Amino acid dipepetide frequency for Fonsecaea erecta

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.365AlaAla: 9.365 ± 0.058	1.112AlaCys: 1.112 ± 0.018	4.406AlaAsp: 4.406 ± 0.035	5.262AlaGlu: 5.262 ± 0.036	3.235AlaPhe: 3.235 ± 0.025	6.016AlaGly: 6.016 ± 0.04	1.851AlaHis: 1.851 ± 0.018	4.27AlaIle: 4.27 ± 0.031	3.953AlaLys: 3.953 ± 0.03	7.938AlaLeu: 7.938 ± 0.048	1.995AlaMet: 1.995 ± 0.021	2.916AlaAsn: 2.916 ± 0.022	4.638AlaPro: 4.638 ± 0.036	3.589AlaGln: 3.589 ± 0.025	5.228AlaArg: 5.228 ± 0.034	7.184AlaSer: 7.184 ± 0.045	5.486AlaThr: 5.486 ± 0.037	5.581AlaVal: 5.581 ± 0.037	1.204AlaTrp: 1.204 ± 0.017	2.221AlaTyr: 2.221 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	0.979CysAla: 0.979 ± 0.014	0.243CysCys: 0.243 ± 0.008	0.647CysAsp: 0.647 ± 0.011	0.584CysGlu: 0.584 ± 0.01	0.562CysPhe: 0.562 ± 0.009	0.918CysGly: 0.918 ± 0.014	0.335CysHis: 0.335 ± 0.009	0.702CysIle: 0.702 ± 0.012	0.468CysLys: 0.468 ± 0.01	1.298CysLeu: 1.298 ± 0.018	0.266CysMet: 0.266 ± 0.007	0.399CysAsn: 0.399 ± 0.009	0.661CysPro: 0.661 ± 0.012	0.449CysGln: 0.449 ± 0.008	0.761CysArg: 0.761 ± 0.011	0.862CysSer: 0.862 ± 0.013	0.681CysThr: 0.681 ± 0.012	0.833CysVal: 0.833 ± 0.013	0.21CysTrp: 0.21 ± 0.006	0.378CysTyr: 0.378 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	4.714AspAla: 4.714 ± 0.031	0.607AspCys: 0.607 ± 0.012	4.269AspAsp: 4.269 ± 0.042	4.5AspGlu: 4.5 ± 0.036	2.249AspPhe: 2.249 ± 0.023	4.054AspGly: 4.054 ± 0.032	1.354AspHis: 1.354 ± 0.016	2.957AspIle: 2.957 ± 0.023	2.327AspLys: 2.327 ± 0.021	5.22AspLeu: 5.22 ± 0.033	1.271AspMet: 1.271 ± 0.016	1.826AspAsn: 1.826 ± 0.02	3.489AspPro: 3.489 ± 0.027	2.017AspGln: 2.017 ± 0.02	3.117AspArg: 3.117 ± 0.023	3.89AspSer: 3.89 ± 0.029	2.979AspThr: 2.979 ± 0.023	3.821AspVal: 3.821 ± 0.03	0.901AspTrp: 0.901 ± 0.015	1.539AspTyr: 1.539 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	5.399GluAla: 5.399 ± 0.037	0.617GluCys: 0.617 ± 0.01	4.201GluAsp: 4.201 ± 0.036	5.303GluGlu: 5.303 ± 0.05	1.899GluPhe: 1.899 ± 0.018	3.701GluGly: 3.701 ± 0.028	1.471GluHis: 1.471 ± 0.017	3.072GluIle: 3.072 ± 0.021	3.589GluLys: 3.589 ± 0.031	5.119GluLeu: 5.119 ± 0.04	1.478GluMet: 1.478 ± 0.016	2.161GluAsn: 2.161 ± 0.018	2.744GluPro: 2.744 ± 0.025	2.581GluGln: 2.581 ± 0.025	3.928GluArg: 3.928 ± 0.031	4.097GluSer: 4.097 ± 0.031	3.405GluThr: 3.405 ± 0.026	3.642GluVal: 3.642 ± 0.026	0.872GluTrp: 0.872 ± 0.013	1.631GluTyr: 1.631 ± 0.017	0.0GluXaa: 0.0 ± 0.0
Phe	3.16PheAla: 3.16 ± 0.025	0.568PheCys: 0.568 ± 0.01	2.326PheAsp: 2.326 ± 0.023	2.19PheGlu: 2.19 ± 0.018	1.663PhePhe: 1.663 ± 0.02	2.896PheGly: 2.896 ± 0.03	0.92PheHis: 0.92 ± 0.012	1.733PheIle: 1.733 ± 0.019	1.404PheLys: 1.404 ± 0.016	3.539PheLeu: 3.539 ± 0.029	0.796PheMet: 0.796 ± 0.011	1.363PheAsn: 1.363 ± 0.017	2.002PhePro: 2.002 ± 0.018	1.445PheGln: 1.445 ± 0.015	2.0PheArg: 2.0 ± 0.016	2.899PheSer: 2.899 ± 0.024	2.099PheThr: 2.099 ± 0.018	2.485PheVal: 2.485 ± 0.022	0.665PheTrp: 0.665 ± 0.011	1.114PheTyr: 1.114 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	5.407GlyAla: 5.407 ± 0.039	0.849GlyCys: 0.849 ± 0.012	3.602GlyAsp: 3.602 ± 0.029	3.637GlyGlu: 3.637 ± 0.03	2.864GlyPhe: 2.864 ± 0.023	5.863GlyGly: 5.863 ± 0.049	1.739GlyHis: 1.739 ± 0.02	3.506GlyIle: 3.506 ± 0.029	3.353GlyLys: 3.353 ± 0.029	6.201GlyLeu: 6.201 ± 0.035	1.655GlyMet: 1.655 ± 0.018	2.372GlyAsn: 2.372 ± 0.023	3.428GlyPro: 3.428 ± 0.03	2.653GlyGln: 2.653 ± 0.024	4.25GlyArg: 4.25 ± 0.033	5.502GlySer: 5.502 ± 0.035	4.091GlyThr: 4.091 ± 0.03	4.513GlyVal: 4.513 ± 0.03	1.171GlyTrp: 1.171 ± 0.015	2.13GlyTyr: 2.13 ± 0.02	0.0GlyXaa: 0.0 ± 0.0
His	1.999HisAla: 1.999 ± 0.02	0.328HisCys: 0.328 ± 0.007	1.407HisAsp: 1.407 ± 0.017	1.419HisGlu: 1.419 ± 0.016	0.942HisPhe: 0.942 ± 0.013	1.829HisGly: 1.829 ± 0.02	0.933HisHis: 0.933 ± 0.015	1.19HisIle: 1.19 ± 0.015	0.951HisLys: 0.951 ± 0.013	2.32HisLeu: 2.32 ± 0.021	0.512HisMet: 0.512 ± 0.008	0.835HisAsn: 0.835 ± 0.013	1.745HisPro: 1.745 ± 0.017	1.024HisGln: 1.024 ± 0.014	1.588HisArg: 1.588 ± 0.018	1.803HisSer: 1.803 ± 0.019	1.286HisThr: 1.286 ± 0.016	1.53HisVal: 1.53 ± 0.017	0.359HisTrp: 0.359 ± 0.008	0.699HisTyr: 0.699 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.208IleAla: 4.208 ± 0.028	0.76IleCys: 0.76 ± 0.011	2.795IleAsp: 2.795 ± 0.019	2.778IleGlu: 2.778 ± 0.023	1.957IlePhe: 1.957 ± 0.018	3.172IleGly: 3.172 ± 0.029	1.204IleHis: 1.204 ± 0.016	2.402IleIle: 2.402 ± 0.024	2.072IleLys: 2.072 ± 0.022	4.578IleLeu: 4.578 ± 0.03	0.99IleMet: 0.99 ± 0.014	1.738IleAsn: 1.738 ± 0.016	3.028IlePro: 3.028 ± 0.025	1.919IleGln: 1.919 ± 0.015	2.739IleArg: 2.739 ± 0.021	3.737IleSer: 3.737 ± 0.027	2.764IleThr: 2.764 ± 0.022	3.238IleVal: 3.238 ± 0.026	0.744IleTrp: 0.744 ± 0.014	1.41IleTyr: 1.41 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.116LysAla: 4.116 ± 0.03	0.486LysCys: 0.486 ± 0.009	2.754LysAsp: 2.754 ± 0.025	3.207LysGlu: 3.207 ± 0.027	1.438LysPhe: 1.438 ± 0.017	2.857LysGly: 2.857 ± 0.023	1.159LysHis: 1.159 ± 0.014	2.286LysIle: 2.286 ± 0.022	3.029LysLys: 3.029 ± 0.037	3.901LysLeu: 3.901 ± 0.027	1.024LysMet: 1.024 ± 0.015	1.557LysAsn: 1.557 ± 0.017	2.627LysPro: 2.627 ± 0.023	1.85LysGln: 1.85 ± 0.02	3.341LysArg: 3.341 ± 0.024	3.362LysSer: 3.362 ± 0.029	2.703LysThr: 2.703 ± 0.023	2.768LysVal: 2.768 ± 0.025	0.68LysTrp: 0.68 ± 0.01	1.38LysTyr: 1.38 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	8.01LeuAla: 8.01 ± 0.045	1.281LeuCys: 1.281 ± 0.016	5.274LeuAsp: 5.274 ± 0.028	5.525LeuGlu: 5.525 ± 0.042	3.365LeuPhe: 3.365 ± 0.029	5.96LeuGly: 5.96 ± 0.038	2.292LeuHis: 2.292 ± 0.022	3.878LeuIle: 3.878 ± 0.028	4.165LeuLys: 4.165 ± 0.032	8.477LeuLeu: 8.477 ± 0.057	1.813LeuMet: 1.813 ± 0.019	3.13LeuAsn: 3.13 ± 0.023	5.543LeuPro: 5.543 ± 0.037	3.901LeuGln: 3.901 ± 0.031	5.884LeuArg: 5.884 ± 0.04	7.179LeuSer: 7.179 ± 0.041	4.897LeuThr: 4.897 ± 0.03	5.518LeuVal: 5.518 ± 0.035	1.259LeuTrp: 1.259 ± 0.014	2.37LeuTyr: 2.37 ± 0.019	0.0LeuXaa: 0.0 ± 0.0
Met	2.316MetAla: 2.316 ± 0.02	0.257MetCys: 0.257 ± 0.006	1.23MetAsp: 1.23 ± 0.015	1.201MetGlu: 1.201 ± 0.016	0.763MetPhe: 0.763 ± 0.011	1.475MetGly: 1.475 ± 0.017	0.489MetHis: 0.489 ± 0.009	0.985MetIle: 0.985 ± 0.014	0.97MetLys: 0.97 ± 0.014	1.886MetLeu: 1.886 ± 0.02	0.563MetMet: 0.563 ± 0.011	0.787MetAsn: 0.787 ± 0.014	1.305MetPro: 1.305 ± 0.015	0.86MetGln: 0.86 ± 0.013	1.25MetArg: 1.25 ± 0.016	1.884MetSer: 1.884 ± 0.016	1.349MetThr: 1.349 ± 0.014	1.34MetVal: 1.34 ± 0.014	0.253MetTrp: 0.253 ± 0.006	0.532MetTyr: 0.532 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.134AsnAla: 3.134 ± 0.023	0.426AsnCys: 0.426 ± 0.011	1.882AsnAsp: 1.882 ± 0.018	1.892AsnGlu: 1.892 ± 0.02	1.335AsnPhe: 1.335 ± 0.014	2.911AsnGly: 2.911 ± 0.032	0.873AsnHis: 0.873 ± 0.013	1.932AsnIle: 1.932 ± 0.019	1.458AsnLys: 1.458 ± 0.017	3.157AsnLeu: 3.157 ± 0.024	0.781AsnMet: 0.781 ± 0.012	1.442AsnAsn: 1.442 ± 0.02	2.404AsnPro: 2.404 ± 0.022	1.301AsnGln: 1.301 ± 0.016	1.864AsnArg: 1.864 ± 0.019	2.508AsnSer: 2.508 ± 0.023	2.081AsnThr: 2.081 ± 0.02	2.335AsnVal: 2.335 ± 0.021	0.559AsnTrp: 0.559 ± 0.01	1.009AsnTyr: 1.009 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	5.248ProAla: 5.248 ± 0.042	0.511ProCys: 0.511 ± 0.01	3.335ProAsp: 3.335 ± 0.025	3.808ProGlu: 3.808 ± 0.027	2.092ProPhe: 2.092 ± 0.018	4.106ProGly: 4.106 ± 0.031	1.382ProHis: 1.382 ± 0.016	2.456ProIle: 2.456 ± 0.02	2.542ProLys: 2.542 ± 0.022	4.866ProLeu: 4.866 ± 0.024	1.074ProMet: 1.074 ± 0.014	2.188ProAsn: 2.188 ± 0.021	5.367ProPro: 5.367 ± 0.063	2.614ProGln: 2.614 ± 0.026	3.509ProArg: 3.509 ± 0.028	5.978ProSer: 5.978 ± 0.045	4.037ProThr: 4.037 ± 0.034	3.654ProVal: 3.654 ± 0.028	0.773ProTrp: 0.773 ± 0.011	1.532ProTyr: 1.532 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.625GlnAla: 3.625 ± 0.029	0.445GlnCys: 0.445 ± 0.009	2.167GlnAsp: 2.167 ± 0.019	2.508GlnGlu: 2.508 ± 0.021	1.3GlnPhe: 1.3 ± 0.017	2.526GlnGly: 2.526 ± 0.023	1.152GlnHis: 1.152 ± 0.014	1.968GlnIle: 1.968 ± 0.018	2.002GlnLys: 2.002 ± 0.019	3.474GlnLeu: 3.474 ± 0.027	0.925GlnMet: 0.925 ± 0.014	1.554GlnAsn: 1.554 ± 0.017	2.638GlnPro: 2.638 ± 0.029	2.583GlnGln: 2.583 ± 0.044	2.752GlnArg: 2.752 ± 0.023	3.174GlnSer: 3.174 ± 0.028	2.381GlnThr: 2.381 ± 0.023	2.231GlnVal: 2.231 ± 0.022	0.586GlnTrp: 0.586 ± 0.01	1.22GlnTyr: 1.22 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	4.894ArgAla: 4.894 ± 0.036	0.715ArgCys: 0.715 ± 0.012	3.499ArgAsp: 3.499 ± 0.03	3.877ArgGlu: 3.877 ± 0.032	2.104ArgPhe: 2.104 ± 0.021	3.746ArgGly: 3.746 ± 0.027	1.693ArgHis: 1.693 ± 0.018	2.861ArgIle: 2.861 ± 0.024	3.497ArgLys: 3.497 ± 0.03	5.628ArgLeu: 5.628 ± 0.036	1.303ArgMet: 1.303 ± 0.017	2.177ArgAsn: 2.177 ± 0.019	3.693ArgPro: 3.693 ± 0.035	2.77ArgGln: 2.77 ± 0.026	5.324ArgArg: 5.324 ± 0.043	4.705ArgSer: 4.705 ± 0.034	3.412ArgThr: 3.412 ± 0.027	3.365ArgVal: 3.365 ± 0.028	0.977ArgTrp: 0.977 ± 0.015	1.706ArgTyr: 1.706 ± 0.017	0.0ArgXaa: 0.0 ± 0.0
Ser	6.624SerAla: 6.624 ± 0.038	0.835SerCys: 0.835 ± 0.014	4.053SerAsp: 4.053 ± 0.033	3.982SerGlu: 3.982 ± 0.03	2.915SerPhe: 2.915 ± 0.024	5.399SerGly: 5.399 ± 0.036	1.938SerHis: 1.938 ± 0.021	3.819SerIle: 3.819 ± 0.025	3.499SerLys: 3.499 ± 0.023	7.025SerLeu: 7.025 ± 0.041	1.705SerMet: 1.705 ± 0.018	2.778SerAsn: 2.778 ± 0.026	5.57SerPro: 5.57 ± 0.048	3.304SerGln: 3.304 ± 0.024	5.002SerArg: 5.002 ± 0.04	8.749SerSer: 8.749 ± 0.078	5.744SerThr: 5.744 ± 0.05	4.557SerVal: 4.557 ± 0.029	1.136SerTrp: 1.136 ± 0.014	2.015SerTyr: 2.015 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	5.418ThrAla: 5.418 ± 0.031	0.727ThrCys: 0.727 ± 0.012	2.883ThrAsp: 2.883 ± 0.024	3.022ThrGlu: 3.022 ± 0.024	2.315ThrPhe: 2.315 ± 0.02	4.224ThrGly: 4.224 ± 0.032	1.266ThrHis: 1.266 ± 0.014	3.097ThrIle: 3.097 ± 0.024	2.535ThrLys: 2.535 ± 0.023	5.235ThrLeu: 5.235 ± 0.033	1.227ThrMet: 1.227 ± 0.013	2.132ThrAsn: 2.132 ± 0.022	4.34ThrPro: 4.34 ± 0.039	2.148ThrGln: 2.148 ± 0.023	3.192ThrArg: 3.192 ± 0.025	5.504ThrSer: 5.504 ± 0.056	4.795ThrThr: 4.795 ± 0.078	3.861ThrVal: 3.861 ± 0.029	0.868ThrTrp: 0.868 ± 0.015	1.598ThrTyr: 1.598 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	5.444ValAla: 5.444 ± 0.036	0.834ValCys: 0.834 ± 0.012	3.868ValAsp: 3.868 ± 0.025	3.904ValGlu: 3.904 ± 0.028	2.502ValPhe: 2.502 ± 0.02	4.112ValGly: 4.112 ± 0.03	1.464ValHis: 1.464 ± 0.016	2.956ValIle: 2.956 ± 0.023	2.87ValLys: 2.87 ± 0.021	5.729ValLeu: 5.729 ± 0.035	1.326ValMet: 1.326 ± 0.015	2.256ValAsn: 2.256 ± 0.02	3.684ValPro: 3.684 ± 0.025	2.497ValGln: 2.497 ± 0.02	3.584ValArg: 3.584 ± 0.026	4.594ValSer: 4.594 ± 0.029	3.584ValThr: 3.584 ± 0.032	4.588ValVal: 4.588 ± 0.033	0.89ValTrp: 0.89 ± 0.013	1.713ValTyr: 1.713 ± 0.018	0.0ValXaa: 0.0 ± 0.0
Trp	1.167TrpAla: 1.167 ± 0.014	0.21TrpCys: 0.21 ± 0.006	0.852TrpAsp: 0.852 ± 0.011	0.822TrpGlu: 0.822 ± 0.012	0.557TrpPhe: 0.557 ± 0.01	0.905TrpGly: 0.905 ± 0.014	0.392TrpHis: 0.392 ± 0.008	0.806TrpIle: 0.806 ± 0.011	0.798TrpLys: 0.798 ± 0.013	1.423TrpLeu: 1.423 ± 0.017	0.375TrpMet: 0.375 ± 0.008	0.61TrpAsn: 0.61 ± 0.011	0.649TrpPro: 0.649 ± 0.01	0.589TrpGln: 0.589 ± 0.009	0.997TrpArg: 0.997 ± 0.013	1.068TrpSer: 1.068 ± 0.014	1.008TrpThr: 1.008 ± 0.015	0.871TrpVal: 0.871 ± 0.012	0.292TrpTrp: 0.292 ± 0.007	0.459TrpTyr: 0.459 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.226TyrAla: 2.226 ± 0.02	0.424TyrCys: 0.424 ± 0.008	1.651TyrAsp: 1.651 ± 0.019	1.489TyrGlu: 1.489 ± 0.018	1.207TyrPhe: 1.207 ± 0.016	2.116TyrGly: 2.116 ± 0.023	0.794TyrHis: 0.794 ± 0.014	1.358TyrIle: 1.358 ± 0.015	1.044TyrLys: 1.044 ± 0.013	2.708TyrLeu: 2.708 ± 0.023	0.615TyrMet: 0.615 ± 0.011	1.062TyrAsn: 1.062 ± 0.014	1.517TyrPro: 1.517 ± 0.021	1.115TyrGln: 1.115 ± 0.016	1.637TyrArg: 1.637 ± 0.019	1.968TyrSer: 1.968 ± 0.019	1.605TyrThr: 1.605 ± 0.016	1.668TyrVal: 1.668 ± 0.018	0.45TyrTrp: 0.45 ± 0.009	0.908TyrTyr: 0.908 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 12089 proteins (5948075 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---