Amino acid dipepetide frequency for Microviridae Fen7918_21

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.966AlaAla: 6.966 ± 2.702
1.548AlaCys: 1.548 ± 1.378
0.774AlaAsp: 0.774 ± 0.654
2.322AlaGlu: 2.322 ± 2.124
3.096AlaPhe: 3.096 ± 1.71
6.966AlaGly: 6.966 ± 1.296
3.87AlaHis: 3.87 ± 1.026
3.096AlaIle: 3.096 ± 2.58
5.418AlaLys: 5.418 ± 2.295
2.322AlaLeu: 2.322 ± 0.864
0.0AlaMet: 0.0 ± 0.0
5.418AlaAsn: 5.418 ± 2.848
4.644AlaPro: 4.644 ± 1.508
9.288AlaGln: 9.288 ± 1.828
1.548AlaArg: 1.548 ± 0.661
4.644AlaSer: 4.644 ± 0.883
5.418AlaThr: 5.418 ± 1.575
2.322AlaVal: 2.322 ± 1.099
2.322AlaTrp: 2.322 ± 0.974
2.322AlaTyr: 2.322 ± 0.974
0.0AlaXaa: 0.0 ± 0.0
Cys
0.774CysAla: 0.774 ± 0.689
0.0CysCys: 0.0 ± 0.0
0.774CysAsp: 0.774 ± 0.524
0.774CysGlu: 0.774 ± 0.524
0.0CysPhe: 0.0 ± 0.0
1.548CysGly: 1.548 ± 0.661
0.774CysHis: 0.774 ± 0.689
1.548CysIle: 1.548 ± 1.193
0.0CysLys: 0.0 ± 0.0
0.774CysLeu: 0.774 ± 0.524
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.774CysPro: 0.774 ± 0.689
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
0.774CysThr: 0.774 ± 0.524
0.774CysVal: 0.774 ± 0.524
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.548AspAla: 1.548 ± 1.065
0.0AspCys: 0.0 ± 0.0
3.87AspAsp: 3.87 ± 2.133
0.774AspGlu: 0.774 ± 1.121
2.322AspPhe: 2.322 ± 1.25
3.096AspGly: 3.096 ± 2.096
0.774AspHis: 0.774 ± 0.689
3.87AspIle: 3.87 ± 0.983
3.096AspLys: 3.096 ± 0.618
6.192AspLeu: 6.192 ± 2.182
0.774AspMet: 0.774 ± 0.689
2.322AspAsn: 2.322 ± 0.974
4.644AspPro: 4.644 ± 1.28
3.096AspGln: 3.096 ± 1.036
1.548AspArg: 1.548 ± 1.193
0.0AspSer: 0.0 ± 0.0
4.644AspThr: 4.644 ± 2.197
4.644AspVal: 4.644 ± 2.197
0.774AspTrp: 0.774 ± 0.654
3.87AspTyr: 3.87 ± 2.621
0.0AspXaa: 0.0 ± 0.0
Glu
2.322GluAla: 2.322 ± 1.099
1.548GluCys: 1.548 ± 1.048
1.548GluAsp: 1.548 ± 1.065
0.774GluGlu: 0.774 ± 0.524
0.774GluPhe: 0.774 ± 0.689
1.548GluGly: 1.548 ± 0.661
2.322GluHis: 2.322 ± 0.974
1.548GluIle: 1.548 ± 1.065
5.418GluLys: 5.418 ± 2.3
2.322GluLeu: 2.322 ± 1.018
0.0GluMet: 0.0 ± 0.0
2.322GluAsn: 2.322 ± 0.994
2.322GluPro: 2.322 ± 2.124
1.548GluGln: 1.548 ± 1.065
3.096GluArg: 3.096 ± 1.919
2.322GluSer: 2.322 ± 1.224
3.096GluThr: 3.096 ± 0.969
3.096GluVal: 3.096 ± 1.418
0.774GluTrp: 0.774 ± 0.524
2.322GluTyr: 2.322 ± 0.974
0.0GluXaa: 0.0 ± 0.0
Phe
3.87PheAla: 3.87 ± 2.621
0.0PheCys: 0.0 ± 0.0
1.548PheAsp: 1.548 ± 1.048
1.548PheGlu: 1.548 ± 0.829
2.322PhePhe: 2.322 ± 1.245
3.87PheGly: 3.87 ± 1.359
0.0PheHis: 0.0 ± 0.0
0.774PheIle: 0.774 ± 1.079
1.548PheLys: 1.548 ± 0.661
3.87PheLeu: 3.87 ± 1.914
1.548PheMet: 1.548 ± 0.559
3.096PheAsn: 3.096 ± 1.076
0.774PhePro: 0.774 ± 0.524
0.0PheGln: 0.0 ± 0.0
3.096PheArg: 3.096 ± 1.322
1.548PheSer: 1.548 ± 1.193
2.322PheThr: 2.322 ± 1.018
2.322PheVal: 2.322 ± 0.974
1.548PheTrp: 1.548 ± 1.048
0.774PheTyr: 0.774 ± 1.121
0.0PheXaa: 0.0 ± 0.0
Gly
6.192GlyAla: 6.192 ± 1.822
0.0GlyCys: 0.0 ± 0.0
4.644GlyAsp: 4.644 ± 0.976
3.87GlyGlu: 3.87 ± 1.942
0.774GlyPhe: 0.774 ± 0.524
4.644GlyGly: 4.644 ± 1.02
1.548GlyHis: 1.548 ± 1.048
3.87GlyIle: 3.87 ± 1.807
2.322GlyLys: 2.322 ± 1.378
7.74GlyLeu: 7.74 ± 1.047
1.548GlyMet: 1.548 ± 1.308
3.096GlyAsn: 3.096 ± 1.418
0.774GlyPro: 0.774 ± 0.524
5.418GlyGln: 5.418 ± 2.811
2.322GlyArg: 2.322 ± 0.994
4.644GlySer: 4.644 ± 0.976
6.966GlyThr: 6.966 ± 0.552
2.322GlyVal: 2.322 ± 0.864
0.774GlyTrp: 0.774 ± 0.689
1.548GlyTyr: 1.548 ± 0.661
0.0GlyXaa: 0.0 ± 0.0
His
1.548HisAla: 1.548 ± 0.661
0.774HisCys: 0.774 ± 0.689
1.548HisAsp: 1.548 ± 1.048
0.0HisGlu: 0.0 ± 0.0
1.548HisPhe: 1.548 ± 0.661
2.322HisGly: 2.322 ± 1.337
1.548HisHis: 1.548 ± 0.829
1.548HisIle: 1.548 ± 1.378
1.548HisLys: 1.548 ± 1.096
3.096HisLeu: 3.096 ± 1.901
1.548HisMet: 1.548 ± 0.554
0.0HisAsn: 0.0 ± 0.0
0.774HisPro: 0.774 ± 0.524
0.774HisGln: 0.774 ± 0.524
1.548HisArg: 1.548 ± 0.661
1.548HisSer: 1.548 ± 0.559
1.548HisThr: 1.548 ± 1.378
0.0HisVal: 0.0 ± 0.0
0.774HisTrp: 0.774 ± 1.121
1.548HisTyr: 1.548 ± 0.661
0.0HisXaa: 0.0 ± 0.0
Ile
3.87IleAla: 3.87 ± 1.614
0.774IleCys: 0.774 ± 0.524
1.548IleAsp: 1.548 ± 1.048
1.548IleGlu: 1.548 ± 0.661
3.096IlePhe: 3.096 ± 1.316
3.096IleGly: 3.096 ± 1.339
3.096IleHis: 3.096 ± 1.322
1.548IleIle: 1.548 ± 1.335
3.096IleLys: 3.096 ± 1.728
6.192IleLeu: 6.192 ± 3.381
2.322IleMet: 2.322 ± 1.48
6.966IleAsn: 6.966 ± 1.813
3.096IlePro: 3.096 ± 1.05
2.322IleGln: 2.322 ± 0.51
3.87IleArg: 3.87 ± 1.942
4.644IleSer: 4.644 ± 1.742
3.87IleThr: 3.87 ± 1.026
1.548IleVal: 1.548 ± 0.829
0.774IleTrp: 0.774 ± 1.079
3.87IleTyr: 3.87 ± 0.924
0.0IleXaa: 0.0 ± 0.0
Lys
3.096LysAla: 3.096 ± 1.919
0.0LysCys: 0.0 ± 0.0
2.322LysAsp: 2.322 ± 0.51
0.774LysGlu: 0.774 ± 1.121
3.87LysPhe: 3.87 ± 1.026
2.322LysGly: 2.322 ± 0.51
2.322LysHis: 2.322 ± 2.693
3.096LysIle: 3.096 ± 1.322
4.644LysLys: 4.644 ± 2.399
3.87LysLeu: 3.87 ± 2.167
0.774LysMet: 0.774 ± 0.524
6.966LysAsn: 6.966 ± 2.376
3.096LysPro: 3.096 ± 2.386
6.192LysGln: 6.192 ± 2.717
2.322LysArg: 2.322 ± 1.245
4.644LysSer: 4.644 ± 1.804
3.87LysThr: 3.87 ± 1.273
0.774LysVal: 0.774 ± 0.524
0.774LysTrp: 0.774 ± 0.689
4.644LysTyr: 4.644 ± 1.673
0.0LysXaa: 0.0 ± 0.0
Leu
6.966LeuAla: 6.966 ± 1.084
0.0LeuCys: 0.0 ± 0.0
3.87LeuAsp: 3.87 ± 1.103
4.644LeuGlu: 4.644 ± 2.036
2.322LeuPhe: 2.322 ± 1.378
8.514LeuGly: 8.514 ± 2.263
0.774LeuHis: 0.774 ± 0.689
6.192LeuIle: 6.192 ± 1.921
6.966LeuLys: 6.966 ± 1.831
3.87LeuLeu: 3.87 ± 1.975
2.322LeuMet: 2.322 ± 1.98
6.192LeuAsn: 6.192 ± 1.466
3.096LeuPro: 3.096 ± 1.076
8.514LeuGln: 8.514 ± 2.032
4.644LeuArg: 4.644 ± 0.883
2.322LeuSer: 2.322 ± 1.325
5.418LeuThr: 5.418 ± 1.153
6.192LeuVal: 6.192 ± 1.297
2.322LeuTrp: 2.322 ± 1.25
0.0LeuTyr: 0.0 ± 0.0
0.0LeuXaa: 0.0 ± 0.0
Met
1.548MetAla: 1.548 ± 0.661
0.0MetCys: 0.0 ± 0.0
0.774MetAsp: 0.774 ± 1.121
0.774MetGlu: 0.774 ± 0.689
0.774MetPhe: 0.774 ± 0.654
2.322MetGly: 2.322 ± 0.864
1.548MetHis: 1.548 ± 0.559
0.774MetIle: 0.774 ± 0.524
0.0MetLys: 0.0 ± 0.0
0.774MetLeu: 0.774 ± 0.654
0.774MetMet: 0.774 ± 0.524
1.548MetAsn: 1.548 ± 0.559
3.096MetPro: 3.096 ± 1.418
2.322MetGln: 2.322 ± 1.325
1.548MetArg: 1.548 ± 1.048
2.322MetSer: 2.322 ± 0.974
2.322MetThr: 2.322 ± 1.738
0.774MetVal: 0.774 ± 0.654
0.0MetTrp: 0.0 ± 0.0
0.774MetTyr: 0.774 ± 0.654
0.0MetXaa: 0.0 ± 0.0
Asn
6.192AsnAla: 6.192 ± 2.484
0.0AsnCys: 0.0 ± 0.0
1.548AsnAsp: 1.548 ± 0.661
1.548AsnGlu: 1.548 ± 0.559
0.774AsnPhe: 0.774 ± 1.121
3.87AsnGly: 3.87 ± 0.983
0.774AsnHis: 0.774 ± 0.689
6.966AsnIle: 6.966 ± 1.486
3.87AsnLys: 3.87 ± 2.112
10.062AsnLeu: 10.062 ± 5.814
2.322AsnMet: 2.322 ± 1.099
3.096AsnAsn: 3.096 ± 2.617
1.548AsnPro: 1.548 ± 0.829
3.096AsnGln: 3.096 ± 1.418
5.418AsnArg: 5.418 ± 1.687
4.644AsnSer: 4.644 ± 1.348
9.288AsnThr: 9.288 ± 2.023
3.096AsnVal: 3.096 ± 1.339
0.774AsnTrp: 0.774 ± 0.524
0.774AsnTyr: 0.774 ± 0.689
0.0AsnXaa: 0.0 ± 0.0
Pro
3.87ProAla: 3.87 ± 1.026
0.774ProCys: 0.774 ± 0.524
3.87ProAsp: 3.87 ± 3.168
1.548ProGlu: 1.548 ± 0.661
0.774ProPhe: 0.774 ± 0.524
2.322ProGly: 2.322 ± 1.572
0.774ProHis: 0.774 ± 0.689
0.774ProIle: 0.774 ± 0.689
5.418ProLys: 5.418 ± 0.66
6.192ProLeu: 6.192 ± 1.245
2.322ProMet: 2.322 ± 0.996
4.644ProAsn: 4.644 ± 2.312
1.548ProPro: 1.548 ± 1.048
3.87ProGln: 3.87 ± 1.898
2.322ProArg: 2.322 ± 0.994
2.322ProSer: 2.322 ± 2.21
2.322ProThr: 2.322 ± 1.099
2.322ProVal: 2.322 ± 1.572
1.548ProTrp: 1.548 ± 0.559
1.548ProTyr: 1.548 ± 1.048
0.0ProXaa: 0.0 ± 0.0
Gln
3.87GlnAla: 3.87 ± 1.975
0.0GlnCys: 0.0 ± 0.0
3.87GlnAsp: 3.87 ± 1.573
4.644GlnGlu: 4.644 ± 1.151
1.548GlnPhe: 1.548 ± 0.661
4.644GlnGly: 4.644 ± 1.632
0.0GlnHis: 0.0 ± 0.0
1.548GlnIle: 1.548 ± 1.096
4.644GlnLys: 4.644 ± 1.453
2.322GlnLeu: 2.322 ± 1.099
0.774GlnMet: 0.774 ± 0.654
6.966GlnAsn: 6.966 ± 3.94
2.322GlnPro: 2.322 ± 1.25
5.418GlnGln: 5.418 ± 3.653
4.644GlnArg: 4.644 ± 1.348
4.644GlnSer: 4.644 ± 2.197
5.418GlnThr: 5.418 ± 2.295
4.644GlnVal: 4.644 ± 1.729
0.0GlnTrp: 0.0 ± 0.0
1.548GlnTyr: 1.548 ± 1.244
0.0GlnXaa: 0.0 ± 0.0
Arg
4.644ArgAla: 4.644 ± 1.395
0.774ArgCys: 0.774 ± 0.689
2.322ArgAsp: 2.322 ± 0.974
1.548ArgGlu: 1.548 ± 1.244
1.548ArgPhe: 1.548 ± 1.048
1.548ArgGly: 1.548 ± 1.065
0.0ArgHis: 0.0 ± 0.0
6.966ArgIle: 6.966 ± 0.552
1.548ArgLys: 1.548 ± 1.378
6.192ArgLeu: 6.192 ± 1.42
1.548ArgMet: 1.548 ± 0.559
4.644ArgAsn: 4.644 ± 1.02
5.418ArgPro: 5.418 ± 1.256
0.774ArgGln: 0.774 ± 0.654
3.87ArgArg: 3.87 ± 1.942
0.774ArgSer: 0.774 ± 1.079
2.322ArgThr: 2.322 ± 1.593
0.774ArgVal: 0.774 ± 0.524
0.0ArgTrp: 0.0 ± 0.0
2.322ArgTyr: 2.322 ± 0.974
0.0ArgXaa: 0.0 ± 0.0
Ser
3.096SerAla: 3.096 ± 1.119
1.548SerCys: 1.548 ± 1.065
5.418SerAsp: 5.418 ± 1.251
3.87SerGlu: 3.87 ± 0.983
2.322SerPhe: 2.322 ± 1.245
3.096SerGly: 3.096 ± 0.969
0.774SerHis: 0.774 ± 0.524
3.87SerIle: 3.87 ± 1.616
5.418SerLys: 5.418 ± 2.3
5.418SerLeu: 5.418 ± 1.248
0.0SerMet: 0.0 ± 0.0
0.774SerAsn: 0.774 ± 1.121
3.096SerPro: 3.096 ± 1.036
3.096SerGln: 3.096 ± 1.72
2.322SerArg: 2.322 ± 0.937
6.192SerSer: 6.192 ± 1.56
3.096SerThr: 3.096 ± 1.901
4.644SerVal: 4.644 ± 1.02
1.548SerTrp: 1.548 ± 0.661
1.548SerTyr: 1.548 ± 0.559
0.0SerXaa: 0.0 ± 0.0
Thr
3.87ThrAla: 3.87 ± 1.359
0.0ThrCys: 0.0 ± 0.0
6.192ThrAsp: 6.192 ± 2.238
3.87ThrGlu: 3.87 ± 0.819
3.87ThrPhe: 3.87 ± 1.978
4.644ThrGly: 4.644 ± 1.616
0.774ThrHis: 0.774 ± 0.524
6.966ThrIle: 6.966 ± 3.351
1.548ThrLys: 1.548 ± 1.193
7.74ThrLeu: 7.74 ± 2.623
1.548ThrMet: 1.548 ± 0.941
3.096ThrAsn: 3.096 ± 1.72
3.87ThrPro: 3.87 ± 1.026
3.096ThrGln: 3.096 ± 1.764
2.322ThrArg: 2.322 ± 0.974
5.418ThrSer: 5.418 ± 1.005
4.644ThrThr: 4.644 ± 1.729
0.774ThrVal: 0.774 ± 0.689
3.096ThrTrp: 3.096 ± 1.982
3.87ThrTyr: 3.87 ± 1.919
0.0ThrXaa: 0.0 ± 0.0
Val
5.418ValAla: 5.418 ± 1.251
0.0ValCys: 0.0 ± 0.0
3.87ValAsp: 3.87 ± 2.016
3.096ValGlu: 3.096 ± 0.618
0.774ValPhe: 0.774 ± 0.524
1.548ValGly: 1.548 ± 0.829
0.774ValHis: 0.774 ± 0.524
1.548ValIle: 1.548 ± 1.065
2.322ValLys: 2.322 ± 0.974
3.096ValLeu: 3.096 ± 0.618
2.322ValMet: 2.322 ± 0.864
4.644ValAsn: 4.644 ± 1.02
4.644ValPro: 4.644 ± 1.729
3.096ValGln: 3.096 ± 1.72
0.774ValArg: 0.774 ± 0.654
1.548ValSer: 1.548 ± 0.559
2.322ValThr: 2.322 ± 0.974
0.774ValVal: 0.774 ± 0.524
0.0ValTrp: 0.0 ± 0.0
1.548ValTyr: 1.548 ± 0.559
0.0ValXaa: 0.0 ± 0.0
Trp
0.774TrpAla: 0.774 ± 0.524
0.0TrpCys: 0.0 ± 0.0
0.774TrpAsp: 0.774 ± 1.079
1.548TrpGlu: 1.548 ± 1.048
0.774TrpPhe: 0.774 ± 0.654
0.774TrpGly: 0.774 ± 0.654
2.322TrpHis: 2.322 ± 1.245
0.774TrpIle: 0.774 ± 1.121
0.0TrpLys: 0.0 ± 0.0
2.322TrpLeu: 2.322 ± 1.25
0.0TrpMet: 0.0 ± 0.0
0.774TrpAsn: 0.774 ± 0.654
1.548TrpPro: 1.548 ± 1.048
0.774TrpGln: 0.774 ± 1.079
0.774TrpArg: 0.774 ± 0.689
3.096TrpSer: 3.096 ± 0.618
0.0TrpThr: 0.0 ± 0.0
0.774TrpVal: 0.774 ± 0.654
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.87TyrAla: 3.87 ± 1.432
1.548TyrCys: 1.548 ± 0.661
0.774TyrAsp: 0.774 ± 0.524
1.548TyrGlu: 1.548 ± 1.378
3.096TyrPhe: 3.096 ± 1.71
2.322TyrGly: 2.322 ± 0.51
0.774TyrHis: 0.774 ± 0.689
3.87TyrIle: 3.87 ± 1.58
1.548TyrLys: 1.548 ± 0.661
0.774TyrLeu: 0.774 ± 0.524
1.548TyrMet: 1.548 ± 1.193
3.096TyrAsn: 3.096 ± 2.167
0.774TyrPro: 0.774 ± 1.121
0.774TyrGln: 0.774 ± 0.524
1.548TyrArg: 1.548 ± 1.048
3.87TyrSer: 3.87 ± 1.359
1.548TyrThr: 1.548 ± 0.829
1.548TyrVal: 1.548 ± 1.048
0.0TyrTrp: 0.0 ± 0.0
2.322TyrTyr: 2.322 ± 1.245
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1293 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski