Amino acid dipepetide frequency for Vibrio phage V05

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.563AlaAla: 5.563 ± 0.466
0.795AlaCys: 0.795 ± 0.159
4.554AlaAsp: 4.554 ± 0.343
5.435AlaGlu: 5.435 ± 0.406
2.535AlaPhe: 2.535 ± 0.243
4.361AlaGly: 4.361 ± 0.392
1.246AlaHis: 1.246 ± 0.169
4.898AlaIle: 4.898 ± 0.317
4.382AlaLys: 4.382 ± 0.354
5.198AlaLeu: 5.198 ± 0.372
2.341AlaMet: 2.341 ± 0.238
3.244AlaAsn: 3.244 ± 0.259
2.277AlaPro: 2.277 ± 0.25
3.115AlaGln: 3.115 ± 0.296
3.716AlaArg: 3.716 ± 0.266
4.468AlaSer: 4.468 ± 0.391
4.532AlaThr: 4.532 ± 0.404
5.327AlaVal: 5.327 ± 0.357
0.816AlaTrp: 0.816 ± 0.146
2.878AlaTyr: 2.878 ± 0.264
0.0AlaXaa: 0.0 ± 0.0
Cys
0.709CysAla: 0.709 ± 0.126
0.215CysCys: 0.215 ± 0.064
0.816CysAsp: 0.816 ± 0.141
0.902CysGlu: 0.902 ± 0.161
0.279CysPhe: 0.279 ± 0.091
0.945CysGly: 0.945 ± 0.158
0.408CysHis: 0.408 ± 0.113
0.795CysIle: 0.795 ± 0.146
0.945CysLys: 0.945 ± 0.134
0.752CysLeu: 0.752 ± 0.121
0.236CysMet: 0.236 ± 0.07
0.623CysAsn: 0.623 ± 0.114
0.473CysPro: 0.473 ± 0.096
0.344CysGln: 0.344 ± 0.095
0.687CysArg: 0.687 ± 0.118
0.644CysSer: 0.644 ± 0.13
0.537CysThr: 0.537 ± 0.115
0.644CysVal: 0.644 ± 0.101
0.172CysTrp: 0.172 ± 0.073
0.322CysTyr: 0.322 ± 0.094
0.0CysXaa: 0.0 ± 0.0
Asp
4.468AspAla: 4.468 ± 0.32
0.752AspCys: 0.752 ± 0.137
4.511AspAsp: 4.511 ± 0.33
5.134AspGlu: 5.134 ± 0.335
3.029AspPhe: 3.029 ± 0.254
4.876AspGly: 4.876 ± 0.33
1.181AspHis: 1.181 ± 0.142
4.511AspIle: 4.511 ± 0.404
4.167AspLys: 4.167 ± 0.298
4.554AspLeu: 4.554 ± 0.307
1.718AspMet: 1.718 ± 0.227
2.986AspAsn: 2.986 ± 0.263
2.835AspPro: 2.835 ± 0.257
1.504AspGln: 1.504 ± 0.191
3.007AspArg: 3.007 ± 0.208
3.609AspSer: 3.609 ± 0.303
3.544AspThr: 3.544 ± 0.353
4.919AspVal: 4.919 ± 0.398
1.289AspTrp: 1.289 ± 0.219
3.501AspTyr: 3.501 ± 0.29
0.0AspXaa: 0.0 ± 0.0
Glu
5.198GluAla: 5.198 ± 0.303
0.816GluCys: 0.816 ± 0.139
3.845GluAsp: 3.845 ± 0.308
5.864GluGlu: 5.864 ± 0.517
3.458GluPhe: 3.458 ± 0.294
3.093GluGly: 3.093 ± 0.251
1.998GluHis: 1.998 ± 0.228
5.263GluIle: 5.263 ± 0.317
4.511GluLys: 4.511 ± 0.406
7.024GluLeu: 7.024 ± 0.451
2.449GluMet: 2.449 ± 0.265
3.974GluAsn: 3.974 ± 0.283
1.482GluPro: 1.482 ± 0.156
2.878GluGln: 2.878 ± 0.285
4.06GluArg: 4.06 ± 0.374
4.06GluSer: 4.06 ± 0.3
4.382GluThr: 4.382 ± 0.277
4.489GluVal: 4.489 ± 0.292
1.01GluTrp: 1.01 ± 0.118
3.63GluTyr: 3.63 ± 0.264
0.0GluXaa: 0.0 ± 0.0
Phe
3.351PheAla: 3.351 ± 0.221
0.387PheCys: 0.387 ± 0.089
3.716PheAsp: 3.716 ± 0.304
3.265PheGlu: 3.265 ± 0.288
1.267PhePhe: 1.267 ± 0.19
3.007PheGly: 3.007 ± 0.242
0.838PheHis: 0.838 ± 0.129
2.878PheIle: 2.878 ± 0.269
2.921PheLys: 2.921 ± 0.253
2.427PheLeu: 2.427 ± 0.276
1.418PheMet: 1.418 ± 0.173
2.792PheAsn: 2.792 ± 0.252
1.224PhePro: 1.224 ± 0.149
1.224PheGln: 1.224 ± 0.161
1.654PheArg: 1.654 ± 0.199
2.642PheSer: 2.642 ± 0.25
2.728PheThr: 2.728 ± 0.222
2.814PheVal: 2.814 ± 0.218
0.623PheTrp: 0.623 ± 0.119
1.568PheTyr: 1.568 ± 0.174
0.0PheXaa: 0.0 ± 0.0
Gly
4.189GlyAla: 4.189 ± 0.282
0.752GlyCys: 0.752 ± 0.118
4.403GlyAsp: 4.403 ± 0.465
4.146GlyGlu: 4.146 ± 0.306
2.664GlyPhe: 2.664 ± 0.307
4.79GlyGly: 4.79 ± 0.446
0.752GlyHis: 0.752 ± 0.118
3.845GlyIle: 3.845 ± 0.294
3.716GlyLys: 3.716 ± 0.293
3.824GlyLeu: 3.824 ± 0.258
1.697GlyMet: 1.697 ± 0.197
3.652GlyAsn: 3.652 ± 0.431
0.859GlyPro: 0.859 ± 0.128
2.105GlyGln: 2.105 ± 0.2
2.685GlyArg: 2.685 ± 0.234
4.855GlySer: 4.855 ± 0.457
4.318GlyThr: 4.318 ± 0.343
4.232GlyVal: 4.232 ± 0.301
1.224GlyTrp: 1.224 ± 0.147
2.492GlyTyr: 2.492 ± 0.212
0.0GlyXaa: 0.0 ± 0.0
His
1.654HisAla: 1.654 ± 0.213
0.279HisCys: 0.279 ± 0.079
1.847HisAsp: 1.847 ± 0.23
1.547HisGlu: 1.547 ± 0.198
1.117HisPhe: 1.117 ± 0.14
1.246HisGly: 1.246 ± 0.168
0.558HisHis: 0.558 ± 0.116
1.289HisIle: 1.289 ± 0.173
1.289HisLys: 1.289 ± 0.175
1.504HisLeu: 1.504 ± 0.179
0.537HisMet: 0.537 ± 0.106
0.902HisAsn: 0.902 ± 0.157
1.031HisPro: 1.031 ± 0.166
0.601HisGln: 0.601 ± 0.13
0.773HisArg: 0.773 ± 0.136
1.396HisSer: 1.396 ± 0.164
1.353HisThr: 1.353 ± 0.234
1.976HisVal: 1.976 ± 0.2
0.344HisTrp: 0.344 ± 0.074
1.096HisTyr: 1.096 ± 0.164
0.0HisXaa: 0.0 ± 0.0
Ile
4.919IleAla: 4.919 ± 0.36
0.473IleCys: 0.473 ± 0.101
4.876IleAsp: 4.876 ± 0.314
6.122IleGlu: 6.122 ± 0.369
2.578IlePhe: 2.578 ± 0.243
4.081IleGly: 4.081 ± 0.29
1.117IleHis: 1.117 ± 0.155
4.103IleIle: 4.103 ± 0.387
4.189IleLys: 4.189 ± 0.317
3.716IleLeu: 3.716 ± 0.297
1.718IleMet: 1.718 ± 0.198
3.995IleAsn: 3.995 ± 0.31
2.406IlePro: 2.406 ± 0.251
2.191IleGln: 2.191 ± 0.215
3.007IleArg: 3.007 ± 0.251
4.21IleSer: 4.21 ± 0.275
3.866IleThr: 3.866 ± 0.328
4.64IleVal: 4.64 ± 0.321
0.516IleTrp: 0.516 ± 0.108
2.148IleTyr: 2.148 ± 0.213
0.0IleXaa: 0.0 ± 0.0
Lys
4.747LysAla: 4.747 ± 0.366
0.687LysCys: 0.687 ± 0.133
3.652LysAsp: 3.652 ± 0.289
4.081LysGlu: 4.081 ± 0.289
2.621LysPhe: 2.621 ± 0.251
2.943LysGly: 2.943 ± 0.292
1.933LysHis: 1.933 ± 0.226
3.845LysIle: 3.845 ± 0.316
4.038LysLys: 4.038 ± 0.414
5.585LysLeu: 5.585 ± 0.384
2.406LysMet: 2.406 ± 0.26
2.599LysAsn: 2.599 ± 0.239
2.212LysPro: 2.212 ± 0.236
2.556LysGln: 2.556 ± 0.24
3.695LysArg: 3.695 ± 0.294
3.738LysSer: 3.738 ± 0.258
3.587LysThr: 3.587 ± 0.335
3.845LysVal: 3.845 ± 0.29
1.031LysTrp: 1.031 ± 0.147
2.986LysTyr: 2.986 ± 0.294
0.0LysXaa: 0.0 ± 0.0
Leu
5.585LeuAla: 5.585 ± 0.38
0.795LeuCys: 0.795 ± 0.162
4.983LeuAsp: 4.983 ± 0.393
5.929LeuGlu: 5.929 ± 0.39
3.093LeuPhe: 3.093 ± 0.279
4.361LeuGly: 4.361 ± 0.318
1.568LeuHis: 1.568 ± 0.18
4.21LeuIle: 4.21 ± 0.298
4.94LeuLys: 4.94 ± 0.369
5.563LeuLeu: 5.563 ± 0.341
2.298LeuMet: 2.298 ± 0.25
4.575LeuAsn: 4.575 ± 0.314
3.287LeuPro: 3.287 ± 0.266
2.255LeuGln: 2.255 ± 0.231
3.931LeuArg: 3.931 ± 0.251
4.575LeuSer: 4.575 ± 0.343
4.704LeuThr: 4.704 ± 0.29
4.403LeuVal: 4.403 ± 0.325
0.988LeuTrp: 0.988 ± 0.142
3.201LeuTyr: 3.201 ± 0.236
0.0LeuXaa: 0.0 ± 0.0
Met
1.761MetAla: 1.761 ± 0.251
0.43MetCys: 0.43 ± 0.116
1.01MetAsp: 1.01 ± 0.169
1.203MetGlu: 1.203 ± 0.155
1.117MetPhe: 1.117 ± 0.151
1.181MetGly: 1.181 ± 0.157
0.601MetHis: 0.601 ± 0.11
1.804MetIle: 1.804 ± 0.205
2.363MetLys: 2.363 ± 0.266
2.17MetLeu: 2.17 ± 0.262
0.881MetMet: 0.881 ± 0.132
1.783MetAsn: 1.783 ± 0.202
1.181MetPro: 1.181 ± 0.144
1.461MetGln: 1.461 ± 0.191
1.31MetArg: 1.31 ± 0.192
2.535MetSer: 2.535 ± 0.232
2.17MetThr: 2.17 ± 0.217
1.181MetVal: 1.181 ± 0.145
0.322MetTrp: 0.322 ± 0.077
1.289MetTyr: 1.289 ± 0.152
0.0MetXaa: 0.0 ± 0.0
Asn
4.124AsnAla: 4.124 ± 0.363
0.537AsnCys: 0.537 ± 0.124
3.501AsnAsp: 3.501 ± 0.294
3.866AsnGlu: 3.866 ± 0.288
2.427AsnPhe: 2.427 ± 0.205
4.167AsnGly: 4.167 ± 0.377
1.267AsnHis: 1.267 ± 0.152
3.609AsnIle: 3.609 ± 0.266
3.05AsnLys: 3.05 ± 0.231
4.06AsnLeu: 4.06 ± 0.264
1.16AsnMet: 1.16 ± 0.152
2.964AsnAsn: 2.964 ± 0.318
2.148AsnPro: 2.148 ± 0.262
1.611AsnGln: 1.611 ± 0.159
2.406AsnArg: 2.406 ± 0.215
2.857AsnSer: 2.857 ± 0.229
2.9AsnThr: 2.9 ± 0.271
3.566AsnVal: 3.566 ± 0.347
0.752AsnTrp: 0.752 ± 0.133
2.406AsnTyr: 2.406 ± 0.279
0.0AsnXaa: 0.0 ± 0.0
Pro
2.062ProAla: 2.062 ± 0.211
0.387ProCys: 0.387 ± 0.104
2.191ProAsp: 2.191 ± 0.23
3.072ProGlu: 3.072 ± 0.265
1.675ProPhe: 1.675 ± 0.193
1.504ProGly: 1.504 ± 0.21
0.967ProHis: 0.967 ± 0.144
1.847ProIle: 1.847 ± 0.222
1.675ProLys: 1.675 ± 0.242
2.363ProLeu: 2.363 ± 0.233
0.795ProMet: 0.795 ± 0.136
2.041ProAsn: 2.041 ± 0.193
0.859ProPro: 0.859 ± 0.126
1.074ProGln: 1.074 ± 0.151
1.332ProArg: 1.332 ± 0.17
2.105ProSer: 2.105 ± 0.233
2.084ProThr: 2.084 ± 0.225
2.492ProVal: 2.492 ± 0.231
0.365ProTrp: 0.365 ± 0.084
1.547ProTyr: 1.547 ± 0.192
0.0ProXaa: 0.0 ± 0.0
Gln
2.749GlnAla: 2.749 ± 0.255
0.43GlnCys: 0.43 ± 0.108
2.019GlnAsp: 2.019 ± 0.225
2.857GlnGlu: 2.857 ± 0.263
1.633GlnPhe: 1.633 ± 0.178
1.998GlnGly: 1.998 ± 0.219
0.601GlnHis: 0.601 ± 0.12
2.642GlnIle: 2.642 ± 0.242
2.277GlnLys: 2.277 ± 0.19
3.093GlnLeu: 3.093 ± 0.231
1.01GlnMet: 1.01 ± 0.144
1.718GlnAsn: 1.718 ± 0.234
0.988GlnPro: 0.988 ± 0.153
1.16GlnGln: 1.16 ± 0.2
1.611GlnArg: 1.611 ± 0.189
1.998GlnSer: 1.998 ± 0.2
1.89GlnThr: 1.89 ± 0.23
1.976GlnVal: 1.976 ± 0.194
0.752GlnTrp: 0.752 ± 0.126
1.504GlnTyr: 1.504 ± 0.172
0.0GlnXaa: 0.0 ± 0.0
Arg
3.158ArgAla: 3.158 ± 0.286
0.623ArgCys: 0.623 ± 0.135
2.835ArgAsp: 2.835 ± 0.246
3.394ArgGlu: 3.394 ± 0.281
2.449ArgPhe: 2.449 ± 0.201
2.771ArgGly: 2.771 ± 0.255
1.16ArgHis: 1.16 ± 0.17
3.201ArgIle: 3.201 ± 0.281
3.329ArgLys: 3.329 ± 0.325
4.038ArgLeu: 4.038 ± 0.303
1.246ArgMet: 1.246 ± 0.16
2.212ArgAsn: 2.212 ± 0.194
1.332ArgPro: 1.332 ± 0.161
1.59ArgGln: 1.59 ± 0.166
2.127ArgArg: 2.127 ± 0.195
2.771ArgSer: 2.771 ± 0.256
2.857ArgThr: 2.857 ± 0.29
3.716ArgVal: 3.716 ± 0.284
0.816ArgTrp: 0.816 ± 0.133
2.47ArgTyr: 2.47 ± 0.253
0.0ArgXaa: 0.0 ± 0.0
Ser
4.124SerAla: 4.124 ± 0.307
0.752SerCys: 0.752 ± 0.163
4.296SerAsp: 4.296 ± 0.364
3.63SerGlu: 3.63 ± 0.271
2.621SerPhe: 2.621 ± 0.238
3.974SerGly: 3.974 ± 0.467
1.525SerHis: 1.525 ± 0.174
4.296SerIle: 4.296 ± 0.291
3.673SerLys: 3.673 ± 0.304
5.241SerLeu: 5.241 ± 0.417
1.375SerMet: 1.375 ± 0.181
3.609SerAsn: 3.609 ± 0.297
1.826SerPro: 1.826 ± 0.194
2.191SerGln: 2.191 ± 0.204
2.857SerArg: 2.857 ± 0.251
3.974SerSer: 3.974 ± 0.409
4.318SerThr: 4.318 ± 0.439
4.489SerVal: 4.489 ± 0.349
0.816SerTrp: 0.816 ± 0.144
2.599SerTyr: 2.599 ± 0.22
0.0SerXaa: 0.0 ± 0.0
Thr
4.468ThrAla: 4.468 ± 0.547
0.558ThrCys: 0.558 ± 0.119
3.888ThrAsp: 3.888 ± 0.267
3.974ThrGlu: 3.974 ± 0.285
2.814ThrPhe: 2.814 ± 0.232
4.511ThrGly: 4.511 ± 0.411
1.267ThrHis: 1.267 ± 0.168
4.683ThrIle: 4.683 ± 0.382
2.986ThrLys: 2.986 ± 0.265
5.198ThrLeu: 5.198 ± 0.431
1.396ThrMet: 1.396 ± 0.159
2.814ThrAsn: 2.814 ± 0.271
2.363ThrPro: 2.363 ± 0.239
2.621ThrGln: 2.621 ± 0.263
2.749ThrArg: 2.749 ± 0.24
3.888ThrSer: 3.888 ± 0.411
4.425ThrThr: 4.425 ± 0.692
4.79ThrVal: 4.79 ± 0.387
0.924ThrTrp: 0.924 ± 0.172
2.341ThrTyr: 2.341 ± 0.251
0.0ThrXaa: 0.0 ± 0.0
Val
4.876ValAla: 4.876 ± 0.328
0.881ValCys: 0.881 ± 0.16
4.64ValAsp: 4.64 ± 0.315
5.026ValGlu: 5.026 ± 0.376
3.115ValPhe: 3.115 ± 0.219
3.952ValGly: 3.952 ± 0.293
1.396ValHis: 1.396 ± 0.169
4.275ValIle: 4.275 ± 0.381
4.618ValLys: 4.618 ± 0.357
4.704ValLeu: 4.704 ± 0.301
1.482ValMet: 1.482 ± 0.163
3.351ValAsn: 3.351 ± 0.306
2.32ValPro: 2.32 ± 0.189
2.384ValGln: 2.384 ± 0.229
3.523ValArg: 3.523 ± 0.233
4.403ValSer: 4.403 ± 0.334
4.704ValThr: 4.704 ± 0.334
4.898ValVal: 4.898 ± 0.31
1.031ValTrp: 1.031 ± 0.148
2.792ValTyr: 2.792 ± 0.247
0.0ValXaa: 0.0 ± 0.0
Trp
0.902TrpAla: 0.902 ± 0.122
0.258TrpCys: 0.258 ± 0.079
0.924TrpAsp: 0.924 ± 0.14
1.031TrpGlu: 1.031 ± 0.166
0.666TrpPhe: 0.666 ± 0.131
0.838TrpGly: 0.838 ± 0.134
0.451TrpHis: 0.451 ± 0.094
0.516TrpIle: 0.516 ± 0.092
0.967TrpLys: 0.967 ± 0.137
1.16TrpLeu: 1.16 ± 0.177
0.43TrpMet: 0.43 ± 0.091
0.881TrpAsn: 0.881 ± 0.157
0.193TrpPro: 0.193 ± 0.068
0.58TrpGln: 0.58 ± 0.108
0.73TrpArg: 0.73 ± 0.125
0.988TrpSer: 0.988 ± 0.162
0.902TrpThr: 0.902 ± 0.171
1.203TrpVal: 1.203 ± 0.144
0.279TrpTrp: 0.279 ± 0.067
0.967TrpTyr: 0.967 ± 0.154
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.072TyrAla: 3.072 ± 0.272
0.644TyrCys: 0.644 ± 0.11
3.587TyrAsp: 3.587 ± 0.265
3.007TyrGlu: 3.007 ± 0.296
1.59TyrPhe: 1.59 ± 0.175
2.599TyrGly: 2.599 ± 0.246
1.504TyrHis: 1.504 ± 0.248
2.363TyrIle: 2.363 ± 0.221
2.749TyrLys: 2.749 ± 0.322
3.093TyrLeu: 3.093 ± 0.292
1.138TyrMet: 1.138 ± 0.16
2.664TyrAsn: 2.664 ± 0.22
1.138TyrPro: 1.138 ± 0.169
1.461TyrGln: 1.461 ± 0.206
2.234TyrArg: 2.234 ± 0.201
2.47TyrSer: 2.47 ± 0.247
2.857TyrThr: 2.857 ± 0.217
2.771TyrVal: 2.771 ± 0.213
0.795TyrTrp: 0.795 ± 0.152
1.718TyrTyr: 1.718 ± 0.21
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 237 proteins (46555 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski