Amino acid dipepetide frequency for Brachyspira pilosicoli (strain ATCC BAA-1826 / 95/1000)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.608AlaAla: 3.608 ± 0.101	0.674AlaCys: 0.674 ± 0.034	3.122AlaAsp: 3.122 ± 0.073	3.146AlaGlu: 3.146 ± 0.073	2.811AlaPhe: 2.811 ± 0.075	3.635AlaGly: 3.635 ± 0.093	0.771AlaHis: 0.771 ± 0.032	6.184AlaIle: 6.184 ± 0.113	5.049AlaLys: 5.049 ± 0.094	6.328AlaLeu: 6.328 ± 0.116	1.708AlaMet: 1.708 ± 0.05	3.751AlaAsn: 3.751 ± 0.078	1.385AlaPro: 1.385 ± 0.045	1.45AlaGln: 1.45 ± 0.05	1.866AlaArg: 1.866 ± 0.06	4.308AlaSer: 4.308 ± 0.096	2.581AlaThr: 2.581 ± 0.066	3.859AlaVal: 3.859 ± 0.086	0.362AlaTrp: 0.362 ± 0.026	2.572AlaTyr: 2.572 ± 0.069	0.0AlaXaa: 0.0 ± 0.0
Cys	0.549CysAla: 0.549 ± 0.029	0.08CysCys: 0.08 ± 0.011	0.528CysAsp: 0.528 ± 0.025	0.528CysGlu: 0.528 ± 0.028	0.439CysPhe: 0.439 ± 0.026	0.748CysGly: 0.748 ± 0.031	0.157CysHis: 0.157 ± 0.015	0.862CysIle: 0.862 ± 0.031	0.746CysLys: 0.746 ± 0.034	0.663CysLeu: 0.663 ± 0.028	0.201CysMet: 0.201 ± 0.015	0.581CysAsn: 0.581 ± 0.028	0.357CysPro: 0.357 ± 0.024	0.13CysGln: 0.13 ± 0.013	0.262CysArg: 0.262 ± 0.019	0.663CysSer: 0.663 ± 0.033	0.354CysThr: 0.354 ± 0.023	0.506CysVal: 0.506 ± 0.029	0.037CysTrp: 0.037 ± 0.007	0.409CysTyr: 0.409 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	3.089AspAla: 3.089 ± 0.067	0.427AspCys: 0.427 ± 0.025	3.718AspAsp: 3.718 ± 0.129	4.222AspGlu: 4.222 ± 0.111	3.113AspPhe: 3.113 ± 0.066	3.055AspGly: 3.055 ± 0.083	0.431AspHis: 0.431 ± 0.025	7.332AspIle: 7.332 ± 0.11	5.784AspLys: 5.784 ± 0.092	4.539AspLeu: 4.539 ± 0.086	1.637AspMet: 1.637 ± 0.045	4.869AspAsn: 4.869 ± 0.127	1.265AspPro: 1.265 ± 0.04	0.528AspGln: 0.528 ± 0.028	1.849AspArg: 1.849 ± 0.054	3.608AspSer: 3.608 ± 0.088	2.805AspThr: 2.805 ± 0.064	3.409AspVal: 3.409 ± 0.077	0.376AspTrp: 0.376 ± 0.024	3.336AspTyr: 3.336 ± 0.076	0.0AspXaa: 0.0 ± 0.0
Glu	4.468GluAla: 4.468 ± 0.084	0.545GluCys: 0.545 ± 0.028	4.093GluAsp: 4.093 ± 0.091	6.308GluGlu: 6.308 ± 0.217	2.515GluPhe: 2.515 ± 0.064	3.192GluGly: 3.192 ± 0.062	1.018GluHis: 1.018 ± 0.038	6.26GluIle: 6.26 ± 0.117	6.627GluLys: 6.627 ± 0.129	5.964GluLeu: 5.964 ± 0.148	1.632GluMet: 1.632 ± 0.049	5.974GluAsn: 5.974 ± 0.126	1.355GluPro: 1.355 ± 0.046	1.429GluGln: 1.429 ± 0.043	2.454GluArg: 2.454 ± 0.076	3.699GluSer: 3.699 ± 0.101	2.967GluThr: 2.967 ± 0.061	3.832GluVal: 3.832 ± 0.078	0.435GluTrp: 0.435 ± 0.026	3.797GluTyr: 3.797 ± 0.089	0.0GluXaa: 0.0 ± 0.0
Phe	2.889PheAla: 2.889 ± 0.068	0.489PheCys: 0.489 ± 0.023	3.144PheAsp: 3.144 ± 0.074	2.92PheGlu: 2.92 ± 0.08	2.627PhePhe: 2.627 ± 0.072	2.844PheGly: 2.844 ± 0.077	0.582PheHis: 0.582 ± 0.028	5.167PheIle: 5.167 ± 0.117	3.349PheLys: 3.349 ± 0.063	4.354PheLeu: 4.354 ± 0.084	1.181PheMet: 1.181 ± 0.045	3.863PheAsn: 3.863 ± 0.087	1.298PhePro: 1.298 ± 0.043	0.933PheGln: 0.933 ± 0.037	1.515PheArg: 1.515 ± 0.045	3.53PheSer: 3.53 ± 0.078	2.399PheThr: 2.399 ± 0.062	2.78PheVal: 2.78 ± 0.08	0.271PheTrp: 0.271 ± 0.021	2.306PheTyr: 2.306 ± 0.064	0.0PheXaa: 0.0 ± 0.0
Gly	3.842GlyAla: 3.842 ± 0.106	0.579GlyCys: 0.579 ± 0.034	2.961GlyAsp: 2.961 ± 0.077	3.323GlyGlu: 3.323 ± 0.075	3.033GlyPhe: 3.033 ± 0.08	3.95GlyGly: 3.95 ± 0.119	0.819GlyHis: 0.819 ± 0.032	5.699GlyIle: 5.699 ± 0.113	4.189GlyLys: 4.189 ± 0.09	4.49GlyLeu: 4.49 ± 0.102	1.409GlyMet: 1.409 ± 0.048	3.241GlyAsn: 3.241 ± 0.069	0.921GlyPro: 0.921 ± 0.038	1.042GlyGln: 1.042 ± 0.046	1.824GlyArg: 1.824 ± 0.053	3.573GlySer: 3.573 ± 0.089	2.653GlyThr: 2.653 ± 0.077	3.985GlyVal: 3.985 ± 0.097	0.391GlyTrp: 0.391 ± 0.025	2.898GlyTyr: 2.898 ± 0.08	0.0GlyXaa: 0.0 ± 0.0
His	0.727HisAla: 0.727 ± 0.032	0.152HisCys: 0.152 ± 0.015	0.594HisAsp: 0.594 ± 0.033	0.632HisGlu: 0.632 ± 0.029	0.682HisPhe: 0.682 ± 0.027	0.759HisGly: 0.759 ± 0.033	0.277HisHis: 0.277 ± 0.023	1.457HisIle: 1.457 ± 0.045	1.011HisLys: 1.011 ± 0.042	1.101HisLeu: 1.101 ± 0.043	0.257HisMet: 0.257 ± 0.017	0.946HisAsn: 0.946 ± 0.038	0.514HisPro: 0.514 ± 0.032	0.288HisGln: 0.288 ± 0.021	0.469HisArg: 0.469 ± 0.025	0.941HisSer: 0.941 ± 0.037	0.705HisThr: 0.705 ± 0.032	0.6HisVal: 0.6 ± 0.025	0.098HisTrp: 0.098 ± 0.012	0.717HisTyr: 0.717 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	6.299IleAla: 6.299 ± 0.093	0.887IleCys: 0.887 ± 0.038	6.73IleAsp: 6.73 ± 0.124	7.605IleGlu: 7.605 ± 0.143	5.169IlePhe: 5.169 ± 0.129	5.454IleGly: 5.454 ± 0.12	1.062IleHis: 1.062 ± 0.038	10.597IleIle: 10.597 ± 0.17	9.601IleLys: 9.601 ± 0.13	9.138IleLeu: 9.138 ± 0.139	2.317IleMet: 2.317 ± 0.066	7.556IleAsn: 7.556 ± 0.119	3.26IlePro: 3.26 ± 0.07	1.683IleGln: 1.683 ± 0.051	2.89IleArg: 2.89 ± 0.065	7.466IleSer: 7.466 ± 0.128	5.07IleThr: 5.07 ± 0.082	6.166IleVal: 6.166 ± 0.111	0.463IleTrp: 0.463 ± 0.027	4.451IleTyr: 4.451 ± 0.09	0.0IleXaa: 0.0 ± 0.0
Lys	4.785LysAla: 4.785 ± 0.095	0.582LysCys: 0.582 ± 0.027	6.211LysAsp: 6.211 ± 0.098	8.59LysGlu: 8.59 ± 0.126	2.962LysPhe: 2.962 ± 0.068	3.691LysGly: 3.691 ± 0.078	1.165LysHis: 1.165 ± 0.042	8.437LysIle: 8.437 ± 0.125	9.277LysLys: 9.277 ± 0.152	7.323LysLeu: 7.323 ± 0.127	2.3LysMet: 2.3 ± 0.056	7.506LysAsn: 7.506 ± 0.117	1.925LysPro: 1.925 ± 0.046	1.793LysGln: 1.793 ± 0.05	2.978LysArg: 2.978 ± 0.068	4.763LysSer: 4.763 ± 0.082	4.584LysThr: 4.584 ± 0.087	4.622LysVal: 4.622 ± 0.077	0.562LysTrp: 0.562 ± 0.028	4.707LysTyr: 4.707 ± 0.091	0.0LysXaa: 0.0 ± 0.0
Leu	5.063LeuAla: 5.063 ± 0.102	0.866LeuCys: 0.866 ± 0.036	5.007LeuAsp: 5.007 ± 0.104	6.335LeuGlu: 6.335 ± 0.162	4.538LeuPhe: 4.538 ± 0.102	5.093LeuGly: 5.093 ± 0.115	1.094LeuHis: 1.094 ± 0.042	8.412LeuIle: 8.412 ± 0.135	8.17LeuLys: 8.17 ± 0.122	7.689LeuLeu: 7.689 ± 0.13	2.193LeuMet: 2.193 ± 0.056	6.138LeuAsn: 6.138 ± 0.103	2.662LeuPro: 2.662 ± 0.066	1.904LeuGln: 1.904 ± 0.049	2.558LeuArg: 2.558 ± 0.06	6.788LeuSer: 6.788 ± 0.1	4.217LeuThr: 4.217 ± 0.078	4.376LeuVal: 4.376 ± 0.086	0.502LeuTrp: 0.502 ± 0.026	4.047LeuTyr: 4.047 ± 0.084	0.0LeuXaa: 0.0 ± 0.0
Met	1.707MetAla: 1.707 ± 0.052	0.173MetCys: 0.173 ± 0.017	1.172MetAsp: 1.172 ± 0.04	1.574MetGlu: 1.574 ± 0.047	1.258MetPhe: 1.258 ± 0.046	1.46MetGly: 1.46 ± 0.053	0.46MetHis: 0.46 ± 0.022	2.25MetIle: 2.25 ± 0.064	2.252MetLys: 2.252 ± 0.055	2.261MetLeu: 2.261 ± 0.058	0.687MetMet: 0.687 ± 0.037	1.61MetAsn: 1.61 ± 0.048	1.075MetPro: 1.075 ± 0.038	0.752MetGln: 0.752 ± 0.03	0.95MetArg: 0.95 ± 0.035	1.848MetSer: 1.848 ± 0.051	1.087MetThr: 1.087 ± 0.04	1.283MetVal: 1.283 ± 0.044	0.144MetTrp: 0.144 ± 0.014	1.0MetTyr: 1.0 ± 0.038	0.0MetXaa: 0.0 ± 0.0
Asn	4.167AsnAla: 4.167 ± 0.088	0.493AsnCys: 0.493 ± 0.025	4.331AsnAsp: 4.331 ± 0.101	4.543AsnGlu: 4.543 ± 0.105	3.144AsnPhe: 3.144 ± 0.072	3.695AsnGly: 3.695 ± 0.081	0.748AsnHis: 0.748 ± 0.03	10.293AsnIle: 10.293 ± 0.17	7.087AsnLys: 7.087 ± 0.11	5.471AsnLeu: 5.471 ± 0.106	1.991AsnMet: 1.991 ± 0.058	7.769AsnAsn: 7.769 ± 0.207	2.034AsnPro: 2.034 ± 0.054	1.476AsnGln: 1.476 ± 0.05	2.22AsnArg: 2.22 ± 0.057	4.34AsnSer: 4.34 ± 0.097	3.982AsnThr: 3.982 ± 0.103	3.939AsnVal: 3.939 ± 0.078	0.457AsnTrp: 0.457 ± 0.025	3.728AsnTyr: 3.728 ± 0.087	0.0AsnXaa: 0.0 ± 0.0
Pro	1.477ProAla: 1.477 ± 0.051	0.231ProCys: 0.231 ± 0.021	1.502ProAsp: 1.502 ± 0.049	1.872ProGlu: 1.872 ± 0.049	1.558ProPhe: 1.558 ± 0.047	1.03ProGly: 1.03 ± 0.038	0.433ProHis: 0.433 ± 0.024	2.872ProIle: 2.872 ± 0.063	2.054ProLys: 2.054 ± 0.053	2.558ProLeu: 2.558 ± 0.068	0.646ProMet: 0.646 ± 0.029	1.918ProAsn: 1.918 ± 0.056	0.737ProPro: 0.737 ± 0.036	0.625ProGln: 0.625 ± 0.029	0.765ProArg: 0.765 ± 0.037	1.713ProSer: 1.713 ± 0.056	1.536ProThr: 1.536 ± 0.049	1.642ProVal: 1.642 ± 0.058	0.16ProTrp: 0.16 ± 0.015	1.41ProTyr: 1.41 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	1.333GlnAla: 1.333 ± 0.044	0.166GlnCys: 0.166 ± 0.015	1.025GlnAsp: 1.025 ± 0.04	1.269GlnGlu: 1.269 ± 0.044	0.862GlnPhe: 0.862 ± 0.035	1.035GlnGly: 1.035 ± 0.046	0.261GlnHis: 0.261 ± 0.017	1.907GlnIle: 1.907 ± 0.054	1.845GlnLys: 1.845 ± 0.046	1.638GlnLeu: 1.638 ± 0.051	0.642GlnMet: 0.642 ± 0.032	1.73GlnAsn: 1.73 ± 0.054	0.448GlnPro: 0.448 ± 0.029	0.492GlnGln: 0.492 ± 0.027	0.734GlnArg: 0.734 ± 0.036	1.22GlnSer: 1.22 ± 0.037	1.226GlnThr: 1.226 ± 0.035	1.115GlnVal: 1.115 ± 0.045	0.153GlnTrp: 0.153 ± 0.014	1.038GlnTyr: 1.038 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	1.975ArgAla: 1.975 ± 0.057	0.248ArgCys: 0.248 ± 0.02	2.112ArgAsp: 2.112 ± 0.057	2.776ArgGlu: 2.776 ± 0.069	1.53ArgPhe: 1.53 ± 0.043	1.893ArgGly: 1.893 ± 0.057	0.456ArgHis: 0.456 ± 0.025	2.88ArgIle: 2.88 ± 0.08	2.61ArgLys: 2.61 ± 0.062	2.785ArgLeu: 2.785 ± 0.07	0.864ArgMet: 0.864 ± 0.033	2.033ArgAsn: 2.033 ± 0.05	0.776ArgPro: 0.776 ± 0.035	0.695ArgGln: 0.695 ± 0.033	1.219ArgArg: 1.219 ± 0.05	1.384ArgSer: 1.384 ± 0.047	1.351ArgThr: 1.351 ± 0.045	2.148ArgVal: 2.148 ± 0.057	0.199ArgTrp: 0.199 ± 0.016	1.615ArgTyr: 1.615 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	3.555SerAla: 3.555 ± 0.072	0.712SerCys: 0.712 ± 0.03	3.426SerAsp: 3.426 ± 0.083	3.471SerGlu: 3.471 ± 0.072	3.889SerPhe: 3.889 ± 0.083	3.747SerGly: 3.747 ± 0.081	0.92SerHis: 0.92 ± 0.036	7.436SerIle: 7.436 ± 0.11	5.854SerLys: 5.854 ± 0.097	6.592SerLeu: 6.592 ± 0.116	1.661SerMet: 1.661 ± 0.043	4.37SerAsn: 4.37 ± 0.095	1.645SerPro: 1.645 ± 0.048	1.465SerGln: 1.465 ± 0.05	2.018SerArg: 2.018 ± 0.053	5.028SerSer: 5.028 ± 0.107	2.939SerThr: 2.939 ± 0.069	3.88SerVal: 3.88 ± 0.073	0.431SerTrp: 0.431 ± 0.026	3.289SerTyr: 3.289 ± 0.076	0.0SerXaa: 0.0 ± 0.0
Thr	3.041ThrAla: 3.041 ± 0.079	0.342ThrCys: 0.342 ± 0.022	2.798ThrAsp: 2.798 ± 0.062	2.784ThrGlu: 2.784 ± 0.067	2.365ThrPhe: 2.365 ± 0.062	2.902ThrGly: 2.902 ± 0.078	0.724ThrHis: 0.724 ± 0.032	5.159ThrIle: 5.159 ± 0.103	3.792ThrLys: 3.792 ± 0.08	4.725ThrLeu: 4.725 ± 0.08	1.064ThrMet: 1.064 ± 0.039	3.564ThrAsn: 3.564 ± 0.1	1.813ThrPro: 1.813 ± 0.064	1.085ThrGln: 1.085 ± 0.037	1.324ThrArg: 1.324 ± 0.043	3.08ThrSer: 3.08 ± 0.069	2.775ThrThr: 2.775 ± 0.083	3.131ThrVal: 3.131 ± 0.068	0.311ThrTrp: 0.311 ± 0.025	2.012ThrTyr: 2.012 ± 0.051	0.0ThrXaa: 0.0 ± 0.0
Val	3.538ValAla: 3.538 ± 0.081	0.645ValCys: 0.645 ± 0.033	3.379ValAsp: 3.379 ± 0.075	3.679ValGlu: 3.679 ± 0.078	2.914ValPhe: 2.914 ± 0.068	3.493ValGly: 3.493 ± 0.088	0.754ValHis: 0.754 ± 0.032	5.188ValIle: 5.188 ± 0.089	4.594ValLys: 4.594 ± 0.072	5.424ValLeu: 5.424 ± 0.084	1.332ValMet: 1.332 ± 0.049	3.767ValAsn: 3.767 ± 0.09	1.756ValPro: 1.756 ± 0.048	1.115ValGln: 1.115 ± 0.036	1.88ValArg: 1.88 ± 0.05	4.48ValSer: 4.48 ± 0.083	2.731ValThr: 2.731 ± 0.065	3.827ValVal: 3.827 ± 0.104	0.38ValTrp: 0.38 ± 0.023	2.808ValTyr: 2.808 ± 0.071	0.0ValXaa: 0.0 ± 0.0
Trp	0.396TrpAla: 0.396 ± 0.023	0.073TrpCys: 0.073 ± 0.011	0.337TrpAsp: 0.337 ± 0.025	0.329TrpGlu: 0.329 ± 0.022	0.315TrpPhe: 0.315 ± 0.021	0.438TrpGly: 0.438 ± 0.024	0.119TrpHis: 0.119 ± 0.013	0.505TrpIle: 0.505 ± 0.028	0.535TrpLys: 0.535 ± 0.028	0.519TrpLeu: 0.519 ± 0.026	0.151TrpMet: 0.151 ± 0.015	0.451TrpAsn: 0.451 ± 0.025	0.123TrpPro: 0.123 ± 0.014	0.207TrpGln: 0.207 ± 0.019	0.227TrpArg: 0.227 ± 0.017	0.328TrpSer: 0.328 ± 0.022	0.267TrpThr: 0.267 ± 0.018	0.364TrpVal: 0.364 ± 0.021	0.081TrpTrp: 0.081 ± 0.011	0.346TrpTyr: 0.346 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.661TyrAla: 2.661 ± 0.064	0.435TyrCys: 0.435 ± 0.023	3.203TyrAsp: 3.203 ± 0.074	2.661TyrGlu: 2.661 ± 0.065	2.716TyrPhe: 2.716 ± 0.06	2.708TyrGly: 2.708 ± 0.063	0.676TyrHis: 0.676 ± 0.033	4.968TyrIle: 4.968 ± 0.094	4.341TyrLys: 4.341 ± 0.084	4.091TyrLeu: 4.091 ± 0.073	1.13TyrMet: 1.13 ± 0.038	4.272TyrAsn: 4.272 ± 0.096	1.391TyrPro: 1.391 ± 0.044	1.049TyrGln: 1.049 ± 0.046	1.543TyrArg: 1.543 ± 0.049	3.565TyrSer: 3.565 ± 0.076	2.562TyrThr: 2.562 ± 0.067	2.218TyrVal: 2.218 ± 0.05	0.296TyrTrp: 0.296 ± 0.021	2.87TyrTyr: 2.87 ± 0.08	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2301 proteins (762952 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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