Amino acid dipepetide frequency for Pseudogymnoascus sp. VKM F-3775

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.017AlaAla: 9.017 ± 0.066	1.05AlaCys: 1.05 ± 0.017	4.262AlaAsp: 4.262 ± 0.035	5.204AlaGlu: 5.204 ± 0.042	3.128AlaPhe: 3.128 ± 0.034	5.725AlaGly: 5.725 ± 0.04	1.673AlaHis: 1.673 ± 0.019	4.725AlaIle: 4.725 ± 0.037	4.367AlaLys: 4.367 ± 0.041	7.746AlaLeu: 7.746 ± 0.052	2.024AlaMet: 2.024 ± 0.024	3.113AlaAsn: 3.113 ± 0.028	4.511AlaPro: 4.511 ± 0.036	3.294AlaGln: 3.294 ± 0.034	4.539AlaArg: 4.539 ± 0.038	6.913AlaSer: 6.913 ± 0.049	5.457AlaThr: 5.457 ± 0.037	5.402AlaVal: 5.402 ± 0.044	1.164AlaTrp: 1.164 ± 0.019	2.196AlaTyr: 2.196 ± 0.026	0.0AlaXaa: 0.0 ± 0.0
Cys	0.934CysAla: 0.934 ± 0.015	0.238CysCys: 0.238 ± 0.009	0.674CysAsp: 0.674 ± 0.013	0.615CysGlu: 0.615 ± 0.014	0.525CysPhe: 0.525 ± 0.013	0.98CysGly: 0.98 ± 0.017	0.317CysHis: 0.317 ± 0.009	0.756CysIle: 0.756 ± 0.015	0.516CysLys: 0.516 ± 0.011	1.211CysLeu: 1.211 ± 0.02	0.274CysMet: 0.274 ± 0.009	0.441CysAsn: 0.441 ± 0.01	0.605CysPro: 0.605 ± 0.015	0.442CysGln: 0.442 ± 0.011	0.674CysArg: 0.674 ± 0.013	0.911CysSer: 0.911 ± 0.017	0.696CysThr: 0.696 ± 0.013	0.739CysVal: 0.739 ± 0.016	0.199CysTrp: 0.199 ± 0.007	0.354CysTyr: 0.354 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	4.707AspAla: 4.707 ± 0.036	0.619AspCys: 0.619 ± 0.013	4.118AspAsp: 4.118 ± 0.05	4.543AspGlu: 4.543 ± 0.05	2.257AspPhe: 2.257 ± 0.025	4.272AspGly: 4.272 ± 0.039	1.147AspHis: 1.147 ± 0.017	3.472AspIle: 3.472 ± 0.034	2.53AspLys: 2.53 ± 0.027	4.997AspLeu: 4.997 ± 0.04	1.286AspMet: 1.286 ± 0.019	2.1AspAsn: 2.1 ± 0.024	3.025AspPro: 3.025 ± 0.029	1.767AspGln: 1.767 ± 0.023	2.854AspArg: 2.854 ± 0.033	4.202AspSer: 4.202 ± 0.039	3.089AspThr: 3.089 ± 0.027	3.747AspVal: 3.747 ± 0.033	0.882AspTrp: 0.882 ± 0.017	1.669AspTyr: 1.669 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	5.607GluAla: 5.607 ± 0.045	0.633GluCys: 0.633 ± 0.012	4.256GluAsp: 4.256 ± 0.048	5.541GluGlu: 5.541 ± 0.066	2.026GluPhe: 2.026 ± 0.025	4.145GluGly: 4.145 ± 0.04	1.288GluHis: 1.288 ± 0.017	3.328GluIle: 3.328 ± 0.032	3.837GluLys: 3.837 ± 0.039	5.344GluLeu: 5.344 ± 0.048	1.515GluMet: 1.515 ± 0.02	2.438GluAsn: 2.438 ± 0.028	2.621GluPro: 2.621 ± 0.03	2.32GluGln: 2.32 ± 0.029	3.766GluArg: 3.766 ± 0.038	4.409GluSer: 4.409 ± 0.038	3.505GluThr: 3.505 ± 0.029	3.907GluVal: 3.907 ± 0.035	0.909GluTrp: 0.909 ± 0.017	1.777GluTyr: 1.777 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	3.088PheAla: 3.088 ± 0.032	0.544PheCys: 0.544 ± 0.011	2.296PheAsp: 2.296 ± 0.026	2.258PheGlu: 2.258 ± 0.026	1.621PhePhe: 1.621 ± 0.025	2.929PheGly: 2.929 ± 0.033	0.824PheHis: 0.824 ± 0.016	1.983PheIle: 1.983 ± 0.024	1.67PheLys: 1.67 ± 0.022	3.389PheLeu: 3.389 ± 0.034	0.814PheMet: 0.814 ± 0.013	1.509PheAsn: 1.509 ± 0.018	1.869PhePro: 1.869 ± 0.021	1.402PheGln: 1.402 ± 0.019	1.818PheArg: 1.818 ± 0.023	3.011PheSer: 3.011 ± 0.028	2.186PheThr: 2.186 ± 0.024	2.398PheVal: 2.398 ± 0.027	0.647PheTrp: 0.647 ± 0.015	1.152PheTyr: 1.152 ± 0.017	0.0PheXaa: 0.0 ± 0.0
Gly	5.546GlyAla: 5.546 ± 0.044	0.912GlyCys: 0.912 ± 0.015	3.899GlyAsp: 3.899 ± 0.033	3.951GlyGlu: 3.951 ± 0.035	2.888GlyPhe: 2.888 ± 0.031	5.988GlyGly: 5.988 ± 0.061	1.677GlyHis: 1.677 ± 0.023	3.923GlyIle: 3.923 ± 0.035	3.733GlyLys: 3.733 ± 0.036	6.16GlyLeu: 6.16 ± 0.045	1.661GlyMet: 1.661 ± 0.023	2.732GlyAsn: 2.732 ± 0.027	3.176GlyPro: 3.176 ± 0.03	2.558GlyGln: 2.558 ± 0.027	3.963GlyArg: 3.963 ± 0.034	5.631GlySer: 5.631 ± 0.041	4.098GlyThr: 4.098 ± 0.041	4.541GlyVal: 4.541 ± 0.041	1.216GlyTrp: 1.216 ± 0.02	2.181GlyTyr: 2.181 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	1.646HisAla: 1.646 ± 0.022	0.309HisCys: 0.309 ± 0.009	1.224HisAsp: 1.224 ± 0.018	1.274HisGlu: 1.274 ± 0.017	0.902HisPhe: 0.902 ± 0.015	1.652HisGly: 1.652 ± 0.02	0.692HisHis: 0.692 ± 0.014	1.294HisIle: 1.294 ± 0.017	0.924HisLys: 0.924 ± 0.016	2.074HisLeu: 2.074 ± 0.025	0.457HisMet: 0.457 ± 0.01	0.89HisAsn: 0.89 ± 0.015	1.466HisPro: 1.466 ± 0.021	0.897HisGln: 0.897 ± 0.019	1.331HisArg: 1.331 ± 0.019	1.687HisSer: 1.687 ± 0.023	1.216HisThr: 1.216 ± 0.016	1.354HisVal: 1.354 ± 0.02	0.347HisTrp: 0.347 ± 0.009	0.696HisTyr: 0.696 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.597IleAla: 4.597 ± 0.037	0.806IleCys: 0.806 ± 0.013	3.175IleAsp: 3.175 ± 0.032	3.189IleGlu: 3.189 ± 0.031	2.192IlePhe: 2.192 ± 0.03	3.552IleGly: 3.552 ± 0.037	1.193IleHis: 1.193 ± 0.017	3.021IleIle: 3.021 ± 0.033	2.529IleLys: 2.529 ± 0.024	4.867IleLeu: 4.867 ± 0.037	1.125IleMet: 1.125 ± 0.016	2.105IleAsn: 2.105 ± 0.021	3.2IlePro: 3.2 ± 0.027	2.037IleGln: 2.037 ± 0.026	2.841IleArg: 2.841 ± 0.025	4.286IleSer: 4.286 ± 0.039	3.216IleThr: 3.216 ± 0.028	3.396IleVal: 3.396 ± 0.028	0.779IleTrp: 0.779 ± 0.015	1.583IleTyr: 1.583 ± 0.022	0.0IleXaa: 0.0 ± 0.0
Lys	4.562LysAla: 4.562 ± 0.041	0.514LysCys: 0.514 ± 0.013	2.941LysAsp: 2.941 ± 0.029	3.574LysGlu: 3.574 ± 0.039	1.596LysPhe: 1.596 ± 0.02	3.255LysGly: 3.255 ± 0.031	1.128LysHis: 1.128 ± 0.016	2.538LysIle: 2.538 ± 0.023	3.452LysLys: 3.452 ± 0.044	4.377LysLeu: 4.377 ± 0.039	1.083LysMet: 1.083 ± 0.016	1.92LysAsn: 1.92 ± 0.022	2.699LysPro: 2.699 ± 0.029	1.804LysGln: 1.804 ± 0.024	3.335LysArg: 3.335 ± 0.035	3.777LysSer: 3.777 ± 0.039	2.959LysThr: 2.959 ± 0.029	3.062LysVal: 3.062 ± 0.028	0.74LysTrp: 0.74 ± 0.016	1.518LysTyr: 1.518 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	7.647LeuAla: 7.647 ± 0.042	1.211LeuCys: 1.211 ± 0.021	5.153LeuAsp: 5.153 ± 0.043	5.63LeuGlu: 5.63 ± 0.052	3.28LeuPhe: 3.28 ± 0.032	5.998LeuGly: 5.998 ± 0.043	2.116LeuHis: 2.116 ± 0.026	4.215LeuIle: 4.215 ± 0.04	4.507LeuLys: 4.507 ± 0.036	8.346LeuLeu: 8.346 ± 0.065	1.786LeuMet: 1.786 ± 0.02	3.264LeuAsn: 3.264 ± 0.027	5.269LeuPro: 5.269 ± 0.034	3.799LeuGln: 3.799 ± 0.037	5.437LeuArg: 5.437 ± 0.043	7.324LeuSer: 7.324 ± 0.048	4.81LeuThr: 4.81 ± 0.037	5.354LeuVal: 5.354 ± 0.043	1.222LeuTrp: 1.222 ± 0.019	2.42LeuTyr: 2.42 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.241MetAla: 2.241 ± 0.024	0.244MetCys: 0.244 ± 0.008	1.287MetAsp: 1.287 ± 0.017	1.359MetGlu: 1.359 ± 0.019	0.779MetPhe: 0.779 ± 0.014	1.572MetGly: 1.572 ± 0.021	0.471MetHis: 0.471 ± 0.012	1.035MetIle: 1.035 ± 0.016	1.087MetLys: 1.087 ± 0.016	1.849MetLeu: 1.849 ± 0.022	0.594MetMet: 0.594 ± 0.013	0.815MetAsn: 0.815 ± 0.014	1.18MetPro: 1.18 ± 0.019	0.829MetGln: 0.829 ± 0.015	1.265MetArg: 1.265 ± 0.017	1.881MetSer: 1.881 ± 0.025	1.283MetThr: 1.283 ± 0.018	1.39MetVal: 1.39 ± 0.017	0.274MetTrp: 0.274 ± 0.007	0.533MetTyr: 0.533 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	3.227AsnAla: 3.227 ± 0.03	0.487AsnCys: 0.487 ± 0.011	2.085AsnAsp: 2.085 ± 0.024	2.168AsnGlu: 2.168 ± 0.025	1.501AsnPhe: 1.501 ± 0.02	3.21AsnGly: 3.21 ± 0.032	0.859AsnHis: 0.859 ± 0.014	2.369AsnIle: 2.369 ± 0.025	1.688AsnLys: 1.688 ± 0.023	3.394AsnLeu: 3.394 ± 0.03	0.9AsnMet: 0.9 ± 0.015	1.686AsnAsn: 1.686 ± 0.031	2.376AsnPro: 2.376 ± 0.026	1.346AsnGln: 1.346 ± 0.021	1.947AsnArg: 1.947 ± 0.021	3.04AsnSer: 3.04 ± 0.029	2.309AsnThr: 2.309 ± 0.023	2.392AsnVal: 2.392 ± 0.026	0.592AsnTrp: 0.592 ± 0.014	1.19AsnTyr: 1.19 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	4.582ProAla: 4.582 ± 0.036	0.457ProCys: 0.457 ± 0.01	2.977ProAsp: 2.977 ± 0.03	3.687ProGlu: 3.687 ± 0.031	1.938ProPhe: 1.938 ± 0.02	3.681ProGly: 3.681 ± 0.04	1.216ProHis: 1.216 ± 0.021	2.715ProIle: 2.715 ± 0.027	2.731ProLys: 2.731 ± 0.025	4.547ProLeu: 4.547 ± 0.042	1.055ProMet: 1.055 ± 0.017	2.221ProAsn: 2.221 ± 0.027	4.21ProPro: 4.21 ± 0.053	2.319ProGln: 2.319 ± 0.04	3.064ProArg: 3.064 ± 0.033	5.299ProSer: 5.299 ± 0.046	3.926ProThr: 3.926 ± 0.036	3.329ProVal: 3.329 ± 0.031	0.712ProTrp: 0.712 ± 0.014	1.468ProTyr: 1.468 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	3.265GlnAla: 3.265 ± 0.036	0.421GlnCys: 0.421 ± 0.012	1.987GlnAsp: 1.987 ± 0.027	2.314GlnGlu: 2.314 ± 0.028	1.298GlnPhe: 1.298 ± 0.02	2.48GlnGly: 2.48 ± 0.028	0.94GlnHis: 0.94 ± 0.017	1.976GlnIle: 1.976 ± 0.021	2.015GlnLys: 2.015 ± 0.023	3.405GlnLeu: 3.405 ± 0.032	0.841GlnMet: 0.841 ± 0.017	1.601GlnAsn: 1.601 ± 0.022	2.29GlnPro: 2.29 ± 0.035	2.216GlnGln: 2.216 ± 0.054	2.418GlnArg: 2.418 ± 0.026	2.957GlnSer: 2.957 ± 0.033	2.239GlnThr: 2.239 ± 0.028	2.145GlnVal: 2.145 ± 0.023	0.569GlnTrp: 0.569 ± 0.012	1.192GlnTyr: 1.192 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	4.417ArgAla: 4.417 ± 0.037	0.659ArgCys: 0.659 ± 0.012	3.24ArgAsp: 3.24 ± 0.033	3.692ArgGlu: 3.692 ± 0.034	1.996ArgPhe: 1.996 ± 0.024	3.663ArgGly: 3.663 ± 0.038	1.399ArgHis: 1.399 ± 0.021	2.91ArgIle: 2.91 ± 0.026	3.34ArgLys: 3.34 ± 0.033	5.057ArgLeu: 5.057 ± 0.036	1.244ArgMet: 1.244 ± 0.016	2.241ArgAsn: 2.241 ± 0.025	3.055ArgPro: 3.055 ± 0.033	2.409ArgGln: 2.409 ± 0.026	4.467ArgArg: 4.467 ± 0.045	4.363ArgSer: 4.363 ± 0.04	3.062ArgThr: 3.062 ± 0.031	3.222ArgVal: 3.222 ± 0.025	0.858ArgTrp: 0.858 ± 0.015	1.584ArgTyr: 1.584 ± 0.019	0.0ArgXaa: 0.0 ± 0.0
Ser	6.41SerAla: 6.41 ± 0.047	0.86SerCys: 0.86 ± 0.017	4.286SerAsp: 4.286 ± 0.037	4.268SerGlu: 4.268 ± 0.037	2.979SerPhe: 2.979 ± 0.025	5.625SerGly: 5.625 ± 0.044	1.81SerHis: 1.81 ± 0.022	4.386SerIle: 4.386 ± 0.033	3.941SerLys: 3.941 ± 0.036	7.13SerLeu: 7.13 ± 0.049	1.71SerMet: 1.71 ± 0.02	3.184SerAsn: 3.184 ± 0.03	5.05SerPro: 5.05 ± 0.056	3.122SerGln: 3.122 ± 0.036	4.573SerArg: 4.573 ± 0.041	8.064SerSer: 8.064 ± 0.068	5.525SerThr: 5.525 ± 0.04	4.575SerVal: 4.575 ± 0.034	1.157SerTrp: 1.157 ± 0.022	2.174SerTyr: 2.174 ± 0.027	0.0SerXaa: 0.0 ± 0.0
Thr	5.159ThrAla: 5.159 ± 0.033	0.751ThrCys: 0.751 ± 0.017	2.955ThrAsp: 2.955 ± 0.03	3.272ThrGlu: 3.272 ± 0.028	2.329ThrPhe: 2.329 ± 0.022	4.306ThrGly: 4.306 ± 0.037	1.21ThrHis: 1.21 ± 0.018	3.434ThrIle: 3.434 ± 0.031	2.821ThrLys: 2.821 ± 0.027	5.291ThrLeu: 5.291 ± 0.038	1.28ThrMet: 1.28 ± 0.017	2.258ThrAsn: 2.258 ± 0.027	4.112ThrPro: 4.112 ± 0.041	2.077ThrGln: 2.077 ± 0.022	2.932ThrArg: 2.932 ± 0.029	5.286ThrSer: 5.286 ± 0.044	4.374ThrThr: 4.374 ± 0.038	3.771ThrVal: 3.771 ± 0.036	0.893ThrTrp: 0.893 ± 0.015	1.693ThrTyr: 1.693 ± 0.022	0.0ThrXaa: 0.0 ± 0.0
Val	5.48ValAla: 5.48 ± 0.043	0.759ValCys: 0.759 ± 0.015	3.824ValAsp: 3.824 ± 0.033	4.156ValGlu: 4.156 ± 0.035	2.396ValPhe: 2.396 ± 0.027	4.215ValGly: 4.215 ± 0.035	1.296ValHis: 1.296 ± 0.016	3.201ValIle: 3.201 ± 0.028	3.116ValLys: 3.116 ± 0.034	5.613ValLeu: 5.613 ± 0.038	1.357ValMet: 1.357 ± 0.017	2.331ValAsn: 2.331 ± 0.025	3.368ValPro: 3.368 ± 0.03	2.273ValGln: 2.273 ± 0.026	3.177ValArg: 3.177 ± 0.029	4.543ValSer: 4.543 ± 0.034	3.631ValThr: 3.631 ± 0.029	4.454ValVal: 4.454 ± 0.049	0.86ValTrp: 0.86 ± 0.016	1.735ValTyr: 1.735 ± 0.021	0.0ValXaa: 0.0 ± 0.0
Trp	1.195TrpAla: 1.195 ± 0.018	0.197TrpCys: 0.197 ± 0.006	0.916TrpAsp: 0.916 ± 0.017	0.872TrpGlu: 0.872 ± 0.018	0.554TrpPhe: 0.554 ± 0.012	1.002TrpGly: 1.002 ± 0.018	0.348TrpHis: 0.348 ± 0.009	0.817TrpIle: 0.817 ± 0.015	0.813TrpLys: 0.813 ± 0.015	1.317TrpLeu: 1.317 ± 0.018	0.363TrpMet: 0.363 ± 0.01	0.639TrpAsn: 0.639 ± 0.012	0.613TrpPro: 0.613 ± 0.014	0.545TrpGln: 0.545 ± 0.011	0.916TrpArg: 0.916 ± 0.015	1.045TrpSer: 1.045 ± 0.017	0.922TrpThr: 0.922 ± 0.015	0.961TrpVal: 0.961 ± 0.018	0.277TrpTrp: 0.277 ± 0.009	0.439TrpTyr: 0.439 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.182TyrAla: 2.182 ± 0.022	0.428TyrCys: 0.428 ± 0.009	1.727TyrAsp: 1.727 ± 0.02	1.606TyrGlu: 1.606 ± 0.021	1.223TyrPhe: 1.223 ± 0.018	2.185TyrGly: 2.185 ± 0.025	0.732TyrHis: 0.732 ± 0.013	1.589TyrIle: 1.589 ± 0.023	1.215TyrLys: 1.215 ± 0.019	2.674TyrLeu: 2.674 ± 0.026	0.601TyrMet: 0.601 ± 0.012	1.275TyrAsn: 1.275 ± 0.018	1.44TyrPro: 1.44 ± 0.023	1.111TyrGln: 1.111 ± 0.016	1.562TyrArg: 1.562 ± 0.021	2.197TyrSer: 2.197 ± 0.023	1.704TyrThr: 1.704 ± 0.02	1.648TyrVal: 1.648 ± 0.022	0.454TyrTrp: 0.454 ± 0.012	1.007TyrTyr: 1.007 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9472 proteins (4032644 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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