Amino acid dipepetide frequency for Bathycoccus prasinos

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.175AlaAla: 8.175 ± 0.082	1.39AlaCys: 1.39 ± 0.02	3.474AlaAsp: 3.474 ± 0.036	5.354AlaGlu: 5.354 ± 0.056	3.86AlaPhe: 3.86 ± 0.046	4.184AlaGly: 4.184 ± 0.037	1.523AlaHis: 1.523 ± 0.018	3.731AlaIle: 3.731 ± 0.032	6.455AlaLys: 6.455 ± 0.06	7.786AlaLeu: 7.786 ± 0.071	2.386AlaMet: 2.386 ± 0.027	3.547AlaAsn: 3.547 ± 0.032	3.049AlaPro: 3.049 ± 0.038	2.531AlaGln: 2.531 ± 0.03	5.039AlaArg: 5.039 ± 0.047	7.019AlaSer: 7.019 ± 0.055	5.065AlaThr: 5.065 ± 0.038	4.86AlaVal: 4.86 ± 0.037	0.854AlaTrp: 0.854 ± 0.015	1.891AlaTyr: 1.891 ± 0.025	0.0AlaXaa: 0.0 ± 0.0
Cys	1.615CysAla: 1.615 ± 0.025	0.397CysCys: 0.397 ± 0.012	1.035CysAsp: 1.035 ± 0.021	1.381CysGlu: 1.381 ± 0.023	0.766CysPhe: 0.766 ± 0.015	1.166CysGly: 1.166 ± 0.02	0.248CysHis: 0.248 ± 0.008	0.61CysIle: 0.61 ± 0.013	0.804CysLys: 0.804 ± 0.016	1.395CysLeu: 1.395 ± 0.023	0.263CysMet: 0.263 ± 0.009	0.468CysAsn: 0.468 ± 0.012	0.648CysPro: 0.648 ± 0.014	0.375CysGln: 0.375 ± 0.009	0.789CysArg: 0.789 ± 0.015	1.155CysSer: 1.155 ± 0.018	0.757CysThr: 0.757 ± 0.019	1.461CysVal: 1.461 ± 0.019	0.178CysTrp: 0.178 ± 0.007	0.392CysTyr: 0.392 ± 0.01	0.0CysXaa: 0.0 ± 0.0
Asp	5.893AspAla: 5.893 ± 0.048	0.842AspCys: 0.842 ± 0.015	7.841AspAsp: 7.841 ± 0.089	6.934AspGlu: 6.934 ± 0.06	2.377AspPhe: 2.377 ± 0.026	4.616AspGly: 4.616 ± 0.039	0.739AspHis: 0.739 ± 0.016	2.764AspIle: 2.764 ± 0.04	2.8AspLys: 2.8 ± 0.031	4.056AspLeu: 4.056 ± 0.036	1.136AspMet: 1.136 ± 0.029	1.976AspAsn: 1.976 ± 0.022	2.048AspPro: 2.048 ± 0.022	1.248AspGln: 1.248 ± 0.019	2.373AspArg: 2.373 ± 0.027	3.557AspSer: 3.557 ± 0.035	2.35AspThr: 2.35 ± 0.04	4.979AspVal: 4.979 ± 0.048	0.676AspTrp: 0.676 ± 0.018	1.315AspTyr: 1.315 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	5.623GluAla: 5.623 ± 0.053	1.279GluCys: 1.279 ± 0.023	6.096GluAsp: 6.096 ± 0.056	13.182GluGlu: 13.182 ± 0.148	2.409GluPhe: 2.409 ± 0.024	4.031GluGly: 4.031 ± 0.036	1.4GluHis: 1.4 ± 0.021	3.656GluIle: 3.656 ± 0.037	8.161GluLys: 8.161 ± 0.08	5.444GluLeu: 5.444 ± 0.047	2.175GluMet: 2.175 ± 0.026	4.55GluAsn: 4.55 ± 0.041	1.714GluPro: 1.714 ± 0.024	2.704GluGln: 2.704 ± 0.034	5.824GluArg: 5.824 ± 0.058	4.791GluSer: 4.791 ± 0.046	4.588GluThr: 4.588 ± 0.039	3.981GluVal: 3.981 ± 0.037	0.806GluTrp: 0.806 ± 0.014	1.978GluTyr: 1.978 ± 0.023	0.0GluXaa: 0.0 ± 0.0
Phe	3.702PheAla: 3.702 ± 0.035	0.789PheCys: 0.789 ± 0.015	2.637PheAsp: 2.637 ± 0.03	2.997PheGlu: 2.997 ± 0.028	1.899PhePhe: 1.899 ± 0.029	3.088PheGly: 3.088 ± 0.036	0.784PheHis: 0.784 ± 0.018	1.584PheIle: 1.584 ± 0.024	1.947PheLys: 1.947 ± 0.023	3.497PheLeu: 3.497 ± 0.037	0.797PheMet: 0.797 ± 0.014	1.666PheAsn: 1.666 ± 0.069	1.525PhePro: 1.525 ± 0.023	1.21PheGln: 1.21 ± 0.021	2.072PheArg: 2.072 ± 0.029	3.396PheSer: 3.396 ± 0.033	2.089PheThr: 2.089 ± 0.03	3.008PheVal: 3.008 ± 0.031	0.455PheTrp: 0.455 ± 0.011	1.093PheTyr: 1.093 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	5.025GlyAla: 5.025 ± 0.048	1.003GlyCys: 1.003 ± 0.017	3.94GlyAsp: 3.94 ± 0.039	5.12GlyGlu: 5.12 ± 0.045	2.701GlyPhe: 2.701 ± 0.028	8.191GlyGly: 8.191 ± 0.103	1.082GlyHis: 1.082 ± 0.02	2.676GlyIle: 2.676 ± 0.03	4.704GlyLys: 4.704 ± 0.04	4.269GlyLeu: 4.269 ± 0.038	1.464GlyMet: 1.464 ± 0.022	2.841GlyAsn: 2.841 ± 0.036	1.663GlyPro: 1.663 ± 0.028	1.602GlyGln: 1.602 ± 0.025	3.504GlyArg: 3.504 ± 0.042	4.632GlySer: 4.632 ± 0.052	3.367GlyThr: 3.367 ± 0.04	4.434GlyVal: 4.434 ± 0.041	0.761GlyTrp: 0.761 ± 0.019	1.61GlyTyr: 1.61 ± 0.028	0.0GlyXaa: 0.0 ± 0.0
His	1.686HisAla: 1.686 ± 0.023	0.306HisCys: 0.306 ± 0.01	0.957HisAsp: 0.957 ± 0.017	1.349HisGlu: 1.349 ± 0.023	0.824HisPhe: 0.824 ± 0.016	1.186HisGly: 1.186 ± 0.019	0.921HisHis: 0.921 ± 0.027	0.712HisIle: 0.712 ± 0.013	0.893HisLys: 0.893 ± 0.016	1.61HisLeu: 1.61 ± 0.021	0.398HisMet: 0.398 ± 0.011	0.599HisAsn: 0.599 ± 0.013	1.017HisPro: 1.017 ± 0.019	0.777HisGln: 0.777 ± 0.015	1.235HisArg: 1.235 ± 0.019	1.271HisSer: 1.271 ± 0.022	0.843HisThr: 0.843 ± 0.018	1.431HisVal: 1.431 ± 0.022	0.22HisTrp: 0.22 ± 0.008	0.474HisTyr: 0.474 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	3.938IleAla: 3.938 ± 0.037	0.697IleCys: 0.697 ± 0.015	2.866IleAsp: 2.866 ± 0.03	3.549IleGlu: 3.549 ± 0.034	1.726IlePhe: 1.726 ± 0.025	2.846IleGly: 2.846 ± 0.038	0.818IleHis: 0.818 ± 0.017	1.811IleIle: 1.811 ± 0.026	2.34IleLys: 2.34 ± 0.024	3.738IleLeu: 3.738 ± 0.045	0.782IleMet: 0.782 ± 0.013	1.605IleAsn: 1.605 ± 0.019	1.903IlePro: 1.903 ± 0.026	1.354IleGln: 1.354 ± 0.02	2.242IleArg: 2.242 ± 0.026	3.316IleSer: 3.316 ± 0.05	2.089IleThr: 2.089 ± 0.032	3.267IleVal: 3.267 ± 0.033	0.412IleTrp: 0.412 ± 0.01	0.875IleTyr: 0.875 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	5.189LysAla: 5.189 ± 0.054	1.04LysCys: 1.04 ± 0.019	3.632LysAsp: 3.632 ± 0.034	6.914LysGlu: 6.914 ± 0.072	2.274LysPhe: 2.274 ± 0.026	3.566LysGly: 3.566 ± 0.037	1.31LysHis: 1.31 ± 0.019	3.236LysIle: 3.236 ± 0.031	8.694LysLys: 8.694 ± 0.107	5.088LysLeu: 5.088 ± 0.043	1.981LysMet: 1.981 ± 0.026	3.87LysAsn: 3.87 ± 0.038	2.334LysPro: 2.334 ± 0.025	2.395LysGln: 2.395 ± 0.028	5.418LysArg: 5.418 ± 0.056	5.139LysSer: 5.139 ± 0.042	4.59LysThr: 4.59 ± 0.042	3.948LysVal: 3.948 ± 0.033	0.785LysTrp: 0.785 ± 0.016	1.886LysTyr: 1.886 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	6.541LeuAla: 6.541 ± 0.056	1.388LeuCys: 1.388 ± 0.02	4.371LeuAsp: 4.371 ± 0.03	6.297LeuGlu: 6.297 ± 0.052	3.428LeuPhe: 3.428 ± 0.039	4.686LeuGly: 4.686 ± 0.043	1.631LeuHis: 1.631 ± 0.024	3.037LeuIle: 3.037 ± 0.038	5.725LeuLys: 5.725 ± 0.057	7.28LeuLeu: 7.28 ± 0.067	1.759LeuMet: 1.759 ± 0.024	3.168LeuAsn: 3.168 ± 0.027	3.443LeuPro: 3.443 ± 0.039	2.602LeuGln: 2.602 ± 0.027	5.374LeuArg: 5.374 ± 0.046	6.294LeuSer: 6.294 ± 0.044	3.907LeuThr: 3.907 ± 0.041	4.899LeuVal: 4.899 ± 0.04	0.778LeuTrp: 0.778 ± 0.014	1.778LeuTyr: 1.778 ± 0.022	0.0LeuXaa: 0.0 ± 0.0
Met	1.608MetAla: 1.608 ± 0.023	0.385MetCys: 0.385 ± 0.011	1.216MetAsp: 1.216 ± 0.019	1.642MetGlu: 1.642 ± 0.023	1.156MetPhe: 1.156 ± 0.057	1.168MetGly: 1.168 ± 0.019	0.521MetHis: 0.521 ± 0.012	0.97MetIle: 0.97 ± 0.018	1.943MetLys: 1.943 ± 0.024	1.866MetLeu: 1.866 ± 0.021	1.0MetMet: 1.0 ± 0.02	1.187MetAsn: 1.187 ± 0.017	0.92MetPro: 0.92 ± 0.017	0.902MetGln: 0.902 ± 0.018	1.734MetArg: 1.734 ± 0.023	1.867MetSer: 1.867 ± 0.025	1.446MetThr: 1.446 ± 0.019	1.234MetVal: 1.234 ± 0.018	0.212MetTrp: 0.212 ± 0.007	0.58MetTyr: 0.58 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	4.705AsnAla: 4.705 ± 0.042	0.585AsnCys: 0.585 ± 0.013	3.231AsnAsp: 3.231 ± 0.033	3.792AsnGlu: 3.792 ± 0.036	1.526AsnPhe: 1.526 ± 0.022	3.258AsnGly: 3.258 ± 0.04	0.767AsnHis: 0.767 ± 0.015	1.887AsnIle: 1.887 ± 0.023	2.87AsnLys: 2.87 ± 0.031	2.822AsnLeu: 2.822 ± 0.032	0.908AsnMet: 0.908 ± 0.031	4.446AsnAsn: 4.446 ± 0.065	1.699AsnPro: 1.699 ± 0.02	1.261AsnGln: 1.261 ± 0.032	2.221AsnArg: 2.221 ± 0.025	3.27AsnSer: 3.27 ± 0.036	2.664AsnThr: 2.664 ± 0.035	3.259AsnVal: 3.259 ± 0.026	0.504AsnTrp: 0.504 ± 0.018	0.935AsnTyr: 0.935 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	2.48ProAla: 2.48 ± 0.031	0.448ProCys: 0.448 ± 0.011	1.826ProAsp: 1.826 ± 0.02	2.65ProGlu: 2.65 ± 0.023	1.557ProPhe: 1.557 ± 0.023	2.277ProGly: 2.277 ± 0.033	0.711ProHis: 0.711 ± 0.014	1.733ProIle: 1.733 ± 0.022	2.626ProLys: 2.626 ± 0.031	3.067ProLeu: 3.067 ± 0.03	0.85ProMet: 0.85 ± 0.015	1.633ProAsn: 1.633 ± 0.024	3.541ProPro: 3.541 ± 0.092	1.114ProGln: 1.114 ± 0.02	2.082ProArg: 2.082 ± 0.027	3.648ProSer: 3.648 ± 0.039	2.395ProThr: 2.395 ± 0.027	2.065ProVal: 2.065 ± 0.027	0.484ProTrp: 0.484 ± 0.013	0.871ProTyr: 0.871 ± 0.017	0.001ProXaa: 0.001 ± 0.0
Gln	2.044GlnAla: 2.044 ± 0.027	0.428GlnCys: 0.428 ± 0.011	1.208GlnAsp: 1.208 ± 0.027	1.965GlnGlu: 1.965 ± 0.027	1.177GlnPhe: 1.177 ± 0.015	1.348GlnGly: 1.348 ± 0.017	0.807GlnHis: 0.807 ± 0.018	1.439GlnIle: 1.439 ± 0.022	2.686GlnLys: 2.686 ± 0.028	2.509GlnLeu: 2.509 ± 0.025	0.925GlnMet: 0.925 ± 0.016	1.608GlnAsn: 1.608 ± 0.022	1.215GlnPro: 1.215 ± 0.021	3.168GlnGln: 3.168 ± 0.08	2.403GlnArg: 2.403 ± 0.028	2.177GlnSer: 2.177 ± 0.024	1.994GlnThr: 1.994 ± 0.021	1.484GlnVal: 1.484 ± 0.022	0.31GlnTrp: 0.31 ± 0.009	0.773GlnTyr: 0.773 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	5.091ArgAla: 5.091 ± 0.049	0.939ArgCys: 0.939 ± 0.016	3.43ArgAsp: 3.43 ± 0.036	5.789ArgGlu: 5.789 ± 0.064	2.227ArgPhe: 2.227 ± 0.027	4.058ArgGly: 4.058 ± 0.047	1.029ArgHis: 1.029 ± 0.015	2.485ArgIle: 2.485 ± 0.029	5.029ArgLys: 5.029 ± 0.05	4.606ArgLeu: 4.606 ± 0.048	1.54ArgMet: 1.54 ± 0.021	2.679ArgAsn: 2.679 ± 0.028	1.629ArgPro: 1.629 ± 0.02	1.855ArgGln: 1.855 ± 0.026	5.798ArgArg: 5.798 ± 0.06	3.919ArgSer: 3.919 ± 0.036	3.098ArgThr: 3.098 ± 0.029	4.028ArgVal: 4.028 ± 0.037	0.686ArgTrp: 0.686 ± 0.013	1.414ArgTyr: 1.414 ± 0.021	0.0ArgXaa: 0.0 ± 0.0
Ser	6.303SerAla: 6.303 ± 0.058	1.139SerCys: 1.139 ± 0.027	3.959SerAsp: 3.959 ± 0.037	4.986SerGlu: 4.986 ± 0.04	3.517SerPhe: 3.517 ± 0.05	5.417SerGly: 5.417 ± 0.05	1.311SerHis: 1.311 ± 0.022	3.289SerIle: 3.289 ± 0.036	5.201SerLys: 5.201 ± 0.041	6.335SerLeu: 6.335 ± 0.045	1.679SerMet: 1.679 ± 0.027	3.649SerAsn: 3.649 ± 0.039	3.217SerPro: 3.217 ± 0.041	2.025SerGln: 2.025 ± 0.023	4.4SerArg: 4.4 ± 0.037	14.042SerSer: 14.042 ± 0.141	4.396SerThr: 4.396 ± 0.046	4.646SerVal: 4.646 ± 0.044	0.882SerTrp: 0.882 ± 0.031	1.662SerTyr: 1.662 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	4.128ThrAla: 4.128 ± 0.036	0.905ThrCys: 0.905 ± 0.02	2.441ThrAsp: 2.441 ± 0.04	3.156ThrGlu: 3.156 ± 0.03	2.411ThrPhe: 2.411 ± 0.028	3.097ThrGly: 3.097 ± 0.038	1.105ThrHis: 1.105 ± 0.018	2.653ThrIle: 2.653 ± 0.03	4.302ThrLys: 4.302 ± 0.038	4.481ThrLeu: 4.481 ± 0.041	1.387ThrMet: 1.387 ± 0.023	3.078ThrAsn: 3.078 ± 0.038	2.591ThrPro: 2.591 ± 0.033	1.57ThrGln: 1.57 ± 0.018	3.33ThrArg: 3.33 ± 0.03	5.088ThrSer: 5.088 ± 0.083	6.471ThrThr: 6.471 ± 0.073	3.181ThrVal: 3.181 ± 0.041	0.55ThrTrp: 0.55 ± 0.014	1.254ThrTyr: 1.254 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	5.546ValAla: 5.546 ± 0.043	1.261ValCys: 1.261 ± 0.021	3.795ValAsp: 3.795 ± 0.032	4.638ValGlu: 4.638 ± 0.042	2.851ValPhe: 2.851 ± 0.032	4.005ValGly: 4.005 ± 0.036	1.246ValHis: 1.246 ± 0.018	2.551ValIle: 2.551 ± 0.03	4.179ValLys: 4.179 ± 0.042	5.748ValLeu: 5.748 ± 0.048	1.327ValMet: 1.327 ± 0.021	2.556ValAsn: 2.556 ± 0.025	2.676ValPro: 2.676 ± 0.027	1.925ValGln: 1.925 ± 0.021	3.537ValArg: 3.537 ± 0.035	5.027ValSer: 5.027 ± 0.057	3.347ValThr: 3.347 ± 0.081	5.145ValVal: 5.145 ± 0.041	0.682ValTrp: 0.682 ± 0.014	1.554ValTyr: 1.554 ± 0.025	0.0ValXaa: 0.0 ± 0.0
Trp	0.712TrpAla: 0.712 ± 0.015	0.203TrpCys: 0.203 ± 0.008	0.84TrpAsp: 0.84 ± 0.06	0.7TrpGlu: 0.7 ± 0.014	0.458TrpPhe: 0.458 ± 0.011	0.598TrpGly: 0.598 ± 0.015	0.245TrpHis: 0.245 ± 0.007	0.494TrpIle: 0.494 ± 0.012	0.755TrpLys: 0.755 ± 0.015	0.84TrpLeu: 0.84 ± 0.015	0.322TrpMet: 0.322 ± 0.008	0.601TrpAsn: 0.601 ± 0.025	0.354TrpPro: 0.354 ± 0.011	0.373TrpGln: 0.373 ± 0.01	0.724TrpArg: 0.724 ± 0.014	0.763TrpSer: 0.763 ± 0.015	0.675TrpThr: 0.675 ± 0.017	0.563TrpVal: 0.563 ± 0.012	0.165TrpTrp: 0.165 ± 0.006	0.3TrpTyr: 0.3 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.168TyrAla: 2.168 ± 0.023	0.48TyrCys: 0.48 ± 0.011	1.725TyrAsp: 1.725 ± 0.022	1.993TyrGlu: 1.993 ± 0.024	1.092TyrPhe: 1.092 ± 0.02	1.804TyrGly: 1.804 ± 0.034	0.515TyrHis: 0.515 ± 0.011	0.855TyrIle: 0.855 ± 0.017	1.174TyrLys: 1.174 ± 0.02	1.95TyrLeu: 1.95 ± 0.03	0.478TyrMet: 0.478 ± 0.02	0.887TyrAsn: 0.887 ± 0.016	0.871TyrPro: 0.871 ± 0.019	0.676TyrGln: 0.676 ± 0.014	1.232TyrArg: 1.232 ± 0.018	1.685TyrSer: 1.685 ± 0.028	1.047TyrThr: 1.047 ± 0.023	1.719TyrVal: 1.719 ± 0.025	0.282TyrTrp: 0.282 ± 0.009	0.821TyrTyr: 0.821 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.001XaaMet: 0.001 ± 0.001	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	1.431XaaXaa: 1.431 ± 1.036

Statistics based on 7886 proteins (4117150 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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