Amino acid dipepetide frequency for White sucker hepatitis B virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.201AlaAla: 5.201 ± 0.963
0.743AlaCys: 0.743 ± 0.436
2.972AlaAsp: 2.972 ± 0.886
1.486AlaGlu: 1.486 ± 0.819
3.715AlaPhe: 3.715 ± 2.057
0.743AlaGly: 0.743 ± 0.436
1.486AlaHis: 1.486 ± 0.493
2.972AlaIle: 2.972 ± 0.983
3.715AlaLys: 3.715 ± 1.552
11.144AlaLeu: 11.144 ± 0.904
0.743AlaMet: 0.743 ± 0.436
4.458AlaAsn: 4.458 ± 1.668
4.458AlaPro: 4.458 ± 0.547
2.972AlaGln: 2.972 ± 0.886
5.201AlaArg: 5.201 ± 3.472
7.429AlaSer: 7.429 ± 3.396
3.715AlaThr: 3.715 ± 1.298
5.201AlaVal: 5.201 ± 2.109
1.486AlaTrp: 1.486 ± 0.493
3.715AlaTyr: 3.715 ± 1.298
0.0AlaXaa: 0.0 ± 0.0
Cys
0.743CysAla: 0.743 ± 0.436
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.0CysGly: 0.0 ± 0.0
0.743CysHis: 0.743 ± 0.436
3.715CysIle: 3.715 ± 1.275
0.0CysLys: 0.0 ± 0.0
1.486CysLeu: 1.486 ± 2.091
0.0CysMet: 0.0 ± 0.0
0.743CysAsn: 0.743 ± 0.436
1.486CysPro: 1.486 ± 1.472
0.743CysGln: 0.743 ± 0.436
1.486CysArg: 1.486 ± 0.872
2.229CysSer: 2.229 ± 0.793
0.743CysThr: 0.743 ± 0.736
0.743CysVal: 0.743 ± 0.436
0.0CysTrp: 0.0 ± 0.0
1.486CysTyr: 1.486 ± 0.872
0.0CysXaa: 0.0 ± 0.0
Asp
1.486AspAla: 1.486 ± 0.872
0.743AspCys: 0.743 ± 0.736
1.486AspAsp: 1.486 ± 0.872
1.486AspGlu: 1.486 ± 1.298
3.715AspPhe: 3.715 ± 1.298
2.972AspGly: 2.972 ± 1.744
1.486AspHis: 1.486 ± 0.493
0.0AspIle: 0.0 ± 0.0
3.715AspLys: 3.715 ± 2.18
4.458AspLeu: 4.458 ± 0.565
0.0AspMet: 0.0 ± 0.0
0.743AspAsn: 0.743 ± 1.046
1.486AspPro: 1.486 ± 1.298
2.972AspGln: 2.972 ± 1.4
0.0AspArg: 0.0 ± 0.0
2.229AspSer: 2.229 ± 0.793
1.486AspThr: 1.486 ± 0.872
1.486AspVal: 1.486 ± 1.298
0.743AspTrp: 0.743 ± 0.736
0.0AspTyr: 0.0 ± 0.0
0.0AspXaa: 0.0 ± 0.0
Glu
3.715GluAla: 3.715 ± 0.969
0.743GluCys: 0.743 ± 0.436
0.0GluAsp: 0.0 ± 0.0
0.743GluGlu: 0.743 ± 0.736
0.0GluPhe: 0.0 ± 0.0
1.486GluGly: 1.486 ± 0.819
1.486GluHis: 1.486 ± 0.819
0.743GluIle: 0.743 ± 0.736
0.743GluLys: 0.743 ± 0.436
2.972GluLeu: 2.972 ± 0.985
0.743GluMet: 0.743 ± 1.046
0.743GluAsn: 0.743 ± 1.046
2.229GluPro: 2.229 ± 1.174
1.486GluGln: 1.486 ± 1.472
0.743GluArg: 0.743 ± 0.436
3.715GluSer: 3.715 ± 1.532
1.486GluThr: 1.486 ± 0.872
1.486GluVal: 1.486 ± 0.819
0.743GluTrp: 0.743 ± 0.436
1.486GluTyr: 1.486 ± 2.091
0.0GluXaa: 0.0 ± 0.0
Phe
2.229PheAla: 2.229 ± 0.793
0.0PheCys: 0.0 ± 0.0
0.743PheAsp: 0.743 ± 0.736
1.486PheGlu: 1.486 ± 0.872
1.486PhePhe: 1.486 ± 1.298
1.486PheGly: 1.486 ± 0.872
1.486PheHis: 1.486 ± 0.872
0.743PheIle: 0.743 ± 0.736
2.972PheLys: 2.972 ± 0.886
8.172PheLeu: 8.172 ± 3.987
0.743PheMet: 0.743 ± 0.617
0.743PheAsn: 0.743 ± 0.436
2.972PhePro: 2.972 ± 0.983
1.486PheGln: 1.486 ± 1.298
3.715PheArg: 3.715 ± 0.971
4.458PheSer: 4.458 ± 0.565
4.458PheThr: 4.458 ± 1.138
3.715PheVal: 3.715 ± 0.969
2.972PheTrp: 2.972 ± 0.886
2.229PheTyr: 2.229 ± 0.569
0.0PheXaa: 0.0 ± 0.0
Gly
1.486GlyAla: 1.486 ± 0.872
0.743GlyCys: 0.743 ± 1.046
0.743GlyAsp: 0.743 ± 1.046
0.743GlyGlu: 0.743 ± 1.046
4.458GlyPhe: 4.458 ± 1.138
1.486GlyGly: 1.486 ± 0.493
0.0GlyHis: 0.0 ± 0.0
1.486GlyIle: 1.486 ± 0.872
1.486GlyLys: 1.486 ± 0.493
7.429GlyLeu: 7.429 ± 2.244
0.0GlyMet: 0.0 ± 0.0
0.0GlyAsn: 0.0 ± 0.0
2.229GlyPro: 2.229 ± 1.308
2.229GlyGln: 2.229 ± 1.308
0.743GlyArg: 0.743 ± 0.436
8.915GlySer: 8.915 ± 2.814
2.972GlyThr: 2.972 ± 0.886
4.458GlyVal: 4.458 ± 1.586
0.0GlyTrp: 0.0 ± 0.0
0.743GlyTyr: 0.743 ± 0.436
0.0GlyXaa: 0.0 ± 0.0
His
0.0HisAla: 0.0 ± 0.0
0.743HisCys: 0.743 ± 0.436
2.229HisAsp: 2.229 ± 0.793
0.0HisGlu: 0.0 ± 0.0
3.715HisPhe: 3.715 ± 1.644
1.486HisGly: 1.486 ± 0.872
2.229HisHis: 2.229 ± 0.793
2.229HisIle: 2.229 ± 0.569
3.715HisLys: 3.715 ± 1.275
3.715HisLeu: 3.715 ± 0.301
0.743HisMet: 0.743 ± 0.436
0.743HisAsn: 0.743 ± 0.436
2.229HisPro: 2.229 ± 1.308
2.972HisGln: 2.972 ± 1.897
0.0HisArg: 0.0 ± 0.0
5.201HisSer: 5.201 ± 2.064
2.229HisThr: 2.229 ± 0.88
1.486HisVal: 1.486 ± 0.819
0.743HisTrp: 0.743 ± 0.436
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
3.715IleAla: 3.715 ± 0.301
0.0IleCys: 0.0 ± 0.0
0.0IleAsp: 0.0 ± 0.0
2.229IleGlu: 2.229 ± 2.24
5.944IlePhe: 5.944 ± 1.992
0.0IleGly: 0.0 ± 0.0
3.715IleHis: 3.715 ± 0.971
2.972IleIle: 2.972 ± 0.886
2.972IleLys: 2.972 ± 1.4
6.686IleLeu: 6.686 ± 0.811
0.743IleMet: 0.743 ± 0.736
1.486IleAsn: 1.486 ± 0.819
5.201IlePro: 5.201 ± 1.423
2.972IleGln: 2.972 ± 0.886
1.486IleArg: 1.486 ± 0.819
5.944IleSer: 5.944 ± 0.397
0.743IleThr: 0.743 ± 0.436
0.743IleVal: 0.743 ± 0.436
0.0IleTrp: 0.0 ± 0.0
1.486IleTyr: 1.486 ± 0.819
0.0IleXaa: 0.0 ± 0.0
Lys
7.429LysAla: 7.429 ± 0.603
0.0LysCys: 0.0 ± 0.0
2.972LysAsp: 2.972 ± 2.862
2.972LysGlu: 2.972 ± 0.983
0.0LysPhe: 0.0 ± 0.0
1.486LysGly: 1.486 ± 0.493
2.229LysHis: 2.229 ± 1.308
2.229LysIle: 2.229 ± 0.569
1.486LysLys: 1.486 ± 0.872
4.458LysLeu: 4.458 ± 1.759
0.0LysMet: 0.0 ± 0.0
2.972LysAsn: 2.972 ± 1.744
0.743LysPro: 0.743 ± 0.736
0.743LysGln: 0.743 ± 0.436
3.715LysArg: 3.715 ± 0.971
5.201LysSer: 5.201 ± 2.294
5.944LysThr: 5.944 ± 0.397
3.715LysVal: 3.715 ± 0.301
0.0LysTrp: 0.0 ± 0.0
2.229LysTyr: 2.229 ± 1.308
0.0LysXaa: 0.0 ± 0.0
Leu
10.401LeuAla: 10.401 ± 2.079
1.486LeuCys: 1.486 ± 0.493
3.715LeuAsp: 3.715 ± 0.969
2.972LeuGlu: 2.972 ± 1.869
4.458LeuPhe: 4.458 ± 1.687
5.944LeuGly: 5.944 ± 1.971
3.715LeuHis: 3.715 ± 1.275
5.944LeuIle: 5.944 ± 1.785
2.229LeuLys: 2.229 ± 0.88
14.859LeuLeu: 14.859 ± 1.678
2.972LeuMet: 2.972 ± 2.597
2.229LeuAsn: 2.229 ± 0.793
9.658LeuPro: 9.658 ± 3.544
8.915LeuGln: 8.915 ± 2.814
5.944LeuArg: 5.944 ± 1.966
9.658LeuSer: 9.658 ± 1.254
5.201LeuThr: 5.201 ± 0.196
7.429LeuVal: 7.429 ± 2.387
2.972LeuTrp: 2.972 ± 2.597
2.972LeuTyr: 2.972 ± 1.744
0.0LeuXaa: 0.0 ± 0.0
Met
0.743MetAla: 0.743 ± 0.736
0.0MetCys: 0.0 ± 0.0
2.972MetAsp: 2.972 ± 1.4
0.743MetGlu: 0.743 ± 0.736
1.486MetPhe: 1.486 ± 0.819
2.972MetGly: 2.972 ± 0.985
1.486MetHis: 1.486 ± 0.493
0.743MetIle: 0.743 ± 0.736
0.0MetLys: 0.0 ± 0.0
0.0MetLeu: 0.0 ± 0.0
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
2.229MetPro: 2.229 ± 1.308
0.743MetGln: 0.743 ± 0.736
0.0MetArg: 0.0 ± 0.0
0.743MetSer: 0.743 ± 1.046
2.229MetThr: 2.229 ± 1.833
0.0MetVal: 0.0 ± 0.0
0.743MetTrp: 0.743 ± 1.046
0.743MetTyr: 0.743 ± 0.436
0.0MetXaa: 0.0 ± 0.0
Asn
1.486AsnAla: 1.486 ± 0.819
2.229AsnCys: 2.229 ± 1.827
0.0AsnAsp: 0.0 ± 0.0
0.743AsnGlu: 0.743 ± 1.046
0.743AsnPhe: 0.743 ± 0.436
3.715AsnGly: 3.715 ± 1.532
0.743AsnHis: 0.743 ± 0.436
2.229AsnIle: 2.229 ± 0.569
0.743AsnLys: 0.743 ± 0.736
2.229AsnLeu: 2.229 ± 0.793
2.229AsnMet: 2.229 ± 0.569
0.743AsnAsn: 0.743 ± 1.046
2.972AsnPro: 2.972 ± 1.744
2.229AsnGln: 2.229 ± 0.793
1.486AsnArg: 1.486 ± 0.819
2.972AsnSer: 2.972 ± 1.744
1.486AsnThr: 1.486 ± 0.493
0.743AsnVal: 0.743 ± 0.436
1.486AsnTrp: 1.486 ± 0.819
0.743AsnTyr: 0.743 ± 0.436
0.0AsnXaa: 0.0 ± 0.0
Pro
4.458ProAla: 4.458 ± 1.687
1.486ProCys: 1.486 ± 0.872
2.229ProAsp: 2.229 ± 0.569
0.743ProGlu: 0.743 ± 0.436
4.458ProPhe: 4.458 ± 1.478
2.972ProGly: 2.972 ± 0.983
1.486ProHis: 1.486 ± 0.819
2.229ProIle: 2.229 ± 0.569
5.201ProLys: 5.201 ± 1.423
14.859ProLeu: 14.859 ± 2.734
0.0ProMet: 0.0 ± 0.0
3.715ProAsn: 3.715 ± 2.18
5.201ProPro: 5.201 ± 2.124
2.229ProGln: 2.229 ± 0.569
3.715ProArg: 3.715 ± 0.969
6.686ProSer: 6.686 ± 2.965
5.944ProThr: 5.944 ± 2.361
4.458ProVal: 4.458 ± 1.478
0.743ProTrp: 0.743 ± 0.436
0.0ProTyr: 0.0 ± 0.0
0.0ProXaa: 0.0 ± 0.0
Gln
2.972GlnAla: 2.972 ± 0.985
0.0GlnCys: 0.0 ± 0.0
1.486GlnAsp: 1.486 ± 0.872
0.743GlnGlu: 0.743 ± 0.436
2.972GlnPhe: 2.972 ± 0.492
3.715GlnGly: 3.715 ± 0.971
2.229GlnHis: 2.229 ± 0.569
0.743GlnIle: 0.743 ± 0.736
0.743GlnLys: 0.743 ± 0.436
2.972GlnLeu: 2.972 ± 0.492
0.0GlnMet: 0.0 ± 0.0
2.972GlnAsn: 2.972 ± 0.492
4.458GlnPro: 4.458 ± 1.478
3.715GlnGln: 3.715 ± 0.971
3.715GlnArg: 3.715 ± 0.971
4.458GlnSer: 4.458 ± 1.65
3.715GlnThr: 3.715 ± 2.057
1.486GlnVal: 1.486 ± 2.091
1.486GlnTrp: 1.486 ± 0.493
2.229GlnTyr: 2.229 ± 0.88
0.0GlnXaa: 0.0 ± 0.0
Arg
2.972ArgAla: 2.972 ± 0.983
1.486ArgCys: 1.486 ± 0.872
0.743ArgAsp: 0.743 ± 0.736
0.0ArgGlu: 0.0 ± 0.0
0.743ArgPhe: 0.743 ± 0.436
0.0ArgGly: 0.0 ± 0.0
2.229ArgHis: 2.229 ± 0.793
1.486ArgIle: 1.486 ± 0.872
2.229ArgLys: 2.229 ± 1.827
5.201ArgLeu: 5.201 ± 0.196
0.743ArgMet: 0.743 ± 0.736
2.972ArgAsn: 2.972 ± 0.492
2.972ArgPro: 2.972 ± 0.492
0.743ArgGln: 0.743 ± 0.436
5.944ArgArg: 5.944 ± 0.984
8.915ArgSer: 8.915 ± 2.517
7.429ArgThr: 7.429 ± 1.939
4.458ArgVal: 4.458 ± 1.687
0.743ArgTrp: 0.743 ± 0.736
0.743ArgTyr: 0.743 ± 0.436
0.0ArgXaa: 0.0 ± 0.0
Ser
6.686SerAla: 6.686 ± 2.965
2.972SerCys: 2.972 ± 1.744
2.972SerAsp: 2.972 ± 1.744
3.715SerGlu: 3.715 ± 1.275
3.715SerPhe: 3.715 ± 1.644
1.486SerGly: 1.486 ± 0.819
4.458SerHis: 4.458 ± 1.138
5.944SerIle: 5.944 ± 1.384
11.144SerLys: 11.144 ± 2.145
2.972SerLeu: 2.972 ± 0.492
2.229SerMet: 2.229 ± 0.808
3.715SerAsn: 3.715 ± 0.301
9.658SerPro: 9.658 ± 1.8
4.458SerGln: 4.458 ± 1.759
5.944SerArg: 5.944 ± 1.094
11.887SerSer: 11.887 ± 3.005
8.915SerThr: 8.915 ± 3.336
5.944SerVal: 5.944 ± 1.992
2.229SerTrp: 2.229 ± 0.88
5.201SerTyr: 5.201 ± 2.22
0.0SerXaa: 0.0 ± 0.0
Thr
9.658ThrAla: 9.658 ± 2.512
2.229ThrCys: 2.229 ± 1.174
2.972ThrAsp: 2.972 ± 0.886
2.229ThrGlu: 2.229 ± 1.174
2.972ThrPhe: 2.972 ± 1.744
4.458ThrGly: 4.458 ± 0.565
1.486ThrHis: 1.486 ± 0.819
6.686ThrIle: 6.686 ± 2.639
1.486ThrLys: 1.486 ± 0.493
7.429ThrLeu: 7.429 ± 3.396
2.229ThrMet: 2.229 ± 1.889
0.743ThrAsn: 0.743 ± 1.046
2.229ThrPro: 2.229 ± 0.793
0.743ThrGln: 0.743 ± 0.736
2.972ThrArg: 2.972 ± 0.983
8.172ThrSer: 8.172 ± 1.179
2.229ThrThr: 2.229 ± 1.174
4.458ThrVal: 4.458 ± 0.547
2.229ThrTrp: 2.229 ± 0.569
1.486ThrTyr: 1.486 ± 0.493
0.0ThrXaa: 0.0 ± 0.0
Val
5.944ValAla: 5.944 ± 1.384
0.743ValCys: 0.743 ± 0.436
2.972ValAsp: 2.972 ± 1.744
0.743ValGlu: 0.743 ± 1.046
3.715ValPhe: 3.715 ± 1.275
2.972ValGly: 2.972 ± 1.744
1.486ValHis: 1.486 ± 0.872
3.715ValIle: 3.715 ± 1.532
3.715ValLys: 3.715 ± 2.898
4.458ValLeu: 4.458 ± 2.754
0.743ValMet: 0.743 ± 0.736
0.743ValAsn: 0.743 ± 0.736
5.944ValPro: 5.944 ± 1.971
2.972ValGln: 2.972 ± 1.638
2.972ValArg: 2.972 ± 1.4
5.944ValSer: 5.944 ± 1.771
4.458ValThr: 4.458 ± 0.547
4.458ValVal: 4.458 ± 1.478
0.743ValTrp: 0.743 ± 0.736
0.0ValTyr: 0.0 ± 0.0
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
2.229TrpGlu: 2.229 ± 1.174
0.0TrpPhe: 0.0 ± 0.0
1.486TrpGly: 1.486 ± 0.819
1.486TrpHis: 1.486 ± 1.298
0.743TrpIle: 0.743 ± 0.436
0.743TrpLys: 0.743 ± 0.436
4.458TrpLeu: 4.458 ± 0.547
0.743TrpMet: 0.743 ± 0.736
0.0TrpAsn: 0.0 ± 0.0
2.229TrpPro: 2.229 ± 0.569
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.743TrpSer: 0.743 ± 1.046
1.486TrpThr: 1.486 ± 1.298
2.229TrpVal: 2.229 ± 0.569
1.486TrpTrp: 1.486 ± 1.298
1.486TrpTyr: 1.486 ± 0.493
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.229TyrAla: 2.229 ± 1.827
0.0TyrCys: 0.0 ± 0.0
1.486TyrAsp: 1.486 ± 0.819
1.486TyrGlu: 1.486 ± 0.493
0.0TyrPhe: 0.0 ± 0.0
1.486TyrGly: 1.486 ± 0.872
0.743TyrHis: 0.743 ± 0.436
1.486TyrIle: 1.486 ± 1.298
1.486TyrLys: 1.486 ± 0.872
3.715TyrLeu: 3.715 ± 1.275
2.229TyrMet: 2.229 ± 0.569
1.486TyrAsn: 1.486 ± 1.298
2.229TyrPro: 2.229 ± 1.308
1.486TyrGln: 1.486 ± 0.493
2.972TyrArg: 2.972 ± 0.983
1.486TyrSer: 1.486 ± 0.493
2.229TyrThr: 2.229 ± 0.793
0.743TyrVal: 0.743 ± 0.436
0.0TyrTrp: 0.0 ± 0.0
1.486TyrTyr: 1.486 ± 0.872
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (1347 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski