Amino acid dipepetide frequency for Candidatus Nucleicultrix amoebiphila FS5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.916AlaAla: 5.916 ± 0.172	0.712AlaCys: 0.712 ± 0.039	3.071AlaAsp: 3.071 ± 0.096	4.416AlaGlu: 4.416 ± 0.105	3.561AlaPhe: 3.561 ± 0.105	4.615AlaGly: 4.615 ± 0.111	1.791AlaHis: 1.791 ± 0.063	5.05AlaIle: 5.05 ± 0.115	4.535AlaLys: 4.535 ± 0.117	9.479AlaLeu: 9.479 ± 0.162	1.929AlaMet: 1.929 ± 0.07	2.502AlaAsn: 2.502 ± 0.091	2.688AlaPro: 2.688 ± 0.079	3.06AlaGln: 3.06 ± 0.094	3.463AlaArg: 3.463 ± 0.087	4.846AlaSer: 4.846 ± 0.111	3.821AlaThr: 3.821 ± 0.083	4.465AlaVal: 4.465 ± 0.118	0.718AlaTrp: 0.718 ± 0.039	2.308AlaTyr: 2.308 ± 0.085	0.0AlaXaa: 0.0 ± 0.0
Cys	0.564CysAla: 0.564 ± 0.038	0.107CysCys: 0.107 ± 0.019	0.421CysAsp: 0.421 ± 0.037	0.405CysGlu: 0.405 ± 0.035	0.495CysPhe: 0.495 ± 0.034	0.745CysGly: 0.745 ± 0.045	0.253CysHis: 0.253 ± 0.025	0.535CysIle: 0.535 ± 0.032	0.383CysLys: 0.383 ± 0.032	1.11CysLeu: 1.11 ± 0.054	0.152CysMet: 0.152 ± 0.016	0.273CysAsn: 0.273 ± 0.026	0.412CysPro: 0.412 ± 0.031	0.338CysGln: 0.338 ± 0.03	0.405CysArg: 0.405 ± 0.032	0.62CysSer: 0.62 ± 0.039	0.47CysThr: 0.47 ± 0.039	0.62CysVal: 0.62 ± 0.035	0.094CysTrp: 0.094 ± 0.015	0.3CysTyr: 0.3 ± 0.028	0.0CysXaa: 0.0 ± 0.0
Asp	3.51AspAla: 3.51 ± 0.095	0.454AspCys: 0.454 ± 0.031	2.496AspAsp: 2.496 ± 0.094	3.416AspGlu: 3.416 ± 0.114	2.742AspPhe: 2.742 ± 0.073	2.791AspGly: 2.791 ± 0.081	1.271AspHis: 1.271 ± 0.049	3.572AspIle: 3.572 ± 0.089	3.01AspLys: 3.01 ± 0.088	5.934AspLeu: 5.934 ± 0.131	1.13AspMet: 1.13 ± 0.048	1.629AspAsn: 1.629 ± 0.061	2.469AspPro: 2.469 ± 0.078	2.265AspGln: 2.265 ± 0.077	2.406AspArg: 2.406 ± 0.072	2.726AspSer: 2.726 ± 0.088	2.142AspThr: 2.142 ± 0.076	3.46AspVal: 3.46 ± 0.082	0.6AspTrp: 0.6 ± 0.035	1.721AspTyr: 1.721 ± 0.067	0.0AspXaa: 0.0 ± 0.0
Glu	5.175GluAla: 5.175 ± 0.12	0.452GluCys: 0.452 ± 0.033	3.498GluAsp: 3.498 ± 0.094	5.206GluGlu: 5.206 ± 0.162	2.303GluPhe: 2.303 ± 0.066	4.071GluGly: 4.071 ± 0.12	1.341GluHis: 1.341 ± 0.048	5.056GluIle: 5.056 ± 0.11	5.737GluLys: 5.737 ± 0.133	5.229GluLeu: 5.229 ± 0.123	1.531GluMet: 1.531 ± 0.065	3.268GluAsn: 3.268 ± 0.092	1.994GluPro: 1.994 ± 0.066	2.404GluGln: 2.404 ± 0.083	3.523GluArg: 3.523 ± 0.108	3.968GluSer: 3.968 ± 0.106	3.646GluThr: 3.646 ± 0.079	3.942GluVal: 3.942 ± 0.104	0.598GluTrp: 0.598 ± 0.037	1.556GluTyr: 1.556 ± 0.061	0.0GluXaa: 0.0 ± 0.0
Phe	3.091PheAla: 3.091 ± 0.095	0.569PheCys: 0.569 ± 0.036	2.502PheAsp: 2.502 ± 0.07	2.939PheGlu: 2.939 ± 0.086	2.706PhePhe: 2.706 ± 0.095	2.979PheGly: 2.979 ± 0.082	1.074PheHis: 1.074 ± 0.044	3.563PheIle: 3.563 ± 0.091	3.207PheLys: 3.207 ± 0.099	5.452PheLeu: 5.452 ± 0.145	1.249PheMet: 1.249 ± 0.057	2.082PheAsn: 2.082 ± 0.077	1.779PhePro: 1.779 ± 0.064	1.641PheGln: 1.641 ± 0.069	1.71PheArg: 1.71 ± 0.065	3.767PheSer: 3.767 ± 0.106	2.37PheThr: 2.37 ± 0.079	2.896PheVal: 2.896 ± 0.093	0.654PheTrp: 0.654 ± 0.047	1.717PheTyr: 1.717 ± 0.078	0.0PheXaa: 0.0 ± 0.0
Gly	4.768GlyAla: 4.768 ± 0.123	0.689GlyCys: 0.689 ± 0.042	3.116GlyAsp: 3.116 ± 0.093	3.76GlyGlu: 3.76 ± 0.091	3.362GlyPhe: 3.362 ± 0.097	4.638GlyGly: 4.638 ± 0.142	1.582GlyHis: 1.582 ± 0.068	4.868GlyIle: 4.868 ± 0.133	4.199GlyLys: 4.199 ± 0.112	7.064GlyLeu: 7.064 ± 0.147	1.609GlyMet: 1.609 ± 0.066	2.149GlyAsn: 2.149 ± 0.073	1.985GlyPro: 1.985 ± 0.076	2.343GlyGln: 2.343 ± 0.086	3.031GlyArg: 3.031 ± 0.08	3.966GlySer: 3.966 ± 0.098	3.436GlyThr: 3.436 ± 0.083	4.696GlyVal: 4.696 ± 0.121	0.868GlyTrp: 0.868 ± 0.05	2.348GlyTyr: 2.348 ± 0.078	0.0GlyXaa: 0.0 ± 0.0
His	1.58HisAla: 1.58 ± 0.058	0.251HisCys: 0.251 ± 0.026	1.027HisAsp: 1.027 ± 0.055	1.253HisGlu: 1.253 ± 0.059	1.171HisPhe: 1.171 ± 0.054	1.538HisGly: 1.538 ± 0.061	0.788HisHis: 0.788 ± 0.051	1.506HisIle: 1.506 ± 0.067	1.415HisLys: 1.415 ± 0.059	2.594HisLeu: 2.594 ± 0.089	0.569HisMet: 0.569 ± 0.035	0.839HisAsn: 0.839 ± 0.045	1.462HisPro: 1.462 ± 0.064	1.108HisGln: 1.108 ± 0.052	1.191HisArg: 1.191 ± 0.055	1.415HisSer: 1.415 ± 0.067	1.083HisThr: 1.083 ± 0.05	1.466HisVal: 1.466 ± 0.06	0.298HisTrp: 0.298 ± 0.025	0.951HisTyr: 0.951 ± 0.052	0.0HisXaa: 0.0 ± 0.0
Ile	5.75IleAla: 5.75 ± 0.138	0.569IleCys: 0.569 ± 0.037	4.02IleAsp: 4.02 ± 0.099	4.964IleGlu: 4.964 ± 0.118	3.478IlePhe: 3.478 ± 0.105	4.846IleGly: 4.846 ± 0.136	1.627IleHis: 1.627 ± 0.068	5.2IleIle: 5.2 ± 0.122	4.969IleLys: 4.969 ± 0.111	7.834IleLeu: 7.834 ± 0.147	1.385IleMet: 1.385 ± 0.058	2.919IleAsn: 2.919 ± 0.089	3.167IlePro: 3.167 ± 0.102	2.543IleGln: 2.543 ± 0.081	3.004IleArg: 3.004 ± 0.084	5.088IleSer: 5.088 ± 0.099	3.915IleThr: 3.915 ± 0.091	4.597IleVal: 4.597 ± 0.104	0.58IleTrp: 0.58 ± 0.036	1.934IleTyr: 1.934 ± 0.065	0.0IleXaa: 0.0 ± 0.0
Lys	5.428LysAla: 5.428 ± 0.128	0.36LysCys: 0.36 ± 0.028	3.93LysAsp: 3.93 ± 0.103	5.175LysGlu: 5.175 ± 0.14	2.417LysPhe: 2.417 ± 0.079	4.235LysGly: 4.235 ± 0.091	1.435LysHis: 1.435 ± 0.053	5.732LysIle: 5.732 ± 0.12	6.346LysLys: 6.346 ± 0.186	6.193LysLeu: 6.193 ± 0.147	1.755LysMet: 1.755 ± 0.062	3.939LysAsn: 3.939 ± 0.098	2.666LysPro: 2.666 ± 0.088	2.256LysGln: 2.256 ± 0.083	3.445LysArg: 3.445 ± 0.081	4.685LysSer: 4.685 ± 0.107	4.32LysThr: 4.32 ± 0.101	4.114LysVal: 4.114 ± 0.104	0.51LysTrp: 0.51 ± 0.034	1.591LysTyr: 1.591 ± 0.06	0.0LysXaa: 0.0 ± 0.0
Leu	7.626LeuAla: 7.626 ± 0.149	1.108LeuCys: 1.108 ± 0.05	5.247LeuAsp: 5.247 ± 0.115	7.147LeuGlu: 7.147 ± 0.157	4.862LeuPhe: 4.862 ± 0.122	7.039LeuGly: 7.039 ± 0.163	2.296LeuHis: 2.296 ± 0.074	7.666LeuIle: 7.666 ± 0.168	9.202LeuLys: 9.202 ± 0.156	10.54LeuLeu: 10.54 ± 0.211	2.843LeuMet: 2.843 ± 0.083	4.521LeuAsn: 4.521 ± 0.114	4.658LeuPro: 4.658 ± 0.115	3.78LeuGln: 3.78 ± 0.085	4.893LeuArg: 4.893 ± 0.111	8.776LeuSer: 8.776 ± 0.156	6.113LeuThr: 6.113 ± 0.13	5.976LeuVal: 5.976 ± 0.137	1.137LeuTrp: 1.137 ± 0.058	2.966LeuTyr: 2.966 ± 0.088	0.0LeuXaa: 0.0 ± 0.0
Met	2.032MetAla: 2.032 ± 0.076	0.161MetCys: 0.161 ± 0.02	1.041MetAsp: 1.041 ± 0.051	1.189MetGlu: 1.189 ± 0.051	0.828MetPhe: 0.828 ± 0.044	1.804MetGly: 1.804 ± 0.07	0.517MetHis: 0.517 ± 0.035	1.925MetIle: 1.925 ± 0.064	1.86MetLys: 1.86 ± 0.062	2.12MetLeu: 2.12 ± 0.076	0.759MetMet: 0.759 ± 0.043	1.135MetAsn: 1.135 ± 0.053	1.068MetPro: 1.068 ± 0.049	0.913MetGln: 0.913 ± 0.045	1.303MetArg: 1.303 ± 0.053	1.663MetSer: 1.663 ± 0.066	1.683MetThr: 1.683 ± 0.064	1.585MetVal: 1.585 ± 0.061	0.15MetTrp: 0.15 ± 0.021	0.41MetTyr: 0.41 ± 0.037	0.0MetXaa: 0.0 ± 0.0
Asn	2.838AsnAla: 2.838 ± 0.082	0.336AsnCys: 0.336 ± 0.027	1.954AsnAsp: 1.954 ± 0.071	2.256AsnGlu: 2.256 ± 0.076	2.2AsnPhe: 2.2 ± 0.075	2.279AsnGly: 2.279 ± 0.081	0.909AsnHis: 0.909 ± 0.046	3.125AsnIle: 3.125 ± 0.087	2.489AsnLys: 2.489 ± 0.078	4.736AsnLeu: 4.736 ± 0.108	0.819AsnMet: 0.819 ± 0.044	1.701AsnAsn: 1.701 ± 0.064	2.37AsnPro: 2.37 ± 0.082	1.659AsnGln: 1.659 ± 0.074	1.947AsnArg: 1.947 ± 0.06	2.458AsnSer: 2.458 ± 0.078	2.122AsnThr: 2.122 ± 0.077	2.449AsnVal: 2.449 ± 0.081	0.459AsnTrp: 0.459 ± 0.037	1.403AsnTyr: 1.403 ± 0.053	0.0AsnXaa: 0.0 ± 0.0
Pro	2.39ProAla: 2.39 ± 0.085	0.26ProCys: 0.26 ± 0.026	2.05ProAsp: 2.05 ± 0.071	3.221ProGlu: 3.221 ± 0.089	1.981ProPhe: 1.981 ± 0.065	2.565ProGly: 2.565 ± 0.079	1.22ProHis: 1.22 ± 0.05	2.887ProIle: 2.887 ± 0.086	2.914ProLys: 2.914 ± 0.094	4.862ProLeu: 4.862 ± 0.099	0.998ProMet: 0.998 ± 0.051	1.607ProAsn: 1.607 ± 0.055	1.569ProPro: 1.569 ± 0.064	1.99ProGln: 1.99 ± 0.076	1.565ProArg: 1.565 ± 0.062	2.894ProSer: 2.894 ± 0.091	2.261ProThr: 2.261 ± 0.077	2.634ProVal: 2.634 ± 0.071	0.562ProTrp: 0.562 ± 0.032	1.448ProTyr: 1.448 ± 0.06	0.0ProXaa: 0.0 ± 0.0
Gln	3.151GlnAla: 3.151 ± 0.101	0.293GlnCys: 0.293 ± 0.024	1.95GlnAsp: 1.95 ± 0.066	3.024GlnGlu: 3.024 ± 0.097	1.305GlnPhe: 1.305 ± 0.054	2.735GlnGly: 2.735 ± 0.079	0.824GlnHis: 0.824 ± 0.045	2.572GlnIle: 2.572 ± 0.076	3.559GlnLys: 3.559 ± 0.109	3.279GlnLeu: 3.279 ± 0.099	0.976GlnMet: 0.976 ± 0.048	1.979GlnAsn: 1.979 ± 0.078	1.343GlnPro: 1.343 ± 0.062	1.625GlnGln: 1.625 ± 0.083	1.979GlnArg: 1.979 ± 0.079	2.664GlnSer: 2.664 ± 0.071	1.95GlnThr: 1.95 ± 0.064	2.241GlnVal: 2.241 ± 0.066	0.419GlnTrp: 0.419 ± 0.04	0.989GlnTyr: 0.989 ± 0.048	0.0GlnXaa: 0.0 ± 0.0
Arg	3.281ArgAla: 3.281 ± 0.093	0.383ArgCys: 0.383 ± 0.035	2.328ArgAsp: 2.328 ± 0.08	3.006ArgGlu: 3.006 ± 0.092	2.48ArgPhe: 2.48 ± 0.081	2.576ArgGly: 2.576 ± 0.079	1.081ArgHis: 1.081 ± 0.045	3.223ArgIle: 3.223 ± 0.091	2.914ArgLys: 2.914 ± 0.081	5.37ArgLeu: 5.37 ± 0.121	1.126ArgMet: 1.126 ± 0.053	1.739ArgAsn: 1.739 ± 0.063	1.882ArgPro: 1.882 ± 0.055	2.039ArgGln: 2.039 ± 0.068	2.516ArgArg: 2.516 ± 0.089	2.854ArgSer: 2.854 ± 0.081	2.191ArgThr: 2.191 ± 0.076	2.908ArgVal: 2.908 ± 0.084	0.548ArgTrp: 0.548 ± 0.037	1.623ArgTyr: 1.623 ± 0.062	0.0ArgXaa: 0.0 ± 0.0
Ser	4.609SerAla: 4.609 ± 0.113	0.577SerCys: 0.577 ± 0.035	3.27SerAsp: 3.27 ± 0.077	3.939SerGlu: 3.939 ± 0.092	3.955SerPhe: 3.955 ± 0.112	4.47SerGly: 4.47 ± 0.115	1.699SerHis: 1.699 ± 0.064	4.723SerIle: 4.723 ± 0.108	4.262SerLys: 4.262 ± 0.114	8.273SerLeu: 8.273 ± 0.178	1.732SerMet: 1.732 ± 0.06	2.292SerAsn: 2.292 ± 0.075	3.008SerPro: 3.008 ± 0.091	2.628SerGln: 2.628 ± 0.075	2.762SerArg: 2.762 ± 0.085	5.144SerSer: 5.144 ± 0.138	3.783SerThr: 3.783 ± 0.111	4.134SerVal: 4.134 ± 0.092	0.761SerTrp: 0.761 ± 0.039	2.155SerTyr: 2.155 ± 0.072	0.0SerXaa: 0.0 ± 0.0
Thr	3.836ThrAla: 3.836 ± 0.097	0.423ThrCys: 0.423 ± 0.032	2.301ThrAsp: 2.301 ± 0.072	2.896ThrGlu: 2.896 ± 0.088	2.717ThrPhe: 2.717 ± 0.089	3.483ThrGly: 3.483 ± 0.091	1.35ThrHis: 1.35 ± 0.055	3.834ThrIle: 3.834 ± 0.1	3.234ThrLys: 3.234 ± 0.096	6.959ThrLeu: 6.959 ± 0.145	1.079ThrMet: 1.079 ± 0.045	1.925ThrAsn: 1.925 ± 0.063	3.089ThrPro: 3.089 ± 0.094	2.12ThrGln: 2.12 ± 0.085	2.035ThrArg: 2.035 ± 0.066	3.648ThrSer: 3.648 ± 0.106	3.205ThrThr: 3.205 ± 0.116	3.492ThrVal: 3.492 ± 0.085	0.571ThrTrp: 0.571 ± 0.037	1.663ThrTyr: 1.663 ± 0.065	0.0ThrXaa: 0.0 ± 0.0
Val	4.647ValAla: 4.647 ± 0.112	0.584ValCys: 0.584 ± 0.036	3.384ValAsp: 3.384 ± 0.108	4.036ValGlu: 4.036 ± 0.116	3.107ValPhe: 3.107 ± 0.095	4.096ValGly: 4.096 ± 0.117	1.334ValHis: 1.334 ± 0.054	4.745ValIle: 4.745 ± 0.112	3.897ValLys: 3.897 ± 0.099	6.782ValLeu: 6.782 ± 0.145	1.571ValMet: 1.571 ± 0.064	2.484ValAsn: 2.484 ± 0.077	2.493ValPro: 2.493 ± 0.074	2.135ValGln: 2.135 ± 0.071	2.675ValArg: 2.675 ± 0.076	4.421ValSer: 4.421 ± 0.101	3.395ValThr: 3.395 ± 0.088	4.432ValVal: 4.432 ± 0.118	0.544ValTrp: 0.544 ± 0.042	1.73ValTyr: 1.73 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	0.651TrpAla: 0.651 ± 0.039	0.132TrpCys: 0.132 ± 0.018	0.515TrpAsp: 0.515 ± 0.032	0.459TrpGlu: 0.459 ± 0.035	0.526TrpPhe: 0.526 ± 0.04	0.777TrpGly: 0.777 ± 0.048	0.331TrpHis: 0.331 ± 0.03	0.701TrpIle: 0.701 ± 0.04	0.622TrpLys: 0.622 ± 0.04	1.242TrpLeu: 1.242 ± 0.06	0.3TrpMet: 0.3 ± 0.031	0.423TrpAsn: 0.423 ± 0.035	0.414TrpPro: 0.414 ± 0.03	0.645TrpGln: 0.645 ± 0.049	0.651TrpArg: 0.651 ± 0.039	0.692TrpSer: 0.692 ± 0.036	0.475TrpThr: 0.475 ± 0.036	0.658TrpVal: 0.658 ± 0.041	0.179TrpTrp: 0.179 ± 0.04	0.32TrpTyr: 0.32 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.104TyrAla: 2.104 ± 0.062	0.282TyrCys: 0.282 ± 0.026	1.625TyrAsp: 1.625 ± 0.06	1.791TyrGlu: 1.791 ± 0.065	1.753TyrPhe: 1.753 ± 0.069	2.196TyrGly: 2.196 ± 0.084	0.781TyrHis: 0.781 ± 0.049	1.905TyrIle: 1.905 ± 0.065	1.779TyrLys: 1.779 ± 0.07	3.344TyrLeu: 3.344 ± 0.091	0.629TyrMet: 0.629 ± 0.04	1.101TyrAsn: 1.101 ± 0.049	1.361TyrPro: 1.361 ± 0.056	1.363TyrGln: 1.363 ± 0.062	1.567TyrArg: 1.567 ± 0.067	1.882TyrSer: 1.882 ± 0.068	1.479TyrThr: 1.479 ± 0.062	1.728TyrVal: 1.728 ± 0.071	0.463TyrTrp: 0.463 ± 0.032	1.036TyrTyr: 1.036 ± 0.047	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1448 proteins (446774 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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