Amino acid dipepetide frequency for Pepper enamovirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.685AlaAla: 5.685 ± 1.951
1.55AlaCys: 1.55 ± 0.758
4.651AlaAsp: 4.651 ± 2.956
8.269AlaGlu: 8.269 ± 0.93
3.618AlaPhe: 3.618 ± 1.425
4.651AlaGly: 4.651 ± 0.422
1.55AlaHis: 1.55 ± 0.893
3.618AlaIle: 3.618 ± 0.823
3.618AlaLys: 3.618 ± 0.897
7.752AlaLeu: 7.752 ± 1.194
0.517AlaMet: 0.517 ± 0.816
3.101AlaAsn: 3.101 ± 0.77
6.202AlaPro: 6.202 ± 1.634
3.101AlaGln: 3.101 ± 0.981
6.202AlaArg: 6.202 ± 0.597
5.168AlaSer: 5.168 ± 1.489
5.685AlaThr: 5.685 ± 2.228
4.651AlaVal: 4.651 ± 1.282
1.55AlaTrp: 1.55 ± 0.883
3.618AlaTyr: 3.618 ± 0.344
0.0AlaXaa: 0.0 ± 0.0
Cys
3.101CysAla: 3.101 ± 1.283
1.034CysCys: 1.034 ± 0.498
1.55CysAsp: 1.55 ± 0.508
2.067CysGlu: 2.067 ± 0.678
0.517CysPhe: 0.517 ± 0.816
3.618CysGly: 3.618 ± 0.344
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.517CysLys: 0.517 ± 0.845
3.618CysLeu: 3.618 ± 1.425
0.0CysMet: 0.0 ± 0.0
0.517CysAsn: 0.517 ± 0.845
1.034CysPro: 1.034 ± 0.588
0.517CysGln: 0.517 ± 0.64
0.0CysArg: 0.0 ± 0.0
2.584CysSer: 2.584 ± 0.894
1.55CysThr: 1.55 ± 1.651
2.067CysVal: 2.067 ± 1.177
1.034CysTrp: 1.034 ± 1.689
1.034CysTyr: 1.034 ± 0.498
0.0CysXaa: 0.0 ± 0.0
Asp
2.067AspAla: 2.067 ± 0.995
1.55AspCys: 1.55 ± 0.508
5.168AspAsp: 5.168 ± 2.482
3.618AspGlu: 3.618 ± 0.695
2.584AspPhe: 2.584 ± 0.838
3.101AspGly: 3.101 ± 1.248
0.0AspHis: 0.0 ± 0.0
2.067AspIle: 2.067 ± 1.402
3.101AspLys: 3.101 ± 3.308
4.651AspLeu: 4.651 ± 1.295
0.0AspMet: 0.0 ± 0.0
0.517AspAsn: 0.517 ± 0.64
2.067AspPro: 2.067 ± 1.177
2.067AspGln: 2.067 ± 1.177
2.067AspArg: 2.067 ± 0.668
7.235AspSer: 7.235 ± 2.227
0.0AspThr: 0.0 ± 0.0
2.584AspVal: 2.584 ± 0.844
2.584AspTrp: 2.584 ± 0.962
0.517AspTyr: 0.517 ± 0.845
0.0AspXaa: 0.0 ± 0.0
Glu
5.685GluAla: 5.685 ± 1.894
1.55GluCys: 1.55 ± 0.602
4.651GluAsp: 4.651 ± 0.871
9.302GluGlu: 9.302 ± 3.87
2.584GluPhe: 2.584 ± 0.894
4.651GluGly: 4.651 ± 1.168
1.034GluHis: 1.034 ± 0.498
0.517GluIle: 0.517 ± 0.294
2.584GluLys: 2.584 ± 1.493
7.752GluLeu: 7.752 ± 1.253
1.55GluMet: 1.55 ± 0.526
2.584GluAsn: 2.584 ± 0.844
4.651GluPro: 4.651 ± 1.282
2.067GluGln: 2.067 ± 1.177
4.134GluArg: 4.134 ± 2.354
4.651GluSer: 4.651 ± 2.648
1.034GluThr: 1.034 ± 0.672
3.618GluVal: 3.618 ± 1.237
2.584GluTrp: 2.584 ± 1.085
1.55GluTyr: 1.55 ± 0.758
0.0GluXaa: 0.0 ± 0.0
Phe
2.067PheAla: 2.067 ± 0.678
1.55PheCys: 1.55 ± 0.508
2.584PheAsp: 2.584 ± 0.838
1.034PheGlu: 1.034 ± 0.588
1.55PhePhe: 1.55 ± 0.788
2.067PheGly: 2.067 ± 1.237
0.517PheHis: 0.517 ± 0.294
1.55PheIle: 1.55 ± 0.883
3.101PheLys: 3.101 ± 1.412
2.584PheLeu: 2.584 ± 0.894
0.0PheMet: 0.0 ± 0.0
1.55PheAsn: 1.55 ± 0.602
2.067PhePro: 2.067 ± 0.995
2.584PheGln: 2.584 ± 1.241
2.067PheArg: 2.067 ± 0.888
2.584PheSer: 2.584 ± 1.085
3.101PheThr: 3.101 ± 1.765
4.651PheVal: 4.651 ± 0.871
0.0PheTrp: 0.0 ± 0.0
2.584PheTyr: 2.584 ± 2.031
0.0PheXaa: 0.0 ± 0.0
Gly
5.685GlyAla: 5.685 ± 1.907
2.584GlyCys: 2.584 ± 2.162
3.618GlyAsp: 3.618 ± 1.625
5.685GlyGlu: 5.685 ± 2.022
5.685GlyPhe: 5.685 ± 1.051
7.752GlyGly: 7.752 ± 4.373
1.034GlyHis: 1.034 ± 1.144
2.584GlyIle: 2.584 ± 0.894
4.134GlyLys: 4.134 ± 1.071
7.752GlyLeu: 7.752 ± 1.763
1.034GlyMet: 1.034 ± 0.588
2.584GlyAsn: 2.584 ± 1.46
5.685GlyPro: 5.685 ± 1.37
4.651GlyGln: 4.651 ± 0.988
5.685GlyArg: 5.685 ± 1.84
6.718GlySer: 6.718 ± 3.095
3.101GlyThr: 3.101 ± 0.719
4.134GlyVal: 4.134 ± 1.4
2.584GlyTrp: 2.584 ± 0.542
1.55GlyTyr: 1.55 ± 0.998
0.0GlyXaa: 0.0 ± 0.0
His
1.034HisAla: 1.034 ± 0.588
1.034HisCys: 1.034 ± 0.498
0.517HisAsp: 0.517 ± 0.294
1.034HisGlu: 1.034 ± 0.588
1.034HisPhe: 1.034 ± 0.498
0.0HisGly: 0.0 ± 0.0
0.517HisHis: 0.517 ± 0.64
0.517HisIle: 0.517 ± 0.64
0.517HisLys: 0.517 ± 0.294
2.067HisLeu: 2.067 ± 0.888
1.034HisMet: 1.034 ± 0.496
1.034HisAsn: 1.034 ± 1.281
1.55HisPro: 1.55 ± 0.893
0.517HisGln: 0.517 ± 0.294
0.517HisArg: 0.517 ± 0.294
2.067HisSer: 2.067 ± 2.227
0.517HisThr: 0.517 ± 0.294
0.517HisVal: 0.517 ± 0.294
0.0HisTrp: 0.0 ± 0.0
0.517HisTyr: 0.517 ± 0.294
0.0HisXaa: 0.0 ± 0.0
Ile
3.101IleAla: 3.101 ± 1.153
0.517IleCys: 0.517 ± 0.845
1.034IleAsp: 1.034 ± 1.689
2.584IleGlu: 2.584 ± 0.615
1.034IlePhe: 1.034 ± 0.498
2.584IleGly: 2.584 ± 0.838
0.0IleHis: 0.0 ± 0.0
2.584IleIle: 2.584 ± 0.542
0.517IleLys: 0.517 ± 0.294
1.55IleLeu: 1.55 ± 0.508
0.517IleMet: 0.517 ± 0.294
0.0IleAsn: 0.0 ± 0.0
3.618IlePro: 3.618 ± 1.445
2.067IleGln: 2.067 ± 0.665
1.034IleArg: 1.034 ± 0.588
3.618IleSer: 3.618 ± 2.069
4.134IleThr: 4.134 ± 1.344
1.55IleVal: 1.55 ± 1.498
0.517IleTrp: 0.517 ± 0.294
0.0IleTyr: 0.0 ± 0.0
0.0IleXaa: 0.0 ± 0.0
Lys
5.168LysAla: 5.168 ± 2.102
1.034LysCys: 1.034 ± 0.588
2.584LysAsp: 2.584 ± 0.542
2.584LysGlu: 2.584 ± 0.844
2.584LysPhe: 2.584 ± 2.486
6.202LysGly: 6.202 ± 2.122
0.517LysHis: 0.517 ± 0.294
3.618LysIle: 3.618 ± 1.198
1.55LysLys: 1.55 ± 0.758
3.618LysLeu: 3.618 ± 1.347
1.034LysMet: 1.034 ± 0.665
2.067LysAsn: 2.067 ± 0.665
1.55LysPro: 1.55 ± 0.883
0.517LysGln: 0.517 ± 0.294
2.584LysArg: 2.584 ± 0.838
4.651LysSer: 4.651 ± 2.263
2.584LysThr: 2.584 ± 0.894
1.55LysVal: 1.55 ± 0.758
2.067LysTrp: 2.067 ± 2.337
0.0LysTyr: 0.0 ± 0.0
0.0LysXaa: 0.0 ± 0.0
Leu
8.786LeuAla: 8.786 ± 2.195
2.584LeuCys: 2.584 ± 0.615
2.584LeuAsp: 2.584 ± 0.962
8.786LeuGlu: 8.786 ± 2.078
3.618LeuPhe: 3.618 ± 1.425
8.269LeuGly: 8.269 ± 2.425
2.584LeuHis: 2.584 ± 0.962
1.034LeuIle: 1.034 ± 0.588
5.168LeuLys: 5.168 ± 2.229
9.819LeuLeu: 9.819 ± 4.251
2.067LeuMet: 2.067 ± 1.177
2.584LeuAsn: 2.584 ± 0.542
5.685LeuPro: 5.685 ± 0.352
3.618LeuGln: 3.618 ± 1.572
6.718LeuArg: 6.718 ± 2.282
7.752LeuSer: 7.752 ± 2.277
5.685LeuThr: 5.685 ± 1.272
7.235LeuVal: 7.235 ± 2.366
3.618LeuTrp: 3.618 ± 0.849
3.618LeuTyr: 3.618 ± 1.795
0.0LeuXaa: 0.0 ± 0.0
Met
1.55MetAla: 1.55 ± 1.52
0.0MetCys: 0.0 ± 0.0
0.0MetAsp: 0.0 ± 0.0
0.517MetGlu: 0.517 ± 0.294
0.0MetPhe: 0.0 ± 0.0
2.067MetGly: 2.067 ± 0.995
0.0MetHis: 0.0 ± 0.0
0.0MetIle: 0.0 ± 0.0
1.55MetLys: 1.55 ± 1.498
3.101MetLeu: 3.101 ± 1.318
0.0MetMet: 0.0 ± 0.0
0.0MetAsn: 0.0 ± 0.0
1.034MetPro: 1.034 ± 0.73
0.517MetGln: 0.517 ± 0.294
2.067MetArg: 2.067 ± 0.665
0.517MetSer: 0.517 ± 0.294
0.517MetThr: 0.517 ± 0.294
1.034MetVal: 1.034 ± 0.588
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
1.55AsnAla: 1.55 ± 1.928
0.517AsnCys: 0.517 ± 0.294
2.067AsnAsp: 2.067 ± 1.699
0.517AsnGlu: 0.517 ± 0.294
0.517AsnPhe: 0.517 ± 0.294
4.134AsnGly: 4.134 ± 3.39
0.517AsnHis: 0.517 ± 0.64
0.0AsnIle: 0.0 ± 0.0
1.034AsnLys: 1.034 ± 0.588
3.101AsnLeu: 3.101 ± 0.55
0.0AsnMet: 0.0 ± 0.0
1.034AsnAsn: 1.034 ± 1.001
2.067AsnPro: 2.067 ± 1.177
1.034AsnGln: 1.034 ± 1.215
3.618AsnArg: 3.618 ± 0.344
3.101AsnSer: 3.101 ± 2.217
1.034AsnThr: 1.034 ± 0.588
2.067AsnVal: 2.067 ± 0.665
0.517AsnTrp: 0.517 ± 0.294
1.55AsnTyr: 1.55 ± 2.534
0.0AsnXaa: 0.0 ± 0.0
Pro
5.168ProAla: 5.168 ± 1.017
1.034ProCys: 1.034 ± 1.281
4.134ProAsp: 4.134 ± 1.071
1.55ProGlu: 1.55 ± 0.883
0.517ProPhe: 0.517 ± 0.64
7.752ProGly: 7.752 ± 1.794
2.067ProHis: 2.067 ± 0.995
3.618ProIle: 3.618 ± 0.849
3.101ProLys: 3.101 ± 1.318
5.168ProLeu: 5.168 ± 1.018
0.0ProMet: 0.0 ± 0.0
0.517ProAsn: 0.517 ± 0.294
4.651ProPro: 4.651 ± 1.524
1.55ProGln: 1.55 ± 0.508
4.651ProArg: 4.651 ± 1.955
7.235ProSer: 7.235 ± 1.771
3.101ProThr: 3.101 ± 0.719
3.101ProVal: 3.101 ± 0.888
0.517ProTrp: 0.517 ± 0.294
2.067ProTyr: 2.067 ± 1.127
0.0ProXaa: 0.0 ± 0.0
Gln
5.168GlnAla: 5.168 ± 1.574
1.034GlnCys: 1.034 ± 0.73
0.517GlnAsp: 0.517 ± 0.294
3.101GlnGlu: 3.101 ± 1.153
1.55GlnPhe: 1.55 ± 0.758
3.101GlnGly: 3.101 ± 1.153
0.517GlnHis: 0.517 ± 0.294
1.55GlnIle: 1.55 ± 0.883
1.034GlnLys: 1.034 ± 0.588
2.584GlnLeu: 2.584 ± 0.894
0.517GlnMet: 0.517 ± 0.294
0.517GlnAsn: 0.517 ± 0.294
2.067GlnPro: 2.067 ± 0.678
0.517GlnGln: 0.517 ± 0.294
1.55GlnArg: 1.55 ± 0.508
5.168GlnSer: 5.168 ± 1.018
1.55GlnThr: 1.55 ± 0.758
1.55GlnVal: 1.55 ± 0.602
0.517GlnTrp: 0.517 ± 0.816
0.517GlnTyr: 0.517 ± 0.845
0.0GlnXaa: 0.0 ± 0.0
Arg
7.235ArgAla: 7.235 ± 2.406
1.034ArgCys: 1.034 ± 0.588
2.067ArgAsp: 2.067 ± 0.668
4.651ArgGlu: 4.651 ± 2.648
2.584ArgPhe: 2.584 ± 0.542
3.101ArgGly: 3.101 ± 1.248
1.034ArgHis: 1.034 ± 0.498
1.034ArgIle: 1.034 ± 0.588
4.651ArgLys: 4.651 ± 1.861
8.269ArgLeu: 8.269 ± 1.231
1.034ArgMet: 1.034 ± 0.73
2.584ArgAsn: 2.584 ± 1.46
4.651ArgPro: 4.651 ± 2.365
1.55ArgGln: 1.55 ± 0.883
6.718ArgArg: 6.718 ± 5.084
4.651ArgSer: 4.651 ± 1.241
3.101ArgThr: 3.101 ± 1.765
2.584ArgVal: 2.584 ± 0.894
1.034ArgTrp: 1.034 ± 0.588
1.034ArgTyr: 1.034 ± 0.588
0.0ArgXaa: 0.0 ± 0.0
Ser
4.134SerAla: 4.134 ± 1.78
2.584SerCys: 2.584 ± 1.173
2.584SerAsp: 2.584 ± 1.241
3.618SerGlu: 3.618 ± 1.902
3.618SerPhe: 3.618 ± 1.812
9.819SerGly: 9.819 ± 1.946
1.034SerHis: 1.034 ± 0.588
4.651SerIle: 4.651 ± 2.715
5.168SerLys: 5.168 ± 0.725
11.886SerLeu: 11.886 ± 2.333
2.067SerMet: 2.067 ± 1.127
2.584SerAsn: 2.584 ± 1.241
4.134SerPro: 4.134 ± 1.456
2.584SerGln: 2.584 ± 1.085
5.168SerArg: 5.168 ± 1.231
6.718SerSer: 6.718 ± 0.973
3.618SerThr: 3.618 ± 0.344
4.651SerVal: 4.651 ± 1.213
2.067SerTrp: 2.067 ± 1.177
2.584SerTyr: 2.584 ± 1.173
0.0SerXaa: 0.0 ± 0.0
Thr
3.101ThrAla: 3.101 ± 0.573
1.55ThrCys: 1.55 ± 0.508
1.034ThrAsp: 1.034 ± 0.672
2.067ThrGlu: 2.067 ± 0.665
2.067ThrPhe: 2.067 ± 0.888
3.618ThrGly: 3.618 ± 1.347
1.034ThrHis: 1.034 ± 0.588
2.067ThrIle: 2.067 ± 0.83
1.55ThrLys: 1.55 ± 0.883
4.651ThrLeu: 4.651 ± 1.213
1.034ThrMet: 1.034 ± 0.588
1.55ThrAsn: 1.55 ± 0.602
3.618ThrPro: 3.618 ± 0.823
1.55ThrGln: 1.55 ± 0.883
2.584ThrArg: 2.584 ± 0.962
2.584ThrSer: 2.584 ± 1.085
3.101ThrThr: 3.101 ± 0.888
6.202ThrVal: 6.202 ± 0.737
1.034ThrTrp: 1.034 ± 0.588
1.034ThrTyr: 1.034 ± 1.281
0.0ThrXaa: 0.0 ± 0.0
Val
7.235ValAla: 7.235 ± 2.366
1.55ValCys: 1.55 ± 0.998
3.101ValAsp: 3.101 ± 2.217
3.618ValGlu: 3.618 ± 1.11
3.618ValPhe: 3.618 ± 1.425
4.651ValGly: 4.651 ± 1.192
1.55ValHis: 1.55 ± 0.508
1.034ValIle: 1.034 ± 0.588
3.101ValLys: 3.101 ± 0.981
7.752ValLeu: 7.752 ± 1.794
0.0ValMet: 0.0 ± 0.0
2.584ValAsn: 2.584 ± 2.49
4.651ValPro: 4.651 ± 1.861
1.034ValGln: 1.034 ± 0.73
5.168ValArg: 5.168 ± 1.674
5.685ValSer: 5.685 ± 2.132
0.517ValThr: 0.517 ± 0.294
4.651ValVal: 4.651 ± 1.935
1.034ValTrp: 1.034 ± 0.498
0.517ValTyr: 0.517 ± 0.845
0.0ValXaa: 0.0 ± 0.0
Trp
3.618TrpAla: 3.618 ± 1.425
1.034TrpCys: 1.034 ± 0.588
1.034TrpAsp: 1.034 ± 0.498
3.101TrpGlu: 3.101 ± 1.254
0.517TrpPhe: 0.517 ± 0.294
1.034TrpGly: 1.034 ± 0.498
0.517TrpHis: 0.517 ± 0.294
0.0TrpIle: 0.0 ± 0.0
1.034TrpLys: 1.034 ± 0.73
3.101TrpLeu: 3.101 ± 1.065
0.517TrpMet: 0.517 ± 0.294
0.0TrpAsn: 0.0 ± 0.0
0.517TrpPro: 0.517 ± 0.294
1.55TrpGln: 1.55 ± 0.883
1.034TrpArg: 1.034 ± 1.215
2.067TrpSer: 2.067 ± 1.666
1.034TrpThr: 1.034 ± 0.588
1.55TrpVal: 1.55 ± 0.893
1.55TrpTrp: 1.55 ± 0.883
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.618TyrAla: 3.618 ± 2.536
1.034TyrCys: 1.034 ± 0.498
2.067TyrAsp: 2.067 ± 0.665
1.034TyrGlu: 1.034 ± 0.672
0.0TyrPhe: 0.0 ± 0.0
2.067TyrGly: 2.067 ± 1.127
0.517TyrHis: 0.517 ± 0.816
0.517TyrIle: 0.517 ± 0.845
1.55TyrLys: 1.55 ± 0.998
1.034TyrLeu: 1.034 ± 1.215
1.034TyrMet: 1.034 ± 0.498
2.067TyrAsn: 2.067 ± 1.828
0.0TyrPro: 0.0 ± 0.0
1.034TyrGln: 1.034 ± 0.672
1.034TyrArg: 1.034 ± 0.588
0.517TyrSer: 0.517 ± 0.294
2.067TyrThr: 2.067 ± 1.402
3.101TyrVal: 3.101 ± 1.786
0.0TyrTrp: 0.0 ± 0.0
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (1936 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski