Amino acid dipepetide frequency for Ferrimicrobium acidiphilum DSM 19497

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.908AlaAla: 10.908 ± 0.143	0.937AlaCys: 0.937 ± 0.032	5.074AlaAsp: 5.074 ± 0.076	5.747AlaGlu: 5.747 ± 0.116	3.282AlaPhe: 3.282 ± 0.061	8.22AlaGly: 8.22 ± 0.123	2.335AlaHis: 2.335 ± 0.049	6.574AlaIle: 6.574 ± 0.094	3.75AlaLys: 3.75 ± 0.068	11.661AlaLeu: 11.661 ± 0.131	2.62AlaMet: 2.62 ± 0.057	3.234AlaAsn: 3.234 ± 0.058	4.187AlaPro: 4.187 ± 0.073	3.583AlaGln: 3.583 ± 0.067	7.092AlaArg: 7.092 ± 0.095	7.768AlaSer: 7.768 ± 0.104	6.552AlaThr: 6.552 ± 0.11	7.954AlaVal: 7.954 ± 0.11	1.192AlaTrp: 1.192 ± 0.037	2.17AlaTyr: 2.17 ± 0.056	0.002AlaXaa: 0.002 ± 0.002
Cys	0.779CysAla: 0.779 ± 0.031	0.093CysCys: 0.093 ± 0.01	0.508CysAsp: 0.508 ± 0.025	0.496CysGlu: 0.496 ± 0.023	0.317CysPhe: 0.317 ± 0.019	0.911CysGly: 0.911 ± 0.034	0.238CysHis: 0.238 ± 0.016	0.364CysIle: 0.364 ± 0.022	0.173CysLys: 0.173 ± 0.014	0.734CysLeu: 0.734 ± 0.032	0.161CysMet: 0.161 ± 0.016	0.236CysAsn: 0.236 ± 0.018	0.548CysPro: 0.548 ± 0.029	0.296CysGln: 0.296 ± 0.021	0.603CysArg: 0.603 ± 0.026	0.621CysSer: 0.621 ± 0.032	0.476CysThr: 0.476 ± 0.025	0.578CysVal: 0.578 ± 0.026	0.127CysTrp: 0.127 ± 0.012	0.239CysTyr: 0.239 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.222AspAla: 5.222 ± 0.094	0.406AspCys: 0.406 ± 0.022	2.993AspAsp: 2.993 ± 0.07	3.751AspGlu: 3.751 ± 0.077	1.757AspPhe: 1.757 ± 0.043	4.273AspGly: 4.273 ± 0.074	1.342AspHis: 1.342 ± 0.038	2.381AspIle: 2.381 ± 0.053	1.11AspLys: 1.11 ± 0.036	6.445AspLeu: 6.445 ± 0.092	0.867AspMet: 0.867 ± 0.032	1.117AspAsn: 1.117 ± 0.035	3.802AspPro: 3.802 ± 0.068	1.948AspGln: 1.948 ± 0.048	4.275AspArg: 4.275 ± 0.084	2.963AspSer: 2.963 ± 0.061	2.406AspThr: 2.406 ± 0.058	3.808AspVal: 3.808 ± 0.076	0.711AspTrp: 0.711 ± 0.031	1.313AspTyr: 1.313 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	6.143GluAla: 6.143 ± 0.102	0.404GluCys: 0.404 ± 0.023	2.543GluAsp: 2.543 ± 0.058	3.577GluGlu: 3.577 ± 0.083	1.84GluPhe: 1.84 ± 0.055	3.947GluGly: 3.947 ± 0.075	1.457GluHis: 1.457 ± 0.048	3.4GluIle: 3.4 ± 0.055	1.148GluLys: 1.148 ± 0.036	7.84GluLeu: 7.84 ± 0.131	1.332GluMet: 1.332 ± 0.044	1.266GluAsn: 1.266 ± 0.036	2.553GluPro: 2.553 ± 0.061	2.02GluGln: 2.02 ± 0.054	5.146GluArg: 5.146 ± 0.092	3.495GluSer: 3.495 ± 0.061	2.986GluThr: 2.986 ± 0.061	5.352GluVal: 5.352 ± 0.089	0.765GluTrp: 0.765 ± 0.029	1.121GluTyr: 1.121 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.906PheAla: 3.906 ± 0.069	0.345PheCys: 0.345 ± 0.019	2.256PheAsp: 2.256 ± 0.057	1.982PheGlu: 1.982 ± 0.051	1.173PhePhe: 1.173 ± 0.037	3.579PheGly: 3.579 ± 0.068	0.778PheHis: 0.778 ± 0.029	1.45PheIle: 1.45 ± 0.049	0.728PheLys: 0.728 ± 0.033	3.043PheLeu: 3.043 ± 0.074	0.509PheMet: 0.509 ± 0.028	0.863PheAsn: 0.863 ± 0.034	1.418PhePro: 1.418 ± 0.043	0.943PheGln: 0.943 ± 0.029	2.001PheArg: 2.001 ± 0.048	2.251PheSer: 2.251 ± 0.054	1.812PheThr: 1.812 ± 0.049	2.856PheVal: 2.856 ± 0.061	0.404PheTrp: 0.404 ± 0.021	0.793PheTyr: 0.793 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	7.936GlyAla: 7.936 ± 0.099	0.765GlyCys: 0.765 ± 0.031	4.156GlyAsp: 4.156 ± 0.067	4.396GlyGlu: 4.396 ± 0.079	3.252GlyPhe: 3.252 ± 0.062	6.334GlyGly: 6.334 ± 0.096	1.967GlyHis: 1.967 ± 0.05	4.917GlyIle: 4.917 ± 0.071	2.431GlyLys: 2.431 ± 0.055	8.393GlyLeu: 8.393 ± 0.111	1.889GlyMet: 1.889 ± 0.054	1.926GlyAsn: 1.926 ± 0.048	3.291GlyPro: 3.291 ± 0.055	2.638GlyGln: 2.638 ± 0.062	5.239GlyArg: 5.239 ± 0.09	6.304GlySer: 6.304 ± 0.107	4.509GlyThr: 4.509 ± 0.088	7.601GlyVal: 7.601 ± 0.091	1.275GlyTrp: 1.275 ± 0.045	2.576GlyTyr: 2.576 ± 0.062	0.002GlyXaa: 0.002 ± 0.002
His	2.037HisAla: 2.037 ± 0.048	0.249HisCys: 0.249 ± 0.015	1.145HisAsp: 1.145 ± 0.037	1.226HisGlu: 1.226 ± 0.038	0.793HisPhe: 0.793 ± 0.032	2.071HisGly: 2.071 ± 0.045	0.75HisHis: 0.75 ± 0.03	0.937HisIle: 0.937 ± 0.039	0.517HisLys: 0.517 ± 0.026	2.716HisLeu: 2.716 ± 0.068	0.396HisMet: 0.396 ± 0.021	0.583HisAsn: 0.583 ± 0.028	1.589HisPro: 1.589 ± 0.042	0.905HisGln: 0.905 ± 0.032	1.777HisArg: 1.777 ± 0.046	1.408HisSer: 1.408 ± 0.036	0.992HisThr: 0.992 ± 0.034	1.534HisVal: 1.534 ± 0.047	0.363HisTrp: 0.363 ± 0.02	0.665HisTyr: 0.665 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.805IleAla: 6.805 ± 0.106	0.481IleCys: 0.481 ± 0.024	3.737IleAsp: 3.737 ± 0.073	3.873IleGlu: 3.873 ± 0.066	1.66IlePhe: 1.66 ± 0.049	4.969IleGly: 4.969 ± 0.079	1.078IleHis: 1.078 ± 0.037	2.433IleIle: 2.433 ± 0.054	1.257IleLys: 1.257 ± 0.04	4.6IleLeu: 4.6 ± 0.086	0.797IleMet: 0.797 ± 0.033	1.478IleAsn: 1.478 ± 0.04	2.582IlePro: 2.582 ± 0.059	1.414IleGln: 1.414 ± 0.047	3.255IleArg: 3.255 ± 0.059	3.525IleSer: 3.525 ± 0.069	3.194IleThr: 3.194 ± 0.071	4.747IleVal: 4.747 ± 0.08	0.574IleTrp: 0.574 ± 0.026	1.18IleTyr: 1.18 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	2.836LysAla: 2.836 ± 0.072	0.177LysCys: 0.177 ± 0.014	1.251LysAsp: 1.251 ± 0.041	1.545LysGlu: 1.545 ± 0.05	0.728LysPhe: 0.728 ± 0.028	1.992LysGly: 1.992 ± 0.045	0.505LysHis: 0.505 ± 0.022	1.435LysIle: 1.435 ± 0.048	0.737LysLys: 0.737 ± 0.034	2.924LysLeu: 2.924 ± 0.055	0.553LysMet: 0.553 ± 0.023	0.707LysAsn: 0.707 ± 0.029	1.35LysPro: 1.35 ± 0.039	0.834LysGln: 0.834 ± 0.031	1.993LysArg: 1.993 ± 0.051	1.915LysSer: 1.915 ± 0.053	1.726LysThr: 1.726 ± 0.058	2.524LysVal: 2.524 ± 0.056	0.34LysTrp: 0.34 ± 0.021	0.572LysTyr: 0.572 ± 0.026	0.001LysXaa: 0.001 ± 0.001
Leu	13.674LeuAla: 13.674 ± 0.136	0.9LeuCys: 0.9 ± 0.035	6.32LeuAsp: 6.32 ± 0.097	6.432LeuGlu: 6.432 ± 0.096	3.22LeuPhe: 3.22 ± 0.067	9.735LeuGly: 9.735 ± 0.135	2.211LeuHis: 2.211 ± 0.053	5.484LeuIle: 5.484 ± 0.088	2.638LeuLys: 2.638 ± 0.057	11.104LeuLeu: 11.104 ± 0.154	2.069LeuMet: 2.069 ± 0.046	2.668LeuAsn: 2.668 ± 0.052	5.143LeuPro: 5.143 ± 0.083	2.939LeuGln: 2.939 ± 0.071	7.466LeuArg: 7.466 ± 0.102	7.762LeuSer: 7.762 ± 0.104	6.271LeuThr: 6.271 ± 0.091	9.342LeuVal: 9.342 ± 0.109	1.192LeuTrp: 1.192 ± 0.038	2.21LeuTyr: 2.21 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	2.475MetAla: 2.475 ± 0.052	0.123MetCys: 0.123 ± 0.014	0.96MetAsp: 0.96 ± 0.035	1.128MetGlu: 1.128 ± 0.041	0.497MetPhe: 0.497 ± 0.024	1.558MetGly: 1.558 ± 0.05	0.411MetHis: 0.411 ± 0.021	1.184MetIle: 1.184 ± 0.04	0.608MetLys: 0.608 ± 0.028	2.104MetLeu: 2.104 ± 0.051	0.449MetMet: 0.449 ± 0.024	0.753MetAsn: 0.753 ± 0.027	0.954MetPro: 0.954 ± 0.034	0.561MetGln: 0.561 ± 0.026	1.472MetArg: 1.472 ± 0.043	1.58MetSer: 1.58 ± 0.049	1.566MetThr: 1.566 ± 0.042	1.819MetVal: 1.819 ± 0.046	0.153MetTrp: 0.153 ± 0.014	0.314MetTyr: 0.314 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.673AsnAla: 2.673 ± 0.057	0.226AsnCys: 0.226 ± 0.015	1.39AsnAsp: 1.39 ± 0.046	1.465AsnGlu: 1.465 ± 0.046	0.937AsnPhe: 0.937 ± 0.041	2.358AsnGly: 2.358 ± 0.059	0.627AsnHis: 0.627 ± 0.027	1.156AsnIle: 1.156 ± 0.033	0.578AsnLys: 0.578 ± 0.026	2.882AsnLeu: 2.882 ± 0.062	0.459AsnMet: 0.459 ± 0.022	0.718AsnAsn: 0.718 ± 0.034	1.994AsnPro: 1.994 ± 0.047	1.1AsnGln: 1.1 ± 0.039	1.821AsnArg: 1.821 ± 0.047	1.661AsnSer: 1.661 ± 0.044	1.467AsnThr: 1.467 ± 0.041	1.84AsnVal: 1.84 ± 0.046	0.453AsnTrp: 0.453 ± 0.025	0.856AsnTyr: 0.856 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	4.357ProAla: 4.357 ± 0.077	0.3ProCys: 0.3 ± 0.018	2.807ProAsp: 2.807 ± 0.061	3.207ProGlu: 3.207 ± 0.069	1.651ProPhe: 1.651 ± 0.043	3.944ProGly: 3.944 ± 0.07	1.035ProHis: 1.035 ± 0.036	2.755ProIle: 2.755 ± 0.062	1.64ProLys: 1.64 ± 0.044	4.861ProLeu: 4.861 ± 0.079	1.069ProMet: 1.069 ± 0.028	1.579ProAsn: 1.579 ± 0.051	2.302ProPro: 2.302 ± 0.063	1.526ProGln: 1.526 ± 0.042	2.94ProArg: 2.94 ± 0.064	4.179ProSer: 4.179 ± 0.075	3.518ProThr: 3.518 ± 0.071	3.854ProVal: 3.854 ± 0.074	0.656ProTrp: 0.656 ± 0.026	1.169ProTyr: 1.169 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	3.677GlnAla: 3.677 ± 0.071	0.226GlnCys: 0.226 ± 0.014	1.225GlnAsp: 1.225 ± 0.041	1.759GlnGlu: 1.759 ± 0.053	0.978GlnPhe: 0.978 ± 0.039	2.508GlnGly: 2.508 ± 0.062	0.732GlnHis: 0.732 ± 0.03	1.772GlnIle: 1.772 ± 0.044	0.66GlnLys: 0.66 ± 0.028	4.309GlnLeu: 4.309 ± 0.081	0.753GlnMet: 0.753 ± 0.029	0.77GlnAsn: 0.77 ± 0.031	1.709GlnPro: 1.709 ± 0.043	1.318GlnGln: 1.318 ± 0.051	2.673GlnArg: 2.673 ± 0.063	2.109GlnSer: 2.109 ± 0.05	1.611GlnThr: 1.611 ± 0.044	2.86GlnVal: 2.86 ± 0.066	0.426GlnTrp: 0.426 ± 0.022	0.641GlnTyr: 0.641 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	6.415ArgAla: 6.415 ± 0.09	0.606ArgCys: 0.606 ± 0.027	3.49ArgAsp: 3.49 ± 0.064	4.226ArgGlu: 4.226 ± 0.087	2.603ArgPhe: 2.603 ± 0.053	4.683ArgGly: 4.683 ± 0.078	1.66ArgHis: 1.66 ± 0.05	3.726ArgIle: 3.726 ± 0.069	1.798ArgLys: 1.798 ± 0.052	8.347ArgLeu: 8.347 ± 0.101	1.587ArgMet: 1.587 ± 0.047	1.643ArgAsn: 1.643 ± 0.057	3.196ArgPro: 3.196 ± 0.062	2.504ArgGln: 2.504 ± 0.052	6.042ArgArg: 6.042 ± 0.102	5.551ArgSer: 5.551 ± 0.083	3.414ArgThr: 3.414 ± 0.066	5.452ArgVal: 5.452 ± 0.079	1.013ArgTrp: 1.013 ± 0.033	1.971ArgTyr: 1.971 ± 0.055	0.0ArgXaa: 0.0 ± 0.0
Ser	6.58SerAla: 6.58 ± 0.093	0.657SerCys: 0.657 ± 0.031	3.439SerAsp: 3.439 ± 0.065	3.557SerGlu: 3.557 ± 0.064	2.676SerPhe: 2.676 ± 0.049	5.821SerGly: 5.821 ± 0.099	1.58SerHis: 1.58 ± 0.044	3.78SerIle: 3.78 ± 0.061	2.065SerLys: 2.065 ± 0.052	7.619SerLeu: 7.619 ± 0.093	1.779SerMet: 1.779 ± 0.047	2.059SerAsn: 2.059 ± 0.053	3.549SerPro: 3.549 ± 0.074	2.468SerGln: 2.468 ± 0.054	4.555SerArg: 4.555 ± 0.076	5.781SerSer: 5.781 ± 0.114	4.527SerThr: 4.527 ± 0.096	5.613SerVal: 5.613 ± 0.082	1.082SerTrp: 1.082 ± 0.036	2.032SerTyr: 2.032 ± 0.049	0.001SerXaa: 0.001 ± 0.001
Thr	5.304ThrAla: 5.304 ± 0.093	0.499ThrCys: 0.499 ± 0.025	2.746ThrAsp: 2.746 ± 0.07	3.003ThrGlu: 3.003 ± 0.067	1.828ThrPhe: 1.828 ± 0.047	4.767ThrGly: 4.767 ± 0.077	1.279ThrHis: 1.279 ± 0.04	3.303ThrIle: 3.303 ± 0.059	1.901ThrLys: 1.901 ± 0.058	6.055ThrLeu: 6.055 ± 0.089	1.134ThrMet: 1.134 ± 0.034	1.806ThrAsn: 1.806 ± 0.051	3.492ThrPro: 3.492 ± 0.065	1.987ThrGln: 1.987 ± 0.058	3.488ThrArg: 3.488 ± 0.063	4.371ThrSer: 4.371 ± 0.087	4.061ThrThr: 4.061 ± 0.11	4.644ThrVal: 4.644 ± 0.095	0.776ThrTrp: 0.776 ± 0.033	1.49ThrTyr: 1.49 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	9.868ValAla: 9.868 ± 0.125	0.664ValCys: 0.664 ± 0.025	5.041ValAsp: 5.041 ± 0.084	4.935ValGlu: 4.935 ± 0.08	2.585ValPhe: 2.585 ± 0.056	7.141ValGly: 7.141 ± 0.093	1.681ValHis: 1.681 ± 0.044	4.933ValIle: 4.933 ± 0.079	2.144ValLys: 2.144 ± 0.055	8.416ValLeu: 8.416 ± 0.113	1.579ValMet: 1.579 ± 0.049	2.297ValAsn: 2.297 ± 0.048	3.782ValPro: 3.782 ± 0.065	2.154ValGln: 2.154 ± 0.05	5.016ValArg: 5.016 ± 0.071	5.389ValSer: 5.389 ± 0.086	5.139ValThr: 5.139 ± 0.086	8.376ValVal: 8.376 ± 0.134	0.77ValTrp: 0.77 ± 0.034	1.63ValTyr: 1.63 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	1.054TrpAla: 1.054 ± 0.038	0.172TrpCys: 0.172 ± 0.015	0.539TrpAsp: 0.539 ± 0.028	0.635TrpGlu: 0.635 ± 0.028	0.471TrpPhe: 0.471 ± 0.024	0.826TrpGly: 0.826 ± 0.032	0.338TrpHis: 0.338 ± 0.021	0.807TrpIle: 0.807 ± 0.029	0.319TrpLys: 0.319 ± 0.022	1.656TrpLeu: 1.656 ± 0.045	0.35TrpMet: 0.35 ± 0.019	0.41TrpAsn: 0.41 ± 0.023	0.609TrpPro: 0.609 ± 0.029	0.462TrpGln: 0.462 ± 0.024	1.0TrpArg: 1.0 ± 0.037	0.986TrpSer: 0.986 ± 0.034	0.627TrpThr: 0.627 ± 0.026	1.071TrpVal: 1.071 ± 0.038	0.285TrpTrp: 0.285 ± 0.021	0.322TrpTyr: 0.322 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.193TyrAla: 2.193 ± 0.05	0.268TyrCys: 0.268 ± 0.018	1.268TyrAsp: 1.268 ± 0.043	1.391TyrGlu: 1.391 ± 0.04	0.841TyrPhe: 0.841 ± 0.029	2.16TyrGly: 2.16 ± 0.053	0.65TyrHis: 0.65 ± 0.03	0.848TyrIle: 0.848 ± 0.032	0.442TyrLys: 0.442 ± 0.023	3.072TyrLeu: 3.072 ± 0.06	0.316TyrMet: 0.316 ± 0.02	0.547TyrAsn: 0.547 ± 0.029	1.296TyrPro: 1.296 ± 0.04	1.117TyrGln: 1.117 ± 0.039	2.07TyrArg: 2.07 ± 0.047	1.602TyrSer: 1.602 ± 0.045	1.082TyrThr: 1.082 ± 0.038	1.719TyrVal: 1.719 ± 0.046	0.382TyrTrp: 0.382 ± 0.024	0.611TyrTyr: 0.611 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.001XaaCys: 0.001 ± 0.001	0.0XaaAsp: 0.0 ± 0.0	0.002XaaGlu: 0.002 ± 0.002	0.0XaaPhe: 0.0 ± 0.0	0.002XaaGly: 0.002 ± 0.002	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2974 proteins (857107 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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