Amino acid dipepetide frequency for Adelaide River virus (ARV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.212AlaAla: 0.212 ± 0.135
0.424AlaCys: 0.424 ± 0.292
1.696AlaAsp: 1.696 ± 0.45
1.06AlaGlu: 1.06 ± 0.675
1.272AlaPhe: 1.272 ± 0.527
1.272AlaGly: 1.272 ± 0.248
0.424AlaHis: 0.424 ± 0.22
2.12AlaIle: 2.12 ± 0.479
2.12AlaLys: 2.12 ± 0.406
3.179AlaLeu: 3.179 ± 0.507
0.212AlaMet: 0.212 ± 0.135
1.06AlaAsn: 1.06 ± 0.356
0.848AlaPro: 0.848 ± 0.655
0.212AlaGln: 0.212 ± 0.135
1.484AlaArg: 1.484 ± 0.557
2.12AlaSer: 2.12 ± 0.492
1.272AlaThr: 1.272 ± 0.619
1.696AlaVal: 1.696 ± 0.424
0.212AlaTrp: 0.212 ± 0.135
1.484AlaTyr: 1.484 ± 0.434
0.0AlaXaa: 0.0 ± 0.0
Cys
0.212CysAla: 0.212 ± 0.135
0.0CysCys: 0.0 ± 0.0
0.636CysAsp: 0.636 ± 0.398
0.424CysGlu: 0.424 ± 0.33
0.848CysPhe: 0.848 ± 0.397
1.06CysGly: 1.06 ± 0.495
0.636CysHis: 0.636 ± 0.441
1.06CysIle: 1.06 ± 0.527
1.06CysLys: 1.06 ± 0.36
2.331CysLeu: 2.331 ± 0.627
0.636CysMet: 0.636 ± 0.712
1.908CysAsn: 1.908 ± 0.679
0.848CysPro: 0.848 ± 0.368
0.848CysGln: 0.848 ± 0.331
0.636CysArg: 0.636 ± 0.712
1.272CysSer: 1.272 ± 0.41
0.848CysThr: 0.848 ± 0.51
1.06CysVal: 1.06 ± 0.588
0.212CysTrp: 0.212 ± 0.135
1.06CysTyr: 1.06 ± 0.516
0.0CysXaa: 0.0 ± 0.0
Asp
1.06AspAla: 1.06 ± 0.495
1.484AspCys: 1.484 ± 0.328
4.239AspAsp: 4.239 ± 0.817
4.239AspGlu: 4.239 ± 1.061
2.755AspPhe: 2.755 ± 0.46
2.755AspGly: 2.755 ± 0.506
1.272AspHis: 1.272 ± 0.463
3.815AspIle: 3.815 ± 0.807
5.087AspLys: 5.087 ± 0.98
4.663AspLeu: 4.663 ± 0.884
1.908AspMet: 1.908 ± 0.843
4.663AspAsn: 4.663 ± 1.494
2.12AspPro: 2.12 ± 0.525
2.755AspGln: 2.755 ± 0.857
1.908AspArg: 1.908 ± 0.603
3.603AspSer: 3.603 ± 1.399
3.815AspThr: 3.815 ± 1.061
1.908AspVal: 1.908 ± 0.695
1.06AspTrp: 1.06 ± 0.77
4.027AspTyr: 4.027 ± 1.237
0.0AspXaa: 0.0 ± 0.0
Glu
1.484GluAla: 1.484 ± 0.386
1.272GluCys: 1.272 ± 0.66
4.663GluAsp: 4.663 ± 1.314
4.663GluGlu: 4.663 ± 1.185
2.331GluPhe: 2.331 ± 0.822
4.239GluGly: 4.239 ± 0.938
1.696GluHis: 1.696 ± 0.88
6.571GluIle: 6.571 ± 1.518
5.723GluLys: 5.723 ± 1.411
6.147GluLeu: 6.147 ± 1.064
0.848GluMet: 0.848 ± 0.269
5.299GluAsn: 5.299 ± 1.727
1.06GluPro: 1.06 ± 0.429
0.636GluGln: 0.636 ± 0.28
3.391GluArg: 3.391 ± 1.302
5.723GluSer: 5.723 ± 0.394
3.179GluThr: 3.179 ± 0.9
5.723GluVal: 5.723 ± 0.97
1.272GluTrp: 1.272 ± 0.41
2.967GluTyr: 2.967 ± 0.767
0.0GluXaa: 0.0 ± 0.0
Phe
0.848PheAla: 0.848 ± 0.367
1.06PheCys: 1.06 ± 0.461
1.908PheAsp: 1.908 ± 0.446
1.484PheGlu: 1.484 ± 0.32
2.755PhePhe: 2.755 ± 0.499
2.543PheGly: 2.543 ± 0.496
0.424PheHis: 0.424 ± 0.292
3.603PheIle: 3.603 ± 0.673
2.331PheLys: 2.331 ± 0.518
5.935PheLeu: 5.935 ± 1.008
1.484PheMet: 1.484 ± 0.705
3.391PheAsn: 3.391 ± 0.424
1.272PhePro: 1.272 ± 0.547
0.848PheGln: 0.848 ± 0.398
1.696PheArg: 1.696 ± 0.665
2.755PheSer: 2.755 ± 0.531
3.179PheThr: 3.179 ± 1.577
2.755PheVal: 2.755 ± 0.752
0.424PheTrp: 0.424 ± 0.286
0.848PheTyr: 0.848 ± 0.682
0.0PheXaa: 0.0 ± 0.0
Gly
1.06GlyAla: 1.06 ± 0.375
0.212GlyCys: 0.212 ± 0.241
2.755GlyAsp: 2.755 ± 0.544
4.239GlyGlu: 4.239 ± 1.653
2.331GlyPhe: 2.331 ± 0.946
2.331GlyGly: 2.331 ± 0.395
1.696GlyHis: 1.696 ± 0.592
4.875GlyIle: 4.875 ± 0.972
4.239GlyLys: 4.239 ± 1.695
7.418GlyLeu: 7.418 ± 1.648
1.06GlyMet: 1.06 ± 0.434
2.331GlyAsn: 2.331 ± 0.641
0.848GlyPro: 0.848 ± 0.398
2.12GlyGln: 2.12 ± 0.461
1.696GlyArg: 1.696 ± 0.595
4.875GlySer: 4.875 ± 1.298
1.484GlyThr: 1.484 ± 0.504
2.331GlyVal: 2.331 ± 0.872
0.848GlyTrp: 0.848 ± 0.271
1.696GlyTyr: 1.696 ± 0.759
0.0GlyXaa: 0.0 ± 0.0
His
0.848HisAla: 0.848 ± 0.584
0.212HisCys: 0.212 ± 0.237
0.636HisAsp: 0.636 ± 0.356
1.696HisGlu: 1.696 ± 0.679
1.272HisPhe: 1.272 ± 0.274
1.908HisGly: 1.908 ± 0.421
0.636HisHis: 0.636 ± 0.265
2.331HisIle: 2.331 ± 0.584
1.484HisLys: 1.484 ± 0.486
2.12HisLeu: 2.12 ± 0.605
0.212HisMet: 0.212 ± 0.389
0.848HisAsn: 0.848 ± 0.356
1.272HisPro: 1.272 ± 0.481
0.424HisGln: 0.424 ± 0.348
1.272HisArg: 1.272 ± 0.529
1.06HisSer: 1.06 ± 0.483
1.06HisThr: 1.06 ± 0.847
1.272HisVal: 1.272 ± 0.709
0.424HisTrp: 0.424 ± 0.271
2.331HisTyr: 2.331 ± 0.708
0.0HisXaa: 0.0 ± 0.0
Ile
1.696IleAla: 1.696 ± 0.834
1.06IleCys: 1.06 ± 0.438
5.299IleAsp: 5.299 ± 1.412
6.359IleGlu: 6.359 ± 1.265
3.391IlePhe: 3.391 ± 0.784
3.603IleGly: 3.603 ± 0.506
1.908IleHis: 1.908 ± 0.625
8.054IleIle: 8.054 ± 0.971
10.81IleLys: 10.81 ± 1.021
8.054IleLeu: 8.054 ± 1.359
2.543IleMet: 2.543 ± 1.019
9.326IleAsn: 9.326 ± 1.308
3.391IlePro: 3.391 ± 0.915
2.331IleGln: 2.331 ± 0.414
3.603IleArg: 3.603 ± 0.693
5.935IleSer: 5.935 ± 0.869
4.239IleThr: 4.239 ± 1.044
4.663IleVal: 4.663 ± 0.771
1.06IleTrp: 1.06 ± 0.495
4.451IleTyr: 4.451 ± 0.93
0.0IleXaa: 0.0 ± 0.0
Lys
2.755LysAla: 2.755 ± 0.687
1.272LysCys: 1.272 ± 0.54
2.967LysAsp: 2.967 ± 0.576
6.359LysGlu: 6.359 ± 0.744
3.815LysPhe: 3.815 ± 0.86
5.511LysGly: 5.511 ± 0.777
1.484LysHis: 1.484 ± 0.942
8.902LysIle: 8.902 ± 1.059
7.842LysLys: 7.842 ± 2.618
8.266LysLeu: 8.266 ± 2.315
1.484LysMet: 1.484 ± 0.467
6.359LysAsn: 6.359 ± 0.934
3.179LysPro: 3.179 ± 0.658
1.06LysGln: 1.06 ± 0.495
4.451LysArg: 4.451 ± 1.046
7.206LysSer: 7.206 ± 1.354
4.451LysThr: 4.451 ± 2.254
4.663LysVal: 4.663 ± 0.793
1.696LysTrp: 1.696 ± 0.384
2.755LysTyr: 2.755 ± 0.699
0.0LysXaa: 0.0 ± 0.0
Leu
3.179LeuAla: 3.179 ± 1.015
2.12LeuCys: 2.12 ± 0.733
8.054LeuAsp: 8.054 ± 1.422
7.418LeuGlu: 7.418 ± 1.445
2.755LeuPhe: 2.755 ± 0.457
5.299LeuGly: 5.299 ± 0.812
1.908LeuHis: 1.908 ± 0.891
11.234LeuIle: 11.234 ± 1.542
8.902LeuLys: 8.902 ± 1.994
7.63LeuLeu: 7.63 ± 1.619
3.603LeuMet: 3.603 ± 0.758
6.359LeuAsn: 6.359 ± 1.49
1.908LeuPro: 1.908 ± 0.491
3.391LeuGln: 3.391 ± 0.608
5.511LeuArg: 5.511 ± 1.452
8.266LeuSer: 8.266 ± 0.768
2.967LeuThr: 2.967 ± 0.825
2.967LeuVal: 2.967 ± 1.101
0.848LeuTrp: 0.848 ± 0.271
4.027LeuTyr: 4.027 ± 0.816
0.0LeuXaa: 0.0 ± 0.0
Met
0.636MetAla: 0.636 ± 0.31
0.848MetCys: 0.848 ± 0.271
1.908MetAsp: 1.908 ± 0.44
2.755MetGlu: 2.755 ± 1.037
1.272MetPhe: 1.272 ± 0.551
0.848MetGly: 0.848 ± 0.463
0.0MetHis: 0.0 ± 0.0
4.239MetIle: 4.239 ± 0.876
1.06MetLys: 1.06 ± 0.491
2.967MetLeu: 2.967 ± 0.716
1.06MetMet: 1.06 ± 0.353
1.696MetAsn: 1.696 ± 0.362
0.848MetPro: 0.848 ± 0.765
0.212MetGln: 0.212 ± 0.135
1.272MetArg: 1.272 ± 0.337
2.331MetSer: 2.331 ± 0.769
0.848MetThr: 0.848 ± 0.271
0.424MetVal: 0.424 ± 0.232
0.212MetTrp: 0.212 ± 0.241
1.272MetTyr: 1.272 ± 0.39
0.0MetXaa: 0.0 ± 0.0
Asn
2.755AsnAla: 2.755 ± 0.488
1.908AsnCys: 1.908 ± 0.474
3.815AsnAsp: 3.815 ± 0.815
2.967AsnGlu: 2.967 ± 0.609
2.331AsnPhe: 2.331 ± 1.15
4.663AsnGly: 4.663 ± 1.471
3.179AsnHis: 3.179 ± 0.726
4.451AsnIle: 4.451 ± 0.926
5.935AsnLys: 5.935 ± 1.77
8.902AsnLeu: 8.902 ± 1.767
2.331AsnMet: 2.331 ± 0.491
5.087AsnAsn: 5.087 ± 1.443
3.391AsnPro: 3.391 ± 0.602
4.875AsnGln: 4.875 ± 1.462
2.967AsnArg: 2.967 ± 0.561
5.723AsnSer: 5.723 ± 1.702
2.12AsnThr: 2.12 ± 0.746
2.331AsnVal: 2.331 ± 1.184
1.484AsnTrp: 1.484 ± 0.367
3.179AsnTyr: 3.179 ± 1.36
0.0AsnXaa: 0.0 ± 0.0
Pro
1.06ProAla: 1.06 ± 0.603
0.636ProCys: 0.636 ± 0.323
2.12ProAsp: 2.12 ± 0.556
2.12ProGlu: 2.12 ± 0.593
1.272ProPhe: 1.272 ± 0.675
0.848ProGly: 0.848 ± 0.459
0.636ProHis: 0.636 ± 0.356
2.331ProIle: 2.331 ± 0.588
1.908ProLys: 1.908 ± 0.402
4.027ProLeu: 4.027 ± 0.473
0.424ProMet: 0.424 ± 0.487
2.543ProAsn: 2.543 ± 0.526
1.484ProPro: 1.484 ± 0.681
0.424ProGln: 0.424 ± 0.405
1.06ProArg: 1.06 ± 0.314
3.179ProSer: 3.179 ± 0.672
2.543ProThr: 2.543 ± 0.879
2.331ProVal: 2.331 ± 0.758
0.212ProTrp: 0.212 ± 0.135
1.696ProTyr: 1.696 ± 0.548
0.0ProXaa: 0.0 ± 0.0
Gln
0.424GlnAla: 0.424 ± 0.22
0.424GlnCys: 0.424 ± 0.22
2.755GlnAsp: 2.755 ± 0.73
3.391GlnGlu: 3.391 ± 0.844
1.06GlnPhe: 1.06 ± 0.503
0.848GlnGly: 0.848 ± 0.3
0.424GlnHis: 0.424 ± 0.22
2.755GlnIle: 2.755 ± 0.689
2.331GlnLys: 2.331 ± 0.388
1.908GlnLeu: 1.908 ± 0.298
0.212GlnMet: 0.212 ± 0.135
2.967GlnAsn: 2.967 ± 0.783
1.272GlnPro: 1.272 ± 0.248
0.212GlnGln: 0.212 ± 0.337
1.908GlnArg: 1.908 ± 0.423
2.755GlnSer: 2.755 ± 0.749
1.272GlnThr: 1.272 ± 0.607
0.636GlnVal: 0.636 ± 0.369
0.212GlnTrp: 0.212 ± 0.261
1.06GlnTyr: 1.06 ± 0.712
0.0GlnXaa: 0.0 ± 0.0
Arg
1.272ArgAla: 1.272 ± 0.41
1.06ArgCys: 1.06 ± 0.687
1.908ArgAsp: 1.908 ± 0.344
3.815ArgGlu: 3.815 ± 0.617
2.755ArgPhe: 2.755 ± 0.82
2.543ArgGly: 2.543 ± 0.581
1.06ArgHis: 1.06 ± 0.314
2.755ArgIle: 2.755 ± 1.102
4.875ArgLys: 4.875 ± 1.152
4.239ArgLeu: 4.239 ± 0.916
0.636ArgMet: 0.636 ± 0.275
2.967ArgAsn: 2.967 ± 0.732
1.908ArgPro: 1.908 ± 0.66
1.06ArgGln: 1.06 ± 0.345
1.908ArgArg: 1.908 ± 0.514
3.179ArgSer: 3.179 ± 0.561
1.908ArgThr: 1.908 ± 0.397
2.967ArgVal: 2.967 ± 0.608
0.636ArgTrp: 0.636 ± 0.35
1.272ArgTyr: 1.272 ± 0.588
0.0ArgXaa: 0.0 ± 0.0
Ser
2.755SerAla: 2.755 ± 0.568
1.06SerCys: 1.06 ± 0.442
5.299SerAsp: 5.299 ± 1.549
5.299SerGlu: 5.299 ± 0.684
3.815SerPhe: 3.815 ± 1.004
3.815SerGly: 3.815 ± 1.023
2.12SerHis: 2.12 ± 0.604
6.994SerIle: 6.994 ± 1.833
6.994SerLys: 6.994 ± 1.326
6.783SerLeu: 6.783 ± 1.576
2.543SerMet: 2.543 ± 0.707
4.875SerAsn: 4.875 ± 1.132
1.484SerPro: 1.484 ± 0.467
2.12SerGln: 2.12 ± 0.667
2.967SerArg: 2.967 ± 0.601
6.147SerSer: 6.147 ± 1.337
3.603SerThr: 3.603 ± 0.758
3.391SerVal: 3.391 ± 0.958
1.484SerTrp: 1.484 ± 0.493
4.663SerTyr: 4.663 ± 0.856
0.0SerXaa: 0.0 ± 0.0
Thr
0.636ThrAla: 0.636 ± 0.33
0.424ThrCys: 0.424 ± 0.33
2.12ThrAsp: 2.12 ± 0.512
3.179ThrGlu: 3.179 ± 0.725
1.696ThrPhe: 1.696 ± 1.073
1.272ThrGly: 1.272 ± 0.588
1.484ThrHis: 1.484 ± 0.431
4.027ThrIle: 4.027 ± 1.042
4.451ThrLys: 4.451 ± 1.322
4.027ThrLeu: 4.027 ± 0.953
2.331ThrMet: 2.331 ± 0.624
4.027ThrAsn: 4.027 ± 1.081
1.696ThrPro: 1.696 ± 0.676
1.696ThrGln: 1.696 ± 0.557
1.484ThrArg: 1.484 ± 0.622
4.451ThrSer: 4.451 ± 0.871
2.543ThrThr: 2.543 ± 1.364
2.331ThrVal: 2.331 ± 0.555
0.848ThrTrp: 0.848 ± 0.378
1.696ThrTyr: 1.696 ± 0.8
0.0ThrXaa: 0.0 ± 0.0
Val
0.848ValAla: 0.848 ± 0.413
1.272ValCys: 1.272 ± 0.274
2.543ValAsp: 2.543 ± 0.697
3.603ValGlu: 3.603 ± 0.661
0.848ValPhe: 0.848 ± 0.353
2.12ValGly: 2.12 ± 0.48
0.424ValHis: 0.424 ± 0.307
5.935ValIle: 5.935 ± 0.766
4.663ValLys: 4.663 ± 0.775
3.391ValLeu: 3.391 ± 0.959
2.543ValMet: 2.543 ± 0.965
2.967ValAsn: 2.967 ± 1.091
1.696ValPro: 1.696 ± 0.51
1.696ValGln: 1.696 ± 0.771
1.908ValArg: 1.908 ± 0.647
2.967ValSer: 2.967 ± 1.055
3.179ValThr: 3.179 ± 1.4
1.272ValVal: 1.272 ± 0.624
0.636ValTrp: 0.636 ± 0.278
1.696ValTyr: 1.696 ± 0.953
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.212TrpCys: 0.212 ± 0.135
0.848TrpAsp: 0.848 ± 0.542
2.331TrpGlu: 2.331 ± 0.676
1.06TrpPhe: 1.06 ± 0.314
1.272TrpGly: 1.272 ± 0.429
0.212TrpHis: 0.212 ± 0.241
1.696TrpIle: 1.696 ± 0.514
0.636TrpLys: 0.636 ± 0.333
0.424TrpLeu: 0.424 ± 0.271
0.0TrpMet: 0.0 ± 0.0
1.484TrpAsn: 1.484 ± 0.42
0.424TrpPro: 0.424 ± 0.271
0.0TrpGln: 0.0 ± 0.0
0.212TrpArg: 0.212 ± 0.135
1.484TrpSer: 1.484 ± 0.523
0.848TrpThr: 0.848 ± 0.459
0.212TrpVal: 0.212 ± 0.295
0.212TrpTrp: 0.212 ± 0.237
0.848TrpTyr: 0.848 ± 0.568
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.636TyrAla: 0.636 ± 0.35
0.636TyrCys: 0.636 ± 0.43
2.967TyrAsp: 2.967 ± 0.545
1.484TyrGlu: 1.484 ± 0.761
1.908TyrPhe: 1.908 ± 0.656
1.696TyrGly: 1.696 ± 0.553
1.908TyrHis: 1.908 ± 0.51
4.027TyrIle: 4.027 ± 1.058
4.027TyrLys: 4.027 ± 0.444
5.935TyrLeu: 5.935 ± 1.148
0.424TyrMet: 0.424 ± 0.522
4.239TyrAsn: 4.239 ± 1.14
1.908TyrPro: 1.908 ± 0.611
1.908TyrGln: 1.908 ± 0.664
3.391TyrArg: 3.391 ± 0.7
3.179TyrSer: 3.179 ± 0.958
1.06TyrThr: 1.06 ± 0.364
1.272TyrVal: 1.272 ± 0.386
0.424TyrTrp: 0.424 ± 0.22
2.331TyrTyr: 2.331 ± 0.733
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 9 proteins (4719 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski