Amino acid dipepetide frequency for Streptomyces sp. A1136

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.571AlaAla: 22.571 ± 0.169
1.108AlaCys: 1.108 ± 0.029
8.279AlaAsp: 8.279 ± 0.07
8.849AlaGlu: 8.849 ± 0.102
3.588AlaPhe: 3.588 ± 0.044
13.704AlaGly: 13.704 ± 0.092
2.993AlaHis: 2.993 ± 0.041
3.488AlaIle: 3.488 ± 0.048
3.029AlaLys: 3.029 ± 0.055
14.933AlaLeu: 14.933 ± 0.095
2.615AlaMet: 2.615 ± 0.036
1.908AlaAsn: 1.908 ± 0.035
7.756AlaPro: 7.756 ± 0.077
3.826AlaGln: 3.826 ± 0.045
10.632AlaArg: 10.632 ± 0.086
5.929AlaSer: 5.929 ± 0.056
7.018AlaThr: 7.018 ± 0.064
12.425AlaVal: 12.425 ± 0.096
1.946AlaTrp: 1.946 ± 0.033
2.878AlaTyr: 2.878 ± 0.036
0.0AlaXaa: 0.0 ± 0.0
Cys
1.171CysAla: 1.171 ± 0.024
0.096CysCys: 0.096 ± 0.007
0.5CysAsp: 0.5 ± 0.016
0.42CysGlu: 0.42 ± 0.014
0.219CysPhe: 0.219 ± 0.011
1.003CysGly: 1.003 ± 0.021
0.188CysHis: 0.188 ± 0.009
0.151CysIle: 0.151 ± 0.009
0.129CysLys: 0.129 ± 0.008
0.776CysLeu: 0.776 ± 0.022
0.14CysMet: 0.14 ± 0.008
0.141CysAsn: 0.141 ± 0.008
0.532CysPro: 0.532 ± 0.018
0.183CysGln: 0.183 ± 0.009
0.647CysArg: 0.647 ± 0.017
0.421CysSer: 0.421 ± 0.016
0.503CysThr: 0.503 ± 0.017
0.703CysVal: 0.703 ± 0.018
0.142CysTrp: 0.142 ± 0.008
0.151CysTyr: 0.151 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
7.645AspAla: 7.645 ± 0.065
0.452AspCys: 0.452 ± 0.014
3.151AspAsp: 3.151 ± 0.039
3.679AspGlu: 3.679 ± 0.048
1.616AspPhe: 1.616 ± 0.028
6.105AspGly: 6.105 ± 0.053
1.422AspHis: 1.422 ± 0.028
1.862AspIle: 1.862 ± 0.03
1.231AspLys: 1.231 ± 0.027
6.056AspLeu: 6.056 ± 0.054
0.785AspMet: 0.785 ± 0.019
0.951AspAsn: 0.951 ± 0.025
4.521AspPro: 4.521 ± 0.052
1.512AspGln: 1.512 ± 0.03
4.847AspArg: 4.847 ± 0.051
2.46AspSer: 2.46 ± 0.032
3.161AspThr: 3.161 ± 0.043
4.449AspVal: 4.449 ± 0.044
1.015AspTrp: 1.015 ± 0.022
1.072AspTyr: 1.072 ± 0.022
0.0AspXaa: 0.0 ± 0.0
Glu
7.651GluAla: 7.651 ± 0.089
0.382GluCys: 0.382 ± 0.015
2.791GluAsp: 2.791 ± 0.042
3.551GluGlu: 3.551 ± 0.053
1.416GluPhe: 1.416 ± 0.026
4.401GluGly: 4.401 ± 0.05
1.465GluHis: 1.465 ± 0.026
2.29GluIle: 2.29 ± 0.033
1.358GluLys: 1.358 ± 0.028
6.731GluLeu: 6.731 ± 0.072
0.9GluMet: 0.9 ± 0.021
1.03GluAsn: 1.03 ± 0.025
3.413GluPro: 3.413 ± 0.039
2.234GluGln: 2.234 ± 0.037
5.461GluArg: 5.461 ± 0.065
2.49GluSer: 2.49 ± 0.036
2.775GluThr: 2.775 ± 0.036
4.466GluVal: 4.466 ± 0.049
0.741GluTrp: 0.741 ± 0.017
1.127GluTyr: 1.127 ± 0.024
0.0GluXaa: 0.0 ± 0.0
Phe
3.709PheAla: 3.709 ± 0.041
0.283PheCys: 0.283 ± 0.011
1.907PheAsp: 1.907 ± 0.029
1.464PheGlu: 1.464 ± 0.028
0.874PhePhe: 0.874 ± 0.02
3.003PheGly: 3.003 ± 0.039
0.621PheHis: 0.621 ± 0.02
0.729PheIle: 0.729 ± 0.02
0.55PheLys: 0.55 ± 0.016
2.539PheLeu: 2.539 ± 0.036
0.418PheMet: 0.418 ± 0.014
0.569PheAsn: 0.569 ± 0.017
1.415PhePro: 1.415 ± 0.027
0.651PheGln: 0.651 ± 0.018
1.81PheArg: 1.81 ± 0.026
1.412PheSer: 1.412 ± 0.031
1.999PheThr: 1.999 ± 0.032
2.145PheVal: 2.145 ± 0.036
0.412PheTrp: 0.412 ± 0.015
0.59PheTyr: 0.59 ± 0.018
0.0PheXaa: 0.0 ± 0.0
Gly
11.679GlyAla: 11.679 ± 0.083
0.878GlyCys: 0.878 ± 0.023
5.004GlyAsp: 5.004 ± 0.046
5.051GlyGlu: 5.051 ± 0.056
2.886GlyPhe: 2.886 ± 0.038
9.072GlyGly: 9.072 ± 0.091
2.364GlyHis: 2.364 ± 0.032
3.434GlyIle: 3.434 ± 0.04
2.561GlyLys: 2.561 ± 0.043
9.44GlyLeu: 9.44 ± 0.08
2.018GlyMet: 2.018 ± 0.032
1.81GlyAsn: 1.81 ± 0.035
5.602GlyPro: 5.602 ± 0.065
2.608GlyGln: 2.608 ± 0.035
8.156GlyArg: 8.156 ± 0.066
5.347GlySer: 5.347 ± 0.049
6.009GlyThr: 6.009 ± 0.063
7.518GlyVal: 7.518 ± 0.063
1.676GlyTrp: 1.676 ± 0.026
2.314GlyTyr: 2.314 ± 0.033
0.0GlyXaa: 0.0 ± 0.0
His
2.761HisAla: 2.761 ± 0.039
0.215HisCys: 0.215 ± 0.009
1.297HisAsp: 1.297 ± 0.026
1.194HisGlu: 1.194 ± 0.025
0.629HisPhe: 0.629 ± 0.018
2.398HisGly: 2.398 ± 0.032
0.735HisHis: 0.735 ± 0.021
0.685HisIle: 0.685 ± 0.018
0.374HisLys: 0.374 ± 0.015
2.385HisLeu: 2.385 ± 0.037
0.367HisMet: 0.367 ± 0.012
0.372HisAsn: 0.372 ± 0.012
1.914HisPro: 1.914 ± 0.034
0.652HisGln: 0.652 ± 0.02
2.081HisArg: 2.081 ± 0.034
1.039HisSer: 1.039 ± 0.021
1.358HisThr: 1.358 ± 0.026
1.672HisVal: 1.672 ± 0.03
0.375HisTrp: 0.375 ± 0.013
0.468HisTyr: 0.468 ± 0.014
0.0HisXaa: 0.0 ± 0.0
Ile
4.839IleAla: 4.839 ± 0.053
0.306IleCys: 0.306 ± 0.012
2.147IleAsp: 2.147 ± 0.031
2.004IleGlu: 2.004 ± 0.028
0.676IlePhe: 0.676 ± 0.019
3.61IleGly: 3.61 ± 0.048
0.629IleHis: 0.629 ± 0.018
0.846IleIle: 0.846 ± 0.022
0.752IleLys: 0.752 ± 0.022
2.361IleLeu: 2.361 ± 0.034
0.431IleMet: 0.431 ± 0.015
0.715IleAsn: 0.715 ± 0.017
1.769IlePro: 1.769 ± 0.024
0.74IleGln: 0.74 ± 0.019
2.321IleArg: 2.321 ± 0.035
1.672IleSer: 1.672 ± 0.03
2.237IleThr: 2.237 ± 0.035
2.666IleVal: 2.666 ± 0.046
0.354IleTrp: 0.354 ± 0.012
0.493IleTyr: 0.493 ± 0.015
0.0IleXaa: 0.0 ± 0.0
Lys
3.095LysAla: 3.095 ± 0.048
0.114LysCys: 0.114 ± 0.008
1.323LysAsp: 1.323 ± 0.029
1.163LysGlu: 1.163 ± 0.026
0.49LysPhe: 0.49 ± 0.018
1.836LysGly: 1.836 ± 0.037
0.44LysHis: 0.44 ± 0.014
0.898LysIle: 0.898 ± 0.021
0.806LysLys: 0.806 ± 0.027
2.026LysLeu: 2.026 ± 0.03
0.406LysMet: 0.406 ± 0.016
0.532LysAsn: 0.532 ± 0.018
1.469LysPro: 1.469 ± 0.029
0.685LysGln: 0.685 ± 0.02
1.446LysArg: 1.446 ± 0.027
1.133LysSer: 1.133 ± 0.025
1.385LysThr: 1.385 ± 0.029
1.906LysVal: 1.906 ± 0.034
0.263LysTrp: 0.263 ± 0.011
0.455LysTyr: 0.455 ± 0.017
0.0LysXaa: 0.0 ± 0.0
Leu
15.312LeuAla: 15.312 ± 0.103
0.916LeuCys: 0.916 ± 0.024
6.464LeuAsp: 6.464 ± 0.057
4.747LeuGlu: 4.747 ± 0.052
2.61LeuPhe: 2.61 ± 0.037
9.401LeuGly: 9.401 ± 0.074
2.261LeuHis: 2.261 ± 0.034
3.298LeuIle: 3.298 ± 0.043
1.937LeuLys: 1.937 ± 0.034
11.305LeuLeu: 11.305 ± 0.112
1.641LeuMet: 1.641 ± 0.03
1.686LeuAsn: 1.686 ± 0.026
6.536LeuPro: 6.536 ± 0.06
2.144LeuGln: 2.144 ± 0.031
8.761LeuArg: 8.761 ± 0.072
5.137LeuSer: 5.137 ± 0.05
6.773LeuThr: 6.773 ± 0.065
8.743LeuVal: 8.743 ± 0.076
1.331LeuTrp: 1.331 ± 0.028
1.859LeuTyr: 1.859 ± 0.034
0.0LeuXaa: 0.0 ± 0.0
Met
2.333MetAla: 2.333 ± 0.035
0.144MetCys: 0.144 ± 0.008
0.926MetAsp: 0.926 ± 0.022
0.804MetGlu: 0.804 ± 0.018
0.433MetPhe: 0.433 ± 0.016
1.355MetGly: 1.355 ± 0.028
0.344MetHis: 0.344 ± 0.012
0.66MetIle: 0.66 ± 0.018
0.432MetLys: 0.432 ± 0.015
1.703MetLeu: 1.703 ± 0.031
0.295MetMet: 0.295 ± 0.012
0.475MetAsn: 0.475 ± 0.015
1.171MetPro: 1.171 ± 0.023
0.418MetGln: 0.418 ± 0.015
1.45MetArg: 1.45 ± 0.024
1.313MetSer: 1.313 ± 0.025
1.551MetThr: 1.551 ± 0.025
1.276MetVal: 1.276 ± 0.026
0.222MetTrp: 0.222 ± 0.011
0.32MetTyr: 0.32 ± 0.012
0.0MetXaa: 0.0 ± 0.0
Asn
2.241AsnAla: 2.241 ± 0.043
0.163AsnCys: 0.163 ± 0.01
0.97AsnAsp: 0.97 ± 0.023
0.84AsnGlu: 0.84 ± 0.021
0.488AsnPhe: 0.488 ± 0.016
1.841AsnGly: 1.841 ± 0.036
0.415AsnHis: 0.415 ± 0.015
0.625AsnIle: 0.625 ± 0.018
0.413AsnLys: 0.413 ± 0.015
1.687AsnLeu: 1.687 ± 0.03
0.309AsnMet: 0.309 ± 0.012
0.435AsnAsn: 0.435 ± 0.015
1.373AsnPro: 1.373 ± 0.028
0.514AsnGln: 0.514 ± 0.015
1.275AsnArg: 1.275 ± 0.024
0.871AsnSer: 0.871 ± 0.021
1.129AsnThr: 1.129 ± 0.026
1.329AsnVal: 1.329 ± 0.027
0.281AsnTrp: 0.281 ± 0.012
0.364AsnTyr: 0.364 ± 0.014
0.0AsnXaa: 0.0 ± 0.0
Pro
9.48ProAla: 9.48 ± 0.096
0.362ProCys: 0.362 ± 0.012
4.422ProAsp: 4.422 ± 0.052
4.342ProGlu: 4.342 ± 0.054
1.576ProPhe: 1.576 ± 0.03
7.024ProGly: 7.024 ± 0.075
1.425ProHis: 1.425 ± 0.028
1.317ProIle: 1.317 ± 0.026
1.223ProLys: 1.223 ± 0.026
5.442ProLeu: 5.442 ± 0.052
1.053ProMet: 1.053 ± 0.024
0.889ProAsn: 0.889 ± 0.023
3.734ProPro: 3.734 ± 0.062
1.822ProGln: 1.822 ± 0.034
4.233ProArg: 4.233 ± 0.045
3.181ProSer: 3.181 ± 0.048
3.392ProThr: 3.392 ± 0.049
5.631ProVal: 5.631 ± 0.051
0.926ProTrp: 0.926 ± 0.021
1.467ProTyr: 1.467 ± 0.028
0.0ProXaa: 0.0 ± 0.0
Gln
3.841GlnAla: 3.841 ± 0.051
0.172GlnCys: 0.172 ± 0.009
1.413GlnAsp: 1.413 ± 0.027
1.411GlnGlu: 1.411 ± 0.031
0.647GlnPhe: 0.647 ± 0.016
2.311GlnGly: 2.311 ± 0.033
0.641GlnHis: 0.641 ± 0.019
1.069GlnIle: 1.069 ± 0.023
0.596GlnLys: 0.596 ± 0.018
2.897GlnLeu: 2.897 ± 0.044
0.503GlnMet: 0.503 ± 0.017
0.47GlnAsn: 0.47 ± 0.016
1.674GlnPro: 1.674 ± 0.037
1.155GlnGln: 1.155 ± 0.032
2.244GlnArg: 2.244 ± 0.038
1.258GlnSer: 1.258 ± 0.025
1.374GlnThr: 1.374 ± 0.025
2.355GlnVal: 2.355 ± 0.033
0.472GlnTrp: 0.472 ± 0.015
0.608GlnTyr: 0.608 ± 0.017
0.0GlnXaa: 0.0 ± 0.0
Arg
10.183ArgAla: 10.183 ± 0.081
0.628ArgCys: 0.628 ± 0.021
4.267ArgAsp: 4.267 ± 0.047
4.901ArgGlu: 4.901 ± 0.057
2.351ArgPhe: 2.351 ± 0.032
5.957ArgGly: 5.957 ± 0.066
2.123ArgHis: 2.123 ± 0.03
3.188ArgIle: 3.188 ± 0.037
1.661ArgLys: 1.661 ± 0.027
8.931ArgLeu: 8.931 ± 0.088
1.769ArgMet: 1.769 ± 0.026
1.322ArgAsn: 1.322 ± 0.027
5.305ArgPro: 5.305 ± 0.058
2.28ArgGln: 2.28 ± 0.034
7.89ArgArg: 7.89 ± 0.075
4.048ArgSer: 4.048 ± 0.047
5.256ArgThr: 5.256 ± 0.059
5.937ArgVal: 5.937 ± 0.056
1.4ArgTrp: 1.4 ± 0.028
1.817ArgTyr: 1.817 ± 0.031
0.0ArgXaa: 0.0 ± 0.0
Ser
6.825SerAla: 6.825 ± 0.059
0.427SerCys: 0.427 ± 0.014
2.574SerAsp: 2.574 ± 0.039
2.356SerGlu: 2.356 ± 0.032
1.512SerPhe: 1.512 ± 0.029
5.848SerGly: 5.848 ± 0.055
1.02SerHis: 1.02 ± 0.022
1.389SerIle: 1.389 ± 0.028
1.027SerLys: 1.027 ± 0.024
4.735SerLeu: 4.735 ± 0.044
1.047SerMet: 1.047 ± 0.023
0.827SerAsn: 0.827 ± 0.02
3.202SerPro: 3.202 ± 0.046
1.212SerGln: 1.212 ± 0.023
3.68SerArg: 3.68 ± 0.043
2.622SerSer: 2.622 ± 0.037
2.95SerThr: 2.95 ± 0.041
4.16SerVal: 4.16 ± 0.042
0.888SerTrp: 0.888 ± 0.023
1.215SerTyr: 1.215 ± 0.028
0.0SerXaa: 0.0 ± 0.0
Thr
8.978ThrAla: 8.978 ± 0.066
0.437ThrCys: 0.437 ± 0.015
3.527ThrAsp: 3.527 ± 0.047
3.128ThrGlu: 3.128 ± 0.045
1.537ThrPhe: 1.537 ± 0.029
6.76ThrGly: 6.76 ± 0.065
1.206ThrHis: 1.206 ± 0.025
1.695ThrIle: 1.695 ± 0.029
1.168ThrLys: 1.168 ± 0.028
5.654ThrLeu: 5.654 ± 0.051
0.917ThrMet: 0.917 ± 0.022
1.007ThrAsn: 1.007 ± 0.026
4.262ThrPro: 4.262 ± 0.055
1.34ThrGln: 1.34 ± 0.027
3.978ThrArg: 3.978 ± 0.047
3.018ThrSer: 3.018 ± 0.047
3.8ThrThr: 3.8 ± 0.058
5.752ThrVal: 5.752 ± 0.051
0.872ThrTrp: 0.872 ± 0.02
1.281ThrTyr: 1.281 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
10.624ValAla: 10.624 ± 0.082
0.767ValCys: 0.767 ± 0.018
4.753ValAsp: 4.753 ± 0.052
4.697ValGlu: 4.697 ± 0.046
2.41ValPhe: 2.41 ± 0.034
6.452ValGly: 6.452 ± 0.053
1.913ValHis: 1.913 ± 0.031
2.932ValIle: 2.932 ± 0.039
1.816ValLys: 1.816 ± 0.038
9.396ValLeu: 9.396 ± 0.085
1.433ValMet: 1.433 ± 0.023
1.649ValAsn: 1.649 ± 0.031
5.388ValPro: 5.388 ± 0.058
1.933ValGln: 1.933 ± 0.03
7.151ValArg: 7.151 ± 0.065
4.249ValSer: 4.249 ± 0.04
5.434ValThr: 5.434 ± 0.061
7.751ValVal: 7.751 ± 0.082
1.164ValTrp: 1.164 ± 0.026
1.6ValTyr: 1.6 ± 0.026
0.0ValXaa: 0.0 ± 0.0
Trp
1.68TrpAla: 1.68 ± 0.029
0.172TrpCys: 0.172 ± 0.009
0.843TrpAsp: 0.843 ± 0.021
0.735TrpGlu: 0.735 ± 0.018
0.512TrpPhe: 0.512 ± 0.016
1.062TrpGly: 1.062 ± 0.023
0.377TrpHis: 0.377 ± 0.013
0.54TrpIle: 0.54 ± 0.014
0.382TrpLys: 0.382 ± 0.014
1.751TrpLeu: 1.751 ± 0.036
0.306TrpMet: 0.306 ± 0.011
0.411TrpAsn: 0.411 ± 0.016
0.815TrpPro: 0.815 ± 0.023
0.593TrpGln: 0.593 ± 0.016
1.288TrpArg: 1.288 ± 0.025
0.959TrpSer: 0.959 ± 0.019
1.031TrpThr: 1.031 ± 0.023
1.0TrpVal: 1.0 ± 0.021
0.354TrpTrp: 0.354 ± 0.014
0.367TrpTyr: 0.367 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.856TyrAla: 2.856 ± 0.034
0.195TyrCys: 0.195 ± 0.009
1.434TyrAsp: 1.434 ± 0.031
1.336TyrGlu: 1.336 ± 0.026
0.628TyrPhe: 0.628 ± 0.018
2.283TyrGly: 2.283 ± 0.036
0.39TyrHis: 0.39 ± 0.012
0.471TyrIle: 0.471 ± 0.015
0.427TyrLys: 0.427 ± 0.017
2.115TyrLeu: 2.115 ± 0.03
0.27TyrMet: 0.27 ± 0.011
0.366TyrAsn: 0.366 ± 0.012
1.092TyrPro: 1.092 ± 0.026
0.609TyrGln: 0.609 ± 0.017
1.862TyrArg: 1.862 ± 0.03
0.961TyrSer: 0.961 ± 0.022
1.181TyrThr: 1.181 ± 0.023
1.626TyrVal: 1.626 ± 0.028
0.342TyrTrp: 0.342 ± 0.014
0.423TyrTyr: 0.423 ± 0.015
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7243 proteins (2198633 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski