Amino acid dipepetide frequency for Paracoccus isoporae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.3AlaAla: 19.3 ± 0.214	0.965AlaCys: 0.965 ± 0.031	7.545AlaAsp: 7.545 ± 0.106	9.461AlaGlu: 9.461 ± 0.131	4.047AlaPhe: 4.047 ± 0.068	11.808AlaGly: 11.808 ± 0.138	2.273AlaHis: 2.273 ± 0.05	6.084AlaIle: 6.084 ± 0.09	3.038AlaLys: 3.038 ± 0.056	13.616AlaLeu: 13.616 ± 0.164	4.083AlaMet: 4.083 ± 0.064	2.509AlaAsn: 2.509 ± 0.056	6.418AlaPro: 6.418 ± 0.104	4.807AlaGln: 4.807 ± 0.073	10.054AlaArg: 10.054 ± 0.139	5.701AlaSer: 5.701 ± 0.082	5.99AlaThr: 5.99 ± 0.085	8.486AlaVal: 8.486 ± 0.12	1.479AlaTrp: 1.479 ± 0.043	2.321AlaTyr: 2.321 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	1.041CysAla: 1.041 ± 0.036	0.114CysCys: 0.114 ± 0.011	0.545CysAsp: 0.545 ± 0.023	0.384CysGlu: 0.384 ± 0.02	0.304CysPhe: 0.304 ± 0.018	0.898CysGly: 0.898 ± 0.033	0.238CysHis: 0.238 ± 0.015	0.357CysIle: 0.357 ± 0.022	0.132CysLys: 0.132 ± 0.013	0.753CysLeu: 0.753 ± 0.031	0.143CysMet: 0.143 ± 0.012	0.179CysAsn: 0.179 ± 0.012	0.468CysPro: 0.468 ± 0.024	0.223CysGln: 0.223 ± 0.015	0.565CysArg: 0.565 ± 0.023	0.396CysSer: 0.396 ± 0.017	0.334CysThr: 0.334 ± 0.017	0.55CysVal: 0.55 ± 0.023	0.124CysTrp: 0.124 ± 0.01	0.17CysTyr: 0.17 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	8.319AspAla: 8.319 ± 0.122	0.51AspCys: 0.51 ± 0.024	3.808AspAsp: 3.808 ± 0.093	3.684AspGlu: 3.684 ± 0.069	2.249AspPhe: 2.249 ± 0.051	6.239AspGly: 6.239 ± 0.097	1.52AspHis: 1.52 ± 0.04	2.792AspIle: 2.792 ± 0.059	1.384AspLys: 1.384 ± 0.044	6.654AspLeu: 6.654 ± 0.094	1.72AspMet: 1.72 ± 0.039	1.257AspAsn: 1.257 ± 0.041	4.004AspPro: 4.004 ± 0.068	2.049AspGln: 2.049 ± 0.05	5.315AspArg: 5.315 ± 0.081	2.491AspSer: 2.491 ± 0.052	2.677AspThr: 2.677 ± 0.06	3.661AspVal: 3.661 ± 0.069	1.265AspTrp: 1.265 ± 0.037	1.58AspTyr: 1.58 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	8.131GluAla: 8.131 ± 0.102	0.349GluCys: 0.349 ± 0.019	3.414GluAsp: 3.414 ± 0.066	3.402GluGlu: 3.402 ± 0.072	1.886GluPhe: 1.886 ± 0.038	4.513GluGly: 4.513 ± 0.073	1.002GluHis: 1.002 ± 0.035	4.061GluIle: 4.061 ± 0.07	1.835GluLys: 1.835 ± 0.051	5.367GluLeu: 5.367 ± 0.076	2.081GluMet: 2.081 ± 0.042	1.682GluAsn: 1.682 ± 0.044	2.548GluPro: 2.548 ± 0.056	1.921GluGln: 1.921 ± 0.049	4.366GluArg: 4.366 ± 0.071	2.409GluSer: 2.409 ± 0.048	3.648GluThr: 3.648 ± 0.058	3.968GluVal: 3.968 ± 0.072	0.736GluTrp: 0.736 ± 0.029	1.149GluTyr: 1.149 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	4.545PheAla: 4.545 ± 0.076	0.35PheCys: 0.35 ± 0.019	2.779PheAsp: 2.779 ± 0.059	1.851PheGlu: 1.851 ± 0.041	1.351PhePhe: 1.351 ± 0.042	3.627PheGly: 3.627 ± 0.075	0.706PheHis: 0.706 ± 0.025	1.633PheIle: 1.633 ± 0.046	0.697PheLys: 0.697 ± 0.026	3.268PheLeu: 3.268 ± 0.072	0.863PheMet: 0.863 ± 0.028	0.924PheAsn: 0.924 ± 0.033	1.486PhePro: 1.486 ± 0.041	0.926PheGln: 0.926 ± 0.032	2.33PheArg: 2.33 ± 0.045	2.048PheSer: 2.048 ± 0.042	1.934PheThr: 1.934 ± 0.044	2.484PheVal: 2.484 ± 0.05	0.59PheTrp: 0.59 ± 0.03	0.865PheTyr: 0.865 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	10.634GlyAla: 10.634 ± 0.117	0.793GlyCys: 0.793 ± 0.03	5.146GlyAsp: 5.146 ± 0.084	5.03GlyGlu: 5.03 ± 0.081	3.642GlyPhe: 3.642 ± 0.057	7.992GlyGly: 7.992 ± 0.133	1.849GlyHis: 1.849 ± 0.042	4.627GlyIle: 4.627 ± 0.08	2.765GlyLys: 2.765 ± 0.056	9.472GlyLeu: 9.472 ± 0.115	2.812GlyMet: 2.812 ± 0.054	2.212GlyAsn: 2.212 ± 0.065	3.999GlyPro: 3.999 ± 0.069	3.424GlyGln: 3.424 ± 0.063	6.67GlyArg: 6.67 ± 0.098	4.334GlySer: 4.334 ± 0.073	4.426GlyThr: 4.426 ± 0.071	6.344GlyVal: 6.344 ± 0.096	1.677GlyTrp: 1.677 ± 0.042	2.175GlyTyr: 2.175 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.309HisAla: 2.309 ± 0.055	0.216HisCys: 0.216 ± 0.015	1.32HisAsp: 1.32 ± 0.032	1.011HisGlu: 1.011 ± 0.031	0.761HisPhe: 0.761 ± 0.028	1.954HisGly: 1.954 ± 0.046	0.561HisHis: 0.561 ± 0.023	0.86HisIle: 0.86 ± 0.027	0.408HisLys: 0.408 ± 0.019	2.139HisLeu: 2.139 ± 0.055	0.503HisMet: 0.503 ± 0.024	0.386HisAsn: 0.386 ± 0.02	1.351HisPro: 1.351 ± 0.035	0.571HisGln: 0.571 ± 0.022	1.517HisArg: 1.517 ± 0.041	0.861HisSer: 0.861 ± 0.027	0.671HisThr: 0.671 ± 0.026	1.458HisVal: 1.458 ± 0.039	0.318HisTrp: 0.318 ± 0.016	0.54HisTyr: 0.54 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.477IleAla: 7.477 ± 0.106	0.598IleCys: 0.598 ± 0.023	3.543IleAsp: 3.543 ± 0.07	3.356IleGlu: 3.356 ± 0.061	1.853IlePhe: 1.853 ± 0.05	5.333IleGly: 5.333 ± 0.075	0.937IleHis: 0.937 ± 0.031	2.221IleIle: 2.221 ± 0.054	1.027IleLys: 1.027 ± 0.037	4.603IleLeu: 4.603 ± 0.072	1.097IleMet: 1.097 ± 0.039	1.218IleAsn: 1.218 ± 0.036	2.364IlePro: 2.364 ± 0.047	1.114IleGln: 1.114 ± 0.034	3.87IleArg: 3.87 ± 0.064	3.023IleSer: 3.023 ± 0.06	2.739IleThr: 2.739 ± 0.049	3.707IleVal: 3.707 ± 0.067	0.826IleTrp: 0.826 ± 0.027	1.178IleTyr: 1.178 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.07LysAla: 3.07 ± 0.067	0.143LysCys: 0.143 ± 0.012	1.434LysAsp: 1.434 ± 0.038	1.182LysGlu: 1.182 ± 0.04	0.806LysPhe: 0.806 ± 0.03	2.11LysGly: 2.11 ± 0.049	0.464LysHis: 0.464 ± 0.022	1.445LysIle: 1.445 ± 0.044	0.921LysLys: 0.921 ± 0.038	2.634LysLeu: 2.634 ± 0.054	0.701LysMet: 0.701 ± 0.024	0.662LysAsn: 0.662 ± 0.029	1.523LysPro: 1.523 ± 0.042	0.798LysGln: 0.798 ± 0.031	1.805LysArg: 1.805 ± 0.042	1.561LysSer: 1.561 ± 0.043	1.451LysThr: 1.451 ± 0.04	1.704LysVal: 1.704 ± 0.047	0.3LysTrp: 0.3 ± 0.017	0.547LysTyr: 0.547 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	13.273LeuAla: 13.273 ± 0.159	0.9LeuCys: 0.9 ± 0.032	6.508LeuAsp: 6.508 ± 0.104	4.7LeuGlu: 4.7 ± 0.065	3.33LeuPhe: 3.33 ± 0.076	8.317LeuGly: 8.317 ± 0.121	1.835LeuHis: 1.835 ± 0.041	5.682LeuIle: 5.682 ± 0.094	2.622LeuLys: 2.622 ± 0.055	9.136LeuLeu: 9.136 ± 0.144	2.64LeuMet: 2.64 ± 0.059	2.613LeuAsn: 2.613 ± 0.051	5.937LeuPro: 5.937 ± 0.081	2.691LeuGln: 2.691 ± 0.051	7.838LeuArg: 7.838 ± 0.102	6.93LeuSer: 6.93 ± 0.083	5.917LeuThr: 5.917 ± 0.073	6.361LeuVal: 6.361 ± 0.089	1.202LeuTrp: 1.202 ± 0.038	1.903LeuTyr: 1.903 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.742MetAla: 3.742 ± 0.069	0.166MetCys: 0.166 ± 0.014	1.436MetAsp: 1.436 ± 0.036	1.327MetGlu: 1.327 ± 0.041	0.882MetPhe: 0.882 ± 0.031	2.329MetGly: 2.329 ± 0.049	0.382MetHis: 0.382 ± 0.021	1.589MetIle: 1.589 ± 0.045	0.928MetLys: 0.928 ± 0.029	2.86MetLeu: 2.86 ± 0.049	0.802MetMet: 0.802 ± 0.031	0.832MetAsn: 0.832 ± 0.029	1.591MetPro: 1.591 ± 0.04	1.019MetGln: 1.019 ± 0.03	2.146MetArg: 2.146 ± 0.048	1.812MetSer: 1.812 ± 0.042	2.056MetThr: 2.056 ± 0.047	1.828MetVal: 1.828 ± 0.043	0.256MetTrp: 0.256 ± 0.014	0.293MetTyr: 0.293 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.104AsnAla: 3.104 ± 0.055	0.224AsnCys: 0.224 ± 0.015	1.413AsnAsp: 1.413 ± 0.053	1.118AsnGlu: 1.118 ± 0.035	0.882AsnPhe: 0.882 ± 0.027	2.233AsnGly: 2.233 ± 0.072	0.5AsnHis: 0.5 ± 0.022	1.311AsnIle: 1.311 ± 0.038	0.524AsnLys: 0.524 ± 0.028	2.408AsnLeu: 2.408 ± 0.049	0.663AsnMet: 0.663 ± 0.029	0.548AsnAsn: 0.548 ± 0.024	1.747AsnPro: 1.747 ± 0.041	0.682AsnGln: 0.682 ± 0.027	1.797AsnArg: 1.797 ± 0.041	1.187AsnSer: 1.187 ± 0.037	1.109AsnThr: 1.109 ± 0.04	1.615AsnVal: 1.615 ± 0.043	0.419AsnTrp: 0.419 ± 0.021	0.641AsnTyr: 0.641 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	6.653ProAla: 6.653 ± 0.109	0.322ProCys: 0.322 ± 0.018	4.615ProAsp: 4.615 ± 0.075	4.122ProGlu: 4.122 ± 0.062	1.83ProPhe: 1.83 ± 0.042	5.206ProGly: 5.206 ± 0.08	1.033ProHis: 1.033 ± 0.035	2.188ProIle: 2.188 ± 0.048	1.27ProLys: 1.27 ± 0.042	4.526ProLeu: 4.526 ± 0.059	1.341ProMet: 1.341 ± 0.035	1.192ProAsn: 1.192 ± 0.043	2.685ProPro: 2.685 ± 0.062	1.899ProGln: 1.899 ± 0.041	3.264ProArg: 3.264 ± 0.062	2.41ProSer: 2.41 ± 0.048	2.122ProThr: 2.122 ± 0.051	4.494ProVal: 4.494 ± 0.067	0.647ProTrp: 0.647 ± 0.024	1.115ProTyr: 1.115 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	4.192GlnAla: 4.192 ± 0.062	0.194GlnCys: 0.194 ± 0.013	1.929GlnAsp: 1.929 ± 0.044	1.516GlnGlu: 1.516 ± 0.044	1.076GlnPhe: 1.076 ± 0.029	2.811GlnGly: 2.811 ± 0.057	0.618GlnHis: 0.618 ± 0.024	2.246GlnIle: 2.246 ± 0.045	0.911GlnLys: 0.911 ± 0.028	2.797GlnLeu: 2.797 ± 0.057	1.098GlnMet: 1.098 ± 0.034	0.912GlnAsn: 0.912 ± 0.035	1.843GlnPro: 1.843 ± 0.046	1.301GlnGln: 1.301 ± 0.048	2.294GlnArg: 2.294 ± 0.051	1.825GlnSer: 1.825 ± 0.043	1.701GlnThr: 1.701 ± 0.04	2.313GlnVal: 2.313 ± 0.052	0.391GlnTrp: 0.391 ± 0.018	0.533GlnTyr: 0.533 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	8.993ArgAla: 8.993 ± 0.127	0.461ArgCys: 0.461 ± 0.021	5.079ArgAsp: 5.079 ± 0.078	4.292ArgGlu: 4.292 ± 0.074	2.787ArgPhe: 2.787 ± 0.056	5.385ArgGly: 5.385 ± 0.07	1.766ArgHis: 1.766 ± 0.045	4.46ArgIle: 4.46 ± 0.064	2.003ArgLys: 2.003 ± 0.048	8.28ArgLeu: 8.28 ± 0.112	2.283ArgMet: 2.283 ± 0.046	1.886ArgAsn: 1.886 ± 0.041	3.931ArgPro: 3.931 ± 0.066	2.625ArgGln: 2.625 ± 0.045	6.159ArgArg: 6.159 ± 0.104	3.599ArgSer: 3.599 ± 0.057	2.795ArgThr: 2.795 ± 0.05	4.896ArgVal: 4.896 ± 0.071	0.967ArgTrp: 0.967 ± 0.029	1.56ArgTyr: 1.56 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.265SerAla: 6.265 ± 0.095	0.417SerCys: 0.417 ± 0.019	3.464SerAsp: 3.464 ± 0.068	2.891SerGlu: 2.891 ± 0.051	2.146SerPhe: 2.146 ± 0.049	5.667SerGly: 5.667 ± 0.093	1.079SerHis: 1.079 ± 0.032	2.264SerIle: 2.264 ± 0.053	1.182SerLys: 1.182 ± 0.037	4.887SerLeu: 4.887 ± 0.065	1.203SerMet: 1.203 ± 0.032	1.183SerAsn: 1.183 ± 0.038	2.604SerPro: 2.604 ± 0.057	1.588SerGln: 1.588 ± 0.04	3.636SerArg: 3.636 ± 0.07	2.485SerSer: 2.485 ± 0.058	2.28SerThr: 2.28 ± 0.051	3.754SerVal: 3.754 ± 0.063	0.775SerTrp: 0.775 ± 0.023	1.318SerTyr: 1.318 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	6.28ThrAla: 6.28 ± 0.086	0.374ThrCys: 0.374 ± 0.02	3.071ThrAsp: 3.071 ± 0.064	3.093ThrGlu: 3.093 ± 0.055	1.49ThrPhe: 1.49 ± 0.039	5.517ThrGly: 5.517 ± 0.078	0.964ThrHis: 0.964 ± 0.029	2.491ThrIle: 2.491 ± 0.055	1.028ThrLys: 1.028 ± 0.035	5.514ThrLeu: 5.514 ± 0.078	1.168ThrMet: 1.168 ± 0.031	1.152ThrAsn: 1.152 ± 0.039	3.206ThrPro: 3.206 ± 0.057	1.516ThrGln: 1.516 ± 0.04	3.724ThrArg: 3.724 ± 0.065	2.237ThrSer: 2.237 ± 0.046	2.443ThrThr: 2.443 ± 0.054	3.842ThrVal: 3.842 ± 0.076	0.53ThrTrp: 0.53 ± 0.024	1.002ThrTyr: 1.002 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	8.818ValAla: 8.818 ± 0.106	0.474ValCys: 0.474 ± 0.022	3.745ValAsp: 3.745 ± 0.08	4.331ValGlu: 4.331 ± 0.069	2.564ValPhe: 2.564 ± 0.051	5.012ValGly: 5.012 ± 0.08	1.181ValHis: 1.181 ± 0.033	4.249ValIle: 4.249 ± 0.062	1.752ValLys: 1.752 ± 0.045	7.273ValLeu: 7.273 ± 0.114	2.238ValMet: 2.238 ± 0.044	1.852ValAsn: 1.852 ± 0.052	3.435ValPro: 3.435 ± 0.057	1.974ValGln: 1.974 ± 0.046	4.008ValArg: 4.008 ± 0.068	3.962ValSer: 3.962 ± 0.063	4.594ValThr: 4.594 ± 0.088	5.265ValVal: 5.265 ± 0.082	0.918ValTrp: 0.918 ± 0.029	1.339ValTyr: 1.339 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.343TrpAla: 1.343 ± 0.043	0.12TrpCys: 0.12 ± 0.011	0.785TrpAsp: 0.785 ± 0.03	0.575TrpGlu: 0.575 ± 0.026	0.558TrpPhe: 0.558 ± 0.022	0.971TrpGly: 0.971 ± 0.029	0.31TrpHis: 0.31 ± 0.018	0.714TrpIle: 0.714 ± 0.027	0.386TrpLys: 0.386 ± 0.019	1.856TrpLeu: 1.856 ± 0.049	0.406TrpMet: 0.406 ± 0.022	0.406TrpAsn: 0.406 ± 0.02	0.74TrpPro: 0.74 ± 0.028	0.709TrpGln: 0.709 ± 0.025	1.203TrpArg: 1.203 ± 0.043	0.8TrpSer: 0.8 ± 0.027	0.764TrpThr: 0.764 ± 0.024	0.838TrpVal: 0.838 ± 0.027	0.239TrpTrp: 0.239 ± 0.015	0.26TrpTyr: 0.26 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.494TyrAla: 2.494 ± 0.047	0.229TyrCys: 0.229 ± 0.014	1.596TyrAsp: 1.596 ± 0.036	1.142TyrGlu: 1.142 ± 0.037	0.814TyrPhe: 0.814 ± 0.03	2.102TyrGly: 2.102 ± 0.047	0.495TyrHis: 0.495 ± 0.021	0.809TyrIle: 0.809 ± 0.033	0.45TyrLys: 0.45 ± 0.024	2.292TyrLeu: 2.292 ± 0.045	0.432TyrMet: 0.432 ± 0.024	0.521TyrAsn: 0.521 ± 0.023	1.052TyrPro: 1.052 ± 0.034	0.665TyrGln: 0.665 ± 0.023	1.645TyrArg: 1.645 ± 0.037	1.018TyrSer: 1.018 ± 0.031	0.994TyrThr: 0.994 ± 0.034	1.415TyrVal: 1.415 ± 0.039	0.324TyrTrp: 0.324 ± 0.017	0.548TyrTyr: 0.548 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3345 proteins (1059547 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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