Amino acid dipepetide frequency for Sulfitobacter phage NYA-2014a

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.175AlaAla: 16.175 ± 1.391
1.078AlaCys: 1.078 ± 0.322
7.702AlaAsp: 7.702 ± 0.699
8.319AlaGlu: 8.319 ± 0.89
3.697AlaPhe: 3.697 ± 0.486
9.705AlaGly: 9.705 ± 1.005
1.849AlaHis: 1.849 ± 0.42
6.701AlaIle: 6.701 ± 0.688
5.546AlaLys: 5.546 ± 0.672
9.936AlaLeu: 9.936 ± 0.801
4.775AlaMet: 4.775 ± 0.658
3.389AlaAsn: 3.389 ± 0.582
4.775AlaPro: 4.775 ± 0.791
5.854AlaGln: 5.854 ± 1.021
7.856AlaArg: 7.856 ± 0.866
6.855AlaSer: 6.855 ± 0.682
6.778AlaThr: 6.778 ± 0.979
6.316AlaVal: 6.316 ± 0.852
2.234AlaTrp: 2.234 ± 0.423
2.388AlaTyr: 2.388 ± 0.351
0.0AlaXaa: 0.0 ± 0.0
Cys
1.078CysAla: 1.078 ± 0.319
0.154CysCys: 0.154 ± 0.113
0.77CysAsp: 0.77 ± 0.259
0.847CysGlu: 0.847 ± 0.259
0.231CysPhe: 0.231 ± 0.129
0.616CysGly: 0.616 ± 0.176
0.308CysHis: 0.308 ± 0.158
0.308CysIle: 0.308 ± 0.174
0.616CysLys: 0.616 ± 0.208
0.77CysLeu: 0.77 ± 0.228
0.308CysMet: 0.308 ± 0.17
0.539CysAsn: 0.539 ± 0.266
0.616CysPro: 0.616 ± 0.257
0.385CysGln: 0.385 ± 0.159
0.693CysArg: 0.693 ± 0.183
1.001CysSer: 1.001 ± 0.257
0.308CysThr: 0.308 ± 0.163
0.77CysVal: 0.77 ± 0.242
0.231CysTrp: 0.231 ± 0.123
0.308CysTyr: 0.308 ± 0.156
0.0CysXaa: 0.0 ± 0.0
Asp
10.013AspAla: 10.013 ± 0.802
0.847AspCys: 0.847 ± 0.237
4.313AspAsp: 4.313 ± 0.626
4.698AspGlu: 4.698 ± 0.709
2.08AspPhe: 2.08 ± 0.378
5.315AspGly: 5.315 ± 0.574
1.232AspHis: 1.232 ± 0.315
2.619AspIle: 2.619 ± 0.361
2.003AspLys: 2.003 ± 0.4
6.008AspLeu: 6.008 ± 0.433
2.157AspMet: 2.157 ± 0.436
3.004AspAsn: 3.004 ± 0.474
3.543AspPro: 3.543 ± 0.424
1.926AspGln: 1.926 ± 0.386
3.928AspArg: 3.928 ± 0.484
3.004AspSer: 3.004 ± 0.515
3.158AspThr: 3.158 ± 0.486
4.852AspVal: 4.852 ± 0.586
1.155AspTrp: 1.155 ± 0.301
2.234AspTyr: 2.234 ± 0.331
0.0AspXaa: 0.0 ± 0.0
Glu
8.935GluAla: 8.935 ± 1.198
0.462GluCys: 0.462 ± 0.16
3.928GluAsp: 3.928 ± 0.668
3.081GluGlu: 3.081 ± 0.684
2.157GluPhe: 2.157 ± 0.42
5.084GluGly: 5.084 ± 0.566
1.001GluHis: 1.001 ± 0.307
2.388GluIle: 2.388 ± 0.449
3.312GluLys: 3.312 ± 0.687
4.159GluLeu: 4.159 ± 0.481
2.003GluMet: 2.003 ± 0.398
1.772GluAsn: 1.772 ± 0.408
1.386GluPro: 1.386 ± 0.325
2.85GluGln: 2.85 ± 0.575
4.082GluArg: 4.082 ± 0.646
2.388GluSer: 2.388 ± 0.389
4.621GluThr: 4.621 ± 0.432
3.774GluVal: 3.774 ± 0.542
0.77GluTrp: 0.77 ± 0.236
1.772GluTyr: 1.772 ± 0.334
0.0GluXaa: 0.0 ± 0.0
Phe
2.927PheAla: 2.927 ± 0.388
0.231PheCys: 0.231 ± 0.149
2.85PheAsp: 2.85 ± 0.49
1.617PheGlu: 1.617 ± 0.351
0.847PhePhe: 0.847 ± 0.271
3.543PheGly: 3.543 ± 0.597
0.847PheHis: 0.847 ± 0.294
0.693PheIle: 0.693 ± 0.246
1.463PheLys: 1.463 ± 0.265
2.08PheLeu: 2.08 ± 0.403
1.54PheMet: 1.54 ± 0.323
1.463PheAsn: 1.463 ± 0.341
1.001PhePro: 1.001 ± 0.266
0.693PheGln: 0.693 ± 0.239
2.388PheArg: 2.388 ± 0.41
2.003PheSer: 2.003 ± 0.413
1.232PheThr: 1.232 ± 0.307
1.772PheVal: 1.772 ± 0.358
0.539PheTrp: 0.539 ± 0.193
0.77PheTyr: 0.77 ± 0.255
0.0PheXaa: 0.0 ± 0.0
Gly
8.627GlyAla: 8.627 ± 1.259
0.847GlyCys: 0.847 ± 0.238
4.159GlyAsp: 4.159 ± 0.836
4.313GlyGlu: 4.313 ± 0.601
2.388GlyPhe: 2.388 ± 0.426
9.012GlyGly: 9.012 ± 1.37
1.309GlyHis: 1.309 ± 0.327
4.082GlyIle: 4.082 ± 0.481
4.544GlyLys: 4.544 ± 0.772
6.624GlyLeu: 6.624 ± 0.585
2.311GlyMet: 2.311 ± 0.448
3.928GlyAsn: 3.928 ± 0.425
2.927GlyPro: 2.927 ± 0.407
3.004GlyGln: 3.004 ± 0.463
3.466GlyArg: 3.466 ± 0.488
4.467GlySer: 4.467 ± 0.729
5.007GlyThr: 5.007 ± 0.839
6.239GlyVal: 6.239 ± 0.765
1.54GlyTrp: 1.54 ± 0.304
3.774GlyTyr: 3.774 ± 0.583
0.0GlyXaa: 0.0 ± 0.0
His
1.772HisAla: 1.772 ± 0.409
0.385HisCys: 0.385 ± 0.161
1.772HisAsp: 1.772 ± 0.513
1.386HisGlu: 1.386 ± 0.36
0.462HisPhe: 0.462 ± 0.195
1.617HisGly: 1.617 ± 0.389
0.693HisHis: 0.693 ± 0.261
1.695HisIle: 1.695 ± 0.373
0.616HisLys: 0.616 ± 0.282
1.232HisLeu: 1.232 ± 0.398
0.308HisMet: 0.308 ± 0.15
0.693HisAsn: 0.693 ± 0.27
1.155HisPro: 1.155 ± 0.3
0.847HisGln: 0.847 ± 0.279
1.232HisArg: 1.232 ± 0.363
1.001HisSer: 1.001 ± 0.296
1.155HisThr: 1.155 ± 0.248
1.617HisVal: 1.617 ± 0.35
0.385HisTrp: 0.385 ± 0.152
0.385HisTyr: 0.385 ± 0.163
0.0HisXaa: 0.0 ± 0.0
Ile
6.778IleAla: 6.778 ± 0.931
0.231IleCys: 0.231 ± 0.17
3.466IleAsp: 3.466 ± 0.506
3.466IleGlu: 3.466 ± 0.505
0.77IlePhe: 0.77 ± 0.225
3.697IleGly: 3.697 ± 0.534
1.309IleHis: 1.309 ± 0.274
2.388IleIle: 2.388 ± 0.478
2.696IleLys: 2.696 ± 0.482
2.542IleLeu: 2.542 ± 0.339
0.693IleMet: 0.693 ± 0.231
1.309IleAsn: 1.309 ± 0.34
1.463IlePro: 1.463 ± 0.279
1.695IleGln: 1.695 ± 0.296
2.927IleArg: 2.927 ± 0.482
3.312IleSer: 3.312 ± 0.518
3.081IleThr: 3.081 ± 0.557
2.85IleVal: 2.85 ± 0.587
1.155IleTrp: 1.155 ± 0.329
1.155IleTyr: 1.155 ± 0.228
0.0IleXaa: 0.0 ± 0.0
Lys
6.932LysAla: 6.932 ± 0.862
0.693LysCys: 0.693 ± 0.22
1.54LysAsp: 1.54 ± 0.355
2.696LysGlu: 2.696 ± 0.455
1.463LysPhe: 1.463 ± 0.324
3.312LysGly: 3.312 ± 0.574
1.155LysHis: 1.155 ± 0.335
2.003LysIle: 2.003 ± 0.39
2.234LysLys: 2.234 ± 0.634
3.235LysLeu: 3.235 ± 0.452
1.078LysMet: 1.078 ± 0.313
1.232LysAsn: 1.232 ± 0.343
2.619LysPro: 2.619 ± 0.534
1.617LysGln: 1.617 ± 0.413
3.466LysArg: 3.466 ± 0.612
3.158LysSer: 3.158 ± 0.501
2.696LysThr: 2.696 ± 0.427
2.85LysVal: 2.85 ± 0.459
0.77LysTrp: 0.77 ± 0.269
1.54LysTyr: 1.54 ± 0.316
0.0LysXaa: 0.0 ± 0.0
Leu
8.165LeuAla: 8.165 ± 0.676
1.232LeuCys: 1.232 ± 0.382
4.621LeuAsp: 4.621 ± 0.471
4.082LeuGlu: 4.082 ± 0.56
1.617LeuPhe: 1.617 ± 0.377
6.393LeuGly: 6.393 ± 0.677
1.695LeuHis: 1.695 ± 0.411
3.62LeuIle: 3.62 ± 0.572
2.542LeuLys: 2.542 ± 0.407
4.467LeuLeu: 4.467 ± 0.695
1.926LeuMet: 1.926 ± 0.36
2.619LeuAsn: 2.619 ± 0.467
3.158LeuPro: 3.158 ± 0.404
1.849LeuGln: 1.849 ± 0.308
7.163LeuArg: 7.163 ± 0.862
6.547LeuSer: 6.547 ± 0.753
4.005LeuThr: 4.005 ± 0.617
3.851LeuVal: 3.851 ± 0.529
0.693LeuTrp: 0.693 ± 0.234
2.311LeuTyr: 2.311 ± 0.395
0.0LeuXaa: 0.0 ± 0.0
Met
3.081MetAla: 3.081 ± 0.524
0.154MetCys: 0.154 ± 0.101
1.849MetAsp: 1.849 ± 0.368
1.309MetGlu: 1.309 ± 0.359
0.616MetPhe: 0.616 ± 0.246
2.157MetGly: 2.157 ± 0.295
0.308MetHis: 0.308 ± 0.147
1.232MetIle: 1.232 ± 0.282
1.001MetLys: 1.001 ± 0.269
1.926MetLeu: 1.926 ± 0.386
0.847MetMet: 0.847 ± 0.309
1.386MetAsn: 1.386 ± 0.327
1.386MetPro: 1.386 ± 0.274
2.311MetGln: 2.311 ± 0.507
1.617MetArg: 1.617 ± 0.348
1.772MetSer: 1.772 ± 0.415
2.465MetThr: 2.465 ± 0.399
1.463MetVal: 1.463 ± 0.419
0.462MetTrp: 0.462 ± 0.183
0.308MetTyr: 0.308 ± 0.156
0.0MetXaa: 0.0 ± 0.0
Asn
4.467AsnAla: 4.467 ± 0.696
0.693AsnCys: 0.693 ± 0.21
3.235AsnAsp: 3.235 ± 0.522
1.926AsnGlu: 1.926 ± 0.393
0.77AsnPhe: 0.77 ± 0.272
3.697AsnGly: 3.697 ± 0.47
0.924AsnHis: 0.924 ± 0.233
1.232AsnIle: 1.232 ± 0.327
1.463AsnLys: 1.463 ± 0.382
2.003AsnLeu: 2.003 ± 0.405
0.616AsnMet: 0.616 ± 0.208
1.232AsnAsn: 1.232 ± 0.314
2.311AsnPro: 2.311 ± 0.402
1.309AsnGln: 1.309 ± 0.334
2.157AsnArg: 2.157 ± 0.418
1.772AsnSer: 1.772 ± 0.437
2.08AsnThr: 2.08 ± 0.361
2.619AsnVal: 2.619 ± 0.505
0.77AsnTrp: 0.77 ± 0.226
0.77AsnTyr: 0.77 ± 0.198
0.0AsnXaa: 0.0 ± 0.0
Pro
4.313ProAla: 4.313 ± 0.62
0.462ProCys: 0.462 ± 0.213
4.775ProAsp: 4.775 ± 0.713
3.235ProGlu: 3.235 ± 0.629
1.232ProPhe: 1.232 ± 0.275
2.311ProGly: 2.311 ± 0.475
1.386ProHis: 1.386 ± 0.395
2.157ProIle: 2.157 ± 0.37
2.157ProLys: 2.157 ± 0.473
2.85ProLeu: 2.85 ± 0.452
0.924ProMet: 0.924 ± 0.248
2.08ProAsn: 2.08 ± 0.533
2.157ProPro: 2.157 ± 0.386
1.772ProGln: 1.772 ± 0.333
2.388ProArg: 2.388 ± 0.369
2.542ProSer: 2.542 ± 0.486
3.312ProThr: 3.312 ± 0.401
2.234ProVal: 2.234 ± 0.366
0.462ProTrp: 0.462 ± 0.263
1.078ProTyr: 1.078 ± 0.301
0.0ProXaa: 0.0 ± 0.0
Gln
5.238GlnAla: 5.238 ± 0.671
0.616GlnCys: 0.616 ± 0.257
1.386GlnAsp: 1.386 ± 0.378
2.619GlnGlu: 2.619 ± 0.647
1.386GlnPhe: 1.386 ± 0.251
3.312GlnGly: 3.312 ± 0.526
0.847GlnHis: 0.847 ± 0.263
1.849GlnIle: 1.849 ± 0.304
1.772GlnLys: 1.772 ± 0.303
2.234GlnLeu: 2.234 ± 0.399
1.617GlnMet: 1.617 ± 0.473
1.772GlnAsn: 1.772 ± 0.38
1.386GlnPro: 1.386 ± 0.39
2.157GlnGln: 2.157 ± 0.622
3.235GlnArg: 3.235 ± 0.509
2.773GlnSer: 2.773 ± 0.361
2.619GlnThr: 2.619 ± 0.56
1.617GlnVal: 1.617 ± 0.311
1.078GlnTrp: 1.078 ± 0.371
0.77GlnTyr: 0.77 ± 0.24
0.0GlnXaa: 0.0 ± 0.0
Arg
7.394ArgAla: 7.394 ± 0.752
0.693ArgCys: 0.693 ± 0.234
5.623ArgAsp: 5.623 ± 0.661
4.39ArgGlu: 4.39 ± 0.615
2.003ArgPhe: 2.003 ± 0.38
3.928ArgGly: 3.928 ± 0.605
1.695ArgHis: 1.695 ± 0.446
3.697ArgIle: 3.697 ± 0.547
4.082ArgLys: 4.082 ± 0.758
5.238ArgLeu: 5.238 ± 0.595
1.463ArgMet: 1.463 ± 0.286
2.311ArgAsn: 2.311 ± 0.415
2.08ArgPro: 2.08 ± 0.351
2.08ArgGln: 2.08 ± 0.555
5.546ArgArg: 5.546 ± 0.846
3.466ArgSer: 3.466 ± 0.563
3.004ArgThr: 3.004 ± 0.475
4.467ArgVal: 4.467 ± 0.619
1.155ArgTrp: 1.155 ± 0.373
1.617ArgTyr: 1.617 ± 0.318
0.0ArgXaa: 0.0 ± 0.0
Ser
7.933SerAla: 7.933 ± 0.643
0.462SerCys: 0.462 ± 0.219
3.928SerAsp: 3.928 ± 0.404
2.542SerGlu: 2.542 ± 0.55
1.926SerPhe: 1.926 ± 0.408
5.854SerGly: 5.854 ± 0.781
1.001SerHis: 1.001 ± 0.286
2.696SerIle: 2.696 ± 0.5
2.696SerLys: 2.696 ± 0.41
4.621SerLeu: 4.621 ± 0.555
1.695SerMet: 1.695 ± 0.356
1.926SerAsn: 1.926 ± 0.511
2.234SerPro: 2.234 ± 0.694
2.542SerGln: 2.542 ± 0.572
3.928SerArg: 3.928 ± 0.432
3.312SerSer: 3.312 ± 0.574
3.466SerThr: 3.466 ± 0.532
3.928SerVal: 3.928 ± 0.596
0.924SerTrp: 0.924 ± 0.247
1.386SerTyr: 1.386 ± 0.348
0.0SerXaa: 0.0 ± 0.0
Thr
6.085ThrAla: 6.085 ± 0.787
0.539ThrCys: 0.539 ± 0.177
4.236ThrAsp: 4.236 ± 0.665
2.85ThrGlu: 2.85 ± 0.517
3.158ThrPhe: 3.158 ± 0.465
6.162ThrGly: 6.162 ± 0.849
0.924ThrHis: 0.924 ± 0.255
2.927ThrIle: 2.927 ± 0.467
2.311ThrLys: 2.311 ± 0.332
4.313ThrLeu: 4.313 ± 0.642
0.77ThrMet: 0.77 ± 0.234
2.234ThrAsn: 2.234 ± 0.392
5.084ThrPro: 5.084 ± 0.729
2.696ThrGln: 2.696 ± 0.444
3.312ThrArg: 3.312 ± 0.543
2.157ThrSer: 2.157 ± 0.531
3.081ThrThr: 3.081 ± 0.604
5.161ThrVal: 5.161 ± 0.578
0.77ThrTrp: 0.77 ± 0.232
1.001ThrTyr: 1.001 ± 0.276
0.0ThrXaa: 0.0 ± 0.0
Val
7.394ValAla: 7.394 ± 0.824
0.539ValCys: 0.539 ± 0.175
4.775ValAsp: 4.775 ± 0.535
3.928ValGlu: 3.928 ± 0.564
2.157ValPhe: 2.157 ± 0.375
3.774ValGly: 3.774 ± 0.741
0.616ValHis: 0.616 ± 0.235
3.158ValIle: 3.158 ± 0.551
3.466ValLys: 3.466 ± 0.439
4.698ValLeu: 4.698 ± 0.783
1.772ValMet: 1.772 ± 0.386
2.311ValAsn: 2.311 ± 0.453
3.004ValPro: 3.004 ± 0.572
2.85ValGln: 2.85 ± 0.44
3.543ValArg: 3.543 ± 0.528
4.621ValSer: 4.621 ± 0.907
4.852ValThr: 4.852 ± 0.535
4.236ValVal: 4.236 ± 0.587
0.693ValTrp: 0.693 ± 0.227
2.08ValTyr: 2.08 ± 0.396
0.0ValXaa: 0.0 ± 0.0
Trp
1.772TrpAla: 1.772 ± 0.426
0.308TrpCys: 0.308 ± 0.154
1.155TrpAsp: 1.155 ± 0.365
1.078TrpGlu: 1.078 ± 0.231
0.308TrpPhe: 0.308 ± 0.193
1.001TrpGly: 1.001 ± 0.334
0.385TrpHis: 0.385 ± 0.206
0.693TrpIle: 0.693 ± 0.228
0.693TrpLys: 0.693 ± 0.263
1.309TrpLeu: 1.309 ± 0.33
0.077TrpMet: 0.077 ± 0.068
0.385TrpAsn: 0.385 ± 0.186
0.616TrpPro: 0.616 ± 0.186
0.693TrpGln: 0.693 ± 0.24
1.232TrpArg: 1.232 ± 0.312
1.155TrpSer: 1.155 ± 0.344
1.232TrpThr: 1.232 ± 0.321
1.463TrpVal: 1.463 ± 0.323
0.077TrpTrp: 0.077 ± 0.07
0.462TrpTyr: 0.462 ± 0.169
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.85TyrAla: 2.85 ± 0.477
0.231TyrCys: 0.231 ± 0.138
2.08TyrAsp: 2.08 ± 0.465
1.54TyrGlu: 1.54 ± 0.352
1.232TyrPhe: 1.232 ± 0.322
2.08TyrGly: 2.08 ± 0.542
0.924TyrHis: 0.924 ± 0.336
0.847TyrIle: 0.847 ± 0.213
1.078TyrLys: 1.078 ± 0.282
2.311TyrLeu: 2.311 ± 0.338
0.693TyrMet: 0.693 ± 0.216
0.462TyrAsn: 0.462 ± 0.195
0.924TyrPro: 0.924 ± 0.252
1.155TyrGln: 1.155 ± 0.416
1.772TyrArg: 1.772 ± 0.367
1.695TyrSer: 1.695 ± 0.29
1.617TyrThr: 1.617 ± 0.373
2.388TyrVal: 2.388 ± 0.426
0.231TyrTrp: 0.231 ± 0.114
0.693TyrTyr: 0.693 ± 0.248
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 71 proteins (12984 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski