisArg: 1.591 ± 0.017	1.844HisSer: 1.844 ± 0.02	1.294HisThr: 1.294 ± 0.015	1.552HisVal: 1.552 ± 0.017	0.37HisTrp: 0.37 ± 0.009	0.71HisTyr: 0.71 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.176IleAla: 4.176 ± 0.028	0.76IleCys: 0.76 ± 0.013	2.888IleAsp: 2.888 ± 0.024	2.791IleGlu: 2.791 ± 0.022	1.984IlePhe: 1.984 ± 0.021	3.228IleGly: 3.228 ± 0.031	1.21IleHis: 1.21 ± 0.014	2.382IleIle: 2.382 ± 0.023	2.07IleLys: 2.07 ± 0.021	4.606IleLeu: 4.606 ± 0.034	0.987IleMet: 0.987 ± 0.013	1.755IleAsn: 1.755 ± 0.018	3.011IlePro: 3.011 ± 0.024	1.888IleGln: 1.888 ± 0.018	2.715IleArg: 2.715 ± 0.021	3.799IleSer: 3.799 ± 0.025	2.717IleThr: 2.717 ± 0.024	3.248IleVal: 3.248 ± 0.026	0.738IleTrp: 0.738 ± 0.012	1.405IleTyr: 1.405 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	4.175LysAla: 4.175 ± 0.03	0.507LysCys: 0.507 ± 0.01	2.756LysAsp: 2.756 ± 0.026	3.085LysGlu: 3.085 ± 0.027	1.44LysPhe: 1.44 ± 0.016	2.838LysGly: 2.838 ± 0.024	1.168LysHis: 1.168 ± 0.015	2.248LysIle: 2.248 ± 0.021	3.021LysLys: 3.021 ± 0.035	3.889LysLeu: 3.889 ± 0.028	1.012LysMet: 1.012 ± 0.013	1.63LysAsn: 1.63 ± 0.017	2.625LysPro: 2.625 ± 0.025	1.842LysGln: 1.842 ± 0.019	3.288LysArg: 3.288 ± 0.028	3.49LysSer: 3.49 ± 0.025	2.795LysThr: 2.795 ± 0.024	2.871LysVal: 2.871 ± 0.025	0.68LysTrp: 0.68 ± 0.012	1.397LysTyr: 1.397 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	7.952LeuAla: 7.952 ± 0.049	1.254LeuCys: 1.254 ± 0.015	5.296LeuAsp: 5.296 ± 0.033	5.501LeuGlu: 5.501 ± 0.04	3.374LeuPhe: 3.374 ± 0.03	6.016LeuGly: 6.016 ± 0.039	2.238LeuHis: 2.238 ± 0.022	3.913LeuIle: 3.913 ± 0.029	4.169LeuLys: 4.169 ± 0.031	8.466LeuLeu: 8.466 ± 0.056	1.798LeuMet: 1.798 ± 0.018	3.15LeuAsn: 3.15 ± 0.027	5.45LeuPro: 5.45 ± 0.032	3.9LeuGln: 3.9 ± 0.03	5.789LeuArg: 5.789 ± 0.036	7.433LeuSer: 7.433 ± 0.041	4.965LeuThr: 4.965 ± 0.031	5.562LeuVal: 5.562 ± 0.034	1.276LeuTrp: 1.276 ± 0.017	2.393LeuTyr: 2.393 ± 0.02	0.0LeuXaa: 0.0 ± 0.0
Met	2.267MetAla: 2.267 ± 0.023	0.254MetCys: 0.254 ± 0.007	1.184MetAsp: 1.184 ± 0.015	1.134MetGlu: 1.134 ± 0.015	0.77MetPhe: 0.77 ± 0.013	1.432MetGly: 1.432 ± 0.018	0.506MetHis: 0.506 ± 0.008	1.008MetIle: 1.008 ± 0.015	0.952MetLys: 0.952 ± 0.014	1.918MetLeu: 1.918 ± 0.02	0.542MetMet: 0.542 ± 0.011	0.777MetAsn: 0.777 ± 0.011	1.287MetPro: 1.287 ± 0.014	0.855MetGln: 0.855 ± 0.013	1.221MetArg: 1.221 ± 0.015	1.973MetSer: 1.973 ± 0.015	1.379MetThr: 1.379 ± 0.018	1.329MetVal: 1.329 ± 0.014	0.258MetTrp: 0.258 ± 0.007	0.533MetTyr: 0.533 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.121AsnAla: 3.121 ± 0.024	0.415AsnCys: 0.415 ± 0.009	1.995AsnAsp: 1.995 ± 0.019	1.931AsnGlu: 1.931 ± 0.021	1.365AsnPhe: 1.365 ± 0.015	2.899AsnGly: 2.899 ± 0.024	0.868AsnHis: 0.868 ± 0.012	1.976AsnIle: 1.976 ± 0.016	1.482AsnLys: 1.482 ± 0.016	3.214AsnLeu: 3.214 ± 0.024	0.806AsnMet: 0.806 ± 0.014	1.441AsnAsn: 1.441 ± 0.018	2.342AsnPro: 2.342 ± 0.022	1.259AsnGln: 1.259 ± 0.015	1.84AsnArg: 1.84 ± 0.019	2.612AsnSer: 2.612 ± 0.021	2.122AsnThr: 2.122 ± 0.02	2.407AsnVal: 2.407 ± 0.021	0.538AsnTrp: 0.538 ± 0.01	1.026AsnTyr: 1.026 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	4.942ProAla: 4.942 ± 0.038	0.497ProCys: 0.497 ± 0.01	3.243ProAsp: 3.243 ± 0.023	3.761ProGlu: 3.761 ± 0.024	2.071ProPhe: 2.071 ± 0.019	4.01ProGly: 4.01 ± 0.028	1.308ProHis: 1.308 ± 0.017	2.409ProIle: 2.409 ± 0.023	2.53ProLys: 2.53 ± 0.02	4.716ProLeu: 4.716 ± 0.028	1.068ProMet: 1.068 ± 0.013	2.084ProAsn: 2.084 ± 0.017	4.976ProPro: 4.976 ± 0.058	2.467ProGln: 2.467 ± 0.03	3.445ProArg: 3.445 ± 0.028	5.93ProSer: 5.93 ± 0.046	3.915ProThr: 3.915 ± 0.029	3.603ProVal: 3.603 ± 0.028	0.755ProTrp: 0.755 ± 0.01	1.511ProTyr: 1.511 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.57GlnAla: 3.57 ± 0.025	0.438GlnCys: 0.438 ± 0.009	2.184GlnAsp: 2.184 ± 0.02	2.447GlnGlu: 2.447 ± 0.026	1.277GlnPhe: 1.277 ± 0.017	2.485GlnGly: 2.485 ± 0.023	1.148GlnHis: 1.148 ± 0.014	1.939GlnIle: 1.939 ± 0.02	1.972GlnLys: 1.972 ± 0.018	3.437GlnLeu: 3.437 ± 0.028	0.864GlnMet: 0.864 ± 0.012	1.569GlnAsn: 1.569 ± 0.016	2.481GlnPro: 2.481 ± 0.028	2.442GlnGln: 2.442 ± 0.035	2.719GlnArg: 2.719 ± 0.028	3.252GlnSer: 3.252 ± 0.027	2.359GlnThr: 2.359 ± 0.021	2.238GlnVal: 2.238 ± 0.019	0.579GlnTrp: 0.579 ± 0.01	1.212GlnTyr: 1.212 ± 0.012	0.0GlnXaa: 0.0 ± 0.0
Arg	4.752ArgAla: 4.752 ± 0.028	0.697ArgCys: 0.697 ± 0.012	3.483ArgAsp: 3.483 ± 0.032	3.731ArgGlu: 3.731 ± 0.03	2.097ArgPhe: 2.097 ± 0.018	3.759ArgGly: 3.759 ± 0.029	1.708ArgHis: 1.708 ± 0.02	2.849ArgIle: 2.849 ± 0.026	3.485ArgLys: 3.485 ± 0.029	5.61ArgLeu: 5.61 ± 0.038	1.298ArgMet: 1.298 ± 0.016	2.219ArgAsn: 2.219 ± 0.021	3.623ArgPro: 3.623 ± 0.031	2.737ArgGln: 2.737 ± 0.027	5.291ArgArg: 5.291 ± 0.048	4.867ArgSer: 4.867 ± 0.033	3.459ArgThr: 3.459 ± 0.03	3.329ArgVal: 3.329 ± 0.028	0.933ArgTrp: 0.933 ± 0.013	1.728ArgTyr: 1.728 ± 0.02	0.0ArgXaa: 0.0 ± 0.0
Ser	6.708SerAla: 6.708 ± 0.039	0.872SerCys: 0.872 ± 0.012	4.282SerAsp: 4.282 ± 0.028	4.148SerGlu: 4.148 ± 0.03	3.001SerPhe: 3.001 ± 0.025	5.555SerGly: 5.555 ± 0.037	1.999SerHis: 1.999 ± 0.019	3.972SerIle: 3.972 ± 0.028	3.651SerLys: 3.651 ± 0.026	7.267SerLeu: 7.267 ± 0.045	1.751SerMet: 1.751 ± 0.016	2.945SerAsn: 2.945 ± 0.024	5.427SerPro: 5.427 ± 0.045	3.343SerGln: 3.343 ± 0.029	5.219SerArg: 5.219 ± 0.04	9.077SerSer: 9.077 ± 0.084	5.942SerThr: 5.942 ± 0.046	4.683SerVal: 4.683 ± 0.032	1.187SerTrp: 1.187 ± 0.013	2.074SerTyr: 2.074 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	5.313ThrAla: 5.313 ± 0.033	0.741ThrCys: 0.741 ± 0.012	2.917ThrAsp: 2.917 ± 0.021	3.024ThrGlu: 3.024 ± 0.025	2.358ThrPhe: 2.358 ± 0.021	4.227ThrGly: 4.227 ± 0.03	1.301ThrHis: 1.301 ± 0.014	3.128ThrIle: 3.128 ± 0.021	2.623ThrLys: 2.623 ± 0.022	5.313ThrLeu: 5.313 ± 0.033	1.251ThrMet: 1.251 ± 0.014	2.151ThrAsn: 2.151 ± 0.02	4.211ThrPro: 4.211 ± 0.034	2.13ThrGln: 2.13 ± 0.022	3.266ThrArg: 3.266 ± 0.024	5.716ThrSer: 5.716 ± 0.054	4.797ThrThr: 4.797 ± 0.06	3.859ThrVal: 3.859 ± 0.032	0.888ThrTrp: 0.888 ± 0.012	1.628ThrTyr: 1.628 ± 0.016	0.0ThrXaa: 0.0 ± 0.0
Val	5.382ValAla: 5.382 ± 0.032	0.85ValCys: 0.85 ± 0.012	3.932ValAsp: 3.932 ± 0.026	3.834ValGlu: 3.834 ± 0.027	2.511ValPhe: 2.511 ± 0.023	4.15ValGly: 4.15 ± 0.032	1.467ValHis: 1.467 ± 0.016	2.954ValIle: 2.954 ± 0.024	2.886ValLys: 2.886 ± 0.023	5.812ValLeu: 5.812 ± 0.036	1.337ValMet: 1.337 ± 0.015	2.261ValAsn: 2.261 ± 0.02	3.659ValPro: 3.659 ± 0.026	2.477ValGln: 2.477 ± 0.023	3.507ValArg: 3.507 ± 0.027	4.819ValSer: 4.819 ± 0.034	3.6ValThr: 3.6 ± 0.029	4.601ValVal: 4.601 ± 0.036	0.926ValTrp: 0.926 ± 0.013	1.765ValTyr: 1.765 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.159TrpAla: 1.159 ± 0.015	0.202TrpCys: 0.202 ± 0.006	0.854TrpAsp: 0.854 ± 0.014	0.825TrpGlu: 0.825 ± 0.013	0.575TrpPhe: 0.575 ± 0.01	0.894TrpGly: 0.894 ± 0.015	0.392TrpHis: 0.392 ± 0.008	0.793TrpIle: 0.793 ± 0.013	0.793TrpLys: 0.793 ± 0.01	1.434TrpLeu: 1.434 ± 0.016	0.383TrpMet: 0.383 ± 0.008	0.61TrpAsn: 0.61 ± 0.011	0.64TrpPro: 0.64 ± 0.011	0.601TrpGln: 0.601 ± 0.01	0.996TrpArg: 0.996 ± 0.013	1.101TrpSer: 1.101 ± 0.013	1.027TrpThr: 1.027 ± 0.016	0.882TrpVal: 0.882 ± 0.014	0.289TrpTrp: 0.289 ± 0.008	0.461TrpTyr: 0.461 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.221TyrAla: 2.221 ± 0.024	0.424TyrCys: 0.424 ± 0.008	1.668TyrAsp: 1.668 ± 0.017	1.535TyrGlu: 1.535 ± 0.017	1.232TyrPhe: 1.232 ± 0.016	2.128TyrGly: 2.128 ± 0.021	0.781TyrHis: 0.781 ± 0.012	1.365TyrIle: 1.365 ± 0.017	1.083TyrLys: 1.083 ± 0.014	2.716TyrLeu: 2.716 ± 0.026	0.621TyrMet: 0.621 ± 0.01	1.085TyrAsn: 1.085 ± 0.016	1.48TyrPro: 1.48 ± 0.017	1.103TyrGln: 1.103 ± 0.015	1.637TyrArg: 1.637 ± 0.018	2.041TyrSer: 2.041 ± 0.021	1.63TyrThr: 1.63 ± 0.016	1.701TyrVal: 1.701 ± 0.018	0.453TyrTrp: 0.453 ± 0.009	0.919TyrTyr: 0.919 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 12047 proteins (5944843 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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