Amino acid dipepetide frequency for Afifella marina DSM 2698

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.116AlaAla: 17.116 ± 0.179
1.039AlaCys: 1.039 ± 0.031
6.785AlaAsp: 6.785 ± 0.089
8.996AlaGlu: 8.996 ± 0.111
4.798AlaPhe: 4.798 ± 0.08
10.887AlaGly: 10.887 ± 0.112
2.281AlaHis: 2.281 ± 0.048
6.733AlaIle: 6.733 ± 0.077
4.006AlaLys: 4.006 ± 0.062
13.585AlaLeu: 13.585 ± 0.129
3.378AlaMet: 3.378 ± 0.053
2.628AlaAsn: 2.628 ± 0.05
5.45AlaPro: 5.45 ± 0.075
3.51AlaGln: 3.51 ± 0.057
8.67AlaArg: 8.67 ± 0.1
6.681AlaSer: 6.681 ± 0.081
5.741AlaThr: 5.741 ± 0.071
8.606AlaVal: 8.606 ± 0.092
1.39AlaTrp: 1.39 ± 0.036
2.542AlaTyr: 2.542 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
0.902CysAla: 0.902 ± 0.029
0.096CysCys: 0.096 ± 0.009
0.513CysAsp: 0.513 ± 0.022
0.437CysGlu: 0.437 ± 0.018
0.325CysPhe: 0.325 ± 0.017
0.912CysGly: 0.912 ± 0.033
0.276CysHis: 0.276 ± 0.017
0.336CysIle: 0.336 ± 0.015
0.141CysLys: 0.141 ± 0.01
0.845CysLeu: 0.845 ± 0.028
0.13CysMet: 0.13 ± 0.011
0.188CysAsn: 0.188 ± 0.014
0.417CysPro: 0.417 ± 0.019
0.206CysGln: 0.206 ± 0.014
0.659CysArg: 0.659 ± 0.02
0.388CysSer: 0.388 ± 0.02
0.345CysThr: 0.345 ± 0.017
0.602CysVal: 0.602 ± 0.025
0.095CysTrp: 0.095 ± 0.008
0.175CysTyr: 0.175 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
6.421AspAla: 6.421 ± 0.082
0.466AspCys: 0.466 ± 0.024
3.322AspAsp: 3.322 ± 0.078
4.374AspGlu: 4.374 ± 0.066
2.364AspPhe: 2.364 ± 0.055
5.138AspGly: 5.138 ± 0.084
1.17AspHis: 1.17 ± 0.034
2.996AspIle: 2.996 ± 0.051
1.862AspLys: 1.862 ± 0.045
6.055AspLeu: 6.055 ± 0.086
1.277AspMet: 1.277 ± 0.033
1.291AspAsn: 1.291 ± 0.035
3.459AspPro: 3.459 ± 0.058
1.638AspGln: 1.638 ± 0.037
4.202AspArg: 4.202 ± 0.05
2.008AspSer: 2.008 ± 0.04
2.542AspThr: 2.542 ± 0.06
4.225AspVal: 4.225 ± 0.066
0.918AspTrp: 0.918 ± 0.032
1.401AspTyr: 1.401 ± 0.037
0.0AspXaa: 0.0 ± 0.0
Glu
9.314GluAla: 9.314 ± 0.092
0.348GluCys: 0.348 ± 0.019
3.457GluAsp: 3.457 ± 0.061
4.833GluGlu: 4.833 ± 0.077
1.798GluPhe: 1.798 ± 0.045
5.17GluGly: 5.17 ± 0.069
1.327GluHis: 1.327 ± 0.037
3.998GluIle: 3.998 ± 0.071
2.854GluLys: 2.854 ± 0.061
5.705GluLeu: 5.705 ± 0.079
1.697GluMet: 1.697 ± 0.039
1.814GluAsn: 1.814 ± 0.041
3.24GluPro: 3.24 ± 0.061
1.777GluGln: 1.777 ± 0.047
5.881GluArg: 5.881 ± 0.091
2.569GluSer: 2.569 ± 0.052
4.365GluThr: 4.365 ± 0.074
4.328GluVal: 4.328 ± 0.074
0.732GluTrp: 0.732 ± 0.026
0.984GluTyr: 0.984 ± 0.032
0.0GluXaa: 0.0 ± 0.0
Phe
4.814PheAla: 4.814 ± 0.071
0.415PheCys: 0.415 ± 0.02
2.563PheAsp: 2.563 ± 0.045
2.211PheGlu: 2.211 ± 0.042
1.604PhePhe: 1.604 ± 0.039
3.865PheGly: 3.865 ± 0.066
0.768PheHis: 0.768 ± 0.027
1.733PheIle: 1.733 ± 0.042
0.969PheLys: 0.969 ± 0.031
3.945PheLeu: 3.945 ± 0.07
0.837PheMet: 0.837 ± 0.029
0.948PheAsn: 0.948 ± 0.028
1.612PhePro: 1.612 ± 0.034
0.979PheGln: 0.979 ± 0.027
2.344PheArg: 2.344 ± 0.046
2.402PheSer: 2.402 ± 0.041
1.911PheThr: 1.911 ± 0.039
3.038PheVal: 3.038 ± 0.053
0.56PheTrp: 0.56 ± 0.021
0.918PheTyr: 0.918 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
9.353GlyAla: 9.353 ± 0.104
0.773GlyCys: 0.773 ± 0.027
4.668GlyAsp: 4.668 ± 0.085
5.909GlyGlu: 5.909 ± 0.073
3.719GlyPhe: 3.719 ± 0.058
7.391GlyGly: 7.391 ± 0.138
1.924GlyHis: 1.924 ± 0.043
4.408GlyIle: 4.408 ± 0.066
2.893GlyLys: 2.893 ± 0.053
9.072GlyLeu: 9.072 ± 0.1
2.158GlyMet: 2.158 ± 0.044
2.026GlyAsn: 2.026 ± 0.052
3.543GlyPro: 3.543 ± 0.066
2.483GlyGln: 2.483 ± 0.047
6.597GlyArg: 6.597 ± 0.095
4.695GlySer: 4.695 ± 0.068
4.309GlyThr: 4.309 ± 0.068
5.968GlyVal: 5.968 ± 0.067
1.241GlyTrp: 1.241 ± 0.034
2.084GlyTyr: 2.084 ± 0.043
0.0GlyXaa: 0.0 ± 0.0
His
2.175HisAla: 2.175 ± 0.046
0.24HisCys: 0.24 ± 0.015
1.22HisAsp: 1.22 ± 0.037
1.216HisGlu: 1.216 ± 0.035
0.862HisPhe: 0.862 ± 0.025
1.836HisGly: 1.836 ± 0.044
0.567HisHis: 0.567 ± 0.024
0.95HisIle: 0.95 ± 0.029
0.477HisLys: 0.477 ± 0.018
2.173HisLeu: 2.173 ± 0.045
0.452HisMet: 0.452 ± 0.02
0.438HisAsn: 0.438 ± 0.019
1.36HisPro: 1.36 ± 0.036
0.584HisGln: 0.584 ± 0.018
1.466HisArg: 1.466 ± 0.041
0.951HisSer: 0.951 ± 0.029
0.762HisThr: 0.762 ± 0.027
1.428HisVal: 1.428 ± 0.037
0.258HisTrp: 0.258 ± 0.016
0.534HisTyr: 0.534 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
7.321IleAla: 7.321 ± 0.076
0.465IleCys: 0.465 ± 0.02
3.614IleAsp: 3.614 ± 0.062
3.505IleGlu: 3.505 ± 0.056
1.895IlePhe: 1.895 ± 0.05
5.046IleGly: 5.046 ± 0.057
0.86IleHis: 0.86 ± 0.027
2.264IleIle: 2.264 ± 0.048
1.291IleLys: 1.291 ± 0.033
4.943IleLeu: 4.943 ± 0.07
0.903IleMet: 0.903 ± 0.028
1.264IleAsn: 1.264 ± 0.035
2.188IlePro: 2.188 ± 0.046
1.017IleGln: 1.017 ± 0.032
3.194IleArg: 3.194 ± 0.051
3.039IleSer: 3.039 ± 0.059
2.47IleThr: 2.47 ± 0.044
4.479IleVal: 4.479 ± 0.071
0.587IleTrp: 0.587 ± 0.027
1.132IleTyr: 1.132 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
4.267LysAla: 4.267 ± 0.073
0.145LysCys: 0.145 ± 0.012
1.749LysAsp: 1.749 ± 0.042
2.063LysGlu: 2.063 ± 0.051
0.697LysPhe: 0.697 ± 0.027
2.569LysGly: 2.569 ± 0.05
0.54LysHis: 0.54 ± 0.025
1.677LysIle: 1.677 ± 0.036
1.284LysLys: 1.284 ± 0.043
3.158LysLeu: 3.158 ± 0.053
0.765LysMet: 0.765 ± 0.027
0.85LysAsn: 0.85 ± 0.025
2.013LysPro: 2.013 ± 0.051
0.836LysGln: 0.836 ± 0.03
2.507LysArg: 2.507 ± 0.05
1.87LysSer: 1.87 ± 0.039
1.974LysThr: 1.974 ± 0.039
2.437LysVal: 2.437 ± 0.056
0.283LysTrp: 0.283 ± 0.013
0.557LysTyr: 0.557 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
14.029LeuAla: 14.029 ± 0.142
0.875LeuCys: 0.875 ± 0.032
5.811LeuAsp: 5.811 ± 0.071
5.598LeuGlu: 5.598 ± 0.07
3.914LeuPhe: 3.914 ± 0.077
8.266LeuGly: 8.266 ± 0.102
1.77LeuHis: 1.77 ± 0.044
5.15LeuIle: 5.15 ± 0.077
3.916LeuLys: 3.916 ± 0.066
9.648LeuLeu: 9.648 ± 0.119
2.207LeuMet: 2.207 ± 0.048
2.335LeuAsn: 2.335 ± 0.044
5.647LeuPro: 5.647 ± 0.08
2.727LeuGln: 2.727 ± 0.051
6.908LeuArg: 6.908 ± 0.078
6.989LeuSer: 6.989 ± 0.082
5.461LeuThr: 5.461 ± 0.075
7.915LeuVal: 7.915 ± 0.091
1.145LeuTrp: 1.145 ± 0.033
2.105LeuTyr: 2.105 ± 0.046
0.0LeuXaa: 0.0 ± 0.0
Met
3.045MetAla: 3.045 ± 0.052
0.134MetCys: 0.134 ± 0.01
1.055MetAsp: 1.055 ± 0.027
1.218MetGlu: 1.218 ± 0.032
0.633MetPhe: 0.633 ± 0.025
1.643MetGly: 1.643 ± 0.042
0.441MetHis: 0.441 ± 0.019
1.242MetIle: 1.242 ± 0.038
0.88MetLys: 0.88 ± 0.029
2.271MetLeu: 2.271 ± 0.042
0.649MetMet: 0.649 ± 0.027
0.709MetAsn: 0.709 ± 0.026
1.502MetPro: 1.502 ± 0.035
0.871MetGln: 0.871 ± 0.024
1.991MetArg: 1.991 ± 0.047
1.639MetSer: 1.639 ± 0.035
1.681MetThr: 1.681 ± 0.036
1.65MetVal: 1.65 ± 0.035
0.207MetTrp: 0.207 ± 0.016
0.26MetTyr: 0.26 ± 0.015
0.0MetXaa: 0.0 ± 0.0
Asn
2.958AsnAla: 2.958 ± 0.051
0.213AsnCys: 0.213 ± 0.013
1.365AsnAsp: 1.365 ± 0.043
1.458AsnGlu: 1.458 ± 0.037
0.928AsnPhe: 0.928 ± 0.029
2.18AsnGly: 2.18 ± 0.048
0.446AsnHis: 0.446 ± 0.019
1.249AsnIle: 1.249 ± 0.032
0.639AsnLys: 0.639 ± 0.024
2.491AsnLeu: 2.491 ± 0.051
0.544AsnMet: 0.544 ± 0.022
0.59AsnAsn: 0.59 ± 0.024
1.618AsnPro: 1.618 ± 0.041
0.655AsnGln: 0.655 ± 0.026
1.725AsnArg: 1.725 ± 0.041
1.127AsnSer: 1.127 ± 0.031
1.106AsnThr: 1.106 ± 0.035
1.924AsnVal: 1.924 ± 0.041
0.372AsnTrp: 0.372 ± 0.017
0.607AsnTyr: 0.607 ± 0.026
0.0AsnXaa: 0.0 ± 0.0
Pro
6.146ProAla: 6.146 ± 0.082
0.305ProCys: 0.305 ± 0.017
3.562ProAsp: 3.562 ± 0.064
4.358ProGlu: 4.358 ± 0.064
2.164ProPhe: 2.164 ± 0.048
4.342ProGly: 4.342 ± 0.063
1.108ProHis: 1.108 ± 0.032
2.364ProIle: 2.364 ± 0.041
1.694ProLys: 1.694 ± 0.041
4.905ProLeu: 4.905 ± 0.068
1.063ProMet: 1.063 ± 0.027
1.293ProAsn: 1.293 ± 0.035
2.462ProPro: 2.462 ± 0.067
1.741ProGln: 1.741 ± 0.04
2.95ProArg: 2.95 ± 0.052
2.914ProSer: 2.914 ± 0.062
2.312ProThr: 2.312 ± 0.05
3.963ProVal: 3.963 ± 0.06
0.644ProTrp: 0.644 ± 0.025
1.186ProTyr: 1.186 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
3.921GlnAla: 3.921 ± 0.074
0.157GlnCys: 0.157 ± 0.012
1.411GlnAsp: 1.411 ± 0.035
1.884GlnGlu: 1.884 ± 0.048
0.866GlnPhe: 0.866 ± 0.026
2.032GlnGly: 2.032 ± 0.04
0.566GlnHis: 0.566 ± 0.027
1.672GlnIle: 1.672 ± 0.04
1.113GlnLys: 1.113 ± 0.032
2.515GlnLeu: 2.515 ± 0.046
0.825GlnMet: 0.825 ± 0.031
0.881GlnAsn: 0.881 ± 0.026
1.599GlnPro: 1.599 ± 0.042
1.001GlnGln: 1.001 ± 0.038
2.221GlnArg: 2.221 ± 0.051
1.648GlnSer: 1.648 ± 0.035
1.632GlnThr: 1.632 ± 0.038
1.915GlnVal: 1.915 ± 0.046
0.341GlnTrp: 0.341 ± 0.018
0.503GlnTyr: 0.503 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
7.838ArgAla: 7.838 ± 0.09
0.508ArgCys: 0.508 ± 0.022
3.994ArgAsp: 3.994 ± 0.063
4.686ArgGlu: 4.686 ± 0.075
3.107ArgPhe: 3.107 ± 0.057
4.895ArgGly: 4.895 ± 0.078
1.789ArgHis: 1.789 ± 0.041
3.955ArgIle: 3.955 ± 0.062
2.239ArgLys: 2.239 ± 0.042
8.664ArgLeu: 8.664 ± 0.111
1.834ArgMet: 1.834 ± 0.037
1.77ArgAsn: 1.77 ± 0.039
3.868ArgPro: 3.868 ± 0.062
2.69ArgGln: 2.69 ± 0.052
6.258ArgArg: 6.258 ± 0.095
3.886ArgSer: 3.886 ± 0.063
3.185ArgThr: 3.185 ± 0.053
4.599ArgVal: 4.599 ± 0.063
0.902ArgTrp: 0.902 ± 0.029
1.705ArgTyr: 1.705 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
6.362SerAla: 6.362 ± 0.097
0.426SerCys: 0.426 ± 0.019
3.303SerAsp: 3.303 ± 0.057
3.712SerGlu: 3.712 ± 0.058
2.394SerPhe: 2.394 ± 0.047
5.789SerGly: 5.789 ± 0.077
1.035SerHis: 1.035 ± 0.029
2.515SerIle: 2.515 ± 0.05
1.472SerLys: 1.472 ± 0.036
5.736SerLeu: 5.736 ± 0.069
1.272SerMet: 1.272 ± 0.032
1.269SerAsn: 1.269 ± 0.032
2.784SerPro: 2.784 ± 0.052
1.598SerGln: 1.598 ± 0.045
3.737SerArg: 3.737 ± 0.057
3.156SerSer: 3.156 ± 0.066
2.454SerThr: 2.454 ± 0.049
4.103SerVal: 4.103 ± 0.065
0.762SerTrp: 0.762 ± 0.026
1.295SerTyr: 1.295 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
6.018ThrAla: 6.018 ± 0.076
0.412ThrCys: 0.412 ± 0.024
2.64ThrAsp: 2.64 ± 0.051
2.828ThrGlu: 2.828 ± 0.05
2.066ThrPhe: 2.066 ± 0.04
4.794ThrGly: 4.794 ± 0.07
0.997ThrHis: 0.997 ± 0.029
2.888ThrIle: 2.888 ± 0.061
1.396ThrLys: 1.396 ± 0.042
5.667ThrLeu: 5.667 ± 0.072
1.154ThrMet: 1.154 ± 0.03
1.195ThrAsn: 1.195 ± 0.03
3.158ThrPro: 3.158 ± 0.055
1.336ThrGln: 1.336 ± 0.038
3.237ThrArg: 3.237 ± 0.049
2.895ThrSer: 2.895 ± 0.054
2.606ThrThr: 2.606 ± 0.05
3.944ThrVal: 3.944 ± 0.063
0.59ThrTrp: 0.59 ± 0.023
1.182ThrTyr: 1.182 ± 0.033
0.0ThrXaa: 0.0 ± 0.0
Val
9.309ValAla: 9.309 ± 0.091
0.614ValCys: 0.614 ± 0.022
4.088ValAsp: 4.088 ± 0.068
4.958ValGlu: 4.958 ± 0.08
2.939ValPhe: 2.939 ± 0.051
5.53ValGly: 5.53 ± 0.074
1.336ValHis: 1.336 ± 0.035
3.886ValIle: 3.886 ± 0.058
2.187ValLys: 2.187 ± 0.049
7.198ValLeu: 7.198 ± 0.087
1.853ValMet: 1.853 ± 0.04
1.784ValAsn: 1.784 ± 0.044
3.818ValPro: 3.818 ± 0.051
1.771ValGln: 1.771 ± 0.038
4.876ValArg: 4.876 ± 0.071
4.46ValSer: 4.46 ± 0.069
4.505ValThr: 4.505 ± 0.066
6.105ValVal: 6.105 ± 0.083
0.856ValTrp: 0.856 ± 0.024
1.477ValTyr: 1.477 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
1.141TrpAla: 1.141 ± 0.034
0.126TrpCys: 0.126 ± 0.01
0.606TrpAsp: 0.606 ± 0.026
0.573TrpGlu: 0.573 ± 0.019
0.461TrpPhe: 0.461 ± 0.023
0.866TrpGly: 0.866 ± 0.029
0.302TrpHis: 0.302 ± 0.016
0.628TrpIle: 0.628 ± 0.023
0.397TrpLys: 0.397 ± 0.021
1.555TrpLeu: 1.555 ± 0.038
0.343TrpMet: 0.343 ± 0.018
0.36TrpAsn: 0.36 ± 0.019
0.692TrpPro: 0.692 ± 0.024
0.581TrpGln: 0.581 ± 0.024
1.154TrpArg: 1.154 ± 0.029
0.748TrpSer: 0.748 ± 0.025
0.65TrpThr: 0.65 ± 0.025
0.753TrpVal: 0.753 ± 0.025
0.224TrpTrp: 0.224 ± 0.014
0.276TrpTyr: 0.276 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.371TyrAla: 2.371 ± 0.045
0.228TyrCys: 0.228 ± 0.013
1.406TyrAsp: 1.406 ± 0.042
1.372TyrGlu: 1.372 ± 0.039
0.902TyrPhe: 0.902 ± 0.033
2.064TyrGly: 2.064 ± 0.049
0.445TyrHis: 0.445 ± 0.02
0.833TyrIle: 0.833 ± 0.029
0.529TyrLys: 0.529 ± 0.024
2.289TyrLeu: 2.289 ± 0.049
0.376TyrMet: 0.376 ± 0.017
0.562TyrAsn: 0.562 ± 0.023
1.048TyrPro: 1.048 ± 0.031
0.703TyrGln: 0.703 ± 0.027
1.796TyrArg: 1.796 ± 0.041
1.112TyrSer: 1.112 ± 0.031
0.994TyrThr: 0.994 ± 0.032
1.568TyrVal: 1.568 ± 0.035
0.326TyrTrp: 0.326 ± 0.018
0.584TyrTyr: 0.584 ± 0.023
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3662 proteins (1182367 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski