Amino acid dipepetide frequency for Micrococcus endophyticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.668AlaAla: 17.668 ± 0.265
0.734AlaCys: 0.734 ± 0.045
7.73AlaAsp: 7.73 ± 0.138
9.312AlaGlu: 9.312 ± 0.179
3.84AlaPhe: 3.84 ± 0.104
11.954AlaGly: 11.954 ± 0.206
2.748AlaHis: 2.748 ± 0.093
4.169AlaIle: 4.169 ± 0.12
2.764AlaLys: 2.764 ± 0.102
13.113AlaLeu: 13.113 ± 0.182
3.318AlaMet: 3.318 ± 0.1
2.07AlaAsn: 2.07 ± 0.08
5.822AlaPro: 5.822 ± 0.118
4.182AlaGln: 4.182 ± 0.109
8.923AlaArg: 8.923 ± 0.166
6.093AlaSer: 6.093 ± 0.126
6.188AlaThr: 6.188 ± 0.128
11.952AlaVal: 11.952 ± 0.194
2.059AlaTrp: 2.059 ± 0.089
2.372AlaTyr: 2.372 ± 0.089
0.0AlaXaa: 0.0 ± 0.0
Cys
0.716CysAla: 0.716 ± 0.046
0.082CysCys: 0.082 ± 0.015
0.329CysAsp: 0.329 ± 0.033
0.297CysGlu: 0.297 ± 0.028
0.164CysPhe: 0.164 ± 0.022
0.655CysGly: 0.655 ± 0.036
0.159CysHis: 0.159 ± 0.019
0.223CysIle: 0.223 ± 0.024
0.064CysLys: 0.064 ± 0.012
0.525CysLeu: 0.525 ± 0.039
0.103CysMet: 0.103 ± 0.017
0.085CysAsn: 0.085 ± 0.016
0.368CysPro: 0.368 ± 0.034
0.186CysGln: 0.186 ± 0.022
0.424CysArg: 0.424 ± 0.039
0.379CysSer: 0.379 ± 0.034
0.44CysThr: 0.44 ± 0.038
0.498CysVal: 0.498 ± 0.04
0.08CysTrp: 0.08 ± 0.014
0.13CysTyr: 0.13 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
8.25AspAla: 8.25 ± 0.171
0.281AspCys: 0.281 ± 0.023
3.498AspAsp: 3.498 ± 0.12
4.542AspGlu: 4.542 ± 0.109
1.797AspPhe: 1.797 ± 0.069
5.679AspGly: 5.679 ± 0.123
1.452AspHis: 1.452 ± 0.064
1.852AspIle: 1.852 ± 0.066
1.108AspLys: 1.108 ± 0.051
6.456AspLeu: 6.456 ± 0.152
0.973AspMet: 0.973 ± 0.055
0.835AspAsn: 0.835 ± 0.044
4.412AspPro: 4.412 ± 0.104
1.617AspGln: 1.617 ± 0.061
4.593AspArg: 4.593 ± 0.118
2.441AspSer: 2.441 ± 0.084
2.814AspThr: 2.814 ± 0.092
6.016AspVal: 6.016 ± 0.117
0.933AspTrp: 0.933 ± 0.053
1.264AspTyr: 1.264 ± 0.063
0.0AspXaa: 0.0 ± 0.0
Glu
8.218GluAla: 8.218 ± 0.157
0.257GluCys: 0.257 ± 0.027
4.505GluAsp: 4.505 ± 0.121
4.362GluGlu: 4.362 ± 0.128
1.911GluPhe: 1.911 ± 0.067
4.881GluGly: 4.881 ± 0.128
2.046GluHis: 2.046 ± 0.073
2.73GluIle: 2.73 ± 0.092
1.662GluLys: 1.662 ± 0.075
6.681GluLeu: 6.681 ± 0.159
1.169GluMet: 1.169 ± 0.06
1.367GluAsn: 1.367 ± 0.068
2.777GluPro: 2.777 ± 0.09
2.462GluGln: 2.462 ± 0.083
5.388GluArg: 5.388 ± 0.116
2.894GluSer: 2.894 ± 0.082
3.294GluThr: 3.294 ± 0.095
5.358GluVal: 5.358 ± 0.102
0.824GluTrp: 0.824 ± 0.049
1.182GluTyr: 1.182 ± 0.059
0.0GluXaa: 0.0 ± 0.0
Phe
3.885PheAla: 3.885 ± 0.109
0.22PheCys: 0.22 ± 0.026
2.149PheAsp: 2.149 ± 0.087
1.831PheGlu: 1.831 ± 0.073
1.087PhePhe: 1.087 ± 0.056
3.265PheGly: 3.265 ± 0.104
0.705PheHis: 0.705 ± 0.036
1.134PheIle: 1.134 ± 0.052
0.538PheLys: 0.538 ± 0.036
3.021PheLeu: 3.021 ± 0.104
0.575PheMet: 0.575 ± 0.041
0.737PheAsn: 0.737 ± 0.043
1.415PhePro: 1.415 ± 0.067
0.872PheGln: 0.872 ± 0.047
1.935PheArg: 1.935 ± 0.07
1.723PheSer: 1.723 ± 0.064
2.279PheThr: 2.279 ± 0.099
2.677PheVal: 2.677 ± 0.079
0.488PheTrp: 0.488 ± 0.044
0.734PheTyr: 0.734 ± 0.042
0.0PheXaa: 0.0 ± 0.0
Gly
9.678GlyAla: 9.678 ± 0.211
0.617GlyCys: 0.617 ± 0.038
4.68GlyAsp: 4.68 ± 0.109
5.335GlyGlu: 5.335 ± 0.118
3.122GlyPhe: 3.122 ± 0.086
7.245GlyGly: 7.245 ± 0.183
2.247GlyHis: 2.247 ± 0.087
3.75GlyIle: 3.75 ± 0.104
2.234GlyLys: 2.234 ± 0.074
9.389GlyLeu: 9.389 ± 0.165
2.491GlyMet: 2.491 ± 0.089
1.643GlyAsn: 1.643 ± 0.063
3.941GlyPro: 3.941 ± 0.082
2.976GlyGln: 2.976 ± 0.101
7.261GlyArg: 7.261 ± 0.149
4.545GlySer: 4.545 ± 0.111
5.698GlyThr: 5.698 ± 0.133
8.202GlyVal: 8.202 ± 0.166
1.619GlyTrp: 1.619 ± 0.068
2.056GlyTyr: 2.056 ± 0.067
0.0GlyXaa: 0.0 ± 0.0
His
2.764HisAla: 2.764 ± 0.1
0.167HisCys: 0.167 ± 0.021
1.304HisAsp: 1.304 ± 0.058
1.463HisGlu: 1.463 ± 0.056
0.58HisPhe: 0.58 ± 0.041
2.279HisGly: 2.279 ± 0.091
0.716HisHis: 0.716 ± 0.05
0.631HisIle: 0.631 ± 0.035
0.313HisLys: 0.313 ± 0.032
2.377HisLeu: 2.377 ± 0.094
0.376HisMet: 0.376 ± 0.033
0.443HisAsn: 0.443 ± 0.033
1.826HisPro: 1.826 ± 0.081
0.684HisGln: 0.684 ± 0.044
2.234HisArg: 2.234 ± 0.085
1.018HisSer: 1.018 ± 0.052
1.301HisThr: 1.301 ± 0.061
2.155HisVal: 2.155 ± 0.081
0.339HisTrp: 0.339 ± 0.03
0.456HisTyr: 0.456 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
5.075IleAla: 5.075 ± 0.12
0.223IleCys: 0.223 ± 0.024
2.417IleAsp: 2.417 ± 0.076
2.327IleGlu: 2.327 ± 0.08
0.973IlePhe: 0.973 ± 0.055
3.843IleGly: 3.843 ± 0.105
0.8IleHis: 0.8 ± 0.048
1.275IleIle: 1.275 ± 0.058
0.835IleLys: 0.835 ± 0.044
3.705IleLeu: 3.705 ± 0.12
0.663IleMet: 0.663 ± 0.044
0.731IleAsn: 0.731 ± 0.04
2.099IlePro: 2.099 ± 0.073
0.93IleGln: 0.93 ± 0.052
2.496IleArg: 2.496 ± 0.083
1.911IleSer: 1.911 ± 0.078
2.605IleThr: 2.605 ± 0.089
3.639IleVal: 3.639 ± 0.108
0.424IleTrp: 0.424 ± 0.032
0.61IleTyr: 0.61 ± 0.043
0.0IleXaa: 0.0 ± 0.0
Lys
2.865LysAla: 2.865 ± 0.086
0.087LysCys: 0.087 ± 0.016
1.601LysAsp: 1.601 ± 0.064
1.33LysGlu: 1.33 ± 0.058
0.511LysPhe: 0.511 ± 0.033
1.728LysGly: 1.728 ± 0.08
0.501LysHis: 0.501 ± 0.034
1.026LysIle: 1.026 ± 0.055
0.893LysLys: 0.893 ± 0.058
1.688LysLeu: 1.688 ± 0.073
0.466LysMet: 0.466 ± 0.032
0.625LysAsn: 0.625 ± 0.045
1.087LysPro: 1.087 ± 0.059
0.602LysGln: 0.602 ± 0.045
1.381LysArg: 1.381 ± 0.062
1.161LysSer: 1.161 ± 0.054
1.405LysThr: 1.405 ± 0.062
2.001LysVal: 2.001 ± 0.081
0.254LysTrp: 0.254 ± 0.028
0.501LysTyr: 0.501 ± 0.034
0.0LysXaa: 0.0 ± 0.0
Leu
13.889LeuAla: 13.889 ± 0.192
0.501LeuCys: 0.501 ± 0.037
6.376LeuAsp: 6.376 ± 0.158
6.093LeuGlu: 6.093 ± 0.135
3.185LeuPhe: 3.185 ± 0.095
9.074LeuGly: 9.074 ± 0.16
2.255LeuHis: 2.255 ± 0.082
3.723LeuIle: 3.723 ± 0.099
2.152LeuLys: 2.152 ± 0.084
10.216LeuLeu: 10.216 ± 0.224
2.255LeuMet: 2.255 ± 0.082
1.879LeuAsn: 1.879 ± 0.073
5.284LeuPro: 5.284 ± 0.105
2.865LeuGln: 2.865 ± 0.086
7.388LeuArg: 7.388 ± 0.136
5.385LeuSer: 5.385 ± 0.119
6.885LeuThr: 6.885 ± 0.144
9.344LeuVal: 9.344 ± 0.138
1.277LeuTrp: 1.277 ± 0.055
1.802LeuTyr: 1.802 ± 0.071
0.0LeuXaa: 0.0 ± 0.0
Met
2.785MetAla: 2.785 ± 0.093
0.13MetCys: 0.13 ± 0.018
1.378MetAsp: 1.378 ± 0.058
1.034MetGlu: 1.034 ± 0.052
0.657MetPhe: 0.657 ± 0.045
1.688MetGly: 1.688 ± 0.07
0.421MetHis: 0.421 ± 0.033
0.912MetIle: 0.912 ± 0.049
0.586MetLys: 0.586 ± 0.042
2.279MetLeu: 2.279 ± 0.081
0.464MetMet: 0.464 ± 0.041
0.551MetAsn: 0.551 ± 0.036
1.171MetPro: 1.171 ± 0.056
0.62MetGln: 0.62 ± 0.043
1.508MetArg: 1.508 ± 0.062
1.532MetSer: 1.532 ± 0.072
1.89MetThr: 1.89 ± 0.068
1.919MetVal: 1.919 ± 0.067
0.244MetTrp: 0.244 ± 0.026
0.329MetTyr: 0.329 ± 0.032
0.0MetXaa: 0.0 ± 0.0
Asn
2.287AsnAla: 2.287 ± 0.093
0.111AsnCys: 0.111 ± 0.02
1.02AsnAsp: 1.02 ± 0.056
1.002AsnGlu: 1.002 ± 0.049
0.554AsnPhe: 0.554 ± 0.042
1.786AsnGly: 1.786 ± 0.067
0.427AsnHis: 0.427 ± 0.041
0.75AsnIle: 0.75 ± 0.047
0.363AsnLys: 0.363 ± 0.031
1.818AsnLeu: 1.818 ± 0.059
0.339AsnMet: 0.339 ± 0.031
0.432AsnAsn: 0.432 ± 0.038
1.489AsnPro: 1.489 ± 0.067
0.498AsnGln: 0.498 ± 0.036
1.386AsnArg: 1.386 ± 0.058
0.837AsnSer: 0.837 ± 0.05
1.253AsnThr: 1.253 ± 0.058
1.707AsnVal: 1.707 ± 0.067
0.278AsnTrp: 0.278 ± 0.025
0.427AsnTyr: 0.427 ± 0.031
0.0AsnXaa: 0.0 ± 0.0
Pro
7.335ProAla: 7.335 ± 0.152
0.244ProCys: 0.244 ± 0.024
3.7ProAsp: 3.7 ± 0.101
4.452ProGlu: 4.452 ± 0.112
1.617ProPhe: 1.617 ± 0.059
5.046ProGly: 5.046 ± 0.129
1.216ProHis: 1.216 ± 0.058
1.545ProIle: 1.545 ± 0.06
1.057ProLys: 1.057 ± 0.058
4.548ProLeu: 4.548 ± 0.117
1.15ProMet: 1.15 ± 0.052
0.872ProAsn: 0.872 ± 0.042
2.056ProPro: 2.056 ± 0.085
1.683ProGln: 1.683 ± 0.067
3.456ProArg: 3.456 ± 0.092
2.743ProSer: 2.743 ± 0.092
2.987ProThr: 2.987 ± 0.091
5.136ProVal: 5.136 ± 0.127
0.835ProTrp: 0.835 ± 0.048
1.063ProTyr: 1.063 ± 0.055
0.0ProXaa: 0.0 ± 0.0
Gln
4.071GlnAla: 4.071 ± 0.113
0.138GlnCys: 0.138 ± 0.019
1.95GlnAsp: 1.95 ± 0.082
1.847GlnGlu: 1.847 ± 0.065
0.904GlnPhe: 0.904 ± 0.055
2.367GlnGly: 2.367 ± 0.09
0.792GlnHis: 0.792 ± 0.046
1.253GlnIle: 1.253 ± 0.066
0.676GlnLys: 0.676 ± 0.049
2.897GlnLeu: 2.897 ± 0.085
0.657GlnMet: 0.657 ± 0.034
0.631GlnAsn: 0.631 ± 0.048
1.352GlnPro: 1.352 ± 0.06
1.163GlnGln: 1.163 ± 0.06
2.48GlnArg: 2.48 ± 0.089
1.431GlnSer: 1.431 ± 0.061
1.582GlnThr: 1.582 ± 0.065
2.82GlnVal: 2.82 ± 0.097
0.533GlnTrp: 0.533 ± 0.039
0.625GlnTyr: 0.625 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
8.589ArgAla: 8.589 ± 0.157
0.49ArgCys: 0.49 ± 0.038
4.142ArgAsp: 4.142 ± 0.11
4.614ArgGlu: 4.614 ± 0.106
2.52ArgPhe: 2.52 ± 0.096
5.817ArgGly: 5.817 ± 0.127
1.884ArgHis: 1.884 ± 0.079
3.546ArgIle: 3.546 ± 0.099
1.423ArgLys: 1.423 ± 0.063
7.804ArgLeu: 7.804 ± 0.15
1.982ArgMet: 1.982 ± 0.076
1.264ArgAsn: 1.264 ± 0.051
4.187ArgPro: 4.187 ± 0.106
2.422ArgGln: 2.422 ± 0.084
7.436ArgArg: 7.436 ± 0.181
3.718ArgSer: 3.718 ± 0.101
4.627ArgThr: 4.627 ± 0.122
5.918ArgVal: 5.918 ± 0.129
1.322ArgTrp: 1.322 ± 0.058
1.561ArgTyr: 1.561 ± 0.063
0.0ArgXaa: 0.0 ± 0.0
Ser
6.082SerAla: 6.082 ± 0.136
0.339SerCys: 0.339 ± 0.029
2.473SerAsp: 2.473 ± 0.083
2.69SerGlu: 2.69 ± 0.096
1.603SerPhe: 1.603 ± 0.068
5.022SerGly: 5.022 ± 0.122
1.004SerHis: 1.004 ± 0.041
1.842SerIle: 1.842 ± 0.059
1.097SerLys: 1.097 ± 0.058
5.168SerLeu: 5.168 ± 0.111
1.208SerMet: 1.208 ± 0.055
0.951SerAsn: 0.951 ± 0.046
2.963SerPro: 2.963 ± 0.084
1.389SerGln: 1.389 ± 0.057
3.827SerArg: 3.827 ± 0.099
3.048SerSer: 3.048 ± 0.118
3.416SerThr: 3.416 ± 0.09
4.508SerVal: 4.508 ± 0.116
0.885SerTrp: 0.885 ± 0.053
1.081SerTyr: 1.081 ± 0.06
0.0SerXaa: 0.0 ± 0.0
Thr
7.561ThrAla: 7.561 ± 0.157
0.368ThrCys: 0.368 ± 0.033
3.509ThrAsp: 3.509 ± 0.103
3.366ThrGlu: 3.366 ± 0.104
1.858ThrPhe: 1.858 ± 0.065
6.077ThrGly: 6.077 ± 0.122
1.23ThrHis: 1.23 ± 0.048
2.075ThrIle: 2.075 ± 0.084
1.124ThrLys: 1.124 ± 0.061
6.204ThrLeu: 6.204 ± 0.132
1.158ThrMet: 1.158 ± 0.056
0.925ThrAsn: 0.925 ± 0.055
3.975ThrPro: 3.975 ± 0.105
1.569ThrGln: 1.569 ± 0.071
4.023ThrArg: 4.023 ± 0.116
3.077ThrSer: 3.077 ± 0.093
3.824ThrThr: 3.824 ± 0.096
6.477ThrVal: 6.477 ± 0.146
0.848ThrTrp: 0.848 ± 0.055
1.253ThrTyr: 1.253 ± 0.058
0.0ThrXaa: 0.0 ± 0.0
Val
11.279ValAla: 11.279 ± 0.166
0.617ValCys: 0.617 ± 0.037
5.955ValAsp: 5.955 ± 0.114
5.886ValGlu: 5.886 ± 0.135
3.074ValPhe: 3.074 ± 0.087
7.211ValGly: 7.211 ± 0.144
2.165ValHis: 2.165 ± 0.082
3.782ValIle: 3.782 ± 0.102
2.091ValLys: 2.091 ± 0.079
10.105ValLeu: 10.105 ± 0.186
1.99ValMet: 1.99 ± 0.086
1.9ValAsn: 1.9 ± 0.07
4.876ValPro: 4.876 ± 0.106
2.435ValGln: 2.435 ± 0.089
6.252ValArg: 6.252 ± 0.136
4.757ValSer: 4.757 ± 0.105
5.865ValThr: 5.865 ± 0.142
9.265ValVal: 9.265 ± 0.187
1.251ValTrp: 1.251 ± 0.061
1.715ValTyr: 1.715 ± 0.063
0.0ValXaa: 0.0 ± 0.0
Trp
1.659TrpAla: 1.659 ± 0.076
0.138TrpCys: 0.138 ± 0.02
0.869TrpAsp: 0.869 ± 0.052
0.882TrpGlu: 0.882 ± 0.044
0.639TrpPhe: 0.639 ± 0.048
1.081TrpGly: 1.081 ± 0.062
0.292TrpHis: 0.292 ± 0.027
0.731TrpIle: 0.731 ± 0.043
0.331TrpLys: 0.331 ± 0.027
1.778TrpLeu: 1.778 ± 0.069
0.405TrpMet: 0.405 ± 0.037
0.392TrpAsn: 0.392 ± 0.033
0.692TrpPro: 0.692 ± 0.044
0.472TrpGln: 0.472 ± 0.031
1.11TrpArg: 1.11 ± 0.058
0.848TrpSer: 0.848 ± 0.052
0.991TrpThr: 0.991 ± 0.053
1.246TrpVal: 1.246 ± 0.057
0.366TrpTrp: 0.366 ± 0.038
0.307TrpTyr: 0.307 ± 0.031
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.356TyrAla: 2.356 ± 0.075
0.159TyrCys: 0.159 ± 0.022
1.227TyrAsp: 1.227 ± 0.06
1.304TyrGlu: 1.304 ± 0.062
0.673TyrPhe: 0.673 ± 0.049
2.033TyrGly: 2.033 ± 0.07
0.363TyrHis: 0.363 ± 0.034
0.631TyrIle: 0.631 ± 0.043
0.403TyrLys: 0.403 ± 0.032
2.062TyrLeu: 2.062 ± 0.069
0.352TyrMet: 0.352 ± 0.027
0.432TyrAsn: 0.432 ± 0.037
0.946TyrPro: 0.946 ± 0.056
0.543TyrGln: 0.543 ± 0.034
1.765TyrArg: 1.765 ± 0.078
1.057TyrSer: 1.057 ± 0.063
1.155TyrThr: 1.155 ± 0.064
1.635TyrVal: 1.635 ± 0.065
0.371TyrTrp: 0.371 ± 0.033
0.469TyrTyr: 0.469 ± 0.032
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2319 proteins (377349 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski