Amino acid dipepetide frequency for Pseudooceanicola flagellatus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.181AlaAla: 15.181 ± 0.165	1.111AlaCys: 1.111 ± 0.03	6.957AlaAsp: 6.957 ± 0.075	7.806AlaGlu: 7.806 ± 0.098	4.325AlaPhe: 4.325 ± 0.066	9.847AlaGly: 9.847 ± 0.111	2.328AlaHis: 2.328 ± 0.045	5.811AlaIle: 5.811 ± 0.071	3.871AlaLys: 3.871 ± 0.066	13.218AlaLeu: 13.218 ± 0.14	3.768AlaMet: 3.768 ± 0.06	2.819AlaAsn: 2.819 ± 0.045	5.335AlaPro: 5.335 ± 0.077	4.577AlaGln: 4.577 ± 0.068	8.336AlaArg: 8.336 ± 0.102	5.867AlaSer: 5.867 ± 0.082	5.899AlaThr: 5.899 ± 0.061	7.959AlaVal: 7.959 ± 0.081	1.392AlaTrp: 1.392 ± 0.038	2.467AlaTyr: 2.467 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	1.096CysAla: 1.096 ± 0.029	0.135CysCys: 0.135 ± 0.012	0.648CysAsp: 0.648 ± 0.026	0.456CysGlu: 0.456 ± 0.02	0.35CysPhe: 0.35 ± 0.017	1.003CysGly: 1.003 ± 0.032	0.284CysHis: 0.284 ± 0.017	0.456CysIle: 0.456 ± 0.019	0.233CysLys: 0.233 ± 0.013	0.891CysLeu: 0.891 ± 0.028	0.199CysMet: 0.199 ± 0.013	0.254CysAsn: 0.254 ± 0.013	0.513CysPro: 0.513 ± 0.022	0.265CysGln: 0.265 ± 0.014	0.597CysArg: 0.597 ± 0.022	0.466CysSer: 0.466 ± 0.021	0.442CysThr: 0.442 ± 0.019	0.665CysVal: 0.665 ± 0.025	0.126CysTrp: 0.126 ± 0.01	0.219CysTyr: 0.219 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.626AspAla: 7.626 ± 0.086	0.531AspCys: 0.531 ± 0.021	3.572AspAsp: 3.572 ± 0.068	3.711AspGlu: 3.711 ± 0.057	2.363AspPhe: 2.363 ± 0.047	5.701AspGly: 5.701 ± 0.077	1.353AspHis: 1.353 ± 0.038	3.208AspIle: 3.208 ± 0.05	1.792AspLys: 1.792 ± 0.038	6.529AspLeu: 6.529 ± 0.071	1.761AspMet: 1.761 ± 0.035	1.427AspAsn: 1.427 ± 0.037	3.621AspPro: 3.621 ± 0.056	1.951AspGln: 1.951 ± 0.042	4.371AspArg: 4.371 ± 0.062	2.358AspSer: 2.358 ± 0.043	3.191AspThr: 3.191 ± 0.055	4.483AspVal: 4.483 ± 0.058	1.226AspTrp: 1.226 ± 0.035	1.595AspTyr: 1.595 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	7.554GluAla: 7.554 ± 0.088	0.412GluCys: 0.412 ± 0.019	3.464GluAsp: 3.464 ± 0.062	3.456GluGlu: 3.456 ± 0.052	1.777GluPhe: 1.777 ± 0.036	4.655GluGly: 4.655 ± 0.059	1.173GluHis: 1.173 ± 0.033	3.641GluIle: 3.641 ± 0.05	2.267GluLys: 2.267 ± 0.047	5.058GluLeu: 5.058 ± 0.064	1.859GluMet: 1.859 ± 0.038	1.829GluAsn: 1.829 ± 0.039	2.409GluPro: 2.409 ± 0.045	2.036GluGln: 2.036 ± 0.043	4.153GluArg: 4.153 ± 0.059	2.278GluSer: 2.278 ± 0.045	3.935GluThr: 3.935 ± 0.056	4.179GluVal: 4.179 ± 0.058	0.75GluTrp: 0.75 ± 0.027	1.135GluTyr: 1.135 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.337PheAla: 4.337 ± 0.062	0.41PheCys: 0.41 ± 0.018	2.955PheAsp: 2.955 ± 0.055	2.243PheGlu: 2.243 ± 0.046	1.448PhePhe: 1.448 ± 0.038	3.7PheGly: 3.7 ± 0.061	0.749PheHis: 0.749 ± 0.024	1.714PheIle: 1.714 ± 0.038	0.994PheLys: 0.994 ± 0.033	3.4PheLeu: 3.4 ± 0.066	0.879PheMet: 0.879 ± 0.027	1.093PheAsn: 1.093 ± 0.03	1.598PhePro: 1.598 ± 0.037	1.046PheGln: 1.046 ± 0.028	2.282PheArg: 2.282 ± 0.042	2.178PheSer: 2.178 ± 0.036	2.018PheThr: 2.018 ± 0.046	2.829PheVal: 2.829 ± 0.052	0.558PheTrp: 0.558 ± 0.022	0.972PheTyr: 0.972 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	9.383GlyAla: 9.383 ± 0.1	0.873GlyCys: 0.873 ± 0.029	4.82GlyAsp: 4.82 ± 0.085	4.432GlyGlu: 4.432 ± 0.061	3.67GlyPhe: 3.67 ± 0.059	7.259GlyGly: 7.259 ± 0.102	1.881GlyHis: 1.881 ± 0.045	4.547GlyIle: 4.547 ± 0.064	3.275GlyLys: 3.275 ± 0.065	8.999GlyLeu: 8.999 ± 0.085	2.57GlyMet: 2.57 ± 0.051	2.275GlyAsn: 2.275 ± 0.073	3.466GlyPro: 3.466 ± 0.052	3.169GlyGln: 3.169 ± 0.051	5.632GlyArg: 5.632 ± 0.069	4.275GlySer: 4.275 ± 0.065	4.734GlyThr: 4.734 ± 0.083	6.175GlyVal: 6.175 ± 0.063	1.467GlyTrp: 1.467 ± 0.037	2.272GlyTyr: 2.272 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.282HisAla: 2.282 ± 0.045	0.259HisCys: 0.259 ± 0.016	1.343HisAsp: 1.343 ± 0.032	1.086HisGlu: 1.086 ± 0.029	0.847HisPhe: 0.847 ± 0.025	1.944HisGly: 1.944 ± 0.045	0.542HisHis: 0.542 ± 0.022	1.046HisIle: 1.046 ± 0.031	0.578HisLys: 0.578 ± 0.02	2.11HisLeu: 2.11 ± 0.049	0.592HisMet: 0.592 ± 0.022	0.493HisAsn: 0.493 ± 0.021	1.38HisPro: 1.38 ± 0.029	0.619HisGln: 0.619 ± 0.023	1.384HisArg: 1.384 ± 0.037	1.013HisSer: 1.013 ± 0.027	0.848HisThr: 0.848 ± 0.027	1.563HisVal: 1.563 ± 0.04	0.342HisTrp: 0.342 ± 0.017	0.602HisTyr: 0.602 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.943IleAla: 6.943 ± 0.068	0.689IleCys: 0.689 ± 0.023	3.578IleAsp: 3.578 ± 0.055	3.501IleGlu: 3.501 ± 0.056	1.903IlePhe: 1.903 ± 0.049	4.854IleGly: 4.854 ± 0.066	0.96IleHis: 0.96 ± 0.027	2.387IleIle: 2.387 ± 0.053	1.522IleLys: 1.522 ± 0.034	4.818IleLeu: 4.818 ± 0.063	1.138IleMet: 1.138 ± 0.031	1.44IleAsn: 1.44 ± 0.035	2.346IlePro: 2.346 ± 0.045	1.273IleGln: 1.273 ± 0.032	3.275IleArg: 3.275 ± 0.055	3.22IleSer: 3.22 ± 0.057	2.856IleThr: 2.856 ± 0.05	3.926IleVal: 3.926 ± 0.075	0.754IleTrp: 0.754 ± 0.022	1.19IleTyr: 1.19 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	4.04LysAla: 4.04 ± 0.061	0.209LysCys: 0.209 ± 0.013	1.866LysAsp: 1.866 ± 0.045	1.67LysGlu: 1.67 ± 0.036	0.962LysPhe: 0.962 ± 0.028	2.702LysGly: 2.702 ± 0.056	0.679LysHis: 0.679 ± 0.024	1.789LysIle: 1.789 ± 0.034	1.221LysLys: 1.221 ± 0.036	3.229LysLeu: 3.229 ± 0.055	0.919LysMet: 0.919 ± 0.029	0.886LysAsn: 0.886 ± 0.033	1.894LysPro: 1.894 ± 0.038	1.043LysGln: 1.043 ± 0.033	2.395LysArg: 2.395 ± 0.044	1.928LysSer: 1.928 ± 0.039	2.097LysThr: 2.097 ± 0.049	2.333LysVal: 2.333 ± 0.046	0.432LysTrp: 0.432 ± 0.019	0.676LysTyr: 0.676 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	12.184LeuAla: 12.184 ± 0.129	1.01LeuCys: 1.01 ± 0.025	6.298LeuAsp: 6.298 ± 0.071	5.411LeuGlu: 5.411 ± 0.067	3.534LeuPhe: 3.534 ± 0.074	8.318LeuGly: 8.318 ± 0.083	1.954LeuHis: 1.954 ± 0.04	5.304LeuIle: 5.304 ± 0.07	3.278LeuLys: 3.278 ± 0.058	8.961LeuLeu: 8.961 ± 0.117	2.666LeuMet: 2.666 ± 0.051	2.795LeuAsn: 2.795 ± 0.054	5.368LeuPro: 5.368 ± 0.068	2.767LeuGln: 2.767 ± 0.049	7.138LeuArg: 7.138 ± 0.093	6.707LeuSer: 6.707 ± 0.08	6.177LeuThr: 6.177 ± 0.082	6.791LeuVal: 6.791 ± 0.088	1.231LeuTrp: 1.231 ± 0.033	1.927LeuTyr: 1.927 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.439MetAla: 3.439 ± 0.051	0.192MetCys: 0.192 ± 0.014	1.441MetAsp: 1.441 ± 0.033	1.278MetGlu: 1.278 ± 0.035	0.839MetPhe: 0.839 ± 0.027	2.221MetGly: 2.221 ± 0.05	0.502MetHis: 0.502 ± 0.021	1.606MetIle: 1.606 ± 0.032	1.128MetLys: 1.128 ± 0.027	2.758MetLeu: 2.758 ± 0.052	0.793MetMet: 0.793 ± 0.027	0.898MetAsn: 0.898 ± 0.025	1.531MetPro: 1.531 ± 0.035	1.1MetGln: 1.1 ± 0.028	1.926MetArg: 1.926 ± 0.035	1.825MetSer: 1.825 ± 0.039	2.167MetThr: 2.167 ± 0.041	1.907MetVal: 1.907 ± 0.042	0.245MetTrp: 0.245 ± 0.016	0.374MetTyr: 0.374 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.339AsnAla: 3.339 ± 0.044	0.289AsnCys: 0.289 ± 0.015	1.656AsnAsp: 1.656 ± 0.062	1.253AsnGlu: 1.253 ± 0.03	1.033AsnPhe: 1.033 ± 0.03	2.438AsnGly: 2.438 ± 0.058	0.559AsnHis: 0.559 ± 0.021	1.498AsnIle: 1.498 ± 0.036	0.751AsnLys: 0.751 ± 0.026	2.652AsnLeu: 2.652 ± 0.046	0.748AsnMet: 0.748 ± 0.028	0.725AsnAsn: 0.725 ± 0.026	1.889AsnPro: 1.889 ± 0.046	0.744AsnGln: 0.744 ± 0.026	1.888AsnArg: 1.888 ± 0.039	1.342AsnSer: 1.342 ± 0.037	1.456AsnThr: 1.456 ± 0.038	1.891AsnVal: 1.891 ± 0.042	0.481AsnTrp: 0.481 ± 0.021	0.699AsnTyr: 0.699 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	5.348ProAla: 5.348 ± 0.078	0.392ProCys: 0.392 ± 0.017	4.088ProAsp: 4.088 ± 0.062	3.992ProGlu: 3.992 ± 0.053	1.902ProPhe: 1.902 ± 0.041	4.089ProGly: 4.089 ± 0.057	1.094ProHis: 1.094 ± 0.031	2.245ProIle: 2.245 ± 0.04	1.697ProLys: 1.697 ± 0.04	4.563ProLeu: 4.563 ± 0.065	1.364ProMet: 1.364 ± 0.03	1.323ProAsn: 1.323 ± 0.033	2.204ProPro: 2.204 ± 0.047	1.711ProGln: 1.711 ± 0.037	2.74ProArg: 2.74 ± 0.048	2.594ProSer: 2.594 ± 0.049	2.422ProThr: 2.422 ± 0.04	4.052ProVal: 4.052 ± 0.057	0.668ProTrp: 0.668 ± 0.025	1.182ProTyr: 1.182 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	4.03GlnAla: 4.03 ± 0.061	0.259GlnCys: 0.259 ± 0.015	1.912GlnAsp: 1.912 ± 0.039	1.64GlnGlu: 1.64 ± 0.037	1.16GlnPhe: 1.16 ± 0.034	2.582GlnGly: 2.582 ± 0.051	0.692GlnHis: 0.692 ± 0.026	2.161GlnIle: 2.161 ± 0.04	1.149GlnLys: 1.149 ± 0.033	2.926GlnLeu: 2.926 ± 0.053	1.094GlnMet: 1.094 ± 0.034	0.994GlnAsn: 0.994 ± 0.03	1.634GlnPro: 1.634 ± 0.034	1.2GlnGln: 1.2 ± 0.035	2.209GlnArg: 2.209 ± 0.044	1.895GlnSer: 1.895 ± 0.036	1.946GlnThr: 1.946 ± 0.042	2.393GlnVal: 2.393 ± 0.04	0.421GlnTrp: 0.421 ± 0.017	0.609GlnTyr: 0.609 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	7.715ArgAla: 7.715 ± 0.096	0.519ArgCys: 0.519 ± 0.023	4.371ArgAsp: 4.371 ± 0.064	3.717ArgGlu: 3.717 ± 0.062	2.708ArgPhe: 2.708 ± 0.043	4.537ArgGly: 4.537 ± 0.061	1.587ArgHis: 1.587 ± 0.038	3.953ArgIle: 3.953 ± 0.058	2.501ArgLys: 2.501 ± 0.049	7.156ArgLeu: 7.156 ± 0.096	1.995ArgMet: 1.995 ± 0.042	1.987ArgAsn: 1.987 ± 0.039	3.218ArgPro: 3.218 ± 0.051	2.469ArgGln: 2.469 ± 0.042	4.974ArgArg: 4.974 ± 0.072	3.454ArgSer: 3.454 ± 0.062	3.194ArgThr: 3.194 ± 0.054	4.543ArgVal: 4.543 ± 0.064	0.923ArgTrp: 0.923 ± 0.028	1.588ArgTyr: 1.588 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.051SerAla: 6.051 ± 0.073	0.465SerCys: 0.465 ± 0.022	3.548SerAsp: 3.548 ± 0.061	3.03SerGlu: 3.03 ± 0.052	2.19SerPhe: 2.19 ± 0.045	5.56SerGly: 5.56 ± 0.074	1.169SerHis: 1.169 ± 0.029	2.537SerIle: 2.537 ± 0.051	1.695SerLys: 1.695 ± 0.04	5.098SerLeu: 5.098 ± 0.059	1.396SerMet: 1.396 ± 0.034	1.532SerAsn: 1.532 ± 0.039	2.58SerPro: 2.58 ± 0.042	1.738SerGln: 1.738 ± 0.031	3.378SerArg: 3.378 ± 0.049	2.795SerSer: 2.795 ± 0.049	2.683SerThr: 2.683 ± 0.048	3.983SerVal: 3.983 ± 0.057	0.694SerTrp: 0.694 ± 0.025	1.351SerTyr: 1.351 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.071ThrAla: 6.071 ± 0.068	0.5ThrCys: 0.5 ± 0.023	3.426ThrAsp: 3.426 ± 0.049	3.086ThrGlu: 3.086 ± 0.047	2.034ThrPhe: 2.034 ± 0.041	5.405ThrGly: 5.405 ± 0.074	1.161ThrHis: 1.161 ± 0.03	2.74ThrIle: 2.74 ± 0.044	1.639ThrLys: 1.639 ± 0.038	6.053ThrLeu: 6.053 ± 0.09	1.368ThrMet: 1.368 ± 0.032	1.421ThrAsn: 1.421 ± 0.034	3.353ThrPro: 3.353 ± 0.057	1.712ThrGln: 1.712 ± 0.034	3.62ThrArg: 3.62 ± 0.052	2.922ThrSer: 2.922 ± 0.048	2.93ThrThr: 2.93 ± 0.056	4.27ThrVal: 4.27 ± 0.057	0.662ThrTrp: 0.662 ± 0.024	1.281ThrTyr: 1.281 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	8.364ValAla: 8.364 ± 0.096	0.651ValCys: 0.651 ± 0.023	4.023ValAsp: 4.023 ± 0.062	4.335ValGlu: 4.335 ± 0.068	2.898ValPhe: 2.898 ± 0.053	5.307ValGly: 5.307 ± 0.076	1.335ValHis: 1.335 ± 0.034	4.207ValIle: 4.207 ± 0.065	2.241ValLys: 2.241 ± 0.041	7.427ValLeu: 7.427 ± 0.09	2.148ValMet: 2.148 ± 0.041	2.031ValAsn: 2.031 ± 0.041	3.513ValPro: 3.513 ± 0.057	2.15ValGln: 2.15 ± 0.039	4.22ValArg: 4.22 ± 0.055	4.383ValSer: 4.383 ± 0.065	4.703ValThr: 4.703 ± 0.061	5.581ValVal: 5.581 ± 0.088	0.943ValTrp: 0.943 ± 0.029	1.468ValTyr: 1.468 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.343TrpAla: 1.343 ± 0.034	0.149TrpCys: 0.149 ± 0.011	0.769TrpAsp: 0.769 ± 0.025	0.616TrpGlu: 0.616 ± 0.022	0.541TrpPhe: 0.541 ± 0.02	0.999TrpGly: 0.999 ± 0.027	0.352TrpHis: 0.352 ± 0.018	0.709TrpIle: 0.709 ± 0.025	0.495TrpLys: 0.495 ± 0.019	1.659TrpLeu: 1.659 ± 0.042	0.427TrpMet: 0.427 ± 0.02	0.463TrpAsn: 0.463 ± 0.02	0.699TrpPro: 0.699 ± 0.022	0.65TrpGln: 0.65 ± 0.025	1.073TrpArg: 1.073 ± 0.031	0.778TrpSer: 0.778 ± 0.023	0.786TrpThr: 0.786 ± 0.025	0.888TrpVal: 0.888 ± 0.029	0.226TrpTrp: 0.226 ± 0.012	0.269TrpTyr: 0.269 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.55TyrAla: 2.55 ± 0.048	0.245TyrCys: 0.245 ± 0.014	1.634TyrAsp: 1.634 ± 0.037	1.303TyrGlu: 1.303 ± 0.033	0.92TyrPhe: 0.92 ± 0.029	2.052TyrGly: 2.052 ± 0.047	0.52TyrHis: 0.52 ± 0.023	1.013TyrIle: 1.013 ± 0.027	0.642TyrLys: 0.642 ± 0.023	2.317TyrLeu: 2.317 ± 0.043	0.484TyrMet: 0.484 ± 0.02	0.644TyrAsn: 0.644 ± 0.025	1.12TyrPro: 1.12 ± 0.032	0.686TyrGln: 0.686 ± 0.025	1.517TyrArg: 1.517 ± 0.035	1.194TyrSer: 1.194 ± 0.029	1.169TyrThr: 1.169 ± 0.035	1.514TyrVal: 1.514 ± 0.031	0.349TyrTrp: 0.349 ± 0.017	0.617TyrTyr: 0.617 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4189 proteins (1299626 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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