Amino acid dipepetide frequency for Brochothrix phage A9

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.026AlaAla: 0.026 ± 0.024
0.389AlaCys: 0.389 ± 0.096
4.509AlaAsp: 4.509 ± 0.363
4.198AlaGlu: 4.198 ± 0.314
2.28AlaPhe: 2.28 ± 0.262
4.535AlaGly: 4.535 ± 0.564
1.736AlaHis: 1.736 ± 0.183
4.509AlaIle: 4.509 ± 0.331
4.82AlaLys: 4.82 ± 0.446
5.545AlaLeu: 5.545 ± 0.426
1.814AlaMet: 1.814 ± 0.246
3.421AlaAsn: 3.421 ± 0.339
2.254AlaPro: 2.254 ± 0.298
2.928AlaGln: 2.928 ± 0.338
3.498AlaArg: 3.498 ± 0.301
4.457AlaSer: 4.457 ± 0.321
5.571AlaThr: 5.571 ± 0.416
4.716AlaVal: 4.716 ± 0.314
0.518AlaTrp: 0.518 ± 0.132
3.369AlaTyr: 3.369 ± 0.281
0.0AlaXaa: 0.0 ± 0.0
Cys
0.415CysAla: 0.415 ± 0.113
0.104CysCys: 0.104 ± 0.054
0.363CysAsp: 0.363 ± 0.113
0.441CysGlu: 0.441 ± 0.131
0.181CysPhe: 0.181 ± 0.075
0.518CysGly: 0.518 ± 0.102
0.13CysHis: 0.13 ± 0.054
0.415CysIle: 0.415 ± 0.097
0.415CysLys: 0.415 ± 0.103
0.907CysLeu: 0.907 ± 0.181
0.155CysMet: 0.155 ± 0.073
0.259CysAsn: 0.259 ± 0.084
0.181CysPro: 0.181 ± 0.08
0.078CysGln: 0.078 ± 0.049
0.311CysArg: 0.311 ± 0.088
0.829CysSer: 0.829 ± 0.166
0.441CysThr: 0.441 ± 0.132
0.829CysVal: 0.829 ± 0.19
0.104CysTrp: 0.104 ± 0.047
0.415CysTyr: 0.415 ± 0.103
0.0CysXaa: 0.0 ± 0.0
Asp
3.887AspAla: 3.887 ± 0.34
0.466AspCys: 0.466 ± 0.102
2.98AspAsp: 2.98 ± 0.287
4.664AspGlu: 4.664 ± 0.456
2.514AspPhe: 2.514 ± 0.282
4.276AspGly: 4.276 ± 0.418
0.518AspHis: 0.518 ± 0.112
5.442AspIle: 5.442 ± 0.477
4.302AspLys: 4.302 ± 0.376
4.924AspLeu: 4.924 ± 0.4
1.788AspMet: 1.788 ± 0.218
3.317AspAsn: 3.317 ± 0.309
1.918AspPro: 1.918 ± 0.199
0.829AspGln: 0.829 ± 0.145
2.358AspArg: 2.358 ± 0.228
3.576AspSer: 3.576 ± 0.33
3.68AspThr: 3.68 ± 0.317
4.846AspVal: 4.846 ± 0.361
0.596AspTrp: 0.596 ± 0.113
3.213AspTyr: 3.213 ± 0.366
0.0AspXaa: 0.0 ± 0.0
Glu
5.131GluAla: 5.131 ± 0.431
0.285GluCys: 0.285 ± 0.094
5.882GluAsp: 5.882 ± 0.647
7.308GluGlu: 7.308 ± 0.652
2.021GluPhe: 2.021 ± 0.226
4.198GluGly: 4.198 ± 0.389
1.84GluHis: 1.84 ± 0.216
4.457GluIle: 4.457 ± 0.364
4.613GluLys: 4.613 ± 0.354
6.401GluLeu: 6.401 ± 0.489
2.203GluMet: 2.203 ± 0.227
2.954GluAsn: 2.954 ± 0.284
1.658GluPro: 1.658 ± 0.21
3.11GluGln: 3.11 ± 0.306
3.732GluArg: 3.732 ± 0.28
3.395GluSer: 3.395 ± 0.354
4.483GluThr: 4.483 ± 0.323
5.701GluVal: 5.701 ± 0.449
0.674GluTrp: 0.674 ± 0.121
2.902GluTyr: 2.902 ± 0.313
0.0GluXaa: 0.0 ± 0.0
Phe
1.969PheAla: 1.969 ± 0.216
0.285PheCys: 0.285 ± 0.088
2.488PheAsp: 2.488 ± 0.23
2.073PheGlu: 2.073 ± 0.219
1.037PhePhe: 1.037 ± 0.175
2.125PheGly: 2.125 ± 0.259
0.544PheHis: 0.544 ± 0.129
2.488PheIle: 2.488 ± 0.295
2.203PheLys: 2.203 ± 0.305
2.85PheLeu: 2.85 ± 0.246
0.959PheMet: 0.959 ± 0.168
1.944PheAsn: 1.944 ± 0.228
1.192PhePro: 1.192 ± 0.183
0.674PheGln: 0.674 ± 0.142
1.71PheArg: 1.71 ± 0.195
3.187PheSer: 3.187 ± 0.321
2.643PheThr: 2.643 ± 0.332
2.747PheVal: 2.747 ± 0.299
0.233PheTrp: 0.233 ± 0.08
1.399PheTyr: 1.399 ± 0.232
0.0PheXaa: 0.0 ± 0.0
Gly
4.042GlyAla: 4.042 ± 0.371
0.492GlyCys: 0.492 ± 0.105
4.198GlyAsp: 4.198 ± 0.354
4.483GlyGlu: 4.483 ± 0.378
2.617GlyPhe: 2.617 ± 0.275
4.509GlyGly: 4.509 ± 0.582
1.166GlyHis: 1.166 ± 0.203
3.55GlyIle: 3.55 ± 0.291
5.235GlyLys: 5.235 ± 0.447
4.664GlyLeu: 4.664 ± 0.363
1.451GlyMet: 1.451 ± 0.231
3.524GlyAsn: 3.524 ± 0.298
0.933GlyPro: 0.933 ± 0.151
1.218GlyGln: 1.218 ± 0.173
2.643GlyArg: 2.643 ± 0.27
3.602GlySer: 3.602 ± 0.418
4.457GlyThr: 4.457 ± 0.431
5.908GlyVal: 5.908 ± 0.374
0.829GlyTrp: 0.829 ± 0.144
3.136GlyTyr: 3.136 ± 0.332
0.0GlyXaa: 0.0 ± 0.0
His
1.037HisAla: 1.037 ± 0.181
0.13HisCys: 0.13 ± 0.065
1.14HisAsp: 1.14 ± 0.19
1.14HisGlu: 1.14 ± 0.209
0.648HisPhe: 0.648 ± 0.127
1.114HisGly: 1.114 ± 0.207
0.415HisHis: 0.415 ± 0.103
1.581HisIle: 1.581 ± 0.212
1.322HisLys: 1.322 ± 0.178
1.944HisLeu: 1.944 ± 0.298
0.389HisMet: 0.389 ± 0.115
0.933HisAsn: 0.933 ± 0.131
0.855HisPro: 0.855 ± 0.149
0.648HisGln: 0.648 ± 0.107
0.829HisArg: 0.829 ± 0.145
1.451HisSer: 1.451 ± 0.201
1.27HisThr: 1.27 ± 0.179
1.477HisVal: 1.477 ± 0.18
0.207HisTrp: 0.207 ± 0.104
1.166HisTyr: 1.166 ± 0.193
0.0HisXaa: 0.0 ± 0.0
Ile
4.82IleAla: 4.82 ± 0.365
0.518IleCys: 0.518 ± 0.105
3.213IleAsp: 3.213 ± 0.276
5.105IleGlu: 5.105 ± 0.37
1.633IlePhe: 1.633 ± 0.213
3.732IleGly: 3.732 ± 0.326
1.166IleHis: 1.166 ± 0.163
3.835IleIle: 3.835 ± 0.347
4.768IleLys: 4.768 ± 0.367
4.898IleLeu: 4.898 ± 0.381
1.477IleMet: 1.477 ± 0.237
3.654IleAsn: 3.654 ± 0.261
2.695IlePro: 2.695 ± 0.315
1.84IleGln: 1.84 ± 0.19
2.902IleArg: 2.902 ± 0.306
4.561IleSer: 4.561 ± 0.37
4.975IleThr: 4.975 ± 0.371
3.783IleVal: 3.783 ± 0.343
0.363IleTrp: 0.363 ± 0.08
2.591IleTyr: 2.591 ± 0.355
0.0IleXaa: 0.0 ± 0.0
Lys
5.131LysAla: 5.131 ± 0.419
0.389LysCys: 0.389 ± 0.112
4.353LysAsp: 4.353 ± 0.427
7.541LysGlu: 7.541 ± 0.6
1.529LysPhe: 1.529 ± 0.239
5.338LysGly: 5.338 ± 0.366
1.373LysHis: 1.373 ± 0.196
3.084LysIle: 3.084 ± 0.278
3.861LysLys: 3.861 ± 0.327
5.571LysLeu: 5.571 ± 0.407
2.073LysMet: 2.073 ± 0.234
3.136LysAsn: 3.136 ± 0.278
2.488LysPro: 2.488 ± 0.325
2.695LysGln: 2.695 ± 0.314
3.058LysArg: 3.058 ± 0.271
3.835LysSer: 3.835 ± 0.374
4.328LysThr: 4.328 ± 0.343
5.105LysVal: 5.105 ± 0.356
0.492LysTrp: 0.492 ± 0.115
2.514LysTyr: 2.514 ± 0.287
0.0LysXaa: 0.0 ± 0.0
Leu
6.271LeuAla: 6.271 ± 0.361
0.596LeuCys: 0.596 ± 0.117
5.053LeuAsp: 5.053 ± 0.397
6.323LeuGlu: 6.323 ± 0.485
3.861LeuPhe: 3.861 ± 0.402
5.338LeuGly: 5.338 ± 0.443
1.451LeuHis: 1.451 ± 0.204
5.001LeuIle: 5.001 ± 0.396
5.545LeuLys: 5.545 ± 0.452
7.8LeuLeu: 7.8 ± 0.587
1.944LeuMet: 1.944 ± 0.251
4.017LeuAsn: 4.017 ± 0.289
4.276LeuPro: 4.276 ± 0.343
2.747LeuGln: 2.747 ± 0.357
4.198LeuArg: 4.198 ± 0.291
6.66LeuSer: 6.66 ± 0.471
7.074LeuThr: 7.074 ± 0.601
5.545LeuVal: 5.545 ± 0.389
0.907LeuTrp: 0.907 ± 0.161
2.695LeuTyr: 2.695 ± 0.278
0.0LeuXaa: 0.0 ± 0.0
Met
1.633MetAla: 1.633 ± 0.197
0.207MetCys: 0.207 ± 0.072
1.14MetAsp: 1.14 ± 0.173
1.607MetGlu: 1.607 ± 0.201
0.803MetPhe: 0.803 ± 0.163
1.918MetGly: 1.918 ± 0.308
0.337MetHis: 0.337 ± 0.09
1.14MetIle: 1.14 ± 0.18
1.71MetLys: 1.71 ± 0.177
2.773MetLeu: 2.773 ± 0.295
0.57MetMet: 0.57 ± 0.131
1.399MetAsn: 1.399 ± 0.199
0.933MetPro: 0.933 ± 0.134
0.959MetGln: 0.959 ± 0.16
1.114MetArg: 1.114 ± 0.154
1.71MetSer: 1.71 ± 0.233
1.918MetThr: 1.918 ± 0.238
1.607MetVal: 1.607 ± 0.193
0.233MetTrp: 0.233 ± 0.083
1.425MetTyr: 1.425 ± 0.198
0.0MetXaa: 0.0 ± 0.0
Asn
3.395AsnAla: 3.395 ± 0.315
0.363AsnCys: 0.363 ± 0.09
2.514AsnAsp: 2.514 ± 0.241
2.85AsnGlu: 2.85 ± 0.29
1.347AsnPhe: 1.347 ± 0.172
3.498AsnGly: 3.498 ± 0.38
1.296AsnHis: 1.296 ± 0.215
3.706AsnIle: 3.706 ± 0.246
3.654AsnLys: 3.654 ± 0.308
4.017AsnLeu: 4.017 ± 0.305
1.503AsnMet: 1.503 ± 0.205
2.695AsnAsn: 2.695 ± 0.31
1.892AsnPro: 1.892 ± 0.258
1.322AsnGln: 1.322 ± 0.179
2.021AsnArg: 2.021 ± 0.22
3.032AsnSer: 3.032 ± 0.382
4.017AsnThr: 4.017 ± 0.385
3.939AsnVal: 3.939 ± 0.341
0.492AsnTrp: 0.492 ± 0.131
2.151AsnTyr: 2.151 ± 0.195
0.0AsnXaa: 0.0 ± 0.0
Pro
1.969ProAla: 1.969 ± 0.285
0.311ProCys: 0.311 ± 0.101
1.788ProAsp: 1.788 ± 0.232
2.85ProGlu: 2.85 ± 0.268
1.296ProPhe: 1.296 ± 0.216
0.855ProGly: 0.855 ± 0.127
0.907ProHis: 0.907 ± 0.163
2.643ProIle: 2.643 ± 0.347
2.721ProLys: 2.721 ± 0.36
3.265ProLeu: 3.265 ± 0.278
0.803ProMet: 0.803 ± 0.163
1.633ProAsn: 1.633 ± 0.2
1.062ProPro: 1.062 ± 0.196
1.14ProGln: 1.14 ± 0.174
1.011ProArg: 1.011 ± 0.168
3.161ProSer: 3.161 ± 0.262
2.565ProThr: 2.565 ± 0.292
3.213ProVal: 3.213 ± 0.409
0.233ProTrp: 0.233 ± 0.082
1.607ProTyr: 1.607 ± 0.2
0.0ProXaa: 0.0 ± 0.0
Gln
3.136GlnAla: 3.136 ± 0.424
0.181GlnCys: 0.181 ± 0.074
1.658GlnAsp: 1.658 ± 0.208
2.41GlnGlu: 2.41 ± 0.289
1.037GlnPhe: 1.037 ± 0.162
1.918GlnGly: 1.918 ± 0.278
0.492GlnHis: 0.492 ± 0.126
1.192GlnIle: 1.192 ± 0.176
2.177GlnLys: 2.177 ± 0.287
3.084GlnLeu: 3.084 ± 0.233
0.674GlnMet: 0.674 ± 0.127
1.244GlnAsn: 1.244 ± 0.174
1.555GlnPro: 1.555 ± 0.373
2.28GlnGln: 2.28 ± 0.893
1.633GlnArg: 1.633 ± 0.203
1.995GlnSer: 1.995 ± 0.253
1.866GlnThr: 1.866 ± 0.25
2.721GlnVal: 2.721 ± 0.254
0.311GlnTrp: 0.311 ± 0.082
1.399GlnTyr: 1.399 ± 0.212
0.0GlnXaa: 0.0 ± 0.0
Arg
3.421ArgAla: 3.421 ± 0.344
0.337ArgCys: 0.337 ± 0.109
2.229ArgAsp: 2.229 ± 0.281
3.524ArgGlu: 3.524 ± 0.328
1.71ArgPhe: 1.71 ± 0.215
3.084ArgGly: 3.084 ± 0.259
0.829ArgHis: 0.829 ± 0.147
2.306ArgIle: 2.306 ± 0.255
2.928ArgLys: 2.928 ± 0.314
4.379ArgLeu: 4.379 ± 0.381
1.477ArgMet: 1.477 ± 0.184
2.177ArgAsn: 2.177 ± 0.228
1.373ArgPro: 1.373 ± 0.234
1.477ArgGln: 1.477 ± 0.179
1.866ArgArg: 1.866 ± 0.223
2.617ArgSer: 2.617 ± 0.331
2.695ArgThr: 2.695 ± 0.223
3.239ArgVal: 3.239 ± 0.314
0.415ArgTrp: 0.415 ± 0.088
1.866ArgTyr: 1.866 ± 0.185
0.0ArgXaa: 0.0 ± 0.0
Ser
5.079SerAla: 5.079 ± 0.419
0.441SerCys: 0.441 ± 0.116
3.706SerAsp: 3.706 ± 0.345
3.991SerGlu: 3.991 ± 0.326
2.54SerPhe: 2.54 ± 0.273
3.939SerGly: 3.939 ± 0.389
1.166SerHis: 1.166 ± 0.187
4.224SerIle: 4.224 ± 0.364
5.235SerLys: 5.235 ± 0.443
6.09SerLeu: 6.09 ± 0.34
1.736SerMet: 1.736 ± 0.198
3.369SerAsn: 3.369 ± 0.285
2.514SerPro: 2.514 ± 0.326
2.047SerGln: 2.047 ± 0.226
2.669SerArg: 2.669 ± 0.295
4.302SerSer: 4.302 ± 0.509
4.587SerThr: 4.587 ± 0.416
5.26SerVal: 5.26 ± 0.405
0.622SerTrp: 0.622 ± 0.128
3.654SerTyr: 3.654 ± 0.407
0.0SerXaa: 0.0 ± 0.0
Thr
4.768ThrAla: 4.768 ± 0.479
0.518ThrCys: 0.518 ± 0.12
4.483ThrAsp: 4.483 ± 0.425
4.379ThrGlu: 4.379 ± 0.319
3.084ThrPhe: 3.084 ± 0.289
4.613ThrGly: 4.613 ± 0.372
1.477ThrHis: 1.477 ± 0.196
5.338ThrIle: 5.338 ± 0.362
4.613ThrLys: 4.613 ± 0.364
6.193ThrLeu: 6.193 ± 0.373
1.322ThrMet: 1.322 ± 0.175
3.369ThrAsn: 3.369 ± 0.411
2.825ThrPro: 2.825 ± 0.281
2.85ThrGln: 2.85 ± 0.278
2.773ThrArg: 2.773 ± 0.25
4.457ThrSer: 4.457 ± 0.347
5.183ThrThr: 5.183 ± 0.513
6.401ThrVal: 6.401 ± 0.484
0.907ThrTrp: 0.907 ± 0.152
3.369ThrTyr: 3.369 ± 0.355
0.0ThrXaa: 0.0 ± 0.0
Val
5.235ValAla: 5.235 ± 0.41
0.985ValCys: 0.985 ± 0.176
4.846ValAsp: 4.846 ± 0.365
4.535ValGlu: 4.535 ± 0.328
2.876ValPhe: 2.876 ± 0.245
4.12ValGly: 4.12 ± 0.324
1.684ValHis: 1.684 ± 0.222
4.198ValIle: 4.198 ± 0.329
4.768ValLys: 4.768 ± 0.37
6.582ValLeu: 6.582 ± 0.481
1.607ValMet: 1.607 ± 0.184
3.939ValAsn: 3.939 ± 0.292
2.721ValPro: 2.721 ± 0.297
2.125ValGln: 2.125 ± 0.268
3.602ValArg: 3.602 ± 0.302
6.375ValSer: 6.375 ± 0.482
6.478ValThr: 6.478 ± 0.455
6.789ValVal: 6.789 ± 0.51
0.726ValTrp: 0.726 ± 0.12
3.68ValTyr: 3.68 ± 0.375
0.0ValXaa: 0.0 ± 0.0
Trp
0.726TrpAla: 0.726 ± 0.141
0.052TrpCys: 0.052 ± 0.033
0.726TrpAsp: 0.726 ± 0.129
0.959TrpGlu: 0.959 ± 0.157
0.492TrpPhe: 0.492 ± 0.107
0.596TrpGly: 0.596 ± 0.156
0.233TrpHis: 0.233 ± 0.078
0.285TrpIle: 0.285 ± 0.094
0.596TrpLys: 0.596 ± 0.111
0.596TrpLeu: 0.596 ± 0.147
0.155TrpMet: 0.155 ± 0.059
0.466TrpAsn: 0.466 ± 0.119
0.0TrpPro: 0.0 ± 0.0
0.363TrpGln: 0.363 ± 0.087
0.544TrpArg: 0.544 ± 0.13
0.415TrpSer: 0.415 ± 0.101
0.648TrpThr: 0.648 ± 0.116
0.726TrpVal: 0.726 ± 0.148
0.285TrpTrp: 0.285 ± 0.098
0.492TrpTyr: 0.492 ± 0.119
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.006TyrAla: 3.006 ± 0.256
0.441TyrCys: 0.441 ± 0.101
2.825TyrAsp: 2.825 ± 0.265
2.565TyrGlu: 2.565 ± 0.23
1.244TyrPhe: 1.244 ± 0.203
2.436TyrGly: 2.436 ± 0.256
0.933TyrHis: 0.933 ± 0.162
3.136TyrIle: 3.136 ± 0.372
2.41TyrLys: 2.41 ± 0.244
4.82TyrLeu: 4.82 ± 0.697
1.011TyrMet: 1.011 ± 0.184
2.254TyrAsn: 2.254 ± 0.227
1.71TyrPro: 1.71 ± 0.182
1.633TyrGln: 1.633 ± 0.246
1.477TyrArg: 1.477 ± 0.195
3.55TyrSer: 3.55 ± 0.305
4.042TyrThr: 4.042 ± 0.404
3.317TyrVal: 3.317 ± 0.297
0.207TyrTrp: 0.207 ± 0.075
2.436TyrTyr: 2.436 ± 0.293
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 199 proteins (38591 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski