Amino acid dipepetide frequency for Klugiella xanthotipulae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.14AlaAla: 17.14 ± 0.239
0.722AlaCys: 0.722 ± 0.03
6.864AlaAsp: 6.864 ± 0.096
7.918AlaGlu: 7.918 ± 0.125
3.319AlaPhe: 3.319 ± 0.068
11.041AlaGly: 11.041 ± 0.149
2.544AlaHis: 2.544 ± 0.065
5.426AlaIle: 5.426 ± 0.088
2.361AlaLys: 2.361 ± 0.065
12.606AlaLeu: 12.606 ± 0.145
2.062AlaMet: 2.062 ± 0.052
2.537AlaAsn: 2.537 ± 0.061
5.679AlaPro: 5.679 ± 0.105
4.011AlaGln: 4.011 ± 0.073
7.836AlaArg: 7.836 ± 0.124
6.987AlaSer: 6.987 ± 0.09
8.07AlaThr: 8.07 ± 0.147
10.202AlaVal: 10.202 ± 0.118
1.487AlaTrp: 1.487 ± 0.039
2.225AlaTyr: 2.225 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
0.87CysAla: 0.87 ± 0.033
0.06CysCys: 0.06 ± 0.012
0.372CysAsp: 0.372 ± 0.024
0.3CysGlu: 0.3 ± 0.018
0.181CysPhe: 0.181 ± 0.014
0.662CysGly: 0.662 ± 0.029
0.124CysHis: 0.124 ± 0.012
0.254CysIle: 0.254 ± 0.015
0.067CysLys: 0.067 ± 0.008
0.526CysLeu: 0.526 ± 0.027
0.079CysMet: 0.079 ± 0.009
0.126CysAsn: 0.126 ± 0.011
0.302CysPro: 0.302 ± 0.022
0.146CysGln: 0.146 ± 0.015
0.332CysArg: 0.332 ± 0.021
0.394CysSer: 0.394 ± 0.02
0.445CysThr: 0.445 ± 0.029
0.605CysVal: 0.605 ± 0.026
0.087CysTrp: 0.087 ± 0.014
0.136CysTyr: 0.136 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
6.773AspAla: 6.773 ± 0.113
0.283AspCys: 0.283 ± 0.017
3.168AspAsp: 3.168 ± 0.078
3.716AspGlu: 3.716 ± 0.072
1.656AspPhe: 1.656 ± 0.047
5.078AspGly: 5.078 ± 0.106
1.079AspHis: 1.079 ± 0.033
2.733AspIle: 2.733 ± 0.06
1.062AspLys: 1.062 ± 0.041
5.682AspLeu: 5.682 ± 0.089
0.782AspMet: 0.782 ± 0.029
1.394AspAsn: 1.394 ± 0.046
3.786AspPro: 3.786 ± 0.081
1.553AspGln: 1.553 ± 0.045
3.775AspArg: 3.775 ± 0.078
3.367AspSer: 3.367 ± 0.071
3.669AspThr: 3.669 ± 0.083
4.339AspVal: 4.339 ± 0.07
0.773AspTrp: 0.773 ± 0.038
1.432AspTyr: 1.432 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
6.562GluAla: 6.562 ± 0.114
0.355GluCys: 0.355 ± 0.026
2.697GluAsp: 2.697 ± 0.059
2.926GluGlu: 2.926 ± 0.067
1.739GluPhe: 1.739 ± 0.045
4.035GluGly: 4.035 ± 0.068
1.471GluHis: 1.471 ± 0.047
2.675GluIle: 2.675 ± 0.061
1.561GluLys: 1.561 ± 0.053
6.279GluLeu: 6.279 ± 0.101
1.077GluMet: 1.077 ± 0.036
1.577GluAsn: 1.577 ± 0.04
2.686GluPro: 2.686 ± 0.063
1.985GluGln: 1.985 ± 0.056
4.651GluArg: 4.651 ± 0.102
3.381GluSer: 3.381 ± 0.072
3.383GluThr: 3.383 ± 0.066
4.536GluVal: 4.536 ± 0.065
0.942GluTrp: 0.942 ± 0.037
1.343GluTyr: 1.343 ± 0.049
0.0GluXaa: 0.0 ± 0.0
Phe
3.506PheAla: 3.506 ± 0.072
0.215PheCys: 0.215 ± 0.018
2.116PheAsp: 2.116 ± 0.059
1.661PheGlu: 1.661 ± 0.05
1.183PhePhe: 1.183 ± 0.046
2.889PheGly: 2.889 ± 0.061
0.535PheHis: 0.535 ± 0.026
1.452PheIle: 1.452 ± 0.045
0.46PheLys: 0.46 ± 0.026
2.863PheLeu: 2.863 ± 0.065
0.493PheMet: 0.493 ± 0.026
0.798PheAsn: 0.798 ± 0.032
1.466PhePro: 1.466 ± 0.049
0.816PheGln: 0.816 ± 0.033
1.803PheArg: 1.803 ± 0.053
2.237PheSer: 2.237 ± 0.05
2.567PheThr: 2.567 ± 0.066
2.793PheVal: 2.793 ± 0.066
0.422PheTrp: 0.422 ± 0.023
0.769PheTyr: 0.769 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
9.16GlyAla: 9.16 ± 0.133
0.657GlyCys: 0.657 ± 0.027
4.73GlyAsp: 4.73 ± 0.089
4.97GlyGlu: 4.97 ± 0.084
3.16GlyPhe: 3.16 ± 0.059
7.598GlyGly: 7.598 ± 0.153
1.774GlyHis: 1.774 ± 0.045
4.681GlyIle: 4.681 ± 0.073
2.234GlyLys: 2.234 ± 0.058
8.433GlyLeu: 8.433 ± 0.107
1.871GlyMet: 1.871 ± 0.057
2.375GlyAsn: 2.375 ± 0.105
3.493GlyPro: 3.493 ± 0.071
2.687GlyGln: 2.687 ± 0.063
5.519GlyArg: 5.519 ± 0.103
6.132GlySer: 6.132 ± 0.133
6.527GlyThr: 6.527 ± 0.205
7.821GlyVal: 7.821 ± 0.105
1.544GlyTrp: 1.544 ± 0.048
2.359GlyTyr: 2.359 ± 0.053
0.0GlyXaa: 0.0 ± 0.0
His
1.999HisAla: 1.999 ± 0.058
0.132HisCys: 0.132 ± 0.013
1.164HisAsp: 1.164 ± 0.04
1.175HisGlu: 1.175 ± 0.041
0.576HisPhe: 0.576 ± 0.026
1.873HisGly: 1.873 ± 0.05
0.536HisHis: 0.536 ± 0.026
0.882HisIle: 0.882 ± 0.029
0.346HisLys: 0.346 ± 0.02
1.95HisLeu: 1.95 ± 0.049
0.261HisMet: 0.261 ± 0.018
0.594HisAsn: 0.594 ± 0.029
1.61HisPro: 1.61 ± 0.049
0.526HisGln: 0.526 ± 0.027
1.511HisArg: 1.511 ± 0.045
1.345HisSer: 1.345 ± 0.039
1.444HisThr: 1.444 ± 0.047
1.319HisVal: 1.319 ± 0.046
0.25HisTrp: 0.25 ± 0.017
0.507HisTyr: 0.507 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
6.082IleAla: 6.082 ± 0.094
0.283IleCys: 0.283 ± 0.021
3.135IleAsp: 3.135 ± 0.059
2.754IleGlu: 2.754 ± 0.065
1.463IlePhe: 1.463 ± 0.049
4.035IleGly: 4.035 ± 0.072
0.813IleHis: 0.813 ± 0.032
2.344IleIle: 2.344 ± 0.067
0.846IleLys: 0.846 ± 0.035
4.465IleLeu: 4.465 ± 0.082
0.687IleMet: 0.687 ± 0.034
1.357IleAsn: 1.357 ± 0.048
2.805IlePro: 2.805 ± 0.06
1.18IleGln: 1.18 ± 0.034
3.017IleArg: 3.017 ± 0.063
2.886IleSer: 2.886 ± 0.065
3.748IleThr: 3.748 ± 0.091
4.566IleVal: 4.566 ± 0.077
0.498IleTrp: 0.498 ± 0.027
0.901IleTyr: 0.901 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
2.187LysAla: 2.187 ± 0.056
0.086LysCys: 0.086 ± 0.01
1.082LysAsp: 1.082 ± 0.042
0.946LysGlu: 0.946 ± 0.035
0.579LysPhe: 0.579 ± 0.025
1.475LysGly: 1.475 ± 0.046
0.411LysHis: 0.411 ± 0.02
1.156LysIle: 1.156 ± 0.04
1.016LysLys: 1.016 ± 0.048
1.981LysLeu: 1.981 ± 0.053
0.461LysMet: 0.461 ± 0.024
0.88LysAsn: 0.88 ± 0.034
1.247LysPro: 1.247 ± 0.049
0.699LysGln: 0.699 ± 0.03
1.634LysArg: 1.634 ± 0.048
1.285LysSer: 1.285 ± 0.042
1.547LysThr: 1.547 ± 0.048
1.6LysVal: 1.6 ± 0.044
0.235LysTrp: 0.235 ± 0.016
0.478LysTyr: 0.478 ± 0.026
0.0LysXaa: 0.0 ± 0.0
Leu
13.284LeuAla: 13.284 ± 0.158
0.694LeuCys: 0.694 ± 0.031
5.89LeuAsp: 5.89 ± 0.093
4.189LeuGlu: 4.189 ± 0.086
2.778LeuPhe: 2.778 ± 0.069
9.378LeuGly: 9.378 ± 0.147
1.831LeuHis: 1.831 ± 0.049
4.766LeuIle: 4.766 ± 0.084
1.796LeuLys: 1.796 ± 0.054
10.059LeuLeu: 10.059 ± 0.154
1.728LeuMet: 1.728 ± 0.053
2.662LeuAsn: 2.662 ± 0.06
5.541LeuPro: 5.541 ± 0.086
2.175LeuGln: 2.175 ± 0.06
6.906LeuArg: 6.906 ± 0.127
7.033LeuSer: 7.033 ± 0.093
7.567LeuThr: 7.567 ± 0.105
8.853LeuVal: 8.853 ± 0.121
1.302LeuTrp: 1.302 ± 0.046
1.818LeuTyr: 1.818 ± 0.051
0.0LeuXaa: 0.0 ± 0.0
Met
1.943MetAla: 1.943 ± 0.047
0.109MetCys: 0.109 ± 0.011
0.677MetAsp: 0.677 ± 0.026
0.652MetGlu: 0.652 ± 0.03
0.542MetPhe: 0.542 ± 0.024
1.365MetGly: 1.365 ± 0.044
0.297MetHis: 0.297 ± 0.018
0.917MetIle: 0.917 ± 0.035
0.478MetLys: 0.478 ± 0.025
1.726MetLeu: 1.726 ± 0.049
0.36MetMet: 0.36 ± 0.022
0.567MetAsn: 0.567 ± 0.028
1.056MetPro: 1.056 ± 0.038
0.454MetGln: 0.454 ± 0.025
1.202MetArg: 1.202 ± 0.044
1.645MetSer: 1.645 ± 0.041
1.7MetThr: 1.7 ± 0.042
1.312MetVal: 1.312 ± 0.043
0.201MetTrp: 0.201 ± 0.014
0.286MetTyr: 0.286 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
2.902AsnAla: 2.902 ± 0.063
0.146AsnCys: 0.146 ± 0.015
1.459AsnAsp: 1.459 ± 0.043
1.269AsnGlu: 1.269 ± 0.042
0.795AsnPhe: 0.795 ± 0.032
2.45AsnGly: 2.45 ± 0.082
0.418AsnHis: 0.418 ± 0.021
1.193AsnIle: 1.193 ± 0.034
0.552AsnLys: 0.552 ± 0.028
2.448AsnLeu: 2.448 ± 0.059
0.438AsnMet: 0.438 ± 0.023
0.899AsnAsn: 0.899 ± 0.041
2.015AsnPro: 2.015 ± 0.083
0.714AsnGln: 0.714 ± 0.029
1.754AsnArg: 1.754 ± 0.054
1.613AsnSer: 1.613 ± 0.05
1.805AsnThr: 1.805 ± 0.057
2.006AsnVal: 2.006 ± 0.05
0.341AsnTrp: 0.341 ± 0.021
0.649AsnTyr: 0.649 ± 0.029
0.0AsnXaa: 0.0 ± 0.0
Pro
6.536ProAla: 6.536 ± 0.133
0.21ProCys: 0.21 ± 0.018
3.28ProAsp: 3.28 ± 0.073
3.976ProGlu: 3.976 ± 0.071
1.611ProPhe: 1.611 ± 0.042
5.155ProGly: 5.155 ± 0.095
1.265ProHis: 1.265 ± 0.048
2.072ProIle: 2.072 ± 0.051
0.938ProLys: 0.938 ± 0.04
5.21ProLeu: 5.21 ± 0.081
0.723ProMet: 0.723 ± 0.031
1.138ProAsn: 1.138 ± 0.043
2.459ProPro: 2.459 ± 0.067
1.66ProGln: 1.66 ± 0.048
3.331ProArg: 3.331 ± 0.071
3.322ProSer: 3.322 ± 0.072
3.976ProThr: 3.976 ± 0.079
5.236ProVal: 5.236 ± 0.108
0.742ProTrp: 0.742 ± 0.03
1.113ProTyr: 1.113 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
3.359GlnAla: 3.359 ± 0.08
0.126GlnCys: 0.126 ± 0.013
1.186GlnAsp: 1.186 ± 0.041
1.371GlnGlu: 1.371 ± 0.04
0.886GlnPhe: 0.886 ± 0.031
1.985GlnGly: 1.985 ± 0.045
0.674GlnHis: 0.674 ± 0.029
1.552GlnIle: 1.552 ± 0.044
0.889GlnLys: 0.889 ± 0.038
3.361GlnLeu: 3.361 ± 0.064
0.543GlnMet: 0.543 ± 0.023
0.846GlnAsn: 0.846 ± 0.037
1.765GlnPro: 1.765 ± 0.054
1.181GlnGln: 1.181 ± 0.046
2.438GlnArg: 2.438 ± 0.066
1.67GlnSer: 1.67 ± 0.047
1.695GlnThr: 1.695 ± 0.044
2.435GlnVal: 2.435 ± 0.056
0.372GlnTrp: 0.372 ± 0.02
0.669GlnTyr: 0.669 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
7.762ArgAla: 7.762 ± 0.132
0.336ArgCys: 0.336 ± 0.021
3.961ArgAsp: 3.961 ± 0.09
4.361ArgGlu: 4.361 ± 0.09
2.133ArgPhe: 2.133 ± 0.054
5.101ArgGly: 5.101 ± 0.089
1.421ArgHis: 1.421 ± 0.045
3.353ArgIle: 3.353 ± 0.062
1.412ArgLys: 1.412 ± 0.05
6.662ArgLeu: 6.662 ± 0.105
1.597ArgMet: 1.597 ± 0.042
1.654ArgAsn: 1.654 ± 0.04
3.281ArgPro: 3.281 ± 0.069
2.081ArgGln: 2.081 ± 0.052
5.204ArgArg: 5.204 ± 0.114
4.117ArgSer: 4.117 ± 0.079
3.963ArgThr: 3.963 ± 0.074
6.274ArgVal: 6.274 ± 0.098
1.033ArgTrp: 1.033 ± 0.033
1.703ArgTyr: 1.703 ± 0.05
0.0ArgXaa: 0.0 ± 0.0
Ser
7.771SerAla: 7.771 ± 0.12
0.386SerCys: 0.386 ± 0.026
3.498SerAsp: 3.498 ± 0.05
3.307SerGlu: 3.307 ± 0.077
2.218SerPhe: 2.218 ± 0.057
6.551SerGly: 6.551 ± 0.144
1.205SerHis: 1.205 ± 0.038
3.12SerIle: 3.12 ± 0.058
1.177SerLys: 1.177 ± 0.036
6.375SerLeu: 6.375 ± 0.088
1.2SerMet: 1.2 ± 0.037
1.476SerAsn: 1.476 ± 0.046
3.594SerPro: 3.594 ± 0.069
1.694SerGln: 1.694 ± 0.052
4.041SerArg: 4.041 ± 0.085
4.178SerSer: 4.178 ± 0.081
4.391SerThr: 4.391 ± 0.084
5.724SerVal: 5.724 ± 0.091
0.955SerTrp: 0.955 ± 0.034
1.492SerTyr: 1.492 ± 0.044
0.0SerXaa: 0.0 ± 0.0
Thr
8.585ThrAla: 8.585 ± 0.185
0.387ThrCys: 0.387 ± 0.025
3.879ThrAsp: 3.879 ± 0.094
3.811ThrGlu: 3.811 ± 0.067
2.191ThrPhe: 2.191 ± 0.066
6.645ThrGly: 6.645 ± 0.138
1.412ThrHis: 1.412 ± 0.038
3.328ThrIle: 3.328 ± 0.07
1.357ThrLys: 1.357 ± 0.051
7.151ThrLeu: 7.151 ± 0.105
1.01ThrMet: 1.01 ± 0.032
1.712ThrAsn: 1.712 ± 0.063
4.821ThrPro: 4.821 ± 0.086
1.874ThrGln: 1.874 ± 0.05
4.097ThrArg: 4.097 ± 0.081
4.145ThrSer: 4.145 ± 0.091
4.9ThrThr: 4.9 ± 0.118
7.368ThrVal: 7.368 ± 0.24
0.925ThrTrp: 0.925 ± 0.04
1.471ThrTyr: 1.471 ± 0.06
0.0ThrXaa: 0.0 ± 0.0
Val
10.687ValAla: 10.687 ± 0.108
0.61ValCys: 0.61 ± 0.029
4.908ValAsp: 4.908 ± 0.099
4.8ValGlu: 4.8 ± 0.091
2.752ValPhe: 2.752 ± 0.057
7.23ValGly: 7.23 ± 0.096
1.587ValHis: 1.587 ± 0.044
4.54ValIle: 4.54 ± 0.076
1.714ValLys: 1.714 ± 0.053
8.549ValLeu: 8.549 ± 0.12
1.525ValMet: 1.525 ± 0.047
2.242ValAsn: 2.242 ± 0.055
4.555ValPro: 4.555 ± 0.089
2.318ValGln: 2.318 ± 0.053
5.439ValArg: 5.439 ± 0.091
6.286ValSer: 6.286 ± 0.138
7.309ValThr: 7.309 ± 0.223
8.351ValVal: 8.351 ± 0.153
1.191ValTrp: 1.191 ± 0.034
1.605ValTyr: 1.605 ± 0.049
0.0ValXaa: 0.0 ± 0.0
Trp
1.482TrpAla: 1.482 ± 0.045
0.121TrpCys: 0.121 ± 0.012
0.682TrpAsp: 0.682 ± 0.033
0.619TrpGlu: 0.619 ± 0.028
0.51TrpPhe: 0.51 ± 0.026
1.159TrpGly: 1.159 ± 0.041
0.283TrpHis: 0.283 ± 0.017
0.635TrpIle: 0.635 ± 0.028
0.336TrpLys: 0.336 ± 0.024
1.645TrpLeu: 1.645 ± 0.049
0.297TrpMet: 0.297 ± 0.017
0.435TrpAsn: 0.435 ± 0.02
0.588TrpPro: 0.588 ± 0.026
0.559TrpGln: 0.559 ± 0.026
1.086TrpArg: 1.086 ± 0.036
0.931TrpSer: 0.931 ± 0.033
0.837TrpThr: 0.837 ± 0.037
1.156TrpVal: 1.156 ± 0.038
0.338TrpTrp: 0.338 ± 0.019
0.274TrpTyr: 0.274 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.449TyrAla: 2.449 ± 0.06
0.15TyrCys: 0.15 ± 0.014
1.352TyrAsp: 1.352 ± 0.063
1.142TyrGlu: 1.142 ± 0.041
0.772TyrPhe: 0.772 ± 0.027
2.022TyrGly: 2.022 ± 0.05
0.32TyrHis: 0.32 ± 0.021
0.787TyrIle: 0.787 ± 0.029
0.381TyrLys: 0.381 ± 0.024
2.28TyrLeu: 2.28 ± 0.053
0.291TyrMet: 0.291 ± 0.019
0.598TyrAsn: 0.598 ± 0.031
1.202TyrPro: 1.202 ± 0.04
0.689TyrGln: 0.689 ± 0.031
1.835TyrArg: 1.835 ± 0.053
1.399TyrSer: 1.399 ± 0.048
1.528TyrThr: 1.528 ± 0.061
1.702TyrVal: 1.702 ± 0.039
0.332TyrTrp: 0.332 ± 0.02
0.518TyrTyr: 0.518 ± 0.03
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2573 proteins (880817 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski