Amino acid dipepetide frequency for Thalassomonas sp. M1454

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.749AlaAla: 6.749 ± 0.107	0.948AlaCys: 0.948 ± 0.029	4.853AlaAsp: 4.853 ± 0.067	5.186AlaGlu: 5.186 ± 0.078	3.375AlaPhe: 3.375 ± 0.066	5.526AlaGly: 5.526 ± 0.076	1.46AlaHis: 1.46 ± 0.04	6.322AlaIle: 6.322 ± 0.084	5.711AlaLys: 5.711 ± 0.1	8.415AlaLeu: 8.415 ± 0.108	2.269AlaMet: 2.269 ± 0.048	4.321AlaAsn: 4.321 ± 0.073	2.738AlaPro: 2.738 ± 0.052	3.679AlaGln: 3.679 ± 0.061	2.849AlaArg: 2.849 ± 0.056	5.285AlaSer: 5.285 ± 0.069	4.531AlaThr: 4.531 ± 0.084	5.36AlaVal: 5.36 ± 0.074	0.872AlaTrp: 0.872 ± 0.032	2.328AlaTyr: 2.328 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.753CysAla: 0.753 ± 0.026	0.15CysCys: 0.15 ± 0.012	0.618CysAsp: 0.618 ± 0.027	0.575CysGlu: 0.575 ± 0.023	0.453CysPhe: 0.453 ± 0.018	0.841CysGly: 0.841 ± 0.033	0.317CysHis: 0.317 ± 0.019	0.715CysIle: 0.715 ± 0.03	0.499CysLys: 0.499 ± 0.022	0.898CysLeu: 0.898 ± 0.03	0.19CysMet: 0.19 ± 0.012	0.453CysAsn: 0.453 ± 0.023	0.421CysPro: 0.421 ± 0.02	0.443CysGln: 0.443 ± 0.023	0.348CysArg: 0.348 ± 0.018	0.777CysSer: 0.777 ± 0.032	0.491CysThr: 0.491 ± 0.023	0.581CysVal: 0.581 ± 0.021	0.109CysTrp: 0.109 ± 0.01	0.291CysTyr: 0.291 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.347AspAla: 4.347 ± 0.071	0.609AspCys: 0.609 ± 0.024	3.635AspAsp: 3.635 ± 0.07	4.068AspGlu: 4.068 ± 0.069	2.796AspPhe: 2.796 ± 0.053	3.919AspGly: 3.919 ± 0.083	1.069AspHis: 1.069 ± 0.032	4.615AspIle: 4.615 ± 0.069	3.868AspLys: 3.868 ± 0.063	5.463AspLeu: 5.463 ± 0.074	1.425AspMet: 1.425 ± 0.034	3.236AspAsn: 3.236 ± 0.053	1.949AspPro: 1.949 ± 0.048	1.727AspGln: 1.727 ± 0.042	1.858AspArg: 1.858 ± 0.049	3.663AspSer: 3.663 ± 0.067	2.747AspThr: 2.747 ± 0.052	4.031AspVal: 4.031 ± 0.068	0.787AspTrp: 0.787 ± 0.024	2.238AspTyr: 2.238 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	4.233GluAla: 4.233 ± 0.067	0.436GluCys: 0.436 ± 0.02	3.051GluAsp: 3.051 ± 0.058	3.733GluGlu: 3.733 ± 0.083	2.9GluPhe: 2.9 ± 0.05	3.283GluGly: 3.283 ± 0.058	1.644GluHis: 1.644 ± 0.036	4.25GluIle: 4.25 ± 0.07	3.788GluLys: 3.788 ± 0.071	7.052GluLeu: 7.052 ± 0.092	1.546GluMet: 1.546 ± 0.041	3.343GluAsn: 3.343 ± 0.056	1.802GluPro: 1.802 ± 0.044	4.54GluGln: 4.54 ± 0.079	2.605GluArg: 2.605 ± 0.059	3.535GluSer: 3.535 ± 0.065	3.002GluThr: 3.002 ± 0.052	4.29GluVal: 4.29 ± 0.079	0.572GluTrp: 0.572 ± 0.022	1.94GluTyr: 1.94 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.942PheAla: 3.942 ± 0.077	0.505PheCys: 0.505 ± 0.022	3.052PheAsp: 3.052 ± 0.052	2.558PheGlu: 2.558 ± 0.05	1.9PhePhe: 1.9 ± 0.047	3.157PheGly: 3.157 ± 0.058	0.815PheHis: 0.815 ± 0.026	3.543PheIle: 3.543 ± 0.063	2.481PheLys: 2.481 ± 0.046	3.429PheLeu: 3.429 ± 0.06	1.027PheMet: 1.027 ± 0.034	2.701PheAsn: 2.701 ± 0.049	1.438PhePro: 1.438 ± 0.041	1.134PheGln: 1.134 ± 0.035	1.313PheArg: 1.313 ± 0.035	3.632PheSer: 3.632 ± 0.064	2.654PheThr: 2.654 ± 0.047	2.791PheVal: 2.791 ± 0.059	0.521PheTrp: 0.521 ± 0.025	1.596PheTyr: 1.596 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	4.946GlyAla: 4.946 ± 0.08	0.809GlyCys: 0.809 ± 0.028	3.731GlyAsp: 3.731 ± 0.064	4.144GlyGlu: 4.144 ± 0.066	3.497GlyPhe: 3.497 ± 0.056	4.59GlyGly: 4.59 ± 0.084	1.415GlyHis: 1.415 ± 0.033	4.725GlyIle: 4.725 ± 0.068	4.25GlyLys: 4.25 ± 0.069	6.405GlyLeu: 6.405 ± 0.085	1.767GlyMet: 1.767 ± 0.044	2.914GlyAsn: 2.914 ± 0.066	1.684GlyPro: 1.684 ± 0.047	2.405GlyGln: 2.405 ± 0.044	2.564GlyArg: 2.564 ± 0.058	4.171GlySer: 4.171 ± 0.067	3.318GlyThr: 3.318 ± 0.059	4.875GlyVal: 4.875 ± 0.075	0.885GlyTrp: 0.885 ± 0.029	2.463GlyTyr: 2.463 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	1.373HisAla: 1.373 ± 0.035	0.282HisCys: 0.282 ± 0.014	0.99HisAsp: 0.99 ± 0.031	0.999HisGlu: 0.999 ± 0.028	1.043HisPhe: 1.043 ± 0.029	1.459HisGly: 1.459 ± 0.039	0.569HisHis: 0.569 ± 0.024	1.389HisIle: 1.389 ± 0.032	1.247HisLys: 1.247 ± 0.035	2.112HisLeu: 2.112 ± 0.049	0.471HisMet: 0.471 ± 0.021	1.045HisAsn: 1.045 ± 0.033	0.975HisPro: 0.975 ± 0.029	1.066HisGln: 1.066 ± 0.031	0.812HisArg: 0.812 ± 0.027	1.34HisSer: 1.34 ± 0.035	0.982HisThr: 0.982 ± 0.031	1.202HisVal: 1.202 ± 0.035	0.32HisTrp: 0.32 ± 0.015	0.778HisTyr: 0.778 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.846IleAla: 6.846 ± 0.104	0.77IleCys: 0.77 ± 0.027	4.963IleAsp: 4.963 ± 0.072	5.002IleGlu: 5.002 ± 0.067	2.761IlePhe: 2.761 ± 0.054	4.651IleGly: 4.651 ± 0.081	1.233IleHis: 1.233 ± 0.034	4.51IleIle: 4.51 ± 0.068	4.538IleLys: 4.538 ± 0.072	5.568IleLeu: 5.568 ± 0.083	1.425IleMet: 1.425 ± 0.043	4.256IleAsn: 4.256 ± 0.064	2.618IlePro: 2.618 ± 0.048	2.08IleGln: 2.08 ± 0.046	2.528IleArg: 2.528 ± 0.05	5.275IleSer: 5.275 ± 0.078	4.237IleThr: 4.237 ± 0.066	4.306IleVal: 4.306 ± 0.064	0.699IleTrp: 0.699 ± 0.027	2.011IleTyr: 2.011 ± 0.048	0.001IleXaa: 0.001 ± 0.001
Lys	5.384LysAla: 5.384 ± 0.082	0.377LysCys: 0.377 ± 0.022	3.22LysAsp: 3.22 ± 0.047	3.589LysGlu: 3.589 ± 0.064	2.267LysPhe: 2.267 ± 0.042	3.374LysGly: 3.374 ± 0.057	1.479LysHis: 1.479 ± 0.037	3.835LysIle: 3.835 ± 0.059	3.501LysLys: 3.501 ± 0.07	6.233LysLeu: 6.233 ± 0.097	1.489LysMet: 1.489 ± 0.037	2.915LysAsn: 2.915 ± 0.062	2.552LysPro: 2.552 ± 0.047	3.751LysGln: 3.751 ± 0.072	2.568LysArg: 2.568 ± 0.049	3.901LysSer: 3.901 ± 0.057	3.365LysThr: 3.365 ± 0.055	4.466LysVal: 4.466 ± 0.063	0.586LysTrp: 0.586 ± 0.026	1.818LysTyr: 1.818 ± 0.05	0.0LysXaa: 0.0 ± 0.0
Leu	9.474LeuAla: 9.474 ± 0.104	0.929LeuCys: 0.929 ± 0.031	5.513LeuAsp: 5.513 ± 0.081	5.628LeuGlu: 5.628 ± 0.083	4.232LeuPhe: 4.232 ± 0.067	6.332LeuGly: 6.332 ± 0.088	1.792LeuHis: 1.792 ± 0.044	6.791LeuIle: 6.791 ± 0.095	5.788LeuLys: 5.788 ± 0.071	9.804LeuLeu: 9.804 ± 0.135	2.42LeuMet: 2.42 ± 0.053	5.259LeuAsn: 5.259 ± 0.078	4.308LeuPro: 4.308 ± 0.06	3.568LeuGln: 3.568 ± 0.072	3.463LeuArg: 3.463 ± 0.06	7.574LeuSer: 7.574 ± 0.103	6.293LeuThr: 6.293 ± 0.077	6.571LeuVal: 6.571 ± 0.084	0.939LeuTrp: 0.939 ± 0.034	2.646LeuTyr: 2.646 ± 0.046	0.001LeuXaa: 0.001 ± 0.001
Met	2.294MetAla: 2.294 ± 0.046	0.181MetCys: 0.181 ± 0.013	1.15MetAsp: 1.15 ± 0.035	1.085MetGlu: 1.085 ± 0.033	0.977MetPhe: 0.977 ± 0.031	1.594MetGly: 1.594 ± 0.045	0.485MetHis: 0.485 ± 0.022	1.446MetIle: 1.446 ± 0.039	1.435MetLys: 1.435 ± 0.037	2.503MetLeu: 2.503 ± 0.05	0.647MetMet: 0.647 ± 0.029	1.187MetAsn: 1.187 ± 0.03	1.191MetPro: 1.191 ± 0.033	1.204MetGln: 1.204 ± 0.039	0.969MetArg: 0.969 ± 0.033	1.819MetSer: 1.819 ± 0.047	1.441MetThr: 1.441 ± 0.038	1.645MetVal: 1.645 ± 0.041	0.207MetTrp: 0.207 ± 0.012	0.557MetTyr: 0.557 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.804AsnAla: 3.804 ± 0.065	0.509AsnCys: 0.509 ± 0.023	3.077AsnAsp: 3.077 ± 0.058	3.125AsnGlu: 3.125 ± 0.059	2.185AsnPhe: 2.185 ± 0.045	3.278AsnGly: 3.278 ± 0.061	1.02AsnHis: 1.02 ± 0.032	3.858AsnIle: 3.858 ± 0.056	3.569AsnLys: 3.569 ± 0.06	5.005AsnLeu: 5.005 ± 0.078	1.083AsnMet: 1.083 ± 0.032	3.054AsnAsn: 3.054 ± 0.073	2.163AsnPro: 2.163 ± 0.047	2.137AsnGln: 2.137 ± 0.046	1.868AsnArg: 1.868 ± 0.046	3.476AsnSer: 3.476 ± 0.061	2.763AsnThr: 2.763 ± 0.054	3.203AsnVal: 3.203 ± 0.058	0.691AsnTrp: 0.691 ± 0.027	1.829AsnTyr: 1.829 ± 0.05	0.0AsnXaa: 0.0 ± 0.0
Pro	2.745ProAla: 2.745 ± 0.053	0.289ProCys: 0.289 ± 0.017	2.182ProAsp: 2.182 ± 0.053	3.077ProGlu: 3.077 ± 0.049	1.634ProPhe: 1.634 ± 0.04	2.361ProGly: 2.361 ± 0.049	0.74ProHis: 0.74 ± 0.027	2.574ProIle: 2.574 ± 0.056	2.216ProLys: 2.216 ± 0.045	3.593ProLeu: 3.593 ± 0.064	0.892ProMet: 0.892 ± 0.031	1.89ProAsn: 1.89 ± 0.048	0.918ProPro: 0.918 ± 0.034	1.434ProGln: 1.434 ± 0.04	1.155ProArg: 1.155 ± 0.036	2.384ProSer: 2.384 ± 0.055	2.109ProThr: 2.109 ± 0.041	2.866ProVal: 2.866 ± 0.054	0.469ProTrp: 0.469 ± 0.021	1.194ProTyr: 1.194 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.154GlnAla: 4.154 ± 0.073	0.391GlnCys: 0.391 ± 0.018	2.049GlnAsp: 2.049 ± 0.045	2.397GlnGlu: 2.397 ± 0.052	1.659GlnPhe: 1.659 ± 0.04	2.862GlnGly: 2.862 ± 0.048	1.014GlnHis: 1.014 ± 0.032	2.655GlnIle: 2.655 ± 0.06	2.294GlnLys: 2.294 ± 0.054	5.002GlnLeu: 5.002 ± 0.084	1.018GlnMet: 1.018 ± 0.034	1.844GlnAsn: 1.844 ± 0.043	1.528GlnPro: 1.528 ± 0.04	3.248GlnGln: 3.248 ± 0.088	1.796GlnArg: 1.796 ± 0.037	2.602GlnSer: 2.602 ± 0.048	2.235GlnThr: 2.235 ± 0.056	3.168GlnVal: 3.168 ± 0.048	0.603GlnTrp: 0.603 ± 0.024	1.476GlnTyr: 1.476 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	2.814ArgAla: 2.814 ± 0.051	0.357ArgCys: 0.357 ± 0.017	2.106ArgAsp: 2.106 ± 0.045	2.369ArgGlu: 2.369 ± 0.053	1.882ArgPhe: 1.882 ± 0.043	2.249ArgGly: 2.249 ± 0.047	0.772ArgHis: 0.772 ± 0.029	2.608ArgIle: 2.608 ± 0.056	2.173ArgLys: 2.173 ± 0.051	3.949ArgLeu: 3.949 ± 0.06	0.927ArgMet: 0.927 ± 0.034	1.789ArgAsn: 1.789 ± 0.044	1.276ArgPro: 1.276 ± 0.041	1.548ArgGln: 1.548 ± 0.036	1.661ArgArg: 1.661 ± 0.047	2.251ArgSer: 2.251 ± 0.047	1.784ArgThr: 1.784 ± 0.041	2.639ArgVal: 2.639 ± 0.049	0.455ArgTrp: 0.455 ± 0.021	1.389ArgTyr: 1.389 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	5.554SerAla: 5.554 ± 0.074	0.653SerCys: 0.653 ± 0.027	3.846SerAsp: 3.846 ± 0.064	4.128SerGlu: 4.128 ± 0.068	3.2SerPhe: 3.2 ± 0.058	4.916SerGly: 4.916 ± 0.075	1.369SerHis: 1.369 ± 0.036	4.838SerIle: 4.838 ± 0.068	4.124SerLys: 4.124 ± 0.059	6.851SerLeu: 6.851 ± 0.086	1.597SerMet: 1.597 ± 0.041	3.33SerAsn: 3.33 ± 0.057	2.288SerPro: 2.288 ± 0.049	2.76SerGln: 2.76 ± 0.047	2.377SerArg: 2.377 ± 0.046	4.72SerSer: 4.72 ± 0.092	3.397SerThr: 3.397 ± 0.062	4.601SerVal: 4.601 ± 0.072	0.846SerTrp: 0.846 ± 0.028	2.411SerTyr: 2.411 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	4.402ThrAla: 4.402 ± 0.073	0.514ThrCys: 0.514 ± 0.019	3.302ThrAsp: 3.302 ± 0.062	3.308ThrGlu: 3.308 ± 0.065	2.343ThrPhe: 2.343 ± 0.048	3.996ThrGly: 3.996 ± 0.063	0.977ThrHis: 0.977 ± 0.027	3.921ThrIle: 3.921 ± 0.064	2.924ThrLys: 2.924 ± 0.051	5.723ThrLeu: 5.723 ± 0.084	1.131ThrMet: 1.131 ± 0.034	2.595ThrAsn: 2.595 ± 0.05	2.666ThrPro: 2.666 ± 0.053	2.132ThrGln: 2.132 ± 0.044	1.889ThrArg: 1.889 ± 0.042	3.666ThrSer: 3.666 ± 0.061	3.026ThrThr: 3.026 ± 0.059	3.72ThrVal: 3.72 ± 0.059	0.631ThrTrp: 0.631 ± 0.024	1.666ThrTyr: 1.666 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	5.986ValAla: 5.986 ± 0.092	0.735ValCys: 0.735 ± 0.027	4.289ValAsp: 4.289 ± 0.071	4.57ValGlu: 4.57 ± 0.085	2.871ValPhe: 2.871 ± 0.058	4.288ValGly: 4.288 ± 0.073	1.159ValHis: 1.159 ± 0.035	5.072ValIle: 5.072 ± 0.071	4.008ValLys: 4.008 ± 0.063	6.272ValLeu: 6.272 ± 0.088	1.735ValMet: 1.735 ± 0.043	3.583ValAsn: 3.583 ± 0.065	2.344ValPro: 2.344 ± 0.051	2.113ValGln: 2.113 ± 0.042	2.343ValArg: 2.343 ± 0.049	4.795ValSer: 4.795 ± 0.071	3.983ValThr: 3.983 ± 0.07	4.967ValVal: 4.967 ± 0.081	0.697ValTrp: 0.697 ± 0.024	1.974ValTyr: 1.974 ± 0.052	0.0ValXaa: 0.0 ± 0.0
Trp	0.733TrpAla: 0.733 ± 0.026	0.126TrpCys: 0.126 ± 0.011	0.618TrpAsp: 0.618 ± 0.028	0.418TrpGlu: 0.418 ± 0.024	0.563TrpPhe: 0.563 ± 0.026	0.741TrpGly: 0.741 ± 0.03	0.366TrpHis: 0.366 ± 0.019	0.626TrpIle: 0.626 ± 0.026	0.442TrpLys: 0.442 ± 0.02	1.583TrpLeu: 1.583 ± 0.041	0.28TrpMet: 0.28 ± 0.015	0.483TrpAsn: 0.483 ± 0.021	0.479TrpPro: 0.479 ± 0.023	1.087TrpGln: 1.087 ± 0.037	0.523TrpArg: 0.523 ± 0.025	0.671TrpSer: 0.671 ± 0.027	0.536TrpThr: 0.536 ± 0.024	0.711TrpVal: 0.711 ± 0.023	0.165TrpTrp: 0.165 ± 0.014	0.368TrpTyr: 0.368 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.245TyrAla: 2.245 ± 0.047	0.356TyrCys: 0.356 ± 0.02	1.804TyrAsp: 1.804 ± 0.044	1.587TyrGlu: 1.587 ± 0.044	1.651TyrPhe: 1.651 ± 0.048	2.142TyrGly: 2.142 ± 0.052	0.76TyrHis: 0.76 ± 0.029	1.985TyrIle: 1.985 ± 0.043	1.814TyrLys: 1.814 ± 0.046	3.464TyrLeu: 3.464 ± 0.068	0.676TyrMet: 0.676 ± 0.025	1.499TyrAsn: 1.499 ± 0.042	1.382TyrPro: 1.382 ± 0.035	1.939TyrGln: 1.939 ± 0.046	1.508TyrArg: 1.508 ± 0.041	2.271TyrSer: 2.271 ± 0.051	1.635TyrThr: 1.635 ± 0.044	1.792TyrVal: 1.792 ± 0.041	0.464TyrTrp: 0.464 ± 0.022	1.183TyrTyr: 1.183 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3137 proteins (1074329 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---