Amino acid dipepetide frequency for Changjiang picorna-like virus 6

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.076AlaAla: 9.076 ± 1.112
1.238AlaCys: 1.238 ± 0.013
2.888AlaAsp: 2.888 ± 0.787
2.888AlaGlu: 2.888 ± 1.662
3.713AlaPhe: 3.713 ± 0.038
8.251AlaGly: 8.251 ± 1.512
2.063AlaHis: 2.063 ± 0.225
3.3AlaIle: 3.3 ± 0.85
3.3AlaLys: 3.3 ± 0.987
6.601AlaLeu: 6.601 ± 1.362
3.713AlaMet: 3.713 ± 1.187
4.125AlaAsn: 4.125 ± 0.45
7.426AlaPro: 7.426 ± 0.075
1.65AlaGln: 1.65 ± 0.187
2.888AlaArg: 2.888 ± 1.399
7.426AlaSer: 7.426 ± 0.537
7.838AlaThr: 7.838 ± 4.16
6.188AlaVal: 6.188 ± 1.162
1.238AlaTrp: 1.238 ± 0.013
2.475AlaTyr: 2.475 ± 0.025
0.0AlaXaa: 0.0 ± 0.0
Cys
1.238CysAla: 1.238 ± 0.013
0.0CysCys: 0.0 ± 0.0
0.413CysAsp: 0.413 ± 0.2
0.825CysGlu: 0.825 ± 0.212
1.238CysPhe: 1.238 ± 0.625
0.825CysGly: 0.825 ± 0.4
0.0CysHis: 0.0 ± 0.0
0.413CysIle: 0.413 ± 0.2
0.0CysLys: 0.0 ± 0.0
0.0CysLeu: 0.0 ± 0.0
0.825CysMet: 0.825 ± 0.4
1.238CysAsn: 1.238 ± 0.013
1.238CysPro: 1.238 ± 0.6
0.825CysGln: 0.825 ± 0.212
0.0CysArg: 0.0 ± 0.0
0.825CysSer: 0.825 ± 0.212
0.413CysThr: 0.413 ± 0.2
1.238CysVal: 1.238 ± 0.013
0.0CysTrp: 0.0 ± 0.0
0.413CysTyr: 0.413 ± 0.2
0.0CysXaa: 0.0 ± 0.0
Asp
4.538AspAla: 4.538 ± 1.474
0.825AspCys: 0.825 ± 0.4
3.713AspAsp: 3.713 ± 0.038
3.3AspGlu: 3.3 ± 0.375
2.888AspPhe: 2.888 ± 1.399
4.538AspGly: 4.538 ± 0.974
0.0AspHis: 0.0 ± 0.0
4.95AspIle: 4.95 ± 0.05
4.538AspLys: 4.538 ± 0.974
3.3AspLeu: 3.3 ± 0.85
2.475AspMet: 2.475 ± 0.025
2.475AspAsn: 2.475 ± 0.587
0.413AspPro: 0.413 ± 0.2
0.413AspGln: 0.413 ± 0.412
0.825AspArg: 0.825 ± 0.4
3.3AspSer: 3.3 ± 0.375
2.475AspThr: 2.475 ± 0.025
5.776AspVal: 5.776 ± 1.574
2.475AspTrp: 2.475 ± 0.025
0.825AspTyr: 0.825 ± 0.4
0.0AspXaa: 0.0 ± 0.0
Glu
4.538GluAla: 4.538 ± 0.974
0.413GluCys: 0.413 ± 0.2
2.063GluAsp: 2.063 ± 0.225
2.475GluGlu: 2.475 ± 1.199
2.475GluPhe: 2.475 ± 0.637
2.888GluGly: 2.888 ± 0.787
1.65GluHis: 1.65 ± 0.187
2.063GluIle: 2.063 ± 0.387
2.888GluLys: 2.888 ± 0.787
4.538GluLeu: 4.538 ± 0.974
0.825GluMet: 0.825 ± 0.212
1.65GluAsn: 1.65 ± 0.187
2.475GluPro: 2.475 ± 1.199
0.825GluGln: 0.825 ± 0.212
1.238GluArg: 1.238 ± 0.6
3.3GluSer: 3.3 ± 0.375
2.475GluThr: 2.475 ± 0.025
4.95GluVal: 4.95 ± 1.174
0.0GluTrp: 0.0 ± 0.0
2.475GluTyr: 2.475 ± 0.025
0.0GluXaa: 0.0 ± 0.0
Phe
2.888PheAla: 2.888 ± 2.274
0.825PheCys: 0.825 ± 0.212
4.538PheAsp: 4.538 ± 0.862
4.95PheGlu: 4.95 ± 0.562
0.825PhePhe: 0.825 ± 0.212
2.888PheGly: 2.888 ± 0.437
0.413PheHis: 0.413 ± 0.412
2.063PheIle: 2.063 ± 0.225
2.888PheLys: 2.888 ± 0.437
2.888PheLeu: 2.888 ± 1.399
1.65PheMet: 1.65 ± 0.493
2.888PheAsn: 2.888 ± 0.175
2.475PhePro: 2.475 ± 0.587
3.3PheGln: 3.3 ± 1.462
2.888PheArg: 2.888 ± 1.662
4.125PheSer: 4.125 ± 0.45
4.538PheThr: 4.538 ± 3.311
1.65PheVal: 1.65 ± 0.8
0.413PheTrp: 0.413 ± 0.412
0.413PheTyr: 0.413 ± 0.412
0.0PheXaa: 0.0 ± 0.0
Gly
7.838GlyAla: 7.838 ± 0.125
0.0GlyCys: 0.0 ± 0.0
4.538GlyAsp: 4.538 ± 0.362
3.713GlyGlu: 3.713 ± 0.575
1.238GlyPhe: 1.238 ± 0.625
5.776GlyGly: 5.776 ± 0.962
0.825GlyHis: 0.825 ± 0.212
4.538GlyIle: 4.538 ± 0.974
4.125GlyLys: 4.125 ± 0.162
5.776GlyLeu: 5.776 ± 0.262
1.238GlyMet: 1.238 ± 0.6
3.3GlyAsn: 3.3 ± 2.074
3.713GlyPro: 3.713 ± 0.038
2.063GlyGln: 2.063 ± 0.387
2.475GlyArg: 2.475 ± 0.025
8.663GlySer: 8.663 ± 3.148
4.538GlyThr: 4.538 ± 0.862
4.538GlyVal: 4.538 ± 1.474
0.413GlyTrp: 0.413 ± 0.2
4.538GlyTyr: 4.538 ± 0.362
0.0GlyXaa: 0.0 ± 0.0
His
1.65HisAla: 1.65 ± 0.8
0.0HisCys: 0.0 ± 0.0
0.825HisAsp: 0.825 ± 0.4
0.0HisGlu: 0.0 ± 0.0
0.413HisPhe: 0.413 ± 0.2
1.238HisGly: 1.238 ± 0.013
0.0HisHis: 0.0 ± 0.0
2.475HisIle: 2.475 ± 0.637
1.238HisLys: 1.238 ± 0.6
1.238HisLeu: 1.238 ± 0.6
1.238HisMet: 1.238 ± 0.6
0.0HisAsn: 0.0 ± 0.0
0.825HisPro: 0.825 ± 0.4
0.825HisGln: 0.825 ± 0.212
1.238HisArg: 1.238 ± 0.6
0.825HisSer: 0.825 ± 0.4
0.825HisThr: 0.825 ± 0.825
2.475HisVal: 2.475 ± 0.637
0.0HisTrp: 0.0 ± 0.0
0.825HisTyr: 0.825 ± 0.4
0.0HisXaa: 0.0 ± 0.0
Ile
4.125IleAla: 4.125 ± 0.162
0.413IleCys: 0.413 ± 0.2
2.475IleAsp: 2.475 ± 0.025
0.413IleGlu: 0.413 ± 0.2
1.238IlePhe: 1.238 ± 1.237
6.188IleGly: 6.188 ± 0.063
1.238IleHis: 1.238 ± 0.6
2.888IleIle: 2.888 ± 0.175
1.238IleLys: 1.238 ± 0.013
4.125IleLeu: 4.125 ± 1.387
1.65IleMet: 1.65 ± 0.425
2.475IleAsn: 2.475 ± 1.199
2.475IlePro: 2.475 ± 1.249
1.65IleGln: 1.65 ± 0.187
1.65IleArg: 1.65 ± 0.8
5.776IleSer: 5.776 ± 0.875
4.95IleThr: 4.95 ± 0.05
3.713IleVal: 3.713 ± 0.65
0.413IleTrp: 0.413 ± 0.2
0.825IleTyr: 0.825 ± 0.212
0.0IleXaa: 0.0 ± 0.0
Lys
3.713LysAla: 3.713 ± 0.575
0.0LysCys: 0.0 ± 0.0
4.538LysAsp: 4.538 ± 2.199
2.063LysGlu: 2.063 ± 0.999
2.888LysPhe: 2.888 ± 0.175
3.713LysGly: 3.713 ± 1.187
0.413LysHis: 0.413 ± 0.2
1.65LysIle: 1.65 ± 0.187
2.063LysLys: 2.063 ± 0.225
4.125LysLeu: 4.125 ± 0.45
2.475LysMet: 2.475 ± 1.249
1.238LysAsn: 1.238 ± 0.013
2.888LysPro: 2.888 ± 0.175
4.95LysGln: 4.95 ± 0.562
2.475LysArg: 2.475 ± 1.199
2.888LysSer: 2.888 ± 0.175
3.713LysThr: 3.713 ± 0.038
4.538LysVal: 4.538 ± 0.974
0.413LysTrp: 0.413 ± 0.2
2.888LysTyr: 2.888 ± 0.437
0.0LysXaa: 0.0 ± 0.0
Leu
7.838LeuAla: 7.838 ± 1.961
0.825LeuCys: 0.825 ± 0.212
4.125LeuAsp: 4.125 ± 0.775
2.888LeuGlu: 2.888 ± 0.787
3.713LeuPhe: 3.713 ± 0.575
6.601LeuGly: 6.601 ± 0.137
0.825LeuHis: 0.825 ± 0.4
3.713LeuIle: 3.713 ± 1.187
5.363LeuLys: 5.363 ± 0.762
4.125LeuLeu: 4.125 ± 0.162
2.888LeuMet: 2.888 ± 0.787
3.713LeuAsn: 3.713 ± 0.575
3.713LeuPro: 3.713 ± 1.262
1.65LeuGln: 1.65 ± 0.8
4.125LeuArg: 4.125 ± 0.775
3.713LeuSer: 3.713 ± 0.038
7.426LeuThr: 7.426 ± 0.687
4.538LeuVal: 4.538 ± 0.362
1.65LeuTrp: 1.65 ± 0.8
1.65LeuTyr: 1.65 ± 0.425
0.0LeuXaa: 0.0 ± 0.0
Met
1.238MetAla: 1.238 ± 0.6
0.825MetCys: 0.825 ± 0.4
1.65MetAsp: 1.65 ± 0.8
1.238MetGlu: 1.238 ± 0.625
1.238MetPhe: 1.238 ± 1.237
1.238MetGly: 1.238 ± 0.013
1.65MetHis: 1.65 ± 0.187
2.063MetIle: 2.063 ± 0.225
2.063MetLys: 2.063 ± 0.387
2.063MetLeu: 2.063 ± 0.999
0.825MetMet: 0.825 ± 0.825
0.413MetAsn: 0.413 ± 0.2
2.475MetPro: 2.475 ± 0.025
1.238MetGln: 1.238 ± 0.013
2.063MetArg: 2.063 ± 0.387
2.475MetSer: 2.475 ± 0.587
0.825MetThr: 0.825 ± 0.212
2.888MetVal: 2.888 ± 0.787
0.825MetTrp: 0.825 ± 0.4
2.475MetTyr: 2.475 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
4.95AsnAla: 4.95 ± 0.05
0.413AsnCys: 0.413 ± 0.2
2.063AsnAsp: 2.063 ± 0.387
2.475AsnGlu: 2.475 ± 0.025
1.238AsnPhe: 1.238 ± 0.625
2.888AsnGly: 2.888 ± 0.437
0.413AsnHis: 0.413 ± 0.2
3.3AsnIle: 3.3 ± 0.237
2.475AsnLys: 2.475 ± 0.587
2.888AsnLeu: 2.888 ± 0.787
1.238AsnMet: 1.238 ± 0.013
1.65AsnAsn: 1.65 ± 0.425
1.238AsnPro: 1.238 ± 0.625
1.238AsnGln: 1.238 ± 0.013
2.063AsnArg: 2.063 ± 0.387
3.3AsnSer: 3.3 ± 0.85
2.888AsnThr: 2.888 ± 1.049
3.3AsnVal: 3.3 ± 0.237
0.413AsnTrp: 0.413 ± 0.2
1.238AsnTyr: 1.238 ± 0.625
0.0AsnXaa: 0.0 ± 0.0
Pro
2.063ProAla: 2.063 ± 0.387
0.825ProCys: 0.825 ± 0.4
1.65ProAsp: 1.65 ± 1.649
1.65ProGlu: 1.65 ± 0.8
3.3ProPhe: 3.3 ± 2.074
3.3ProGly: 3.3 ± 0.85
1.238ProHis: 1.238 ± 0.013
2.475ProIle: 2.475 ± 1.249
2.475ProLys: 2.475 ± 1.199
6.188ProLeu: 6.188 ± 1.162
1.238ProMet: 1.238 ± 0.6
2.475ProAsn: 2.475 ± 2.474
2.063ProPro: 2.063 ± 0.225
0.825ProGln: 0.825 ± 0.4
1.238ProArg: 1.238 ± 0.013
5.363ProSer: 5.363 ± 2.911
2.888ProThr: 2.888 ± 0.175
3.3ProVal: 3.3 ± 0.987
1.65ProTrp: 1.65 ± 0.425
2.063ProTyr: 2.063 ± 0.225
0.0ProXaa: 0.0 ± 0.0
Gln
2.475GlnAla: 2.475 ± 1.249
0.0GlnCys: 0.0 ± 0.0
1.65GlnAsp: 1.65 ± 0.187
1.65GlnGlu: 1.65 ± 0.187
1.238GlnPhe: 1.238 ± 0.625
1.238GlnGly: 1.238 ± 0.625
0.413GlnHis: 0.413 ± 0.2
0.825GlnIle: 0.825 ± 0.212
1.65GlnLys: 1.65 ± 0.187
1.65GlnLeu: 1.65 ± 0.187
0.825GlnMet: 0.825 ± 0.212
1.65GlnAsn: 1.65 ± 0.425
0.825GlnPro: 0.825 ± 0.4
0.0GlnGln: 0.0 ± 0.0
2.063GlnArg: 2.063 ± 0.387
4.125GlnSer: 4.125 ± 1.387
1.65GlnThr: 1.65 ± 1.649
3.713GlnVal: 3.713 ± 1.187
1.65GlnTrp: 1.65 ± 0.8
1.238GlnTyr: 1.238 ± 0.013
0.0GlnXaa: 0.0 ± 0.0
Arg
4.125ArgAla: 4.125 ± 1.387
0.413ArgCys: 0.413 ± 0.2
4.125ArgAsp: 4.125 ± 0.775
1.65ArgGlu: 1.65 ± 0.187
2.063ArgPhe: 2.063 ± 0.999
2.888ArgGly: 2.888 ± 1.049
0.413ArgHis: 0.413 ± 0.2
0.825ArgIle: 0.825 ± 0.4
3.713ArgLys: 3.713 ± 0.575
4.95ArgLeu: 4.95 ± 0.562
1.238ArgMet: 1.238 ± 0.013
1.238ArgAsn: 1.238 ± 0.013
2.063ArgPro: 2.063 ± 0.225
1.238ArgGln: 1.238 ± 0.6
3.713ArgArg: 3.713 ± 1.187
2.475ArgSer: 2.475 ± 0.587
2.063ArgThr: 2.063 ± 0.999
5.363ArgVal: 5.363 ± 0.462
0.0ArgTrp: 0.0 ± 0.0
3.713ArgTyr: 3.713 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
6.188SerAla: 6.188 ± 1.899
0.825SerCys: 0.825 ± 0.212
4.125SerAsp: 4.125 ± 0.45
5.363SerGlu: 5.363 ± 1.374
7.838SerPhe: 7.838 ± 2.324
3.713SerGly: 3.713 ± 1.262
1.65SerHis: 1.65 ± 0.187
2.888SerIle: 2.888 ± 0.437
4.95SerLys: 4.95 ± 0.662
5.363SerLeu: 5.363 ± 0.462
3.3SerMet: 3.3 ± 0.375
3.713SerAsn: 3.713 ± 0.038
3.713SerPro: 3.713 ± 3.098
1.238SerGln: 1.238 ± 0.013
6.188SerArg: 6.188 ± 0.55
3.713SerSer: 3.713 ± 1.262
3.713SerThr: 3.713 ± 0.65
4.538SerVal: 4.538 ± 0.974
0.413SerTrp: 0.413 ± 0.2
2.475SerTyr: 2.475 ± 0.587
0.0SerXaa: 0.0 ± 0.0
Thr
7.013ThrAla: 7.013 ± 4.56
1.65ThrCys: 1.65 ± 0.187
3.3ThrAsp: 3.3 ± 0.375
2.063ThrGlu: 2.063 ± 0.999
4.95ThrPhe: 4.95 ± 1.887
4.95ThrGly: 4.95 ± 2.499
0.825ThrHis: 0.825 ± 0.4
3.713ThrIle: 3.713 ± 0.038
2.063ThrLys: 2.063 ± 0.837
6.188ThrLeu: 6.188 ± 0.063
1.65ThrMet: 1.65 ± 0.425
2.475ThrAsn: 2.475 ± 0.025
2.475ThrPro: 2.475 ± 1.249
2.475ThrGln: 2.475 ± 0.025
2.888ThrArg: 2.888 ± 0.437
5.363ThrSer: 5.363 ± 1.687
9.488ThrThr: 9.488 ± 2.749
7.426ThrVal: 7.426 ± 1.912
0.825ThrTrp: 0.825 ± 0.212
0.413ThrTyr: 0.413 ± 0.2
0.0ThrXaa: 0.0 ± 0.0
Val
7.838ValAla: 7.838 ± 1.961
0.825ValCys: 0.825 ± 0.825
3.713ValAsp: 3.713 ± 0.038
4.538ValGlu: 4.538 ± 0.974
4.125ValPhe: 4.125 ± 0.45
8.251ValGly: 8.251 ± 0.325
2.888ValHis: 2.888 ± 1.399
3.3ValIle: 3.3 ± 0.987
4.125ValLys: 4.125 ± 0.775
4.125ValLeu: 4.125 ± 1.387
1.238ValMet: 1.238 ± 0.6
3.3ValAsn: 3.3 ± 0.375
3.713ValPro: 3.713 ± 1.262
2.063ValGln: 2.063 ± 0.387
4.95ValArg: 4.95 ± 1.174
6.188ValSer: 6.188 ± 1.287
4.538ValThr: 4.538 ± 0.862
5.363ValVal: 5.363 ± 0.762
0.413ValTrp: 0.413 ± 0.2
2.888ValTyr: 2.888 ± 0.175
0.0ValXaa: 0.0 ± 0.0
Trp
1.238TrpAla: 1.238 ± 0.6
0.413TrpCys: 0.413 ± 0.2
0.825TrpAsp: 0.825 ± 0.4
1.238TrpGlu: 1.238 ± 0.6
1.65TrpPhe: 1.65 ± 0.425
0.413TrpGly: 0.413 ± 0.2
0.825TrpHis: 0.825 ± 0.212
0.413TrpIle: 0.413 ± 0.2
0.825TrpLys: 0.825 ± 0.4
1.65TrpLeu: 1.65 ± 0.187
0.0TrpMet: 0.0 ± 0.0
0.825TrpAsn: 0.825 ± 0.212
0.413TrpPro: 0.413 ± 0.412
0.413TrpGln: 0.413 ± 0.2
1.65TrpArg: 1.65 ± 0.425
0.0TrpSer: 0.0 ± 0.0
0.413TrpThr: 0.413 ± 0.2
0.825TrpVal: 0.825 ± 0.4
0.0TrpTrp: 0.0 ± 0.0
0.825TrpTyr: 0.825 ± 0.212
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.713TyrAla: 3.713 ± 0.575
1.238TyrCys: 1.238 ± 0.013
0.825TyrAsp: 0.825 ± 0.4
0.825TyrGlu: 0.825 ± 0.4
1.65TyrPhe: 1.65 ± 0.8
2.063TyrGly: 2.063 ± 0.225
0.413TyrHis: 0.413 ± 0.412
2.063TyrIle: 2.063 ± 0.225
1.65TyrLys: 1.65 ± 0.187
3.3TyrLeu: 3.3 ± 0.85
0.825TyrMet: 0.825 ± 0.4
0.825TyrAsn: 0.825 ± 0.4
1.65TyrPro: 1.65 ± 0.187
1.65TyrGln: 1.65 ± 1.037
1.65TyrArg: 1.65 ± 0.425
2.063TyrSer: 2.063 ± 0.225
4.538TyrThr: 4.538 ± 0.862
2.063TyrVal: 2.063 ± 0.999
1.65TyrTrp: 1.65 ± 0.425
2.888TyrTyr: 2.888 ± 0.175
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (2425 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski