Amino acid dipepetide frequency for Rhodoplanes sp. Z2-YC6860

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.914AlaAla: 16.914 ± 0.136
1.033AlaCys: 1.033 ± 0.022
6.466AlaAsp: 6.466 ± 0.056
6.813AlaGlu: 6.813 ± 0.071
4.242AlaPhe: 4.242 ± 0.054
10.36AlaGly: 10.36 ± 0.074
2.177AlaHis: 2.177 ± 0.032
6.351AlaIle: 6.351 ± 0.065
5.265AlaLys: 5.265 ± 0.06
12.662AlaLeu: 12.662 ± 0.107
3.443AlaMet: 3.443 ± 0.044
3.169AlaAsn: 3.169 ± 0.041
5.739AlaPro: 5.739 ± 0.064
4.233AlaGln: 4.233 ± 0.056
7.776AlaArg: 7.776 ± 0.074
6.383AlaSer: 6.383 ± 0.063
6.076AlaThr: 6.076 ± 0.066
8.977AlaVal: 8.977 ± 0.068
1.401AlaTrp: 1.401 ± 0.027
2.517AlaTyr: 2.517 ± 0.034
0.0AlaXaa: 0.0 ± 0.0
Cys
0.935CysAla: 0.935 ± 0.022
0.133CysCys: 0.133 ± 0.008
0.475CysAsp: 0.475 ± 0.015
0.409CysGlu: 0.409 ± 0.014
0.33CysPhe: 0.33 ± 0.012
0.921CysGly: 0.921 ± 0.02
0.235CysHis: 0.235 ± 0.012
0.421CysIle: 0.421 ± 0.015
0.223CysLys: 0.223 ± 0.009
0.739CysLeu: 0.739 ± 0.018
0.196CysMet: 0.196 ± 0.01
0.237CysAsn: 0.237 ± 0.01
0.417CysPro: 0.417 ± 0.014
0.223CysGln: 0.223 ± 0.01
0.603CysArg: 0.603 ± 0.015
0.472CysSer: 0.472 ± 0.015
0.424CysThr: 0.424 ± 0.014
0.634CysVal: 0.634 ± 0.017
0.116CysTrp: 0.116 ± 0.007
0.205CysTyr: 0.205 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
6.167AspAla: 6.167 ± 0.062
0.474AspCys: 0.474 ± 0.015
2.852AspAsp: 2.852 ± 0.048
3.067AspGlu: 3.067 ± 0.037
2.238AspPhe: 2.238 ± 0.035
4.715AspGly: 4.715 ± 0.054
1.168AspHis: 1.168 ± 0.023
3.061AspIle: 3.061 ± 0.039
2.147AspLys: 2.147 ± 0.039
5.401AspLeu: 5.401 ± 0.06
1.289AspMet: 1.289 ± 0.023
1.375AspAsn: 1.375 ± 0.027
3.303AspPro: 3.303 ± 0.04
1.682AspGln: 1.682 ± 0.031
3.89AspArg: 3.89 ± 0.051
2.133AspSer: 2.133 ± 0.031
2.577AspThr: 2.577 ± 0.045
4.446AspVal: 4.446 ± 0.05
0.851AspTrp: 0.851 ± 0.019
1.489AspTyr: 1.489 ± 0.029
0.0AspXaa: 0.0 ± 0.0
Glu
6.455GluAla: 6.455 ± 0.071
0.351GluCys: 0.351 ± 0.013
2.09GluAsp: 2.09 ± 0.03
2.436GluGlu: 2.436 ± 0.034
2.032GluPhe: 2.032 ± 0.027
3.383GluGly: 3.383 ± 0.045
1.218GluHis: 1.218 ± 0.026
3.162GluIle: 3.162 ± 0.038
2.376GluLys: 2.376 ± 0.032
5.296GluLeu: 5.296 ± 0.052
1.49GluMet: 1.49 ± 0.025
1.511GluAsn: 1.511 ± 0.025
2.687GluPro: 2.687 ± 0.036
2.201GluGln: 2.201 ± 0.035
4.609GluArg: 4.609 ± 0.06
2.286GluSer: 2.286 ± 0.03
2.995GluThr: 2.995 ± 0.034
3.556GluVal: 3.556 ± 0.046
0.695GluTrp: 0.695 ± 0.018
1.093GluTyr: 1.093 ± 0.022
0.0GluXaa: 0.0 ± 0.0
Phe
4.758PheAla: 4.758 ± 0.05
0.4PheCys: 0.4 ± 0.013
2.538PheAsp: 2.538 ± 0.037
2.061PheGlu: 2.061 ± 0.029
1.407PhePhe: 1.407 ± 0.03
3.798PheGly: 3.798 ± 0.038
0.729PheHis: 0.729 ± 0.018
1.812PheIle: 1.812 ± 0.031
1.334PheLys: 1.334 ± 0.022
3.111PheLeu: 3.111 ± 0.051
0.857PheMet: 0.857 ± 0.023
1.153PheAsn: 1.153 ± 0.025
1.713PhePro: 1.713 ± 0.031
1.052PheGln: 1.052 ± 0.022
2.157PheArg: 2.157 ± 0.033
2.192PheSer: 2.192 ± 0.04
1.99PheThr: 1.99 ± 0.034
3.119PheVal: 3.119 ± 0.038
0.531PheTrp: 0.531 ± 0.015
0.929PheTyr: 0.929 ± 0.021
0.0PheXaa: 0.0 ± 0.0
Gly
9.127GlyAla: 9.127 ± 0.072
0.809GlyCys: 0.809 ± 0.021
3.965GlyAsp: 3.965 ± 0.056
4.129GlyGlu: 4.129 ± 0.047
3.618GlyPhe: 3.618 ± 0.042
7.456GlyGly: 7.456 ± 0.077
1.909GlyHis: 1.909 ± 0.029
4.645GlyIle: 4.645 ± 0.05
3.666GlyLys: 3.666 ± 0.044
8.326GlyLeu: 8.326 ± 0.069
2.234GlyMet: 2.234 ± 0.033
2.383GlyAsn: 2.383 ± 0.046
3.686GlyPro: 3.686 ± 0.043
2.841GlyGln: 2.841 ± 0.04
5.627GlyArg: 5.627 ± 0.061
4.876GlySer: 4.876 ± 0.058
4.936GlyThr: 4.936 ± 0.072
6.263GlyVal: 6.263 ± 0.058
1.32GlyTrp: 1.32 ± 0.028
2.463GlyTyr: 2.463 ± 0.033
0.0GlyXaa: 0.0 ± 0.0
His
2.204HisAla: 2.204 ± 0.032
0.22HisCys: 0.22 ± 0.009
1.19HisAsp: 1.19 ± 0.025
1.001HisGlu: 1.001 ± 0.022
0.837HisPhe: 0.837 ± 0.02
1.871HisGly: 1.871 ± 0.032
0.618HisHis: 0.618 ± 0.02
1.007HisIle: 1.007 ± 0.021
0.62HisLys: 0.62 ± 0.018
1.89HisLeu: 1.89 ± 0.03
0.494HisMet: 0.494 ± 0.014
0.516HisAsn: 0.516 ± 0.016
1.402HisPro: 1.402 ± 0.027
0.601HisGln: 0.601 ± 0.017
1.399HisArg: 1.399 ± 0.026
1.013HisSer: 1.013 ± 0.023
0.885HisThr: 0.885 ± 0.021
1.752HisVal: 1.752 ± 0.029
0.345HisTrp: 0.345 ± 0.013
0.566HisTyr: 0.566 ± 0.015
0.0HisXaa: 0.0 ± 0.0
Ile
7.553IleAla: 7.553 ± 0.062
0.487IleCys: 0.487 ± 0.015
3.634IleAsp: 3.634 ± 0.049
3.663IleGlu: 3.663 ± 0.047
1.566IlePhe: 1.566 ± 0.031
5.179IleGly: 5.179 ± 0.05
0.916IleHis: 0.916 ± 0.021
2.248IleIle: 2.248 ± 0.034
2.129IleLys: 2.129 ± 0.033
3.913IleLeu: 3.913 ± 0.046
1.031IleMet: 1.031 ± 0.022
1.654IleAsn: 1.654 ± 0.03
2.517IlePro: 2.517 ± 0.034
1.306IleGln: 1.306 ± 0.026
3.04IleArg: 3.04 ± 0.035
2.847IleSer: 2.847 ± 0.041
2.86IleThr: 2.86 ± 0.04
4.715IleVal: 4.715 ± 0.051
0.617IleTrp: 0.617 ± 0.018
1.173IleTyr: 1.173 ± 0.023
0.0IleXaa: 0.0 ± 0.0
Lys
4.937LysAla: 4.937 ± 0.058
0.193LysCys: 0.193 ± 0.009
2.219LysAsp: 2.219 ± 0.036
1.883LysGlu: 1.883 ± 0.032
1.3LysPhe: 1.3 ± 0.022
2.921LysGly: 2.921 ± 0.035
0.766LysHis: 0.766 ± 0.02
2.181LysIle: 2.181 ± 0.035
1.795LysLys: 1.795 ± 0.037
4.353LysLeu: 4.353 ± 0.047
0.995LysMet: 0.995 ± 0.022
1.119LysAsn: 1.119 ± 0.025
2.759LysPro: 2.759 ± 0.04
1.267LysGln: 1.267 ± 0.022
2.797LysArg: 2.797 ± 0.04
2.293LysSer: 2.293 ± 0.034
2.396LysThr: 2.396 ± 0.037
2.877LysVal: 2.877 ± 0.045
0.496LysTrp: 0.496 ± 0.015
0.797LysTyr: 0.797 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
12.814LeuAla: 12.814 ± 0.095
0.822LeuCys: 0.822 ± 0.018
5.478LeuAsp: 5.478 ± 0.055
4.48LeuGlu: 4.48 ± 0.053
3.418LeuPhe: 3.418 ± 0.043
8.111LeuGly: 8.111 ± 0.072
1.762LeuHis: 1.762 ± 0.031
5.012LeuIle: 5.012 ± 0.055
4.31LeuLys: 4.31 ± 0.05
8.865LeuLeu: 8.865 ± 0.084
2.371LeuMet: 2.371 ± 0.03
2.786LeuAsn: 2.786 ± 0.041
5.548LeuPro: 5.548 ± 0.058
2.687LeuGln: 2.687 ± 0.037
6.147LeuArg: 6.147 ± 0.062
6.037LeuSer: 6.037 ± 0.064
5.435LeuThr: 5.435 ± 0.076
7.192LeuVal: 7.192 ± 0.062
1.148LeuTrp: 1.148 ± 0.028
2.042LeuTyr: 2.042 ± 0.029
0.0LeuXaa: 0.0 ± 0.0
Met
3.05MetAla: 3.05 ± 0.044
0.173MetCys: 0.173 ± 0.008
1.071MetAsp: 1.071 ± 0.021
1.047MetGlu: 1.047 ± 0.022
0.856MetPhe: 0.856 ± 0.02
1.684MetGly: 1.684 ± 0.029
0.478MetHis: 0.478 ± 0.014
1.421MetIle: 1.421 ± 0.028
1.191MetLys: 1.191 ± 0.024
2.571MetLeu: 2.571 ± 0.036
0.704MetMet: 0.704 ± 0.022
0.804MetAsn: 0.804 ± 0.021
1.659MetPro: 1.659 ± 0.024
0.897MetGln: 0.897 ± 0.018
1.849MetArg: 1.849 ± 0.029
1.704MetSer: 1.704 ± 0.027
1.814MetThr: 1.814 ± 0.029
1.743MetVal: 1.743 ± 0.028
0.26MetTrp: 0.26 ± 0.011
0.342MetTyr: 0.342 ± 0.012
0.0MetXaa: 0.0 ± 0.0
Asn
3.388AsnAla: 3.388 ± 0.045
0.258AsnCys: 0.258 ± 0.012
1.56AsnAsp: 1.56 ± 0.036
1.322AsnGlu: 1.322 ± 0.024
1.096AsnPhe: 1.096 ± 0.023
2.613AsnGly: 2.613 ± 0.053
0.545AsnHis: 0.545 ± 0.014
1.506AsnIle: 1.506 ± 0.026
0.96AsnLys: 0.96 ± 0.02
2.658AsnLeu: 2.658 ± 0.034
0.695AsnMet: 0.695 ± 0.018
0.833AsnAsn: 0.833 ± 0.025
2.007AsnPro: 2.007 ± 0.029
0.776AsnGln: 0.776 ± 0.018
1.931AsnArg: 1.931 ± 0.033
1.449AsnSer: 1.449 ± 0.028
1.431AsnThr: 1.431 ± 0.031
2.341AsnVal: 2.341 ± 0.038
0.463AsnTrp: 0.463 ± 0.015
0.773AsnTyr: 0.773 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
6.532ProAla: 6.532 ± 0.067
0.302ProCys: 0.302 ± 0.013
3.803ProAsp: 3.803 ± 0.046
3.323ProGlu: 3.323 ± 0.044
2.154ProPhe: 2.154 ± 0.035
4.759ProGly: 4.759 ± 0.05
1.134ProHis: 1.134 ± 0.024
2.704ProIle: 2.704 ± 0.036
2.321ProLys: 2.321 ± 0.032
4.629ProLeu: 4.629 ± 0.053
1.298ProMet: 1.298 ± 0.027
1.781ProAsn: 1.781 ± 0.03
3.029ProPro: 3.029 ± 0.052
1.911ProGln: 1.911 ± 0.028
2.961ProArg: 2.961 ± 0.046
3.119ProSer: 3.119 ± 0.036
2.756ProThr: 2.756 ± 0.04
4.286ProVal: 4.286 ± 0.037
0.728ProTrp: 0.728 ± 0.02
1.501ProTyr: 1.501 ± 0.025
0.0ProXaa: 0.0 ± 0.0
Gln
3.955GlnAla: 3.955 ± 0.047
0.237GlnCys: 0.237 ± 0.01
1.405GlnAsp: 1.405 ± 0.028
1.332GlnGlu: 1.332 ± 0.026
1.221GlnPhe: 1.221 ± 0.026
2.389GlnGly: 2.389 ± 0.038
0.721GlnHis: 0.721 ± 0.018
1.917GlnIle: 1.917 ± 0.039
1.324GlnLys: 1.324 ± 0.024
2.934GlnLeu: 2.934 ± 0.047
0.913GlnMet: 0.913 ± 0.02
0.952GlnAsn: 0.952 ± 0.02
1.936GlnPro: 1.936 ± 0.037
1.466GlnGln: 1.466 ± 0.034
2.496GlnArg: 2.496 ± 0.044
1.934GlnSer: 1.934 ± 0.029
1.831GlnThr: 1.831 ± 0.035
2.34GlnVal: 2.34 ± 0.047
0.427GlnTrp: 0.427 ± 0.013
0.677GlnTyr: 0.677 ± 0.019
0.0GlnXaa: 0.0 ± 0.0
Arg
7.356ArgAla: 7.356 ± 0.076
0.535ArgCys: 0.535 ± 0.016
3.735ArgAsp: 3.735 ± 0.046
3.785ArgGlu: 3.785 ± 0.053
2.712ArgPhe: 2.712 ± 0.043
4.772ArgGly: 4.772 ± 0.054
1.52ArgHis: 1.52 ± 0.032
3.839ArgIle: 3.839 ± 0.042
2.551ArgLys: 2.551 ± 0.039
7.071ArgLeu: 7.071 ± 0.071
1.867ArgMet: 1.867 ± 0.032
1.922ArgAsn: 1.922 ± 0.032
3.572ArgPro: 3.572 ± 0.053
2.25ArgGln: 2.25 ± 0.034
5.091ArgArg: 5.091 ± 0.06
3.647ArgSer: 3.647 ± 0.048
3.342ArgThr: 3.342 ± 0.046
4.681ArgVal: 4.681 ± 0.054
0.99ArgTrp: 0.99 ± 0.021
1.699ArgTyr: 1.699 ± 0.029
0.0ArgXaa: 0.0 ± 0.0
Ser
6.229SerAla: 6.229 ± 0.064
0.431SerCys: 0.431 ± 0.015
2.905SerAsp: 2.905 ± 0.041
2.711SerGlu: 2.711 ± 0.036
2.291SerPhe: 2.291 ± 0.029
5.55SerGly: 5.55 ± 0.069
1.092SerHis: 1.092 ± 0.023
2.907SerIle: 2.907 ± 0.043
2.02SerLys: 2.02 ± 0.028
5.258SerLeu: 5.258 ± 0.051
1.33SerMet: 1.33 ± 0.027
1.594SerAsn: 1.594 ± 0.027
2.967SerPro: 2.967 ± 0.037
1.738SerGln: 1.738 ± 0.03
3.555SerArg: 3.555 ± 0.041
3.253SerSer: 3.253 ± 0.059
3.029SerThr: 3.029 ± 0.069
3.984SerVal: 3.984 ± 0.044
0.792SerTrp: 0.792 ± 0.02
1.409SerTyr: 1.409 ± 0.026
0.0SerXaa: 0.0 ± 0.0
Thr
6.384ThrAla: 6.384 ± 0.083
0.416ThrCys: 0.416 ± 0.014
2.813ThrAsp: 2.813 ± 0.038
2.502ThrGlu: 2.502 ± 0.039
2.117ThrPhe: 2.117 ± 0.036
5.045ThrGly: 5.045 ± 0.067
1.083ThrHis: 1.083 ± 0.024
3.095ThrIle: 3.095 ± 0.044
1.849ThrLys: 1.849 ± 0.03
5.658ThrLeu: 5.658 ± 0.057
1.319ThrMet: 1.319 ± 0.022
1.49ThrAsn: 1.49 ± 0.034
3.457ThrPro: 3.457 ± 0.04
1.631ThrGln: 1.631 ± 0.067
3.169ThrArg: 3.169 ± 0.041
2.988ThrSer: 2.988 ± 0.049
3.199ThrThr: 3.199 ± 0.129
4.544ThrVal: 4.544 ± 0.056
0.689ThrTrp: 0.689 ± 0.02
1.247ThrTyr: 1.247 ± 0.028
0.0ThrXaa: 0.0 ± 0.0
Val
9.501ValAla: 9.501 ± 0.071
0.67ValCys: 0.67 ± 0.018
3.963ValAsp: 3.963 ± 0.052
4.249ValGlu: 4.249 ± 0.047
2.716ValPhe: 2.716 ± 0.034
5.678ValGly: 5.678 ± 0.056
1.515ValHis: 1.515 ± 0.025
4.194ValIle: 4.194 ± 0.041
2.909ValLys: 2.909 ± 0.041
7.383ValLeu: 7.383 ± 0.063
1.981ValMet: 1.981 ± 0.032
2.179ValAsn: 2.179 ± 0.036
4.498ValPro: 4.498 ± 0.054
2.278ValGln: 2.278 ± 0.034
4.932ValArg: 4.932 ± 0.05
4.33ValSer: 4.33 ± 0.05
4.659ValThr: 4.659 ± 0.053
6.46ValVal: 6.46 ± 0.064
0.912ValTrp: 0.912 ± 0.022
1.49ValTyr: 1.49 ± 0.028
0.0ValXaa: 0.0 ± 0.0
Trp
1.198TrpAla: 1.198 ± 0.025
0.138TrpCys: 0.138 ± 0.008
0.618TrpAsp: 0.618 ± 0.015
0.516TrpGlu: 0.516 ± 0.013
0.557TrpPhe: 0.557 ± 0.015
0.934TrpGly: 0.934 ± 0.021
0.361TrpHis: 0.361 ± 0.013
0.653TrpIle: 0.653 ± 0.017
0.544TrpLys: 0.544 ± 0.015
1.534TrpLeu: 1.534 ± 0.032
0.351TrpMet: 0.351 ± 0.011
0.475TrpAsn: 0.475 ± 0.017
0.776TrpPro: 0.776 ± 0.017
0.576TrpGln: 0.576 ± 0.016
1.106TrpArg: 1.106 ± 0.024
0.893TrpSer: 0.893 ± 0.022
0.807TrpThr: 0.807 ± 0.022
0.819TrpVal: 0.819 ± 0.019
0.228TrpTrp: 0.228 ± 0.011
0.289TrpTyr: 0.289 ± 0.012
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.539TyrAla: 2.539 ± 0.036
0.263TyrCys: 0.263 ± 0.011
1.544TyrAsp: 1.544 ± 0.028
1.193TyrGlu: 1.193 ± 0.021
0.935TyrPhe: 0.935 ± 0.022
2.138TyrGly: 2.138 ± 0.035
0.484TyrHis: 0.484 ± 0.016
0.914TyrIle: 0.914 ± 0.017
0.811TyrLys: 0.811 ± 0.021
2.212TyrLeu: 2.212 ± 0.037
0.458TyrMet: 0.458 ± 0.013
0.672TyrAsn: 0.672 ± 0.019
1.359TyrPro: 1.359 ± 0.024
0.788TyrGln: 0.788 ± 0.019
1.804TyrArg: 1.804 ± 0.032
1.198TyrSer: 1.198 ± 0.027
1.254TyrThr: 1.254 ± 0.027
1.768TyrVal: 1.768 ± 0.03
0.366TyrTrp: 0.366 ± 0.012
0.601TyrTyr: 0.601 ± 0.018
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 7007 proteins (2322162 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski