Amino acid dipepetide frequency for Flavobacteriaceae bacterium Ap0902

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.067AlaAla: 4.067 ± 0.101
0.489AlaCys: 0.489 ± 0.031
3.516AlaAsp: 3.516 ± 0.075
4.229AlaGlu: 4.229 ± 0.089
3.215AlaPhe: 3.215 ± 0.069
4.33AlaGly: 4.33 ± 0.091
1.269AlaHis: 1.269 ± 0.045
5.289AlaIle: 5.289 ± 0.091
4.558AlaLys: 4.558 ± 0.087
6.24AlaLeu: 6.24 ± 0.101
1.812AlaMet: 1.812 ± 0.053
3.257AlaAsn: 3.257 ± 0.066
1.746AlaPro: 1.746 ± 0.048
2.604AlaGln: 2.604 ± 0.058
2.229AlaArg: 2.229 ± 0.062
3.711AlaSer: 3.711 ± 0.069
3.317AlaThr: 3.317 ± 0.07
3.913AlaVal: 3.913 ± 0.078
0.7AlaTrp: 0.7 ± 0.032
2.768AlaTyr: 2.768 ± 0.062
0.0AlaXaa: 0.0 ± 0.0
Cys
0.407CysAla: 0.407 ± 0.025
0.083CysCys: 0.083 ± 0.01
0.334CysAsp: 0.334 ± 0.02
0.389CysGlu: 0.389 ± 0.024
0.314CysPhe: 0.314 ± 0.019
0.519CysGly: 0.519 ± 0.027
0.13CysHis: 0.13 ± 0.012
0.462CysIle: 0.462 ± 0.025
0.354CysLys: 0.354 ± 0.018
0.556CysLeu: 0.556 ± 0.029
0.137CysMet: 0.137 ± 0.014
0.346CysAsn: 0.346 ± 0.018
0.278CysPro: 0.278 ± 0.026
0.185CysGln: 0.185 ± 0.016
0.193CysArg: 0.193 ± 0.015
0.424CysSer: 0.424 ± 0.021
0.358CysThr: 0.358 ± 0.024
0.396CysVal: 0.396 ± 0.021
0.056CysTrp: 0.056 ± 0.01
0.252CysTyr: 0.252 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
3.885AspAla: 3.885 ± 0.071
0.342AspCys: 0.342 ± 0.019
3.142AspAsp: 3.142 ± 0.078
4.089AspGlu: 4.089 ± 0.086
3.665AspPhe: 3.665 ± 0.077
3.664AspGly: 3.664 ± 0.083
0.989AspHis: 0.989 ± 0.036
4.692AspIle: 4.692 ± 0.088
4.519AspLys: 4.519 ± 0.076
5.781AspLeu: 5.781 ± 0.086
1.444AspMet: 1.444 ± 0.042
3.164AspAsn: 3.164 ± 0.069
1.74AspPro: 1.74 ± 0.05
1.849AspGln: 1.849 ± 0.053
2.075AspArg: 2.075 ± 0.058
3.159AspSer: 3.159 ± 0.066
2.757AspThr: 2.757 ± 0.058
3.586AspVal: 3.586 ± 0.066
0.801AspTrp: 0.801 ± 0.032
3.158AspTyr: 3.158 ± 0.075
0.0AspXaa: 0.0 ± 0.0
Glu
3.989GluAla: 3.989 ± 0.106
0.304GluCys: 0.304 ± 0.02
4.229GluAsp: 4.229 ± 0.082
5.884GluGlu: 5.884 ± 0.122
3.115GluPhe: 3.115 ± 0.067
3.889GluGly: 3.889 ± 0.073
1.218GluHis: 1.218 ± 0.035
6.126GluIle: 6.126 ± 0.098
5.873GluLys: 5.873 ± 0.114
6.217GluLeu: 6.217 ± 0.102
1.733GluMet: 1.733 ± 0.049
5.149GluAsn: 5.149 ± 0.089
1.872GluPro: 1.872 ± 0.053
2.334GluGln: 2.334 ± 0.059
2.775GluArg: 2.775 ± 0.075
3.497GluSer: 3.497 ± 0.079
3.508GluThr: 3.508 ± 0.066
4.745GluVal: 4.745 ± 0.09
0.708GluTrp: 0.708 ± 0.029
2.627GluTyr: 2.627 ± 0.065
0.0GluXaa: 0.0 ± 0.0
Phe
2.986PheAla: 2.986 ± 0.065
0.345PheCys: 0.345 ± 0.021
3.172PheAsp: 3.172 ± 0.064
3.196PheGlu: 3.196 ± 0.056
2.421PhePhe: 2.421 ± 0.069
3.473PheGly: 3.473 ± 0.067
0.883PheHis: 0.883 ± 0.043
4.101PheIle: 4.101 ± 0.088
3.733PheLys: 3.733 ± 0.075
4.603PheLeu: 4.603 ± 0.088
1.222PheMet: 1.222 ± 0.044
3.281PheAsn: 3.281 ± 0.087
1.711PhePro: 1.711 ± 0.045
1.637PheGln: 1.637 ± 0.051
1.663PheArg: 1.663 ± 0.044
3.38PheSer: 3.38 ± 0.083
2.825PheThr: 2.825 ± 0.069
2.706PheVal: 2.706 ± 0.054
0.613PheTrp: 0.613 ± 0.032
2.326PheTyr: 2.326 ± 0.057
0.0PheXaa: 0.0 ± 0.0
Gly
4.114GlyAla: 4.114 ± 0.094
0.454GlyCys: 0.454 ± 0.023
3.604GlyAsp: 3.604 ± 0.078
4.095GlyGlu: 4.095 ± 0.075
3.445GlyPhe: 3.445 ± 0.07
4.452GlyGly: 4.452 ± 0.103
1.132GlyHis: 1.132 ± 0.043
5.491GlyIle: 5.491 ± 0.099
4.778GlyLys: 4.778 ± 0.08
5.957GlyLeu: 5.957 ± 0.094
1.79GlyMet: 1.79 ± 0.054
3.503GlyAsn: 3.503 ± 0.078
1.187GlyPro: 1.187 ± 0.036
1.915GlyGln: 1.915 ± 0.05
2.247GlyArg: 2.247 ± 0.061
3.889GlySer: 3.889 ± 0.074
3.659GlyThr: 3.659 ± 0.073
4.308GlyVal: 4.308 ± 0.088
0.765GlyTrp: 0.765 ± 0.032
2.943GlyTyr: 2.943 ± 0.063
0.0GlyXaa: 0.0 ± 0.0
His
1.181HisAla: 1.181 ± 0.042
0.159HisCys: 0.159 ± 0.013
0.986HisAsp: 0.986 ± 0.036
1.044HisGlu: 1.044 ± 0.037
1.059HisPhe: 1.059 ± 0.036
1.167HisGly: 1.167 ± 0.036
0.53HisHis: 0.53 ± 0.031
1.621HisIle: 1.621 ± 0.044
1.28HisLys: 1.28 ± 0.043
1.859HisLeu: 1.859 ± 0.052
0.342HisMet: 0.342 ± 0.022
0.967HisAsn: 0.967 ± 0.033
0.926HisPro: 0.926 ± 0.038
0.869HisGln: 0.869 ± 0.033
0.71HisArg: 0.71 ± 0.029
1.058HisSer: 1.058 ± 0.034
1.025HisThr: 1.025 ± 0.034
1.025HisVal: 1.025 ± 0.033
0.259HisTrp: 0.259 ± 0.019
0.88HisTyr: 0.88 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
5.486IleAla: 5.486 ± 0.104
0.558IleCys: 0.558 ± 0.027
5.097IleAsp: 5.097 ± 0.075
5.777IleGlu: 5.777 ± 0.094
3.871IlePhe: 3.871 ± 0.082
5.296IleGly: 5.296 ± 0.088
1.612IleHis: 1.612 ± 0.052
6.451IleIle: 6.451 ± 0.121
5.864IleLys: 5.864 ± 0.099
7.57IleLeu: 7.57 ± 0.134
1.578IleMet: 1.578 ± 0.048
4.614IleAsn: 4.614 ± 0.077
3.455IlePro: 3.455 ± 0.073
3.317IleGln: 3.317 ± 0.069
2.702IleArg: 2.702 ± 0.062
5.246IleSer: 5.246 ± 0.085
4.533IleThr: 4.533 ± 0.074
4.424IleVal: 4.424 ± 0.076
0.733IleTrp: 0.733 ± 0.032
3.069IleTyr: 3.069 ± 0.069
0.0IleXaa: 0.0 ± 0.0
Lys
4.501LysAla: 4.501 ± 0.083
0.275LysCys: 0.275 ± 0.02
4.605LysAsp: 4.605 ± 0.088
6.278LysGlu: 6.278 ± 0.122
3.242LysPhe: 3.242 ± 0.066
4.27LysGly: 4.27 ± 0.082
1.328LysHis: 1.328 ± 0.044
6.208LysIle: 6.208 ± 0.096
6.222LysLys: 6.222 ± 0.111
6.27LysLeu: 6.27 ± 0.089
1.974LysMet: 1.974 ± 0.057
5.015LysAsn: 5.015 ± 0.088
2.584LysPro: 2.584 ± 0.059
2.545LysGln: 2.545 ± 0.065
2.879LysArg: 2.879 ± 0.057
4.497LysSer: 4.497 ± 0.09
4.178LysThr: 4.178 ± 0.078
4.611LysVal: 4.611 ± 0.094
0.69LysTrp: 0.69 ± 0.029
3.042LysTyr: 3.042 ± 0.067
0.0LysXaa: 0.0 ± 0.0
Leu
5.674LeuAla: 5.674 ± 0.092
0.537LeuCys: 0.537 ± 0.027
5.476LeuAsp: 5.476 ± 0.086
6.612LeuGlu: 6.612 ± 0.111
4.416LeuPhe: 4.416 ± 0.094
6.029LeuGly: 6.029 ± 0.097
1.623LeuHis: 1.623 ± 0.046
7.591LeuIle: 7.591 ± 0.127
7.418LeuLys: 7.418 ± 0.114
8.239LeuLeu: 8.239 ± 0.145
2.296LeuMet: 2.296 ± 0.059
6.265LeuAsn: 6.265 ± 0.107
3.527LeuPro: 3.527 ± 0.069
3.192LeuGln: 3.192 ± 0.059
3.265LeuArg: 3.265 ± 0.061
6.391LeuSer: 6.391 ± 0.093
4.812LeuThr: 4.812 ± 0.068
5.146LeuVal: 5.146 ± 0.094
0.88LeuTrp: 0.88 ± 0.044
3.373LeuTyr: 3.373 ± 0.062
0.0LeuXaa: 0.0 ± 0.0
Met
1.802MetAla: 1.802 ± 0.054
0.12MetCys: 0.12 ± 0.014
1.388MetAsp: 1.388 ± 0.049
1.448MetGlu: 1.448 ± 0.046
0.941MetPhe: 0.941 ± 0.037
1.669MetGly: 1.669 ± 0.054
0.454MetHis: 0.454 ± 0.025
1.875MetIle: 1.875 ± 0.046
2.036MetLys: 2.036 ± 0.044
2.165MetLeu: 2.165 ± 0.055
0.766MetMet: 0.766 ± 0.032
1.596MetAsn: 1.596 ± 0.051
0.899MetPro: 0.899 ± 0.036
0.965MetGln: 0.965 ± 0.036
1.085MetArg: 1.085 ± 0.043
1.472MetSer: 1.472 ± 0.041
1.168MetThr: 1.168 ± 0.04
1.535MetVal: 1.535 ± 0.048
0.208MetTrp: 0.208 ± 0.016
0.736MetTyr: 0.736 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
4.015AsnAla: 4.015 ± 0.076
0.358AsnCys: 0.358 ± 0.024
3.082AsnAsp: 3.082 ± 0.063
3.728AsnGlu: 3.728 ± 0.078
3.141AsnPhe: 3.141 ± 0.07
3.767AsnGly: 3.767 ± 0.08
1.404AsnHis: 1.404 ± 0.042
4.766AsnIle: 4.766 ± 0.087
4.283AsnLys: 4.283 ± 0.073
5.755AsnLeu: 5.755 ± 0.121
1.345AsnMet: 1.345 ± 0.043
3.551AsnAsn: 3.551 ± 0.099
3.003AsnPro: 3.003 ± 0.065
3.168AsnGln: 3.168 ± 0.067
2.26AsnArg: 2.26 ± 0.053
3.232AsnSer: 3.232 ± 0.077
3.06AsnThr: 3.06 ± 0.069
3.309AsnVal: 3.309 ± 0.068
0.72AsnTrp: 0.72 ± 0.034
2.908AsnTyr: 2.908 ± 0.072
0.0AsnXaa: 0.0 ± 0.0
Pro
2.034ProAla: 2.034 ± 0.054
0.207ProCys: 0.207 ± 0.016
2.114ProAsp: 2.114 ± 0.056
2.947ProGlu: 2.947 ± 0.066
1.806ProPhe: 1.806 ± 0.048
1.831ProGly: 1.831 ± 0.049
0.718ProHis: 0.718 ± 0.031
2.92ProIle: 2.92 ± 0.061
2.455ProLys: 2.455 ± 0.059
2.967ProLeu: 2.967 ± 0.072
0.855ProMet: 0.855 ± 0.032
2.185ProAsn: 2.185 ± 0.06
0.831ProPro: 0.831 ± 0.035
1.241ProGln: 1.241 ± 0.045
1.057ProArg: 1.057 ± 0.039
2.143ProSer: 2.143 ± 0.049
2.053ProThr: 2.053 ± 0.058
2.243ProVal: 2.243 ± 0.053
0.385ProTrp: 0.385 ± 0.022
1.625ProTyr: 1.625 ± 0.051
0.0ProXaa: 0.0 ± 0.0
Gln
2.234GlnAla: 2.234 ± 0.057
0.159GlnCys: 0.159 ± 0.014
2.028GlnAsp: 2.028 ± 0.055
2.944GlnGlu: 2.944 ± 0.069
1.711GlnPhe: 1.711 ± 0.047
2.019GlnGly: 2.019 ± 0.055
0.647GlnHis: 0.647 ± 0.03
3.065GlnIle: 3.065 ± 0.07
3.012GlnLys: 3.012 ± 0.067
3.633GlnLeu: 3.633 ± 0.076
0.994GlnMet: 0.994 ± 0.036
2.35GlnAsn: 2.35 ± 0.06
1.183GlnPro: 1.183 ± 0.039
1.396GlnGln: 1.396 ± 0.048
1.469GlnArg: 1.469 ± 0.042
2.107GlnSer: 2.107 ± 0.053
1.853GlnThr: 1.853 ± 0.053
2.222GlnVal: 2.222 ± 0.052
0.446GlnTrp: 0.446 ± 0.026
1.547GlnTyr: 1.547 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
2.192ArgAla: 2.192 ± 0.069
0.168ArgCys: 0.168 ± 0.015
2.053ArgAsp: 2.053 ± 0.055
2.658ArgGlu: 2.658 ± 0.057
1.792ArgPhe: 1.792 ± 0.05
2.123ArgGly: 2.123 ± 0.055
0.608ArgHis: 0.608 ± 0.03
2.886ArgIle: 2.886 ± 0.067
3.059ArgLys: 3.059 ± 0.074
3.389ArgLeu: 3.389 ± 0.071
0.967ArgMet: 0.967 ± 0.04
2.265ArgAsn: 2.265 ± 0.053
1.198ArgPro: 1.198 ± 0.045
1.296ArgGln: 1.296 ± 0.046
1.573ArgArg: 1.573 ± 0.062
1.909ArgSer: 1.909 ± 0.057
1.836ArgThr: 1.836 ± 0.047
2.248ArgVal: 2.248 ± 0.056
0.39ArgTrp: 0.39 ± 0.021
1.62ArgTyr: 1.62 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
3.724SerAla: 3.724 ± 0.078
0.526SerCys: 0.526 ± 0.026
3.395SerAsp: 3.395 ± 0.067
3.668SerGlu: 3.668 ± 0.078
3.405SerPhe: 3.405 ± 0.073
4.093SerGly: 4.093 ± 0.085
1.103SerHis: 1.103 ± 0.042
5.051SerIle: 5.051 ± 0.099
4.335SerLys: 4.335 ± 0.073
5.625SerLeu: 5.625 ± 0.093
1.407SerMet: 1.407 ± 0.045
3.559SerAsn: 3.559 ± 0.084
2.069SerPro: 2.069 ± 0.059
2.131SerGln: 2.131 ± 0.057
2.041SerArg: 2.041 ± 0.051
3.737SerSer: 3.737 ± 0.079
3.279SerThr: 3.279 ± 0.077
3.487SerVal: 3.487 ± 0.064
0.673SerTrp: 0.673 ± 0.033
2.714SerTyr: 2.714 ± 0.065
0.0SerXaa: 0.0 ± 0.0
Thr
3.609ThrAla: 3.609 ± 0.063
0.303ThrCys: 0.303 ± 0.021
3.089ThrAsp: 3.089 ± 0.071
3.427ThrGlu: 3.427 ± 0.072
2.747ThrPhe: 2.747 ± 0.067
3.841ThrGly: 3.841 ± 0.078
1.09ThrHis: 1.09 ± 0.036
4.177ThrIle: 4.177 ± 0.072
3.38ThrLys: 3.38 ± 0.062
5.08ThrLeu: 5.08 ± 0.076
1.042ThrMet: 1.042 ± 0.036
2.796ThrAsn: 2.796 ± 0.073
2.393ThrPro: 2.393 ± 0.054
2.122ThrGln: 2.122 ± 0.062
1.759ThrArg: 1.759 ± 0.048
3.233ThrSer: 3.233 ± 0.068
2.99ThrThr: 2.99 ± 0.078
3.184ThrVal: 3.184 ± 0.073
0.561ThrTrp: 0.561 ± 0.032
2.391ThrTyr: 2.391 ± 0.067
0.0ThrXaa: 0.0 ± 0.0
Val
3.954ValAla: 3.954 ± 0.078
0.425ValCys: 0.425 ± 0.022
3.728ValAsp: 3.728 ± 0.066
4.157ValGlu: 4.157 ± 0.083
2.915ValPhe: 2.915 ± 0.071
3.898ValGly: 3.898 ± 0.076
1.047ValHis: 1.047 ± 0.036
4.7ValIle: 4.7 ± 0.076
4.151ValLys: 4.151 ± 0.085
5.737ValLeu: 5.737 ± 0.09
1.456ValMet: 1.456 ± 0.044
3.526ValAsn: 3.526 ± 0.075
2.162ValPro: 2.162 ± 0.053
1.941ValGln: 1.941 ± 0.057
2.149ValArg: 2.149 ± 0.05
3.868ValSer: 3.868 ± 0.071
3.128ValThr: 3.128 ± 0.06
3.962ValVal: 3.962 ± 0.085
0.592ValTrp: 0.592 ± 0.027
2.467ValTyr: 2.467 ± 0.057
0.0ValXaa: 0.0 ± 0.0
Trp
0.7TrpAla: 0.7 ± 0.031
0.094TrpCys: 0.094 ± 0.013
0.688TrpAsp: 0.688 ± 0.031
0.654TrpGlu: 0.654 ± 0.025
0.591TrpPhe: 0.591 ± 0.027
0.634TrpGly: 0.634 ± 0.036
0.228TrpHis: 0.228 ± 0.017
0.791TrpIle: 0.791 ± 0.036
0.788TrpLys: 0.788 ± 0.029
1.001TrpLeu: 1.001 ± 0.037
0.325TrpMet: 0.325 ± 0.024
0.721TrpAsn: 0.721 ± 0.033
0.22TrpPro: 0.22 ± 0.017
0.437TrpGln: 0.437 ± 0.024
0.438TrpArg: 0.438 ± 0.025
0.634TrpSer: 0.634 ± 0.025
0.506TrpThr: 0.506 ± 0.028
0.761TrpVal: 0.761 ± 0.034
0.152TrpTrp: 0.152 ± 0.015
0.463TrpTyr: 0.463 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.701TyrAla: 2.701 ± 0.061
0.267TyrCys: 0.267 ± 0.019
2.775TyrAsp: 2.775 ± 0.069
2.568TyrGlu: 2.568 ± 0.06
2.467TyrPhe: 2.467 ± 0.063
2.762TyrGly: 2.762 ± 0.07
0.936TyrHis: 0.936 ± 0.034
2.99TyrIle: 2.99 ± 0.065
3.114TyrLys: 3.114 ± 0.069
4.121TyrLeu: 4.121 ± 0.088
0.843TyrMet: 0.843 ± 0.038
2.747TyrAsn: 2.747 ± 0.074
1.632TyrPro: 1.632 ± 0.042
1.875TyrGln: 1.875 ± 0.052
1.66TyrArg: 1.66 ± 0.042
2.434TyrSer: 2.434 ± 0.066
2.371TyrThr: 2.371 ± 0.06
2.152TyrVal: 2.152 ± 0.057
0.496TyrTrp: 0.496 ± 0.029
2.103TyrTyr: 2.103 ± 0.07
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2350 proteins (768563 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski