Amino acid dipepetide frequency for human papillomavirus 102

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.964AlaAla: 5.964 ± 1.357
1.988AlaCys: 1.988 ± 0.783
4.374AlaAsp: 4.374 ± 0.667
3.181AlaGlu: 3.181 ± 0.64
2.386AlaPhe: 2.386 ± 0.758
4.771AlaGly: 4.771 ± 1.256
0.795AlaHis: 0.795 ± 0.719
3.181AlaIle: 3.181 ± 0.914
3.181AlaLys: 3.181 ± 1.082
3.976AlaLeu: 3.976 ± 0.758
2.386AlaMet: 2.386 ± 0.835
2.386AlaAsn: 2.386 ± 0.911
5.169AlaPro: 5.169 ± 2.362
2.386AlaGln: 2.386 ± 1.256
3.579AlaArg: 3.579 ± 0.822
4.374AlaSer: 4.374 ± 0.863
8.748AlaThr: 8.748 ± 2.83
3.579AlaVal: 3.579 ± 1.372
0.0AlaTrp: 0.0 ± 0.0
1.988AlaTyr: 1.988 ± 0.594
0.0AlaXaa: 0.0 ± 0.0
Cys
1.988CysAla: 1.988 ± 1.017
0.795CysCys: 0.795 ± 0.482
0.795CysAsp: 0.795 ± 0.817
1.193CysGlu: 1.193 ± 0.782
0.795CysPhe: 0.795 ± 0.817
2.386CysGly: 2.386 ± 1.691
0.0CysHis: 0.0 ± 0.0
1.193CysIle: 1.193 ± 0.851
2.783CysLys: 2.783 ± 1.054
2.783CysLeu: 2.783 ± 1.277
1.59CysMet: 1.59 ± 0.648
1.59CysAsn: 1.59 ± 0.78
2.386CysPro: 2.386 ± 0.502
1.988CysGln: 1.988 ± 0.717
1.988CysArg: 1.988 ± 1.006
0.795CysSer: 0.795 ± 0.482
2.386CysThr: 2.386 ± 1.158
1.193CysVal: 1.193 ± 0.648
1.59CysTrp: 1.59 ± 0.5
0.398CysTyr: 0.398 ± 0.408
0.0CysXaa: 0.0 ± 0.0
Asp
3.976AspAla: 3.976 ± 2.285
1.59AspCys: 1.59 ± 0.856
1.988AspAsp: 1.988 ± 0.901
2.386AspGlu: 2.386 ± 1.267
1.59AspPhe: 1.59 ± 0.277
3.976AspGly: 3.976 ± 0.882
0.398AspHis: 0.398 ± 0.408
4.374AspIle: 4.374 ± 2.688
1.193AspLys: 1.193 ± 0.657
5.169AspLeu: 5.169 ± 0.706
0.795AspMet: 0.795 ± 0.466
3.976AspAsn: 3.976 ± 1.038
2.386AspPro: 2.386 ± 0.793
2.386AspGln: 2.386 ± 0.502
3.579AspArg: 3.579 ± 0.74
5.567AspSer: 5.567 ± 2.247
5.964AspThr: 5.964 ± 2.202
1.59AspVal: 1.59 ± 0.855
1.193AspTrp: 1.193 ± 0.657
1.988AspTyr: 1.988 ± 0.866
0.0AspXaa: 0.0 ± 0.0
Glu
3.181GluAla: 3.181 ± 1.197
1.193GluCys: 1.193 ± 0.568
3.579GluAsp: 3.579 ± 1.169
7.157GluGlu: 7.157 ± 2.492
0.795GluPhe: 0.795 ± 0.719
1.59GluGly: 1.59 ± 0.997
1.59GluHis: 1.59 ± 0.666
0.795GluIle: 0.795 ± 0.39
1.988GluLys: 1.988 ± 0.951
5.169GluLeu: 5.169 ± 1.911
1.193GluMet: 1.193 ± 0.794
0.795GluAsn: 0.795 ± 0.364
3.976GluPro: 3.976 ± 1.028
2.783GluGln: 2.783 ± 1.528
1.193GluArg: 1.193 ± 0.537
1.988GluSer: 1.988 ± 0.999
3.579GluThr: 3.579 ± 1.04
5.169GluVal: 5.169 ± 1.484
0.795GluTrp: 0.795 ± 0.51
1.988GluTyr: 1.988 ± 0.862
0.0GluXaa: 0.0 ± 0.0
Phe
2.783PheAla: 2.783 ± 1.157
0.795PheCys: 0.795 ± 0.364
1.59PheAsp: 1.59 ± 0.6
1.193PheGlu: 1.193 ± 1.019
1.988PhePhe: 1.988 ± 0.607
1.988PheGly: 1.988 ± 0.633
0.795PheHis: 0.795 ± 0.482
1.988PheIle: 1.988 ± 0.873
3.181PheLys: 3.181 ± 1.959
3.976PheLeu: 3.976 ± 0.799
1.193PheMet: 1.193 ± 0.4
1.59PheAsn: 1.59 ± 0.832
1.193PhePro: 1.193 ± 0.611
1.59PheGln: 1.59 ± 0.832
1.59PheArg: 1.59 ± 0.742
0.398PheSer: 0.398 ± 0.36
1.988PheThr: 1.988 ± 1.57
4.771PheVal: 4.771 ± 0.805
0.795PheTrp: 0.795 ± 0.364
2.386PheTyr: 2.386 ± 0.444
0.0PheXaa: 0.0 ± 0.0
Gly
4.771GlyAla: 4.771 ± 1.42
1.59GlyCys: 1.59 ± 1.212
7.157GlyAsp: 7.157 ± 1.17
5.567GlyGlu: 5.567 ± 1.866
1.988GlyPhe: 1.988 ± 1.329
2.386GlyGly: 2.386 ± 1.218
4.374GlyHis: 4.374 ± 1.474
2.386GlyIle: 2.386 ± 0.444
2.783GlyLys: 2.783 ± 0.713
2.386GlyLeu: 2.386 ± 0.444
1.59GlyMet: 1.59 ± 0.655
2.386GlyAsn: 2.386 ± 1.263
1.988GlyPro: 1.988 ± 0.992
3.579GlyGln: 3.579 ± 0.979
2.386GlyArg: 2.386 ± 0.494
2.386GlySer: 2.386 ± 0.755
8.35GlyThr: 8.35 ± 2.076
3.579GlyVal: 3.579 ± 1.206
0.795GlyTrp: 0.795 ± 0.637
1.988GlyTyr: 1.988 ± 0.624
0.0GlyXaa: 0.0 ± 0.0
His
2.783HisAla: 2.783 ± 1.07
0.0HisCys: 0.0 ± 0.0
0.398HisAsp: 0.398 ± 0.34
0.795HisGlu: 0.795 ± 0.816
1.193HisPhe: 1.193 ± 0.311
3.181HisGly: 3.181 ± 1.284
0.0HisHis: 0.0 ± 0.0
2.386HisIle: 2.386 ± 0.444
0.795HisLys: 0.795 ± 0.56
1.988HisLeu: 1.988 ± 0.859
1.193HisMet: 1.193 ± 0.417
0.398HisAsn: 0.398 ± 0.304
1.59HisPro: 1.59 ± 0.478
1.193HisGln: 1.193 ± 1.226
1.193HisArg: 1.193 ± 0.665
0.398HisSer: 0.398 ± 0.304
1.193HisThr: 1.193 ± 0.629
1.59HisVal: 1.59 ± 1.01
1.59HisTrp: 1.59 ± 0.881
0.795HisTyr: 0.795 ± 0.469
0.0HisXaa: 0.0 ± 0.0
Ile
2.783IleAla: 2.783 ± 1.098
1.988IleCys: 1.988 ± 1.117
3.181IleAsp: 3.181 ± 1.212
2.386IleGlu: 2.386 ± 1.266
2.386IlePhe: 2.386 ± 1.192
3.181IleGly: 3.181 ± 1.081
1.193IleHis: 1.193 ± 0.907
1.193IleIle: 1.193 ± 0.665
2.386IleLys: 2.386 ± 1.1
2.783IleLeu: 2.783 ± 1.055
0.795IleMet: 0.795 ± 0.607
0.0IleAsn: 0.0 ± 0.0
3.579IlePro: 3.579 ± 1.364
2.386IleGln: 2.386 ± 1.313
1.193IleArg: 1.193 ± 0.537
3.181IleSer: 3.181 ± 1.212
3.579IleThr: 3.579 ± 1.006
3.181IleVal: 3.181 ± 1.472
0.398IleTrp: 0.398 ± 0.409
1.59IleTyr: 1.59 ± 0.522
0.0IleXaa: 0.0 ± 0.0
Lys
3.181LysAla: 3.181 ± 0.953
3.181LysCys: 3.181 ± 1.585
1.988LysAsp: 1.988 ± 0.668
2.386LysGlu: 2.386 ± 1.406
3.181LysPhe: 3.181 ± 1.248
2.386LysGly: 2.386 ± 0.835
1.59LysHis: 1.59 ± 1.039
1.988LysIle: 1.988 ± 1.01
3.579LysLys: 3.579 ± 1.3
2.386LysLeu: 2.386 ± 0.835
0.398LysMet: 0.398 ± 0.294
1.193LysAsn: 1.193 ± 0.629
1.193LysPro: 1.193 ± 0.695
1.59LysGln: 1.59 ± 0.779
3.976LysArg: 3.976 ± 1.264
3.181LysSer: 3.181 ± 1.972
1.59LysThr: 1.59 ± 0.5
3.181LysVal: 3.181 ± 0.69
0.795LysTrp: 0.795 ± 0.523
2.783LysTyr: 2.783 ± 0.912
0.0LysXaa: 0.0 ± 0.0
Leu
4.771LeuAla: 4.771 ± 1.238
3.579LeuCys: 3.579 ± 2.133
4.771LeuAsp: 4.771 ± 0.737
2.783LeuGlu: 2.783 ± 1.245
5.567LeuPhe: 5.567 ± 1.195
3.976LeuGly: 3.976 ± 0.851
3.976LeuHis: 3.976 ± 1.062
2.783LeuIle: 2.783 ± 1.055
3.976LeuLys: 3.976 ± 0.988
9.94LeuLeu: 9.94 ± 2.69
1.59LeuMet: 1.59 ± 0.654
1.59LeuAsn: 1.59 ± 0.624
6.759LeuPro: 6.759 ± 3.141
7.157LeuGln: 7.157 ± 2.583
4.771LeuArg: 4.771 ± 0.612
4.771LeuSer: 4.771 ± 1.367
1.988LeuThr: 1.988 ± 0.545
5.169LeuVal: 5.169 ± 2.084
1.193LeuTrp: 1.193 ± 0.911
5.169LeuTyr: 5.169 ± 1.09
0.0LeuXaa: 0.0 ± 0.0
Met
2.783MetAla: 2.783 ± 1.055
1.59MetCys: 1.59 ± 0.688
1.59MetAsp: 1.59 ± 0.933
0.0MetGlu: 0.0 ± 0.0
1.988MetPhe: 1.988 ± 1.519
2.386MetGly: 2.386 ± 1.299
0.398MetHis: 0.398 ± 0.609
1.193MetIle: 1.193 ± 0.566
0.0MetLys: 0.0 ± 0.0
1.59MetLeu: 1.59 ± 0.5
0.0MetMet: 0.0 ± 0.0
0.795MetAsn: 0.795 ± 0.364
0.0MetPro: 0.0 ± 0.0
0.795MetGln: 0.795 ± 0.469
0.398MetArg: 0.398 ± 0.408
2.783MetSer: 2.783 ± 0.458
0.795MetThr: 0.795 ± 0.364
1.988MetVal: 1.988 ± 1.117
0.795MetTrp: 0.795 ± 0.658
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.59AsnAla: 1.59 ± 1.051
0.795AsnCys: 0.795 ± 0.51
0.795AsnAsp: 0.795 ± 0.719
2.386AsnGlu: 2.386 ± 0.625
1.193AsnPhe: 1.193 ± 0.911
2.783AsnGly: 2.783 ± 1.161
0.398AsnHis: 0.398 ± 0.616
2.386AsnIle: 2.386 ± 0.839
2.386AsnLys: 2.386 ± 1.15
1.59AsnLeu: 1.59 ± 0.934
0.0AsnMet: 0.0 ± 0.0
2.783AsnAsn: 2.783 ± 1.042
1.988AsnPro: 1.988 ± 0.775
0.0AsnGln: 0.0 ± 0.0
1.988AsnArg: 1.988 ± 0.901
1.988AsnSer: 1.988 ± 1.122
1.988AsnThr: 1.988 ± 0.826
3.579AsnVal: 3.579 ± 0.643
0.0AsnTrp: 0.0 ± 0.0
0.795AsnTyr: 0.795 ± 0.523
0.0AsnXaa: 0.0 ± 0.0
Pro
2.783ProAla: 2.783 ± 1.009
1.988ProCys: 1.988 ± 0.717
4.374ProAsp: 4.374 ± 1.773
2.783ProGlu: 2.783 ± 1.101
0.398ProPhe: 0.398 ± 0.36
3.181ProGly: 3.181 ± 0.831
0.795ProHis: 0.795 ± 0.469
2.783ProIle: 2.783 ± 1.157
3.976ProLys: 3.976 ± 0.922
8.748ProLeu: 8.748 ± 1.178
0.398ProMet: 0.398 ± 0.34
1.193ProAsn: 1.193 ± 0.611
7.555ProPro: 7.555 ± 2.701
2.386ProGln: 2.386 ± 0.667
2.783ProArg: 2.783 ± 1.661
5.169ProSer: 5.169 ± 1.784
5.567ProThr: 5.567 ± 2.397
3.579ProVal: 3.579 ± 0.683
0.795ProTrp: 0.795 ± 0.466
2.386ProTyr: 2.386 ± 1.53
0.0ProXaa: 0.0 ± 0.0
Gln
3.976GlnAla: 3.976 ± 1.602
1.59GlnCys: 1.59 ± 0.769
2.386GlnAsp: 2.386 ± 1.035
2.783GlnGlu: 2.783 ± 0.681
1.988GlnPhe: 1.988 ± 0.901
3.579GlnGly: 3.579 ± 1.558
0.795GlnHis: 0.795 ± 0.469
0.795GlnIle: 0.795 ± 0.364
1.59GlnLys: 1.59 ± 1.154
4.771GlnLeu: 4.771 ± 1.547
1.193GlnMet: 1.193 ± 0.911
0.398GlnAsn: 0.398 ± 0.616
1.988GlnPro: 1.988 ± 0.625
1.988GlnGln: 1.988 ± 1.446
2.783GlnArg: 2.783 ± 0.667
3.976GlnSer: 3.976 ± 1.512
3.579GlnThr: 3.579 ± 1.153
4.374GlnVal: 4.374 ± 1.189
1.193GlnTrp: 1.193 ± 1.079
1.193GlnTyr: 1.193 ± 0.566
0.0GlnXaa: 0.0 ± 0.0
Arg
3.976ArgAla: 3.976 ± 0.726
1.193ArgCys: 1.193 ± 0.782
1.59ArgAsp: 1.59 ± 1.27
2.386ArgGlu: 2.386 ± 0.842
0.795ArgPhe: 0.795 ± 0.51
1.59ArgGly: 1.59 ± 0.832
1.988ArgHis: 1.988 ± 1.24
2.386ArgIle: 2.386 ± 0.757
3.181ArgLys: 3.181 ± 0.864
7.555ArgLeu: 7.555 ± 1.471
0.795ArgMet: 0.795 ± 0.46
0.398ArgAsn: 0.398 ± 0.409
3.579ArgPro: 3.579 ± 1.316
1.988ArgGln: 1.988 ± 0.929
5.169ArgArg: 5.169 ± 1.372
2.783ArgSer: 2.783 ± 1.161
3.579ArgThr: 3.579 ± 1.116
3.976ArgVal: 3.976 ± 1.194
0.0ArgTrp: 0.0 ± 0.0
3.181ArgTyr: 3.181 ± 0.615
0.0ArgXaa: 0.0 ± 0.0
Ser
3.976SerAla: 3.976 ± 1.353
1.59SerCys: 1.59 ± 0.769
4.374SerAsp: 4.374 ± 1.28
1.59SerGlu: 1.59 ± 0.578
3.181SerPhe: 3.181 ± 1.004
5.169SerGly: 5.169 ± 1.261
0.795SerHis: 0.795 ± 0.51
2.783SerIle: 2.783 ± 1.001
1.988SerLys: 1.988 ± 1.117
7.157SerLeu: 7.157 ± 0.961
1.988SerMet: 1.988 ± 0.809
2.386SerAsn: 2.386 ± 0.653
3.181SerPro: 3.181 ± 0.714
2.783SerGln: 2.783 ± 0.747
4.374SerArg: 4.374 ± 0.803
9.145SerSer: 9.145 ± 2.703
7.952SerThr: 7.952 ± 2.87
5.567SerVal: 5.567 ± 1.474
0.795SerTrp: 0.795 ± 0.461
1.988SerTyr: 1.988 ± 0.839
0.0SerXaa: 0.0 ± 0.0
Thr
3.976ThrAla: 3.976 ± 1.224
1.988ThrCys: 1.988 ± 0.882
3.579ThrAsp: 3.579 ± 1.103
3.579ThrGlu: 3.579 ± 1.384
1.988ThrPhe: 1.988 ± 0.458
6.362ThrGly: 6.362 ± 1.738
1.193ThrHis: 1.193 ± 0.71
3.181ThrIle: 3.181 ± 1.381
2.386ThrLys: 2.386 ± 1.728
4.374ThrLeu: 4.374 ± 1.863
1.59ThrMet: 1.59 ± 0.648
3.181ThrAsn: 3.181 ± 1.33
7.555ThrPro: 7.555 ± 2.251
3.181ThrGln: 3.181 ± 1.295
1.988ThrArg: 1.988 ± 0.839
9.94ThrSer: 9.94 ± 3.339
5.567ThrThr: 5.567 ± 1.321
7.555ThrVal: 7.555 ± 1.583
2.783ThrTrp: 2.783 ± 0.634
2.386ThrTyr: 2.386 ± 0.786
0.0ThrXaa: 0.0 ± 0.0
Val
3.579ValAla: 3.579 ± 1.551
1.988ValCys: 1.988 ± 0.868
4.374ValAsp: 4.374 ± 0.865
3.579ValGlu: 3.579 ± 0.584
3.181ValPhe: 3.181 ± 1.081
3.976ValGly: 3.976 ± 0.902
1.988ValHis: 1.988 ± 0.808
3.181ValIle: 3.181 ± 1.086
2.386ValLys: 2.386 ± 0.444
4.771ValLeu: 4.771 ± 0.984
0.398ValMet: 0.398 ± 0.304
2.386ValAsn: 2.386 ± 0.846
5.567ValPro: 5.567 ± 1.323
5.169ValGln: 5.169 ± 1.04
3.976ValArg: 3.976 ± 1.194
7.555ValSer: 7.555 ± 2.029
6.362ValThr: 6.362 ± 2.706
4.374ValVal: 4.374 ± 1.166
0.398ValTrp: 0.398 ± 0.304
1.59ValTyr: 1.59 ± 0.994
0.0ValXaa: 0.0 ± 0.0
Trp
3.181TrpAla: 3.181 ± 1.175
0.0TrpCys: 0.0 ± 0.0
0.398TrpAsp: 0.398 ± 0.408
0.795TrpGlu: 0.795 ± 0.466
0.795TrpPhe: 0.795 ± 0.364
0.795TrpGly: 0.795 ± 0.461
0.398TrpHis: 0.398 ± 0.409
0.795TrpIle: 0.795 ± 0.719
1.193TrpLys: 1.193 ± 0.719
0.795TrpLeu: 0.795 ± 0.364
0.795TrpMet: 0.795 ± 0.391
1.193TrpAsn: 1.193 ± 0.581
0.0TrpPro: 0.0 ± 0.0
0.398TrpGln: 0.398 ± 0.409
0.795TrpArg: 0.795 ± 0.607
0.398TrpSer: 0.398 ± 0.304
2.386TrpThr: 2.386 ± 0.807
0.795TrpVal: 0.795 ± 0.719
0.0TrpTrp: 0.0 ± 0.0
0.795TrpTyr: 0.795 ± 0.461
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.386TyrAla: 2.386 ± 0.758
1.193TyrCys: 1.193 ± 0.707
2.783TyrAsp: 2.783 ± 0.814
1.59TyrGlu: 1.59 ± 1.175
0.398TyrPhe: 0.398 ± 0.34
4.771TyrGly: 4.771 ± 1.008
1.193TyrHis: 1.193 ± 0.709
1.59TyrIle: 1.59 ± 0.548
0.795TyrLys: 0.795 ± 0.466
4.374TyrLeu: 4.374 ± 1.168
1.59TyrMet: 1.59 ± 0.821
0.795TyrAsn: 0.795 ± 0.607
1.988TyrPro: 1.988 ± 0.757
1.193TyrGln: 1.193 ± 0.566
2.783TyrArg: 2.783 ± 0.454
1.988TyrSer: 1.988 ± 0.739
1.193TyrThr: 1.193 ± 0.633
1.988TyrVal: 1.988 ± 1.273
0.795TyrTrp: 0.795 ± 0.364
2.386TyrTyr: 2.386 ± 0.971
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7 proteins (2516 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski