Amino acid dipepetide frequency for Mycolicibacterium moriokaense

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.344AlaAla: 18.344 ± 0.144	0.964AlaCys: 0.964 ± 0.022	8.099AlaAsp: 8.099 ± 0.071	7.831AlaGlu: 7.831 ± 0.072	3.601AlaPhe: 3.601 ± 0.047	10.717AlaGly: 10.717 ± 0.081	2.426AlaHis: 2.426 ± 0.039	5.585AlaIle: 5.585 ± 0.056	3.3AlaLys: 3.3 ± 0.049	12.391AlaLeu: 12.391 ± 0.095	2.947AlaMet: 2.947 ± 0.039	2.736AlaAsn: 2.736 ± 0.038	6.031AlaPro: 6.031 ± 0.064	3.83AlaGln: 3.83 ± 0.046	7.912AlaArg: 7.912 ± 0.076	5.898AlaSer: 5.898 ± 0.069	6.992AlaThr: 6.992 ± 0.06	11.322AlaVal: 11.322 ± 0.094	1.602AlaTrp: 1.602 ± 0.03	2.397AlaTyr: 2.397 ± 0.032	0.0AlaXaa: 0.0 ± 0.0
Cys	1.057CysAla: 1.057 ± 0.026	0.081CysCys: 0.081 ± 0.007	0.559CysAsp: 0.559 ± 0.019	0.462CysGlu: 0.462 ± 0.017	0.237CysPhe: 0.237 ± 0.012	0.89CysGly: 0.89 ± 0.023	0.17CysHis: 0.17 ± 0.009	0.295CysIle: 0.295 ± 0.012	0.127CysLys: 0.127 ± 0.007	0.683CysLeu: 0.683 ± 0.021	0.145CysMet: 0.145 ± 0.009	0.17CysAsn: 0.17 ± 0.011	0.469CysPro: 0.469 ± 0.017	0.221CysGln: 0.221 ± 0.012	0.571CysArg: 0.571 ± 0.018	0.476CysSer: 0.476 ± 0.016	0.499CysThr: 0.499 ± 0.017	0.708CysVal: 0.708 ± 0.021	0.143CysTrp: 0.143 ± 0.008	0.211CysTyr: 0.211 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.616AspAla: 7.616 ± 0.075	0.473AspCys: 0.473 ± 0.017	4.524AspAsp: 4.524 ± 0.057	4.472AspGlu: 4.472 ± 0.05	1.902AspPhe: 1.902 ± 0.029	5.897AspGly: 5.897 ± 0.062	1.424AspHis: 1.424 ± 0.026	2.801AspIle: 2.801 ± 0.041	1.441AspLys: 1.441 ± 0.028	6.077AspLeu: 6.077 ± 0.059	1.079AspMet: 1.079 ± 0.026	1.327AspAsn: 1.327 ± 0.027	4.402AspPro: 4.402 ± 0.055	1.729AspGln: 1.729 ± 0.031	4.489AspArg: 4.489 ± 0.051	2.859AspSer: 2.859 ± 0.037	3.148AspThr: 3.148 ± 0.04	5.588AspVal: 5.588 ± 0.062	1.049AspTrp: 1.049 ± 0.026	1.494AspTyr: 1.494 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	6.376GluAla: 6.376 ± 0.066	0.41GluCys: 0.41 ± 0.015	2.754GluAsp: 2.754 ± 0.04	2.857GluGlu: 2.857 ± 0.04	2.029GluPhe: 2.029 ± 0.036	3.669GluGly: 3.669 ± 0.047	1.514GluHis: 1.514 ± 0.028	2.879GluIle: 2.879 ± 0.041	1.62GluLys: 1.62 ± 0.033	6.764GluLeu: 6.764 ± 0.068	1.134GluMet: 1.134 ± 0.026	1.268GluAsn: 1.268 ± 0.027	3.187GluPro: 3.187 ± 0.053	2.289GluGln: 2.289 ± 0.038	4.644GluArg: 4.644 ± 0.055	2.87GluSer: 2.87 ± 0.042	2.896GluThr: 2.896 ± 0.04	4.66GluVal: 4.66 ± 0.055	0.841GluTrp: 0.841 ± 0.021	1.263GluTyr: 1.263 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.004PheAla: 4.004 ± 0.05	0.355PheCys: 0.355 ± 0.013	2.588PheAsp: 2.588 ± 0.042	1.715PheGlu: 1.715 ± 0.037	1.068PhePhe: 1.068 ± 0.025	3.506PheGly: 3.506 ± 0.044	0.642PheHis: 0.642 ± 0.02	1.298PheIle: 1.298 ± 0.028	0.619PheLys: 0.619 ± 0.019	2.643PheLeu: 2.643 ± 0.041	0.572PheMet: 0.572 ± 0.016	0.872PheAsn: 0.872 ± 0.027	1.471PhePro: 1.471 ± 0.028	0.691PheGln: 0.691 ± 0.019	1.757PheArg: 1.757 ± 0.033	1.768PheSer: 1.768 ± 0.031	2.17PheThr: 2.17 ± 0.037	2.691PheVal: 2.691 ± 0.044	0.49PheTrp: 0.49 ± 0.015	0.747PheTyr: 0.747 ± 0.023	0.0PheXaa: 0.0 ± 0.0
Gly	9.626GlyAla: 9.626 ± 0.08	0.775GlyCys: 0.775 ± 0.022	4.943GlyAsp: 4.943 ± 0.055	4.519GlyGlu: 4.519 ± 0.052	3.112GlyPhe: 3.112 ± 0.04	7.548GlyGly: 7.548 ± 0.084	1.895GlyHis: 1.895 ± 0.03	4.245GlyIle: 4.245 ± 0.057	2.414GlyLys: 2.414 ± 0.037	8.332GlyLeu: 8.332 ± 0.072	2.087GlyMet: 2.087 ± 0.033	1.963GlyAsn: 1.963 ± 0.037	4.456GlyPro: 4.456 ± 0.057	2.679GlyGln: 2.679 ± 0.037	5.913GlyArg: 5.913 ± 0.063	4.947GlySer: 4.947 ± 0.057	5.109GlyThr: 5.109 ± 0.055	7.653GlyVal: 7.653 ± 0.074	1.642GlyTrp: 1.642 ± 0.03	2.351GlyTyr: 2.351 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.301HisAla: 2.301 ± 0.038	0.208HisCys: 0.208 ± 0.01	1.379HisAsp: 1.379 ± 0.027	1.115HisGlu: 1.115 ± 0.028	0.732HisPhe: 0.732 ± 0.021	2.006HisGly: 2.006 ± 0.031	0.643HisHis: 0.643 ± 0.022	0.916HisIle: 0.916 ± 0.023	0.37HisLys: 0.37 ± 0.015	2.09HisLeu: 2.09 ± 0.034	0.381HisMet: 0.381 ± 0.016	0.496HisAsn: 0.496 ± 0.015	1.578HisPro: 1.578 ± 0.031	0.616HisGln: 0.616 ± 0.018	1.778HisArg: 1.778 ± 0.027	1.121HisSer: 1.121 ± 0.023	1.145HisThr: 1.145 ± 0.022	1.724HisVal: 1.724 ± 0.032	0.385HisTrp: 0.385 ± 0.013	0.569HisTyr: 0.569 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.745IleAla: 6.745 ± 0.061	0.436IleCys: 0.436 ± 0.014	3.669IleAsp: 3.669 ± 0.045	2.932IleGlu: 2.932 ± 0.046	1.162IlePhe: 1.162 ± 0.026	4.663IleGly: 4.663 ± 0.058	0.844IleHis: 0.844 ± 0.023	1.677IleIle: 1.677 ± 0.035	1.027IleLys: 1.027 ± 0.028	3.248IleLeu: 3.248 ± 0.05	0.64IleMet: 0.64 ± 0.018	1.273IleAsn: 1.273 ± 0.031	2.564IlePro: 2.564 ± 0.04	1.037IleGln: 1.037 ± 0.021	2.745IleArg: 2.745 ± 0.034	2.362IleSer: 2.362 ± 0.037	2.93IleThr: 2.93 ± 0.038	4.1IleVal: 4.1 ± 0.044	0.528IleTrp: 0.528 ± 0.019	0.89IleTyr: 0.89 ± 0.023	0.0IleXaa: 0.0 ± 0.0
Lys	2.894LysAla: 2.894 ± 0.048	0.128LysCys: 0.128 ± 0.009	1.278LysAsp: 1.278 ± 0.029	1.178LysGlu: 1.178 ± 0.028	0.732LysPhe: 0.732 ± 0.021	1.745LysGly: 1.745 ± 0.037	0.568LysHis: 0.568 ± 0.018	1.158LysIle: 1.158 ± 0.029	0.746LysLys: 0.746 ± 0.025	2.408LysLeu: 2.408 ± 0.037	0.556LysMet: 0.556 ± 0.019	0.586LysAsn: 0.586 ± 0.02	1.613LysPro: 1.613 ± 0.034	0.809LysGln: 0.809 ± 0.024	1.79LysArg: 1.79 ± 0.035	1.339LysSer: 1.339 ± 0.025	1.473LysThr: 1.473 ± 0.035	2.193LysVal: 2.193 ± 0.039	0.391LysTrp: 0.391 ± 0.016	0.583LysTyr: 0.583 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	13.263LeuAla: 13.263 ± 0.094	0.826LeuCys: 0.826 ± 0.019	6.492LeuAsp: 6.492 ± 0.06	4.752LeuGlu: 4.752 ± 0.053	2.791LeuPhe: 2.791 ± 0.039	8.373LeuGly: 8.373 ± 0.071	2.052LeuHis: 2.052 ± 0.035	4.395LeuIle: 4.395 ± 0.05	2.109LeuLys: 2.109 ± 0.036	9.305LeuLeu: 9.305 ± 0.093	1.856LeuMet: 1.856 ± 0.025	2.28LeuAsn: 2.28 ± 0.034	5.65LeuPro: 5.65 ± 0.065	2.579LeuGln: 2.579 ± 0.042	7.213LeuArg: 7.213 ± 0.076	5.573LeuSer: 5.573 ± 0.054	6.284LeuThr: 6.284 ± 0.056	8.318LeuVal: 8.318 ± 0.078	1.237LeuTrp: 1.237 ± 0.028	1.727LeuTyr: 1.727 ± 0.033	0.0LeuXaa: 0.0 ± 0.0
Met	2.693MetAla: 2.693 ± 0.042	0.213MetCys: 0.213 ± 0.011	0.94MetAsp: 0.94 ± 0.025	0.813MetGlu: 0.813 ± 0.022	0.673MetPhe: 0.673 ± 0.019	1.54MetGly: 1.54 ± 0.029	0.478MetHis: 0.478 ± 0.015	0.945MetIle: 0.945 ± 0.021	0.543MetLys: 0.543 ± 0.018	2.083MetLeu: 2.083 ± 0.034	0.458MetMet: 0.458 ± 0.015	0.537MetAsn: 0.537 ± 0.017	1.265MetPro: 1.265 ± 0.025	0.572MetGln: 0.572 ± 0.02	1.645MetArg: 1.645 ± 0.027	1.636MetSer: 1.636 ± 0.028	1.964MetThr: 1.964 ± 0.034	1.667MetVal: 1.667 ± 0.031	0.294MetTrp: 0.294 ± 0.012	0.377MetTyr: 0.377 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.797AsnAla: 2.797 ± 0.036	0.199AsnCys: 0.199 ± 0.01	1.353AsnAsp: 1.353 ± 0.026	1.147AsnGlu: 1.147 ± 0.026	0.732AsnPhe: 0.732 ± 0.019	2.241AsnGly: 2.241 ± 0.036	0.487AsnHis: 0.487 ± 0.015	1.046AsnIle: 1.046 ± 0.025	0.506AsnLys: 0.506 ± 0.018	2.178AsnLeu: 2.178 ± 0.037	0.462AsnMet: 0.462 ± 0.016	0.63AsnAsn: 0.63 ± 0.021	1.875AsnPro: 1.875 ± 0.035	0.682AsnGln: 0.682 ± 0.02	1.659AsnArg: 1.659 ± 0.029	1.188AsnSer: 1.188 ± 0.025	1.399AsnThr: 1.399 ± 0.03	1.916AsnVal: 1.916 ± 0.034	0.41AsnTrp: 0.41 ± 0.015	0.617AsnTyr: 0.617 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	6.717ProAla: 6.717 ± 0.076	0.307ProCys: 0.307 ± 0.014	4.51ProAsp: 4.51 ± 0.054	3.877ProGlu: 3.877 ± 0.048	1.699ProPhe: 1.699 ± 0.033	5.32ProGly: 5.32 ± 0.054	1.209ProHis: 1.209 ± 0.022	2.32ProIle: 2.32 ± 0.034	1.49ProLys: 1.49 ± 0.027	4.891ProLeu: 4.891 ± 0.052	1.365ProMet: 1.365 ± 0.029	1.456ProAsn: 1.456 ± 0.027	3.854ProPro: 3.854 ± 0.081	1.77ProGln: 1.77 ± 0.034	3.252ProArg: 3.252 ± 0.041	3.175ProSer: 3.175 ± 0.045	3.445ProThr: 3.445 ± 0.042	4.973ProVal: 4.973 ± 0.059	0.861ProTrp: 0.861 ± 0.023	1.222ProTyr: 1.222 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.442GlnAla: 3.442 ± 0.046	0.233GlnCys: 0.233 ± 0.009	1.212GlnAsp: 1.212 ± 0.026	1.251GlnGlu: 1.251 ± 0.027	1.029GlnPhe: 1.029 ± 0.024	2.009GlnGly: 2.009 ± 0.037	0.713GlnHis: 0.713 ± 0.019	1.514GlnIle: 1.514 ± 0.029	0.696GlnLys: 0.696 ± 0.022	3.496GlnLeu: 3.496 ± 0.046	0.692GlnMet: 0.692 ± 0.02	0.625GlnAsn: 0.625 ± 0.021	1.823GlnPro: 1.823 ± 0.033	1.242GlnGln: 1.242 ± 0.03	2.702GlnArg: 2.702 ± 0.04	1.495GlnSer: 1.495 ± 0.031	1.624GlnThr: 1.624 ± 0.029	2.407GlnVal: 2.407 ± 0.035	0.607GlnTrp: 0.607 ± 0.018	0.681GlnTyr: 0.681 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	7.664ArgAla: 7.664 ± 0.076	0.582ArgCys: 0.582 ± 0.019	4.209ArgAsp: 4.209 ± 0.051	3.978ArgGlu: 3.978 ± 0.048	2.453ArgPhe: 2.453 ± 0.039	4.914ArgGly: 4.914 ± 0.05	1.653ArgHis: 1.653 ± 0.028	3.63ArgIle: 3.63 ± 0.046	1.803ArgLys: 1.803 ± 0.033	7.237ArgLeu: 7.237 ± 0.076	1.777ArgMet: 1.777 ± 0.032	1.7ArgAsn: 1.7 ± 0.031	3.738ArgPro: 3.738 ± 0.047	2.216ArgGln: 2.216 ± 0.037	6.064ArgArg: 6.064 ± 0.065	3.864ArgSer: 3.864 ± 0.044	4.041ArgThr: 4.041 ± 0.043	5.434ArgVal: 5.434 ± 0.051	1.327ArgTrp: 1.327 ± 0.031	1.972ArgTyr: 1.972 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.637SerAla: 6.637 ± 0.068	0.404SerCys: 0.404 ± 0.014	3.411SerAsp: 3.411 ± 0.039	2.85SerGlu: 2.85 ± 0.04	1.717SerPhe: 1.717 ± 0.031	5.394SerGly: 5.394 ± 0.058	1.05SerHis: 1.05 ± 0.023	2.386SerIle: 2.386 ± 0.042	1.3SerLys: 1.3 ± 0.028	4.798SerLeu: 4.798 ± 0.052	1.416SerMet: 1.416 ± 0.028	1.134SerAsn: 1.134 ± 0.026	3.052SerPro: 3.052 ± 0.04	1.519SerGln: 1.519 ± 0.031	3.635SerArg: 3.635 ± 0.046	3.065SerSer: 3.065 ± 0.053	3.351SerThr: 3.351 ± 0.048	4.545SerVal: 4.545 ± 0.042	0.86SerTrp: 0.86 ± 0.022	1.203SerTyr: 1.203 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	7.55ThrAla: 7.55 ± 0.068	0.429ThrCys: 0.429 ± 0.017	3.673ThrAsp: 3.673 ± 0.047	3.349ThrGlu: 3.349 ± 0.041	1.963ThrPhe: 1.963 ± 0.033	5.595ThrGly: 5.595 ± 0.051	1.111ThrHis: 1.111 ± 0.027	2.578ThrIle: 2.578 ± 0.042	1.393ThrLys: 1.393 ± 0.025	5.65ThrLeu: 5.65 ± 0.052	1.296ThrMet: 1.296 ± 0.028	1.314ThrAsn: 1.314 ± 0.027	3.831ThrPro: 3.831 ± 0.049	1.544ThrGln: 1.544 ± 0.027	3.596ThrArg: 3.596 ± 0.044	3.234ThrSer: 3.234 ± 0.039	3.984ThrThr: 3.984 ± 0.079	5.832ThrVal: 5.832 ± 0.055	0.885ThrTrp: 0.885 ± 0.023	1.394ThrTyr: 1.394 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	11.205ValAla: 11.205 ± 0.09	0.749ValCys: 0.749 ± 0.02	5.926ValAsp: 5.926 ± 0.07	4.884ValGlu: 4.884 ± 0.053	2.66ValPhe: 2.66 ± 0.039	7.035ValGly: 7.035 ± 0.066	1.818ValHis: 1.818 ± 0.034	4.283ValIle: 4.283 ± 0.05	1.867ValLys: 1.867 ± 0.033	8.697ValLeu: 8.697 ± 0.074	1.781ValMet: 1.781 ± 0.033	2.195ValAsn: 2.195 ± 0.038	4.705ValPro: 4.705 ± 0.054	2.109ValGln: 2.109 ± 0.032	5.71ValArg: 5.71 ± 0.067	4.748ValSer: 4.748 ± 0.055	5.551ValThr: 5.551 ± 0.06	8.545ValVal: 8.545 ± 0.081	1.089ValTrp: 1.089 ± 0.024	1.633ValTyr: 1.633 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.55TrpAla: 1.55 ± 0.029	0.16TrpCys: 0.16 ± 0.01	0.824TrpAsp: 0.824 ± 0.021	0.727TrpGlu: 0.727 ± 0.019	0.542TrpPhe: 0.542 ± 0.017	1.057TrpGly: 1.057 ± 0.023	0.374TrpHis: 0.374 ± 0.014	0.712TrpIle: 0.712 ± 0.022	0.358TrpLys: 0.358 ± 0.014	1.736TrpLeu: 1.736 ± 0.032	0.344TrpMet: 0.344 ± 0.013	0.428TrpAsn: 0.428 ± 0.017	0.808TrpPro: 0.808 ± 0.02	0.65TrpGln: 0.65 ± 0.02	1.302TrpArg: 1.302 ± 0.028	0.94TrpSer: 0.94 ± 0.025	0.961TrpThr: 0.961 ± 0.022	1.2TrpVal: 1.2 ± 0.026	0.348TrpTrp: 0.348 ± 0.016	0.343TrpTyr: 0.343 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.443TyrAla: 2.443 ± 0.037	0.244TyrCys: 0.244 ± 0.011	1.448TyrAsp: 1.448 ± 0.029	1.213TyrGlu: 1.213 ± 0.032	0.835TyrPhe: 0.835 ± 0.022	2.09TyrGly: 2.09 ± 0.035	0.483TyrHis: 0.483 ± 0.017	0.808TyrIle: 0.808 ± 0.02	0.441TyrLys: 0.441 ± 0.016	2.367TyrLeu: 2.367 ± 0.036	0.348TyrMet: 0.348 ± 0.014	0.534TyrAsn: 0.534 ± 0.017	1.341TyrPro: 1.341 ± 0.029	0.71TyrGln: 0.71 ± 0.019	1.874TyrArg: 1.874 ± 0.035	1.169TyrSer: 1.169 ± 0.026	1.236TyrThr: 1.236 ± 0.028	1.713TyrVal: 1.713 ± 0.033	0.374TyrTrp: 0.374 ± 0.013	0.569TyrTyr: 0.569 ± 0.018	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5948 proteins (1886812 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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