Amino acid dipepetide frequency for Exophiala xenobiotica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.814AlaAla: 8.814 ± 0.052	1.128AlaCys: 1.128 ± 0.014	4.372AlaAsp: 4.372 ± 0.029	5.15AlaGlu: 5.15 ± 0.035	3.254AlaPhe: 3.254 ± 0.026	5.969AlaGly: 5.969 ± 0.033	1.815AlaHis: 1.815 ± 0.019	4.259AlaIle: 4.259 ± 0.028	4.08AlaLys: 4.08 ± 0.03	7.663AlaLeu: 7.663 ± 0.043	2.08AlaMet: 2.08 ± 0.021	2.984AlaAsn: 2.984 ± 0.021	4.505AlaPro: 4.505 ± 0.035	3.567AlaGln: 3.567 ± 0.027	5.117AlaArg: 5.117 ± 0.033	7.19AlaSer: 7.19 ± 0.039	5.314AlaThr: 5.314 ± 0.032	5.372AlaVal: 5.372 ± 0.033	1.161AlaTrp: 1.161 ± 0.017	2.223AlaTyr: 2.223 ± 0.023	0.0AlaXaa: 0.0 ± 0.0
Cys	0.983CysAla: 0.983 ± 0.014	0.257CysCys: 0.257 ± 0.008	0.671CysAsp: 0.671 ± 0.011	0.593CysGlu: 0.593 ± 0.01	0.565CysPhe: 0.565 ± 0.009	0.919CysGly: 0.919 ± 0.014	0.341CysHis: 0.341 ± 0.007	0.702CysIle: 0.702 ± 0.011	0.519CysLys: 0.519 ± 0.009	1.325CysLeu: 1.325 ± 0.017	0.277CysMet: 0.277 ± 0.006	0.418CysAsn: 0.418 ± 0.009	0.649CysPro: 0.649 ± 0.011	0.46CysGln: 0.46 ± 0.008	0.783CysArg: 0.783 ± 0.011	0.911CysSer: 0.911 ± 0.011	0.706CysThr: 0.706 ± 0.011	0.8CysVal: 0.8 ± 0.012	0.215CysTrp: 0.215 ± 0.006	0.362CysTyr: 0.362 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.657AspAla: 4.657 ± 0.031	0.631AspCys: 0.631 ± 0.009	4.084AspAsp: 4.084 ± 0.034	4.497AspGlu: 4.497 ± 0.036	2.301AspPhe: 2.301 ± 0.022	3.969AspGly: 3.969 ± 0.027	1.323AspHis: 1.323 ± 0.015	2.956AspIle: 2.956 ± 0.024	2.453AspLys: 2.453 ± 0.021	5.186AspLeu: 5.186 ± 0.032	1.367AspMet: 1.367 ± 0.016	1.837AspAsn: 1.837 ± 0.019	3.38AspPro: 3.38 ± 0.024	2.034AspGln: 2.034 ± 0.02	3.071AspArg: 3.071 ± 0.027	3.965AspSer: 3.965 ± 0.027	3.016AspThr: 3.016 ± 0.022	3.77AspVal: 3.77 ± 0.025	0.917AspTrp: 0.917 ± 0.013	1.598AspTyr: 1.598 ± 0.016	0.0AspXaa: 0.0 ± 0.0
Glu	5.376GluAla: 5.376 ± 0.034	0.61GluCys: 0.61 ± 0.009	4.189GluAsp: 4.189 ± 0.037	5.14GluGlu: 5.14 ± 0.046	1.86GluPhe: 1.86 ± 0.017	3.627GluGly: 3.627 ± 0.027	1.462GluHis: 1.462 ± 0.015	3.006GluIle: 3.006 ± 0.025	3.588GluLys: 3.588 ± 0.025	5.012GluLeu: 5.012 ± 0.033	1.455GluMet: 1.455 ± 0.017	2.156GluAsn: 2.156 ± 0.021	2.747GluPro: 2.747 ± 0.025	2.635GluGln: 2.635 ± 0.025	3.939GluArg: 3.939 ± 0.032	4.144GluSer: 4.144 ± 0.032	3.404GluThr: 3.404 ± 0.026	3.632GluVal: 3.632 ± 0.025	0.856GluTrp: 0.856 ± 0.011	1.644GluTyr: 1.644 ± 0.016	0.0GluXaa: 0.0 ± 0.0
Phe	3.119PheAla: 3.119 ± 0.027	0.579PheCys: 0.579 ± 0.009	2.338PheAsp: 2.338 ± 0.018	2.204PheGlu: 2.204 ± 0.018	1.636PhePhe: 1.636 ± 0.02	2.947PheGly: 2.947 ± 0.027	0.906PheHis: 0.906 ± 0.012	1.722PheIle: 1.722 ± 0.016	1.456PheLys: 1.456 ± 0.016	3.491PheLeu: 3.491 ± 0.027	0.816PheMet: 0.816 ± 0.012	1.404PheAsn: 1.404 ± 0.017	1.966PhePro: 1.966 ± 0.017	1.437PheGln: 1.437 ± 0.015	1.971PheArg: 1.971 ± 0.019	2.922PheSer: 2.922 ± 0.023	2.115PheThr: 2.115 ± 0.021	2.466PheVal: 2.466 ± 0.023	0.667PheTrp: 0.667 ± 0.01	1.102PheTyr: 1.102 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.267GlyAla: 5.267 ± 0.033	0.866GlyCys: 0.866 ± 0.013	3.525GlyAsp: 3.525 ± 0.023	3.477GlyGlu: 3.477 ± 0.027	2.836GlyPhe: 2.836 ± 0.025	5.54GlyGly: 5.54 ± 0.05	1.743GlyHis: 1.743 ± 0.02	3.506GlyIle: 3.506 ± 0.028	3.407GlyLys: 3.407 ± 0.024	6.203GlyLeu: 6.203 ± 0.03	1.729GlyMet: 1.729 ± 0.02	2.435GlyAsn: 2.435 ± 0.022	3.405GlyPro: 3.405 ± 0.026	2.803GlyGln: 2.803 ± 0.024	4.22GlyArg: 4.22 ± 0.03	5.57GlySer: 5.57 ± 0.037	4.066GlyThr: 4.066 ± 0.028	4.356GlyVal: 4.356 ± 0.036	1.174GlyTrp: 1.174 ± 0.015	2.172GlyTyr: 2.172 ± 0.021	0.0GlyXaa: 0.0 ± 0.0
His	1.951HisAla: 1.951 ± 0.017	0.343HisCys: 0.343 ± 0.008	1.437HisAsp: 1.437 ± 0.015	1.457HisGlu: 1.457 ± 0.017	0.964HisPhe: 0.964 ± 0.014	1.785HisGly: 1.785 ± 0.019	0.879HisHis: 0.879 ± 0.013	1.228HisIle: 1.228 ± 0.015	0.971HisLys: 0.971 ± 0.012	2.256HisLeu: 2.256 ± 0.021	0.529HisMet: 0.529 ± 0.009	0.871HisAsn: 0.871 ± 0.012	1.666HisPro: 1.666 ± 0.018	1.033HisGln: 1.033 ± 0.014	1.553HisArg: 1.553 ± 0.017	1.845HisSer: 1.845 ± 0.022	1.302HisThr: 1.302 ± 0.015	1.499HisVal: 1.499 ± 0.015	0.367HisTrp: 0.367 ± 0.008	0.708HisTyr: 0.708 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.169IleAla: 4.169 ± 0.031	0.782IleCys: 0.782 ± 0.013	2.864IleAsp: 2.864 ± 0.023	2.783IleGlu: 2.783 ± 0.022	1.965IlePhe: 1.965 ± 0.022	3.262IleGly: 3.262 ± 0.032	1.218IleHis: 1.218 ± 0.014	2.401IleIle: 2.401 ± 0.021	2.15IleLys: 2.15 ± 0.019	4.537IleLeu: 4.537 ± 0.03	1.025IleMet: 1.025 ± 0.014	1.758IleAsn: 1.758 ± 0.018	3.017IlePro: 3.017 ± 0.022	1.858IleGln: 1.858 ± 0.018	2.685IleArg: 2.685 ± 0.024	3.817IleSer: 3.817 ± 0.026	2.754IleThr: 2.754 ± 0.022	3.158IleVal: 3.158 ± 0.023	0.753IleTrp: 0.753 ± 0.011	1.418IleTyr: 1.418 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	4.272LysAla: 4.272 ± 0.031	0.521LysCys: 0.521 ± 0.011	2.856LysAsp: 2.856 ± 0.024	3.273LysGlu: 3.273 ± 0.027	1.438LysPhe: 1.438 ± 0.016	2.901LysGly: 2.901 ± 0.025	1.213LysHis: 1.213 ± 0.015	2.267LysIle: 2.267 ± 0.02	3.136LysLys: 3.136 ± 0.042	3.905LysLeu: 3.905 ± 0.03	1.076LysMet: 1.076 ± 0.014	1.657LysAsn: 1.657 ± 0.017	2.731LysPro: 2.731 ± 0.025	1.903LysGln: 1.903 ± 0.019	3.401LysArg: 3.401 ± 0.026	3.586LysSer: 3.586 ± 0.027	2.794LysThr: 2.794 ± 0.022	2.902LysVal: 2.902 ± 0.024	0.68LysTrp: 0.68 ± 0.012	1.395LysTyr: 1.395 ± 0.014	0.0LysXaa: 0.0 ± 0.0
Leu	7.832LeuAla: 7.832 ± 0.042	1.253LeuCys: 1.253 ± 0.017	5.178LeuAsp: 5.178 ± 0.033	5.398LeuGlu: 5.398 ± 0.036	3.319LeuPhe: 3.319 ± 0.03	5.926LeuGly: 5.926 ± 0.029	2.259LeuHis: 2.259 ± 0.018	3.87LeuIle: 3.87 ± 0.03	4.194LeuLys: 4.194 ± 0.031	8.31LeuLeu: 8.31 ± 0.052	1.838LeuMet: 1.838 ± 0.017	3.134LeuAsn: 3.134 ± 0.021	5.5LeuPro: 5.5 ± 0.03	3.905LeuGln: 3.905 ± 0.025	5.715LeuArg: 5.715 ± 0.033	7.256LeuSer: 7.256 ± 0.044	4.906LeuThr: 4.906 ± 0.03	5.388LeuVal: 5.388 ± 0.032	1.224LeuTrp: 1.224 ± 0.014	2.355LeuTyr: 2.355 ± 0.022	0.0LeuXaa: 0.0 ± 0.0
Met	2.308MetAla: 2.308 ± 0.021	0.247MetCys: 0.247 ± 0.006	1.276MetAsp: 1.276 ± 0.014	1.227MetGlu: 1.227 ± 0.015	0.792MetPhe: 0.792 ± 0.013	1.485MetGly: 1.485 ± 0.017	0.551MetHis: 0.551 ± 0.01	1.025MetIle: 1.025 ± 0.014	1.016MetLys: 1.016 ± 0.013	2.0MetLeu: 2.0 ± 0.019	0.598MetMet: 0.598 ± 0.009	0.828MetAsn: 0.828 ± 0.012	1.408MetPro: 1.408 ± 0.015	0.943MetGln: 0.943 ± 0.015	1.255MetArg: 1.255 ± 0.015	2.03MetSer: 2.03 ± 0.019	1.431MetThr: 1.431 ± 0.016	1.375MetVal: 1.375 ± 0.015	0.255MetTrp: 0.255 ± 0.006	0.551MetTyr: 0.551 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	3.167AsnAla: 3.167 ± 0.027	0.418AsnCys: 0.418 ± 0.008	1.948AsnAsp: 1.948 ± 0.018	1.971AsnGlu: 1.971 ± 0.018	1.377AsnPhe: 1.377 ± 0.016	2.955AsnGly: 2.955 ± 0.025	0.867AsnHis: 0.867 ± 0.012	1.977AsnIle: 1.977 ± 0.018	1.508AsnLys: 1.508 ± 0.016	3.247AsnLeu: 3.247 ± 0.023	0.859AsnMet: 0.859 ± 0.014	1.419AsnAsn: 1.419 ± 0.017	2.356AsnPro: 2.356 ± 0.023	1.345AsnGln: 1.345 ± 0.017	1.846AsnArg: 1.846 ± 0.02	2.579AsnSer: 2.579 ± 0.025	2.149AsnThr: 2.149 ± 0.02	2.417AsnVal: 2.417 ± 0.02	0.552AsnTrp: 0.552 ± 0.009	1.038AsnTyr: 1.038 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	5.086ProAla: 5.086 ± 0.038	0.516ProCys: 0.516 ± 0.01	3.282ProAsp: 3.282 ± 0.025	3.798ProGlu: 3.798 ± 0.024	2.093ProPhe: 2.093 ± 0.018	4.016ProGly: 4.016 ± 0.029	1.347ProHis: 1.347 ± 0.015	2.477ProIle: 2.477 ± 0.021	2.639ProLys: 2.639 ± 0.024	4.692ProLeu: 4.692 ± 0.025	1.131ProMet: 1.131 ± 0.015	2.183ProAsn: 2.183 ± 0.017	5.049ProPro: 5.049 ± 0.055	2.609ProGln: 2.609 ± 0.026	3.499ProArg: 3.499 ± 0.028	5.972ProSer: 5.972 ± 0.039	4.045ProThr: 4.045 ± 0.029	3.549ProVal: 3.549 ± 0.025	0.77ProTrp: 0.77 ± 0.011	1.545ProTyr: 1.545 ± 0.015	0.0ProXaa: 0.0 ± 0.0
Gln	3.734GlnAla: 3.734 ± 0.032	0.469GlnCys: 0.469 ± 0.01	2.218GlnAsp: 2.218 ± 0.022	2.516GlnGlu: 2.516 ± 0.022	1.308GlnPhe: 1.308 ± 0.012	2.576GlnGly: 2.576 ± 0.022	1.171GlnHis: 1.171 ± 0.015	1.968GlnIle: 1.968 ± 0.018	2.068GlnLys: 2.068 ± 0.019	3.421GlnLeu: 3.421 ± 0.024	0.938GlnMet: 0.938 ± 0.016	1.625GlnAsn: 1.625 ± 0.019	2.669GlnPro: 2.669 ± 0.027	2.459GlnGln: 2.459 ± 0.039	2.732GlnArg: 2.732 ± 0.024	3.3GlnSer: 3.3 ± 0.027	2.454GlnThr: 2.454 ± 0.021	2.215GlnVal: 2.215 ± 0.019	0.57GlnTrp: 0.57 ± 0.011	1.248GlnTyr: 1.248 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	4.701ArgAla: 4.701 ± 0.03	0.728ArgCys: 0.728 ± 0.011	3.37ArgAsp: 3.37 ± 0.027	3.718ArgGlu: 3.718 ± 0.034	2.073ArgPhe: 2.073 ± 0.018	3.666ArgGly: 3.666 ± 0.029	1.677ArgHis: 1.677 ± 0.018	2.825ArgIle: 2.825 ± 0.021	3.555ArgLys: 3.555 ± 0.03	5.546ArgLeu: 5.546 ± 0.037	1.36ArgMet: 1.36 ± 0.015	2.223ArgAsn: 2.223 ± 0.021	3.783ArgPro: 3.783 ± 0.029	2.791ArgGln: 2.791 ± 0.026	5.303ArgArg: 5.303 ± 0.035	4.903ArgSer: 4.903 ± 0.038	3.467ArgThr: 3.467 ± 0.024	3.243ArgVal: 3.243 ± 0.022	0.945ArgTrp: 0.945 ± 0.013	1.717ArgTyr: 1.717 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	6.669SerAla: 6.669 ± 0.037	0.882SerCys: 0.882 ± 0.014	4.173SerAsp: 4.173 ± 0.029	4.142SerGlu: 4.142 ± 0.029	2.922SerPhe: 2.922 ± 0.023	5.42SerGly: 5.42 ± 0.037	1.964SerHis: 1.964 ± 0.017	3.995SerIle: 3.995 ± 0.027	3.728SerLys: 3.728 ± 0.03	7.032SerLeu: 7.032 ± 0.037	1.847SerMet: 1.847 ± 0.02	2.916SerAsn: 2.916 ± 0.023	5.487SerPro: 5.487 ± 0.04	3.438SerGln: 3.438 ± 0.029	5.17SerArg: 5.17 ± 0.034	8.777SerSer: 8.777 ± 0.067	5.883SerThr: 5.883 ± 0.045	4.493SerVal: 4.493 ± 0.029	1.143SerTrp: 1.143 ± 0.014	2.064SerTyr: 2.064 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	5.297ThrAla: 5.297 ± 0.036	0.758ThrCys: 0.758 ± 0.013	2.923ThrAsp: 2.923 ± 0.022	2.989ThrGlu: 2.989 ± 0.024	2.356ThrPhe: 2.356 ± 0.02	4.244ThrGly: 4.244 ± 0.029	1.277ThrHis: 1.277 ± 0.012	3.171ThrIle: 3.171 ± 0.026	2.653ThrLys: 2.653 ± 0.025	5.159ThrLeu: 5.159 ± 0.032	1.313ThrMet: 1.313 ± 0.017	2.195ThrAsn: 2.195 ± 0.02	4.221ThrPro: 4.221 ± 0.036	2.171ThrGln: 2.171 ± 0.018	3.202ThrArg: 3.202 ± 0.018	5.731ThrSer: 5.731 ± 0.045	4.707ThrThr: 4.707 ± 0.064	3.726ThrVal: 3.726 ± 0.025	0.877ThrTrp: 0.877 ± 0.014	1.651ThrTyr: 1.651 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	5.233ValAla: 5.233 ± 0.033	0.838ValCys: 0.838 ± 0.012	3.756ValAsp: 3.756 ± 0.025	3.832ValGlu: 3.832 ± 0.025	2.431ValPhe: 2.431 ± 0.021	4.046ValGly: 4.046 ± 0.029	1.447ValHis: 1.447 ± 0.017	2.881ValIle: 2.881 ± 0.024	2.889ValLys: 2.889 ± 0.024	5.655ValLeu: 5.655 ± 0.036	1.364ValMet: 1.364 ± 0.015	2.244ValAsn: 2.244 ± 0.017	3.6ValPro: 3.6 ± 0.023	2.517ValGln: 2.517 ± 0.023	3.512ValArg: 3.512 ± 0.027	4.576ValSer: 4.576 ± 0.029	3.474ValThr: 3.474 ± 0.024	4.308ValVal: 4.308 ± 0.033	0.904ValTrp: 0.904 ± 0.013	1.709ValTyr: 1.709 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.131TrpAla: 1.131 ± 0.015	0.207TrpCys: 0.207 ± 0.006	0.855TrpAsp: 0.855 ± 0.013	0.79TrpGlu: 0.79 ± 0.011	0.555TrpPhe: 0.555 ± 0.01	0.888TrpGly: 0.888 ± 0.013	0.394TrpHis: 0.394 ± 0.008	0.776TrpIle: 0.776 ± 0.013	0.79TrpLys: 0.79 ± 0.01	1.438TrpLeu: 1.438 ± 0.017	0.385TrpMet: 0.385 ± 0.009	0.614TrpAsn: 0.614 ± 0.009	0.638TrpPro: 0.638 ± 0.011	0.62TrpGln: 0.62 ± 0.011	0.993TrpArg: 0.993 ± 0.013	1.096TrpSer: 1.096 ± 0.015	1.011TrpThr: 1.011 ± 0.014	0.86TrpVal: 0.86 ± 0.012	0.282TrpTrp: 0.282 ± 0.007	0.449TrpTyr: 0.449 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.252TyrAla: 2.252 ± 0.021	0.427TyrCys: 0.427 ± 0.008	1.696TyrAsp: 1.696 ± 0.016	1.525TyrGlu: 1.525 ± 0.015	1.221TyrPhe: 1.221 ± 0.016	2.157TyrGly: 2.157 ± 0.021	0.792TyrHis: 0.792 ± 0.01	1.36TyrIle: 1.36 ± 0.015	1.104TyrLys: 1.104 ± 0.013	2.681TyrLeu: 2.681 ± 0.021	0.616TyrMet: 0.616 ± 0.01	1.095TyrAsn: 1.095 ± 0.015	1.523TyrPro: 1.523 ± 0.018	1.131TyrGln: 1.131 ± 0.014	1.629TyrArg: 1.629 ± 0.016	1.973TyrSer: 1.973 ± 0.02	1.625TyrThr: 1.625 ± 0.018	1.684TyrVal: 1.684 ± 0.016	0.46TyrTrp: 0.46 ± 0.009	0.939TyrTyr: 0.939 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 12773 proteins (6285281 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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