Amino acid dipepetide frequency for Streptomyces scabichelini

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.937AlaAla: 19.937 ± 0.113	1.023AlaCys: 1.023 ± 0.019	8.172AlaAsp: 8.172 ± 0.055	8.742AlaGlu: 8.742 ± 0.063	3.499AlaPhe: 3.499 ± 0.038	12.32AlaGly: 12.32 ± 0.067	2.765AlaHis: 2.765 ± 0.034	3.699AlaIle: 3.699 ± 0.047	2.928AlaLys: 2.928 ± 0.043	14.04AlaLeu: 14.04 ± 0.074	2.51AlaMet: 2.51 ± 0.03	1.967AlaAsn: 1.967 ± 0.027	6.553AlaPro: 6.553 ± 0.052	3.798AlaGln: 3.798 ± 0.037	9.736AlaArg: 9.736 ± 0.067	6.104AlaSer: 6.104 ± 0.053	6.94AlaThr: 6.94 ± 0.058	12.008AlaVal: 12.008 ± 0.082	1.841AlaTrp: 1.841 ± 0.026	2.848AlaTyr: 2.848 ± 0.029	0.0AlaXaa: 0.0 ± 0.0
Cys	1.005CysAla: 1.005 ± 0.017	0.09CysCys: 0.09 ± 0.006	0.45CysAsp: 0.45 ± 0.012	0.424CysGlu: 0.424 ± 0.011	0.209CysPhe: 0.209 ± 0.008	0.916CysGly: 0.916 ± 0.017	0.187CysHis: 0.187 ± 0.008	0.164CysIle: 0.164 ± 0.007	0.11CysLys: 0.11 ± 0.006	0.741CysLeu: 0.741 ± 0.018	0.12CysMet: 0.12 ± 0.006	0.125CysAsn: 0.125 ± 0.007	0.452CysPro: 0.452 ± 0.013	0.164CysGln: 0.164 ± 0.007	0.564CysArg: 0.564 ± 0.013	0.42CysSer: 0.42 ± 0.012	0.503CysThr: 0.503 ± 0.013	0.671CysVal: 0.671 ± 0.016	0.124CysTrp: 0.124 ± 0.007	0.152CysTyr: 0.152 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	7.582AspAla: 7.582 ± 0.056	0.434AspCys: 0.434 ± 0.011	3.741AspAsp: 3.741 ± 0.039	4.037AspGlu: 4.037 ± 0.038	1.705AspPhe: 1.705 ± 0.025	6.33AspGly: 6.33 ± 0.053	1.412AspHis: 1.412 ± 0.023	2.052AspIle: 2.052 ± 0.026	1.31AspLys: 1.31 ± 0.025	6.13AspLeu: 6.13 ± 0.048	0.898AspMet: 0.898 ± 0.018	1.031AspAsn: 1.031 ± 0.018	4.334AspPro: 4.334 ± 0.041	1.655AspGln: 1.655 ± 0.023	4.824AspArg: 4.824 ± 0.051	2.792AspSer: 2.792 ± 0.034	3.307AspThr: 3.307 ± 0.037	4.816AspVal: 4.816 ± 0.037	1.064AspTrp: 1.064 ± 0.018	1.126AspTyr: 1.126 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	7.335GluAla: 7.335 ± 0.055	0.359GluCys: 0.359 ± 0.011	2.93GluAsp: 2.93 ± 0.033	3.627GluGlu: 3.627 ± 0.042	1.536GluPhe: 1.536 ± 0.024	4.438GluGly: 4.438 ± 0.044	1.509GluHis: 1.509 ± 0.024	2.347GluIle: 2.347 ± 0.036	1.567GluLys: 1.567 ± 0.026	7.031GluLeu: 7.031 ± 0.054	0.92GluMet: 0.92 ± 0.018	1.124GluAsn: 1.124 ± 0.019	3.438GluPro: 3.438 ± 0.039	2.316GluGln: 2.316 ± 0.029	5.49GluArg: 5.49 ± 0.053	2.784GluSer: 2.784 ± 0.031	2.973GluThr: 2.973 ± 0.027	4.426GluVal: 4.426 ± 0.041	0.813GluTrp: 0.813 ± 0.017	1.229GluTyr: 1.229 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.656PheAla: 3.656 ± 0.039	0.247PheCys: 0.247 ± 0.009	2.02PheAsp: 2.02 ± 0.026	1.45PheGlu: 1.45 ± 0.021	0.892PhePhe: 0.892 ± 0.017	3.091PheGly: 3.091 ± 0.035	0.632PheHis: 0.632 ± 0.014	0.804PheIle: 0.804 ± 0.016	0.549PheLys: 0.549 ± 0.013	2.64PheLeu: 2.64 ± 0.03	0.44PheMet: 0.44 ± 0.013	0.61PheAsn: 0.61 ± 0.014	1.393PhePro: 1.393 ± 0.019	0.714PheGln: 0.714 ± 0.014	1.827PheArg: 1.827 ± 0.024	1.513PheSer: 1.513 ± 0.024	2.061PheThr: 2.061 ± 0.027	2.241PheVal: 2.241 ± 0.03	0.439PheTrp: 0.439 ± 0.012	0.598PheTyr: 0.598 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	10.511GlyAla: 10.511 ± 0.075	0.794GlyCys: 0.794 ± 0.016	5.148GlyAsp: 5.148 ± 0.047	5.091GlyGlu: 5.091 ± 0.044	2.927GlyPhe: 2.927 ± 0.03	8.466GlyGly: 8.466 ± 0.072	2.262GlyHis: 2.262 ± 0.028	3.637GlyIle: 3.637 ± 0.038	2.519GlyLys: 2.519 ± 0.032	9.406GlyLeu: 9.406 ± 0.055	2.058GlyMet: 2.058 ± 0.025	1.826GlyAsn: 1.826 ± 0.028	5.018GlyPro: 5.018 ± 0.049	2.729GlyGln: 2.729 ± 0.03	7.511GlyArg: 7.511 ± 0.05	5.522GlySer: 5.522 ± 0.052	6.21GlyThr: 6.21 ± 0.047	7.468GlyVal: 7.468 ± 0.056	1.661GlyTrp: 1.661 ± 0.025	2.268GlyTyr: 2.268 ± 0.029	0.0GlyXaa: 0.0 ± 0.0
His	2.622HisAla: 2.622 ± 0.034	0.205HisCys: 0.205 ± 0.009	1.358HisAsp: 1.358 ± 0.021	1.266HisGlu: 1.266 ± 0.021	0.67HisPhe: 0.67 ± 0.014	2.343HisGly: 2.343 ± 0.029	0.668HisHis: 0.668 ± 0.014	0.745HisIle: 0.745 ± 0.015	0.377HisLys: 0.377 ± 0.012	2.366HisLeu: 2.366 ± 0.029	0.355HisMet: 0.355 ± 0.012	0.401HisAsn: 0.401 ± 0.014	1.74HisPro: 1.74 ± 0.027	0.651HisGln: 0.651 ± 0.017	2.081HisArg: 2.081 ± 0.027	1.04HisSer: 1.04 ± 0.018	1.306HisThr: 1.306 ± 0.021	1.669HisVal: 1.669 ± 0.022	0.374HisTrp: 0.374 ± 0.011	0.492HisTyr: 0.492 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.991IleAla: 4.991 ± 0.045	0.29IleCys: 0.29 ± 0.008	2.396IleAsp: 2.396 ± 0.028	2.12IleGlu: 2.12 ± 0.028	0.752IlePhe: 0.752 ± 0.017	3.73IleGly: 3.73 ± 0.04	0.647IleHis: 0.647 ± 0.015	0.896IleIle: 0.896 ± 0.02	0.777IleLys: 0.777 ± 0.016	2.573IleLeu: 2.573 ± 0.033	0.483IleMet: 0.483 ± 0.014	0.756IleAsn: 0.756 ± 0.016	1.934IlePro: 1.934 ± 0.026	0.774IleGln: 0.774 ± 0.015	2.428IleArg: 2.428 ± 0.034	1.825IleSer: 1.825 ± 0.022	2.318IleThr: 2.318 ± 0.027	2.872IleVal: 2.872 ± 0.031	0.401IleTrp: 0.401 ± 0.011	0.552IleTyr: 0.552 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	3.042LysAla: 3.042 ± 0.041	0.115LysCys: 0.115 ± 0.006	1.393LysAsp: 1.393 ± 0.025	1.277LysGlu: 1.277 ± 0.025	0.504LysPhe: 0.504 ± 0.013	1.924LysGly: 1.924 ± 0.033	0.47LysHis: 0.47 ± 0.013	0.919LysIle: 0.919 ± 0.02	0.911LysLys: 0.911 ± 0.024	2.121LysLeu: 2.121 ± 0.034	0.386LysMet: 0.386 ± 0.013	0.566LysAsn: 0.566 ± 0.017	1.46LysPro: 1.46 ± 0.025	0.744LysGln: 0.744 ± 0.017	1.494LysArg: 1.494 ± 0.027	1.274LysSer: 1.274 ± 0.019	1.397LysThr: 1.397 ± 0.028	1.956LysVal: 1.956 ± 0.026	0.3LysTrp: 0.3 ± 0.009	0.493LysTyr: 0.493 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	14.712LeuAla: 14.712 ± 0.091	0.824LeuCys: 0.824 ± 0.016	6.765LeuAsp: 6.765 ± 0.053	4.715LeuGlu: 4.715 ± 0.046	2.652LeuPhe: 2.652 ± 0.03	9.19LeuGly: 9.19 ± 0.057	2.323LeuHis: 2.323 ± 0.03	3.508LeuIle: 3.508 ± 0.036	2.165LeuLys: 2.165 ± 0.03	11.195LeuLeu: 11.195 ± 0.084	1.725LeuMet: 1.725 ± 0.028	1.79LeuAsn: 1.79 ± 0.024	6.421LeuPro: 6.421 ± 0.048	2.263LeuGln: 2.263 ± 0.026	8.503LeuArg: 8.503 ± 0.066	5.571LeuSer: 5.571 ± 0.042	6.903LeuThr: 6.903 ± 0.046	8.804LeuVal: 8.804 ± 0.063	1.299LeuTrp: 1.299 ± 0.023	1.873LeuTyr: 1.873 ± 0.024	0.0LeuXaa: 0.0 ± 0.0
Met	2.329MetAla: 2.329 ± 0.03	0.136MetCys: 0.136 ± 0.006	0.943MetAsp: 0.943 ± 0.016	0.789MetGlu: 0.789 ± 0.015	0.483MetPhe: 0.483 ± 0.014	1.377MetGly: 1.377 ± 0.024	0.372MetHis: 0.372 ± 0.011	0.685MetIle: 0.685 ± 0.015	0.444MetLys: 0.444 ± 0.012	1.74MetLeu: 1.74 ± 0.024	0.32MetMet: 0.32 ± 0.01	0.459MetAsn: 0.459 ± 0.012	1.15MetPro: 1.15 ± 0.019	0.448MetGln: 0.448 ± 0.012	1.48MetArg: 1.48 ± 0.023	1.382MetSer: 1.382 ± 0.022	1.596MetThr: 1.596 ± 0.023	1.325MetVal: 1.325 ± 0.018	0.222MetTrp: 0.222 ± 0.008	0.339MetTyr: 0.339 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.294AsnAla: 2.294 ± 0.028	0.179AsnCys: 0.179 ± 0.008	1.024AsnAsp: 1.024 ± 0.019	0.896AsnGlu: 0.896 ± 0.017	0.507AsnPhe: 0.507 ± 0.012	1.951AsnGly: 1.951 ± 0.027	0.408AsnHis: 0.408 ± 0.011	0.695AsnIle: 0.695 ± 0.015	0.456AsnLys: 0.456 ± 0.013	1.732AsnLeu: 1.732 ± 0.024	0.308AsnMet: 0.308 ± 0.011	0.473AsnAsn: 0.473 ± 0.014	1.403AsnPro: 1.403 ± 0.021	0.555AsnGln: 0.555 ± 0.013	1.317AsnArg: 1.317 ± 0.022	1.035AsnSer: 1.035 ± 0.017	1.178AsnThr: 1.178 ± 0.021	1.452AsnVal: 1.452 ± 0.021	0.324AsnTrp: 0.324 ± 0.009	0.446AsnTyr: 0.446 ± 0.012	0.0AsnXaa: 0.0 ± 0.0
Pro	7.879ProAla: 7.879 ± 0.057	0.292ProCys: 0.292 ± 0.01	4.556ProAsp: 4.556 ± 0.044	4.387ProGlu: 4.387 ± 0.04	1.561ProPhe: 1.561 ± 0.024	6.297ProGly: 6.297 ± 0.05	1.358ProHis: 1.358 ± 0.024	1.351ProIle: 1.351 ± 0.02	1.306ProLys: 1.306 ± 0.019	5.364ProLeu: 5.364 ± 0.047	1.049ProMet: 1.049 ± 0.016	0.965ProAsn: 0.965 ± 0.017	3.37ProPro: 3.37 ± 0.045	1.802ProGln: 1.802 ± 0.033	3.756ProArg: 3.756 ± 0.038	3.271ProSer: 3.271 ± 0.034	3.216ProThr: 3.216 ± 0.035	5.387ProVal: 5.387 ± 0.045	0.906ProTrp: 0.906 ± 0.019	1.443ProTyr: 1.443 ± 0.022	0.0ProXaa: 0.0 ± 0.0
Gln	3.712GlnAla: 3.712 ± 0.037	0.175GlnCys: 0.175 ± 0.008	1.467GlnAsp: 1.467 ± 0.021	1.558GlnGlu: 1.558 ± 0.022	0.733GlnPhe: 0.733 ± 0.015	2.324GlnGly: 2.324 ± 0.03	0.675GlnHis: 0.675 ± 0.013	1.095GlnIle: 1.095 ± 0.021	0.667GlnLys: 0.667 ± 0.017	3.26GlnLeu: 3.26 ± 0.033	0.506GlnMet: 0.506 ± 0.013	0.54GlnAsn: 0.54 ± 0.012	1.766GlnPro: 1.766 ± 0.034	1.319GlnGln: 1.319 ± 0.027	2.419GlnArg: 2.419 ± 0.025	1.368GlnSer: 1.368 ± 0.022	1.414GlnThr: 1.414 ± 0.022	2.391GlnVal: 2.391 ± 0.028	0.476GlnTrp: 0.476 ± 0.012	0.651GlnTyr: 0.651 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	9.258ArgAla: 9.258 ± 0.071	0.551ArgCys: 0.551 ± 0.016	4.264ArgAsp: 4.264 ± 0.041	4.804ArgGlu: 4.804 ± 0.04	2.311ArgPhe: 2.311 ± 0.03	5.658ArgGly: 5.658 ± 0.043	2.091ArgHis: 2.091 ± 0.027	3.383ArgIle: 3.383 ± 0.037	1.695ArgLys: 1.695 ± 0.029	8.689ArgLeu: 8.689 ± 0.069	1.754ArgMet: 1.754 ± 0.028	1.406ArgAsn: 1.406 ± 0.023	4.692ArgPro: 4.692 ± 0.049	2.366ArgGln: 2.366 ± 0.027	7.425ArgArg: 7.425 ± 0.067	4.102ArgSer: 4.102 ± 0.037	5.352ArgThr: 5.352 ± 0.045	5.754ArgVal: 5.754 ± 0.045	1.37ArgTrp: 1.37 ± 0.022	1.83ArgTyr: 1.83 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	6.897SerAla: 6.897 ± 0.055	0.388SerCys: 0.388 ± 0.012	2.89SerAsp: 2.89 ± 0.031	2.683SerGlu: 2.683 ± 0.03	1.558SerPhe: 1.558 ± 0.024	6.154SerGly: 6.154 ± 0.055	1.054SerHis: 1.054 ± 0.018	1.528SerIle: 1.528 ± 0.024	1.146SerLys: 1.146 ± 0.022	5.039SerLeu: 5.039 ± 0.041	1.146SerMet: 1.146 ± 0.021	0.94SerAsn: 0.94 ± 0.018	3.307SerPro: 3.307 ± 0.034	1.366SerGln: 1.366 ± 0.02	3.789SerArg: 3.789 ± 0.037	3.034SerSer: 3.034 ± 0.041	3.232SerThr: 3.232 ± 0.037	4.428SerVal: 4.428 ± 0.038	0.941SerTrp: 0.941 ± 0.016	1.289SerTyr: 1.289 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	8.741ThrAla: 8.741 ± 0.063	0.428ThrCys: 0.428 ± 0.012	3.672ThrAsp: 3.672 ± 0.035	3.428ThrGlu: 3.428 ± 0.036	1.639ThrPhe: 1.639 ± 0.029	6.576ThrGly: 6.576 ± 0.05	1.212ThrHis: 1.212 ± 0.021	1.787ThrIle: 1.787 ± 0.025	1.27ThrLys: 1.27 ± 0.025	5.763ThrLeu: 5.763 ± 0.044	1.0ThrMet: 1.0 ± 0.018	1.065ThrAsn: 1.065 ± 0.021	4.084ThrPro: 4.084 ± 0.041	1.399ThrGln: 1.399 ± 0.024	3.89ThrArg: 3.89 ± 0.033	3.334ThrSer: 3.334 ± 0.038	3.919ThrThr: 3.919 ± 0.043	6.079ThrVal: 6.079 ± 0.051	0.901ThrTrp: 0.901 ± 0.017	1.428ThrTyr: 1.428 ± 0.024	0.0ThrXaa: 0.0 ± 0.0
Val	10.456ValAla: 10.456 ± 0.062	0.734ValCys: 0.734 ± 0.015	4.979ValAsp: 4.979 ± 0.044	4.733ValGlu: 4.733 ± 0.04	2.494ValPhe: 2.494 ± 0.03	6.516ValGly: 6.516 ± 0.052	1.93ValHis: 1.93 ± 0.025	3.093ValIle: 3.093 ± 0.037	1.752ValLys: 1.752 ± 0.027	9.454ValLeu: 9.454 ± 0.07	1.466ValMet: 1.466 ± 0.025	1.722ValAsn: 1.722 ± 0.024	5.131ValPro: 5.131 ± 0.038	2.186ValGln: 2.186 ± 0.027	7.059ValArg: 7.059 ± 0.05	4.484ValSer: 4.484 ± 0.04	5.546ValThr: 5.546 ± 0.046	7.91ValVal: 7.91 ± 0.062	1.159ValTrp: 1.159 ± 0.021	1.61ValTyr: 1.61 ± 0.027	0.0ValXaa: 0.0 ± 0.0
Trp	1.618TrpAla: 1.618 ± 0.023	0.141TrpCys: 0.141 ± 0.006	0.876TrpAsp: 0.876 ± 0.017	0.765TrpGlu: 0.765 ± 0.015	0.519TrpPhe: 0.519 ± 0.014	1.071TrpGly: 1.071 ± 0.022	0.365TrpHis: 0.365 ± 0.014	0.585TrpIle: 0.585 ± 0.014	0.38TrpLys: 0.38 ± 0.011	1.807TrpLeu: 1.807 ± 0.027	0.3TrpMet: 0.3 ± 0.011	0.439TrpAsn: 0.439 ± 0.013	0.791TrpPro: 0.791 ± 0.017	0.643TrpGln: 0.643 ± 0.015	1.323TrpArg: 1.323 ± 0.02	0.961TrpSer: 0.961 ± 0.02	1.031TrpThr: 1.031 ± 0.02	0.998TrpVal: 0.998 ± 0.019	0.345TrpTrp: 0.345 ± 0.012	0.384TrpTyr: 0.384 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.854TyrAla: 2.854 ± 0.028	0.183TyrCys: 0.183 ± 0.009	1.538TyrAsp: 1.538 ± 0.028	1.4TyrGlu: 1.4 ± 0.024	0.668TyrPhe: 0.668 ± 0.014	2.361TyrGly: 2.361 ± 0.03	0.391TyrHis: 0.391 ± 0.011	0.54TyrIle: 0.54 ± 0.015	0.42TyrLys: 0.42 ± 0.012	2.107TyrLeu: 2.107 ± 0.026	0.276TyrMet: 0.276 ± 0.01	0.427TyrAsn: 0.427 ± 0.012	1.081TyrPro: 1.081 ± 0.018	0.623TyrGln: 0.623 ± 0.014	1.839TyrArg: 1.839 ± 0.025	0.994TyrSer: 0.994 ± 0.018	1.215TyrThr: 1.215 ± 0.022	1.759TyrVal: 1.759 ± 0.022	0.378TyrTrp: 0.378 ± 0.012	0.481TyrTyr: 0.481 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9567 proteins (3151775 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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