Amino acid dipepetide frequency for Conservatibacter flavescens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.917AlaAla: 6.917 ± 0.139
0.982AlaCys: 0.982 ± 0.037
4.192AlaAsp: 4.192 ± 0.081
5.741AlaGlu: 5.741 ± 0.116
3.435AlaPhe: 3.435 ± 0.073
5.796AlaGly: 5.796 ± 0.11
1.677AlaHis: 1.677 ± 0.049
6.294AlaIle: 6.294 ± 0.104
5.479AlaLys: 5.479 ± 0.105
10.098AlaLeu: 10.098 ± 0.127
2.374AlaMet: 2.374 ± 0.063
3.761AlaAsn: 3.761 ± 0.088
2.526AlaPro: 2.526 ± 0.055
4.234AlaGln: 4.234 ± 0.084
3.311AlaArg: 3.311 ± 0.072
4.097AlaSer: 4.097 ± 0.08
4.398AlaThr: 4.398 ± 0.112
6.02AlaVal: 6.02 ± 0.089
0.879AlaTrp: 0.879 ± 0.034
2.51AlaTyr: 2.51 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
0.843CysAla: 0.843 ± 0.035
0.178CysCys: 0.178 ± 0.017
0.51CysAsp: 0.51 ± 0.029
0.629CysGlu: 0.629 ± 0.034
0.466CysPhe: 0.466 ± 0.024
0.998CysGly: 0.998 ± 0.042
0.341CysHis: 0.341 ± 0.024
0.632CysIle: 0.632 ± 0.031
0.413CysLys: 0.413 ± 0.027
1.055CysLeu: 1.055 ± 0.039
0.181CysMet: 0.181 ± 0.016
0.34CysAsn: 0.34 ± 0.024
0.436CysPro: 0.436 ± 0.026
0.46CysGln: 0.46 ± 0.024
0.451CysArg: 0.451 ± 0.027
0.648CysSer: 0.648 ± 0.03
0.472CysThr: 0.472 ± 0.023
0.67CysVal: 0.67 ± 0.031
0.106CysTrp: 0.106 ± 0.012
0.388CysTyr: 0.388 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
3.107AspAla: 3.107 ± 0.065
0.484AspCys: 0.484 ± 0.029
2.428AspAsp: 2.428 ± 0.069
3.496AspGlu: 3.496 ± 0.075
2.483AspPhe: 2.483 ± 0.063
3.173AspGly: 3.173 ± 0.092
0.994AspHis: 0.994 ± 0.046
4.094AspIle: 4.094 ± 0.079
3.155AspLys: 3.155 ± 0.081
5.071AspLeu: 5.071 ± 0.08
1.22AspMet: 1.22 ± 0.041
2.53AspAsn: 2.53 ± 0.071
2.041AspPro: 2.041 ± 0.052
1.602AspGln: 1.602 ± 0.043
2.066AspArg: 2.066 ± 0.053
2.642AspSer: 2.642 ± 0.066
2.435AspThr: 2.435 ± 0.077
3.529AspVal: 3.529 ± 0.071
0.796AspTrp: 0.796 ± 0.032
2.195AspTyr: 2.195 ± 0.059
0.0AspXaa: 0.0 ± 0.0
Glu
4.84GluAla: 4.84 ± 0.1
0.431GluCys: 0.431 ± 0.026
2.455GluAsp: 2.455 ± 0.062
3.69GluGlu: 3.69 ± 0.097
2.273GluPhe: 2.273 ± 0.053
3.154GluGly: 3.154 ± 0.074
1.465GluHis: 1.465 ± 0.052
4.477GluIle: 4.477 ± 0.084
4.816GluLys: 4.816 ± 0.105
6.41GluLeu: 6.41 ± 0.112
1.665GluMet: 1.665 ± 0.05
3.566GluAsn: 3.566 ± 0.074
1.808GluPro: 1.808 ± 0.05
4.261GluGln: 4.261 ± 0.093
3.213GluArg: 3.213 ± 0.068
2.977GluSer: 2.977 ± 0.069
2.947GluThr: 2.947 ± 0.07
3.773GluVal: 3.773 ± 0.077
0.682GluTrp: 0.682 ± 0.035
1.823GluTyr: 1.823 ± 0.048
0.0GluXaa: 0.0 ± 0.0
Phe
3.744PheAla: 3.744 ± 0.084
0.582PheCys: 0.582 ± 0.025
2.638PheAsp: 2.638 ± 0.065
2.536PheGlu: 2.536 ± 0.061
2.084PhePhe: 2.084 ± 0.067
3.323PheGly: 3.323 ± 0.071
0.906PheHis: 0.906 ± 0.035
3.327PheIle: 3.327 ± 0.082
2.102PheLys: 2.102 ± 0.059
3.997PheLeu: 3.997 ± 0.094
1.099PheMet: 1.099 ± 0.038
2.201PheAsn: 2.201 ± 0.067
1.52PhePro: 1.52 ± 0.046
1.483PheGln: 1.483 ± 0.039
1.494PheArg: 1.494 ± 0.042
3.216PheSer: 3.216 ± 0.065
2.283PheThr: 2.283 ± 0.059
3.006PheVal: 3.006 ± 0.075
0.559PheTrp: 0.559 ± 0.032
1.538PheTyr: 1.538 ± 0.047
0.0PheXaa: 0.0 ± 0.0
Gly
5.397GlyAla: 5.397 ± 0.145
0.803GlyCys: 0.803 ± 0.037
3.292GlyAsp: 3.292 ± 0.103
4.325GlyGlu: 4.325 ± 0.084
3.175GlyPhe: 3.175 ± 0.066
4.728GlyGly: 4.728 ± 0.106
1.466GlyHis: 1.466 ± 0.044
5.632GlyIle: 5.632 ± 0.093
4.562GlyLys: 4.562 ± 0.084
7.035GlyLeu: 7.035 ± 0.107
1.9GlyMet: 1.9 ± 0.046
2.899GlyAsn: 2.899 ± 0.088
1.315GlyPro: 1.315 ± 0.074
2.715GlyGln: 2.715 ± 0.064
2.938GlyArg: 2.938 ± 0.071
3.661GlySer: 3.661 ± 0.082
3.466GlyThr: 3.466 ± 0.09
5.123GlyVal: 5.123 ± 0.087
0.87GlyTrp: 0.87 ± 0.037
2.559GlyTyr: 2.559 ± 0.056
0.0GlyXaa: 0.0 ± 0.0
His
1.606HisAla: 1.606 ± 0.048
0.374HisCys: 0.374 ± 0.021
1.056HisAsp: 1.056 ± 0.048
1.107HisGlu: 1.107 ± 0.043
1.238HisPhe: 1.238 ± 0.042
1.451HisGly: 1.451 ± 0.047
0.696HisHis: 0.696 ± 0.033
1.786HisIle: 1.786 ± 0.045
1.133HisLys: 1.133 ± 0.039
2.442HisLeu: 2.442 ± 0.055
0.457HisMet: 0.457 ± 0.023
1.071HisAsn: 1.071 ± 0.037
1.016HisPro: 1.016 ± 0.041
1.222HisGln: 1.222 ± 0.044
1.023HisArg: 1.023 ± 0.036
1.462HisSer: 1.462 ± 0.05
1.162HisThr: 1.162 ± 0.048
1.196HisVal: 1.196 ± 0.039
0.35HisTrp: 0.35 ± 0.022
0.992HisTyr: 0.992 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
6.916IleAla: 6.916 ± 0.098
0.87IleCys: 0.87 ± 0.037
4.107IleAsp: 4.107 ± 0.07
4.566IleGlu: 4.566 ± 0.099
2.979IlePhe: 2.979 ± 0.075
5.391IleGly: 5.391 ± 0.097
1.549IleHis: 1.549 ± 0.051
4.872IleIle: 4.872 ± 0.098
3.743IleLys: 3.743 ± 0.071
6.826IleLeu: 6.826 ± 0.129
1.434IleMet: 1.434 ± 0.046
3.325IleAsn: 3.325 ± 0.079
2.958IlePro: 2.958 ± 0.069
2.978IleGln: 2.978 ± 0.07
2.951IleArg: 2.951 ± 0.067
4.645IleSer: 4.645 ± 0.087
3.997IleThr: 3.997 ± 0.078
4.571IleVal: 4.571 ± 0.084
0.778IleTrp: 0.778 ± 0.033
2.249IleTyr: 2.249 ± 0.061
0.0IleXaa: 0.0 ± 0.0
Lys
4.971LysAla: 4.971 ± 0.104
0.382LysCys: 0.382 ± 0.026
2.681LysAsp: 2.681 ± 0.062
3.535LysGlu: 3.535 ± 0.082
1.852LysPhe: 1.852 ± 0.051
3.817LysGly: 3.817 ± 0.091
1.296LysHis: 1.296 ± 0.049
4.085LysIle: 4.085 ± 0.07
3.639LysLys: 3.639 ± 0.088
5.643LysLeu: 5.643 ± 0.09
1.754LysMet: 1.754 ± 0.049
3.114LysAsn: 3.114 ± 0.074
2.231LysPro: 2.231 ± 0.056
3.159LysGln: 3.159 ± 0.08
2.749LysArg: 2.749 ± 0.068
3.163LysSer: 3.163 ± 0.071
3.336LysThr: 3.336 ± 0.072
3.739LysVal: 3.739 ± 0.08
0.606LysTrp: 0.606 ± 0.029
1.738LysTyr: 1.738 ± 0.051
0.0LysXaa: 0.0 ± 0.0
Leu
9.813LeuAla: 9.813 ± 0.112
1.13LeuCys: 1.13 ± 0.041
5.449LeuAsp: 5.449 ± 0.095
5.584LeuGlu: 5.584 ± 0.098
4.784LeuPhe: 4.784 ± 0.101
7.253LeuGly: 7.253 ± 0.117
2.167LeuHis: 2.167 ± 0.059
7.086LeuIle: 7.086 ± 0.133
5.601LeuLys: 5.601 ± 0.091
11.041LeuLeu: 11.041 ± 0.185
2.531LeuMet: 2.531 ± 0.075
5.196LeuAsn: 5.196 ± 0.1
4.744LeuPro: 4.744 ± 0.075
4.504LeuGln: 4.504 ± 0.087
4.572LeuArg: 4.572 ± 0.087
7.603LeuSer: 7.603 ± 0.132
6.169LeuThr: 6.169 ± 0.1
6.511LeuVal: 6.511 ± 0.1
1.189LeuTrp: 1.189 ± 0.041
2.895LeuTyr: 2.895 ± 0.063
0.0LeuXaa: 0.0 ± 0.0
Met
2.321MetAla: 2.321 ± 0.063
0.205MetCys: 0.205 ± 0.015
1.002MetAsp: 1.002 ± 0.038
1.123MetGlu: 1.123 ± 0.041
0.902MetPhe: 0.902 ± 0.043
1.658MetGly: 1.658 ± 0.046
0.459MetHis: 0.459 ± 0.023
1.631MetIle: 1.631 ± 0.051
1.672MetLys: 1.672 ± 0.045
2.677MetLeu: 2.677 ± 0.059
0.775MetMet: 0.775 ± 0.036
1.189MetAsn: 1.189 ± 0.036
1.087MetPro: 1.087 ± 0.032
1.249MetGln: 1.249 ± 0.038
1.083MetArg: 1.083 ± 0.035
1.662MetSer: 1.662 ± 0.045
1.52MetThr: 1.52 ± 0.037
1.493MetVal: 1.493 ± 0.045
0.228MetTrp: 0.228 ± 0.018
0.542MetTyr: 0.542 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
4.021AsnAla: 4.021 ± 0.083
0.397AsnCys: 0.397 ± 0.027
2.153AsnAsp: 2.153 ± 0.059
2.627AsnGlu: 2.627 ± 0.065
1.73AsnPhe: 1.73 ± 0.046
3.22AsnGly: 3.22 ± 0.094
1.099AsnHis: 1.099 ± 0.043
3.598AsnIle: 3.598 ± 0.068
2.687AsnLys: 2.687 ± 0.063
4.757AsnLeu: 4.757 ± 0.08
1.107AsnMet: 1.107 ± 0.035
2.485AsnAsn: 2.485 ± 0.084
2.405AsnPro: 2.405 ± 0.059
2.558AsnGln: 2.558 ± 0.093
2.095AsnArg: 2.095 ± 0.058
2.431AsnSer: 2.431 ± 0.065
2.636AsnThr: 2.636 ± 0.072
3.125AsnVal: 3.125 ± 0.084
0.651AsnTrp: 0.651 ± 0.03
1.606AsnTyr: 1.606 ± 0.058
0.0AsnXaa: 0.0 ± 0.0
Pro
2.795ProAla: 2.795 ± 0.069
0.293ProCys: 0.293 ± 0.02
1.938ProAsp: 1.938 ± 0.048
2.855ProGlu: 2.855 ± 0.061
1.84ProPhe: 1.84 ± 0.051
1.631ProGly: 1.631 ± 0.059
1.066ProHis: 1.066 ± 0.04
2.819ProIle: 2.819 ± 0.058
2.108ProLys: 2.108 ± 0.052
3.893ProLeu: 3.893 ± 0.079
1.029ProMet: 1.029 ± 0.033
2.168ProAsn: 2.168 ± 0.06
1.137ProPro: 1.137 ± 0.038
1.958ProGln: 1.958 ± 0.071
1.335ProArg: 1.335 ± 0.05
2.118ProSer: 2.118 ± 0.051
2.336ProThr: 2.336 ± 0.074
2.649ProVal: 2.649 ± 0.061
0.356ProTrp: 0.356 ± 0.022
1.419ProTyr: 1.419 ± 0.048
0.0ProXaa: 0.0 ± 0.0
Gln
4.604GlnAla: 4.604 ± 0.075
0.441GlnCys: 0.441 ± 0.027
2.241GlnAsp: 2.241 ± 0.055
2.614GlnGlu: 2.614 ± 0.069
2.121GlnPhe: 2.121 ± 0.056
3.389GlnGly: 3.389 ± 0.121
1.39GlnHis: 1.39 ± 0.045
3.147GlnIle: 3.147 ± 0.073
2.826GlnLys: 2.826 ± 0.06
5.309GlnLeu: 5.309 ± 0.106
1.052GlnMet: 1.052 ± 0.039
2.234GlnAsn: 2.234 ± 0.059
1.82GlnPro: 1.82 ± 0.059
3.702GlnGln: 3.702 ± 0.125
2.439GlnArg: 2.439 ± 0.07
2.696GlnSer: 2.696 ± 0.069
2.473GlnThr: 2.473 ± 0.077
2.968GlnVal: 2.968 ± 0.068
0.706GlnTrp: 0.706 ± 0.032
1.638GlnTyr: 1.638 ± 0.046
0.0GlnXaa: 0.0 ± 0.0
Arg
3.177ArgAla: 3.177 ± 0.073
0.429ArgCys: 0.429 ± 0.026
2.125ArgAsp: 2.125 ± 0.052
2.951ArgGlu: 2.951 ± 0.07
2.255ArgPhe: 2.255 ± 0.059
2.504ArgGly: 2.504 ± 0.056
1.147ArgHis: 1.147 ± 0.039
3.107ArgIle: 3.107 ± 0.053
2.364ArgLys: 2.364 ± 0.06
4.98ArgLeu: 4.98 ± 0.094
0.994ArgMet: 0.994 ± 0.035
1.95ArgAsn: 1.95 ± 0.046
1.521ArgPro: 1.521 ± 0.046
2.378ArgGln: 2.378 ± 0.064
2.061ArgArg: 2.061 ± 0.054
2.26ArgSer: 2.26 ± 0.055
2.196ArgThr: 2.196 ± 0.056
2.802ArgVal: 2.802 ± 0.065
0.584ArgTrp: 0.584 ± 0.025
1.839ArgTyr: 1.839 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
5.402SerAla: 5.402 ± 0.086
0.515SerCys: 0.515 ± 0.026
2.897SerAsp: 2.897 ± 0.062
3.286SerGlu: 3.286 ± 0.069
2.603SerPhe: 2.603 ± 0.06
4.475SerGly: 4.475 ± 0.092
1.462SerHis: 1.462 ± 0.045
3.937SerIle: 3.937 ± 0.079
2.756SerLys: 2.756 ± 0.053
6.428SerLeu: 6.428 ± 0.105
1.337SerMet: 1.337 ± 0.043
2.366SerAsn: 2.366 ± 0.064
2.351SerPro: 2.351 ± 0.056
2.958SerGln: 2.958 ± 0.075
2.527SerArg: 2.527 ± 0.052
3.419SerSer: 3.419 ± 0.081
3.069SerThr: 3.069 ± 0.081
3.925SerVal: 3.925 ± 0.083
0.698SerTrp: 0.698 ± 0.031
1.848SerTyr: 1.848 ± 0.051
0.0SerXaa: 0.0 ± 0.0
Thr
5.041ThrAla: 5.041 ± 0.088
0.415ThrCys: 0.415 ± 0.026
2.655ThrAsp: 2.655 ± 0.069
3.441ThrGlu: 3.441 ± 0.07
2.319ThrPhe: 2.319 ± 0.052
4.093ThrGly: 4.093 ± 0.141
1.248ThrHis: 1.248 ± 0.048
3.565ThrIle: 3.565 ± 0.085
2.495ThrLys: 2.495 ± 0.058
6.053ThrLeu: 6.053 ± 0.106
1.041ThrMet: 1.041 ± 0.036
2.123ThrAsn: 2.123 ± 0.063
2.603ThrPro: 2.603 ± 0.068
2.741ThrGln: 2.741 ± 0.075
2.078ThrArg: 2.078 ± 0.054
2.778ThrSer: 2.778 ± 0.08
2.975ThrThr: 2.975 ± 0.094
3.589ThrVal: 3.589 ± 0.102
0.668ThrTrp: 0.668 ± 0.028
1.529ThrTyr: 1.529 ± 0.049
0.0ThrXaa: 0.0 ± 0.0
Val
5.664ValAla: 5.664 ± 0.102
0.695ValCys: 0.695 ± 0.03
3.534ValAsp: 3.534 ± 0.08
4.356ValGlu: 4.356 ± 0.074
2.814ValPhe: 2.814 ± 0.063
4.718ValGly: 4.718 ± 0.087
1.124ValHis: 1.124 ± 0.039
4.9ValIle: 4.9 ± 0.075
3.908ValLys: 3.908 ± 0.082
6.739ValLeu: 6.739 ± 0.106
1.724ValMet: 1.724 ± 0.052
3.118ValAsn: 3.118 ± 0.084
2.5ValPro: 2.5 ± 0.059
2.513ValGln: 2.513 ± 0.064
2.793ValArg: 2.793 ± 0.068
4.3ValSer: 4.3 ± 0.077
3.418ValThr: 3.418 ± 0.093
4.743ValVal: 4.743 ± 0.091
0.63ValTrp: 0.63 ± 0.029
1.823ValTyr: 1.823 ± 0.046
0.0ValXaa: 0.0 ± 0.0
Trp
0.888TrpAla: 0.888 ± 0.037
0.149TrpCys: 0.149 ± 0.014
0.559TrpAsp: 0.559 ± 0.026
0.61TrpGlu: 0.61 ± 0.027
0.625TrpPhe: 0.625 ± 0.028
0.753TrpGly: 0.753 ± 0.034
0.31TrpHis: 0.31 ± 0.022
0.789TrpIle: 0.789 ± 0.031
0.633TrpLys: 0.633 ± 0.03
1.671TrpLeu: 1.671 ± 0.052
0.195TrpMet: 0.195 ± 0.015
0.491TrpAsn: 0.491 ± 0.026
0.227TrpPro: 0.227 ± 0.015
1.051TrpGln: 1.051 ± 0.045
0.633TrpArg: 0.633 ± 0.028
0.604TrpSer: 0.604 ± 0.03
0.533TrpThr: 0.533 ± 0.026
0.766TrpVal: 0.766 ± 0.032
0.169TrpTrp: 0.169 ± 0.014
0.342TrpTyr: 0.342 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.654TyrAla: 2.654 ± 0.06
0.461TyrCys: 0.461 ± 0.024
1.63TyrAsp: 1.63 ± 0.047
1.654TyrGlu: 1.654 ± 0.043
1.658TyrPhe: 1.658 ± 0.052
2.337TyrGly: 2.337 ± 0.064
0.978TyrHis: 0.978 ± 0.039
1.925TyrIle: 1.925 ± 0.054
1.397TyrLys: 1.397 ± 0.045
3.698TyrLeu: 3.698 ± 0.077
0.607TyrMet: 0.607 ± 0.03
1.262TyrAsn: 1.262 ± 0.045
1.499TyrPro: 1.499 ± 0.046
2.084TyrGln: 2.084 ± 0.055
1.814TyrArg: 1.814 ± 0.048
1.875TyrSer: 1.875 ± 0.045
1.63TyrThr: 1.63 ± 0.049
1.816TyrVal: 1.816 ± 0.049
0.492TyrTrp: 0.492 ± 0.026
1.208TyrTyr: 1.208 ± 0.044
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2416 proteins (780385 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski