Amino acid dipepetide frequency for Daphne virus S

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.418AlaAla: 7.418 ± 4.134
1.413AlaCys: 1.413 ± 1.526
3.179AlaAsp: 3.179 ± 1.031
4.592AlaGlu: 4.592 ± 1.203
3.179AlaPhe: 3.179 ± 2.423
6.711AlaGly: 6.711 ± 1.913
2.119AlaHis: 2.119 ± 1.387
4.592AlaIle: 4.592 ± 1.203
6.005AlaLys: 6.005 ± 1.432
5.652AlaLeu: 5.652 ± 2.308
2.119AlaMet: 2.119 ± 0.433
3.532AlaAsn: 3.532 ± 1.395
2.473AlaPro: 2.473 ± 0.976
2.826AlaGln: 2.826 ± 0.491
3.532AlaArg: 3.532 ± 0.886
6.005AlaSer: 6.005 ± 2.168
4.945AlaThr: 4.945 ± 1.572
5.298AlaVal: 5.298 ± 2.403
0.353AlaTrp: 0.353 ± 0.189
0.706AlaTyr: 0.706 ± 0.379
0.0AlaXaa: 0.0 ± 0.0
Cys
1.413CysAla: 1.413 ± 0.865
0.353CysCys: 0.353 ± 0.189
1.06CysAsp: 1.06 ± 0.666
2.473CysGlu: 2.473 ± 1.763
2.119CysPhe: 2.119 ± 0.742
1.413CysGly: 1.413 ± 0.757
0.706CysHis: 0.706 ± 0.721
1.413CysIle: 1.413 ± 0.872
0.706CysLys: 0.706 ± 0.379
2.473CysLeu: 2.473 ± 1.077
0.353CysMet: 0.353 ± 0.189
0.706CysAsn: 0.706 ± 0.591
0.0CysPro: 0.0 ± 0.0
0.353CysGln: 0.353 ± 0.189
2.473CysArg: 2.473 ± 1.074
0.0CysSer: 0.0 ± 0.0
1.06CysThr: 1.06 ± 0.469
3.886CysVal: 3.886 ± 1.721
0.0CysTrp: 0.0 ± 0.0
2.119CysTyr: 2.119 ± 0.992
0.0CysXaa: 0.0 ± 0.0
Asp
2.826AspAla: 2.826 ± 0.964
1.06AspCys: 1.06 ± 0.685
2.119AspAsp: 2.119 ± 0.687
4.239AspGlu: 4.239 ± 1.099
4.239AspPhe: 4.239 ± 1.171
3.179AspGly: 3.179 ± 0.901
1.766AspHis: 1.766 ± 1.255
2.119AspIle: 2.119 ± 0.432
1.766AspLys: 1.766 ± 0.982
4.592AspLeu: 4.592 ± 1.023
0.706AspMet: 0.706 ± 0.529
2.826AspAsn: 2.826 ± 0.979
3.886AspPro: 3.886 ± 2.809
0.706AspGln: 0.706 ± 0.379
3.179AspArg: 3.179 ± 0.613
0.706AspSer: 0.706 ± 0.379
1.06AspThr: 1.06 ± 0.54
4.239AspVal: 4.239 ± 0.8
1.766AspTrp: 1.766 ± 0.563
2.119AspTyr: 2.119 ± 0.716
0.0AspXaa: 0.0 ± 0.0
Glu
7.771GluAla: 7.771 ± 1.177
1.06GluCys: 1.06 ± 0.568
2.473GluAsp: 2.473 ± 0.932
3.886GluGlu: 3.886 ± 1.408
2.473GluPhe: 2.473 ± 0.786
4.239GluGly: 4.239 ± 0.8
2.473GluHis: 2.473 ± 0.837
5.652GluIle: 5.652 ± 1.682
3.179GluLys: 3.179 ± 1.704
7.418GluLeu: 7.418 ± 3.394
2.826GluMet: 2.826 ± 1.129
2.473GluAsn: 2.473 ± 0.665
2.119GluPro: 2.119 ± 0.742
2.826GluGln: 2.826 ± 1.032
5.298GluArg: 5.298 ± 3.271
4.945GluSer: 4.945 ± 1.544
2.826GluThr: 2.826 ± 1.515
3.532GluVal: 3.532 ± 1.381
0.353GluTrp: 0.353 ± 0.189
2.473GluTyr: 2.473 ± 1.103
0.0GluXaa: 0.0 ± 0.0
Phe
2.119PheAla: 2.119 ± 1.136
1.06PheCys: 1.06 ± 0.568
3.179PheAsp: 3.179 ± 0.723
6.358PheGlu: 6.358 ± 0.691
2.119PhePhe: 2.119 ± 0.432
3.179PheGly: 3.179 ± 1.62
1.413PheHis: 1.413 ± 0.648
3.532PheIle: 3.532 ± 0.978
2.119PheLys: 2.119 ± 1.136
5.652PheLeu: 5.652 ± 1.49
1.06PheMet: 1.06 ± 0.683
2.119PheAsn: 2.119 ± 1.192
1.06PhePro: 1.06 ± 0.995
2.826PheGln: 2.826 ± 0.823
1.413PheArg: 1.413 ± 0.757
4.592PheSer: 4.592 ± 1.439
2.473PheThr: 2.473 ± 1.593
3.532PheVal: 3.532 ± 1.729
0.353PheTrp: 0.353 ± 0.189
1.766PheTyr: 1.766 ± 1.616
0.0PheXaa: 0.0 ± 0.0
Gly
4.945GlyAla: 4.945 ± 1.365
1.06GlyCys: 1.06 ± 0.54
3.532GlyAsp: 3.532 ± 0.555
4.945GlyGlu: 4.945 ± 1.024
3.179GlyPhe: 3.179 ± 1.173
3.532GlyGly: 3.532 ± 2.528
1.06GlyHis: 1.06 ± 0.685
2.826GlyIle: 2.826 ± 0.696
4.592GlyLys: 4.592 ± 1.439
5.298GlyLeu: 5.298 ± 1.651
1.06GlyMet: 1.06 ± 0.568
1.413GlyAsn: 1.413 ± 1.057
0.706GlyPro: 0.706 ± 0.529
2.473GlyGln: 2.473 ± 1.702
6.358GlyArg: 6.358 ± 1.067
4.592GlySer: 4.592 ± 2.133
2.473GlyThr: 2.473 ± 1.13
6.711GlyVal: 6.711 ± 1.2
1.06GlyTrp: 1.06 ± 0.568
1.766GlyTyr: 1.766 ± 0.753
0.0GlyXaa: 0.0 ± 0.0
His
1.766HisAla: 1.766 ± 0.947
1.06HisCys: 1.06 ± 0.54
1.766HisAsp: 1.766 ± 0.563
1.06HisGlu: 1.06 ± 0.568
1.06HisPhe: 1.06 ± 0.54
1.413HisGly: 1.413 ± 1.121
0.706HisHis: 0.706 ± 0.379
0.706HisIle: 0.706 ± 0.969
1.766HisLys: 1.766 ± 0.947
3.886HisLeu: 3.886 ± 2.083
0.353HisMet: 0.353 ± 0.189
0.353HisAsn: 0.353 ± 0.189
1.06HisPro: 1.06 ± 0.666
0.353HisGln: 0.353 ± 0.189
2.473HisArg: 2.473 ± 1.471
2.119HisSer: 2.119 ± 0.788
1.413HisThr: 1.413 ± 0.865
2.473HisVal: 2.473 ± 2.247
0.353HisTrp: 0.353 ± 0.189
1.413HisTyr: 1.413 ± 0.695
0.0HisXaa: 0.0 ± 0.0
Ile
4.592IleAla: 4.592 ± 0.833
2.119IleCys: 2.119 ± 1.501
1.413IleAsp: 1.413 ± 0.757
4.592IleGlu: 4.592 ± 1.519
2.473IlePhe: 2.473 ± 0.883
3.179IleGly: 3.179 ± 1.162
2.119IleHis: 2.119 ± 0.716
3.179IleIle: 3.179 ± 1.859
2.826IleLys: 2.826 ± 1.44
3.532IleLeu: 3.532 ± 3.049
2.473IleMet: 2.473 ± 1.225
3.886IleAsn: 3.886 ± 0.927
2.473IlePro: 2.473 ± 1.289
1.413IleGln: 1.413 ± 0.757
3.886IleArg: 3.886 ± 1.625
3.886IleSer: 3.886 ± 2.802
1.413IleThr: 1.413 ± 0.872
3.532IleVal: 3.532 ± 1.133
0.353IleTrp: 0.353 ± 0.189
2.119IleTyr: 2.119 ± 0.742
0.0IleXaa: 0.0 ± 0.0
Lys
3.886LysAla: 3.886 ± 0.927
0.353LysCys: 0.353 ± 0.189
3.179LysAsp: 3.179 ± 0.901
3.179LysGlu: 3.179 ± 1.704
3.179LysPhe: 3.179 ± 1.274
4.945LysGly: 4.945 ± 1.616
2.826LysHis: 2.826 ± 1.04
2.826LysIle: 2.826 ± 1.129
3.886LysLys: 3.886 ± 1.089
6.005LysLeu: 6.005 ± 3.219
0.353LysMet: 0.353 ± 0.189
1.766LysAsn: 1.766 ± 0.947
3.532LysPro: 3.532 ± 2.643
2.119LysGln: 2.119 ± 0.938
3.179LysArg: 3.179 ± 1.218
3.532LysSer: 3.532 ± 0.762
2.119LysThr: 2.119 ± 0.8
4.945LysVal: 4.945 ± 1.024
0.706LysTrp: 0.706 ± 0.379
2.473LysTyr: 2.473 ± 0.783
0.0LysXaa: 0.0 ± 0.0
Leu
6.005LeuAla: 6.005 ± 1.589
3.179LeuCys: 3.179 ± 1.258
4.592LeuAsp: 4.592 ± 1.115
8.124LeuGlu: 8.124 ± 1.124
4.592LeuPhe: 4.592 ± 1.956
5.652LeuGly: 5.652 ± 0.888
1.413LeuHis: 1.413 ± 1.934
5.652LeuIle: 5.652 ± 1.408
8.124LeuLys: 8.124 ± 3.769
7.065LeuLeu: 7.065 ± 2.074
1.413LeuMet: 1.413 ± 0.757
2.826LeuAsn: 2.826 ± 2.181
4.239LeuPro: 4.239 ± 0.678
3.179LeuGln: 3.179 ± 0.613
5.298LeuArg: 5.298 ± 1.095
6.711LeuSer: 6.711 ± 1.93
7.418LeuThr: 7.418 ± 1.874
4.239LeuVal: 4.239 ± 1.218
1.413LeuTrp: 1.413 ± 0.863
3.179LeuTyr: 3.179 ± 0.87
0.0LeuXaa: 0.0 ± 0.0
Met
2.826MetAla: 2.826 ± 0.999
0.706MetCys: 0.706 ± 0.379
1.06MetAsp: 1.06 ± 0.54
1.413MetGlu: 1.413 ± 0.757
0.0MetPhe: 0.0 ± 0.0
2.473MetGly: 2.473 ± 0.837
0.706MetHis: 0.706 ± 0.529
1.06MetIle: 1.06 ± 0.568
1.06MetLys: 1.06 ± 0.568
2.119MetLeu: 2.119 ± 0.687
0.706MetMet: 0.706 ± 0.379
1.413MetAsn: 1.413 ± 0.661
1.413MetPro: 1.413 ± 0.865
0.353MetGln: 0.353 ± 0.189
1.06MetArg: 1.06 ± 1.159
1.413MetSer: 1.413 ± 0.872
1.413MetThr: 1.413 ± 0.872
1.413MetVal: 1.413 ± 0.482
0.0MetTrp: 0.0 ± 0.0
0.353MetTyr: 0.353 ± 0.189
0.0MetXaa: 0.0 ± 0.0
Asn
3.179AsnAla: 3.179 ± 2.526
1.413AsnCys: 1.413 ± 0.872
1.766AsnAsp: 1.766 ± 0.626
3.532AsnGlu: 3.532 ± 1.346
2.473AsnPhe: 2.473 ± 0.76
1.766AsnGly: 1.766 ± 0.947
1.06AsnHis: 1.06 ± 0.568
2.826AsnIle: 2.826 ± 1.594
1.413AsnLys: 1.413 ± 1.443
4.592AsnLeu: 4.592 ± 0.907
1.06AsnMet: 1.06 ± 0.469
1.766AsnAsn: 1.766 ± 2.437
1.06AsnPro: 1.06 ± 0.469
1.413AsnGln: 1.413 ± 0.648
2.119AsnArg: 2.119 ± 1.025
2.119AsnSer: 2.119 ± 0.716
1.06AsnThr: 1.06 ± 0.987
1.413AsnVal: 1.413 ± 0.553
0.353AsnTrp: 0.353 ± 0.189
2.826AsnTyr: 2.826 ± 0.964
0.0AsnXaa: 0.0 ± 0.0
Pro
3.179ProAla: 3.179 ± 2.375
0.353ProCys: 0.353 ± 0.189
3.886ProAsp: 3.886 ± 1.267
2.826ProGlu: 2.826 ± 1.515
1.06ProPhe: 1.06 ± 1.531
3.532ProGly: 3.532 ± 1.806
1.06ProHis: 1.06 ± 1.225
1.413ProIle: 1.413 ± 0.757
1.766ProLys: 1.766 ± 1.77
3.179ProLeu: 3.179 ± 1.087
0.706ProMet: 0.706 ± 0.548
1.06ProAsn: 1.06 ± 1.272
3.179ProPro: 3.179 ± 2.405
1.766ProGln: 1.766 ± 1.359
3.886ProArg: 3.886 ± 1.884
3.179ProSer: 3.179 ± 1.291
2.119ProThr: 2.119 ± 1.586
1.766ProVal: 1.766 ± 0.626
1.413ProTrp: 1.413 ± 0.695
1.413ProTyr: 1.413 ± 0.482
0.0ProXaa: 0.0 ± 0.0
Gln
1.413GlnAla: 1.413 ± 0.482
0.706GlnCys: 0.706 ± 1.48
2.826GlnAsp: 2.826 ± 0.657
2.473GlnGlu: 2.473 ± 0.883
1.413GlnPhe: 1.413 ± 0.553
1.766GlnGly: 1.766 ± 0.563
1.413GlnHis: 1.413 ± 0.757
1.06GlnIle: 1.06 ± 0.54
0.706GlnLys: 0.706 ± 0.379
2.826GlnLeu: 2.826 ± 1.445
1.06GlnMet: 1.06 ± 1.076
1.06GlnAsn: 1.06 ± 1.159
1.766GlnPro: 1.766 ± 1.4
0.706GlnGln: 0.706 ± 0.379
1.766GlnArg: 1.766 ± 0.517
3.179GlnSer: 3.179 ± 0.774
0.706GlnThr: 0.706 ± 0.591
2.473GlnVal: 2.473 ± 0.783
0.0GlnTrp: 0.0 ± 0.0
0.706GlnTyr: 0.706 ± 0.379
0.0GlnXaa: 0.0 ± 0.0
Arg
6.005ArgAla: 6.005 ± 3.395
1.413ArgCys: 1.413 ± 2.347
3.886ArgAsp: 3.886 ± 0.935
3.179ArgGlu: 3.179 ± 0.613
5.298ArgPhe: 5.298 ± 1.879
3.532ArgGly: 3.532 ± 2.059
1.413ArgHis: 1.413 ± 0.553
2.826ArgIle: 2.826 ± 1.152
4.945ArgLys: 4.945 ± 1.181
4.239ArgLeu: 4.239 ± 1.447
1.413ArgMet: 1.413 ± 0.639
1.766ArgAsn: 1.766 ± 1.088
1.766ArgPro: 1.766 ± 2.437
0.353ArgGln: 0.353 ± 0.641
3.886ArgArg: 3.886 ± 1.217
6.358ArgSer: 6.358 ± 1.291
2.119ArgThr: 2.119 ± 0.687
3.532ArgVal: 3.532 ± 1.141
0.706ArgTrp: 0.706 ± 0.379
2.473ArgTyr: 2.473 ± 0.837
0.0ArgXaa: 0.0 ± 0.0
Ser
6.358SerAla: 6.358 ± 1.869
1.766SerCys: 1.766 ± 0.947
2.826SerAsp: 2.826 ± 0.491
4.592SerGlu: 4.592 ± 0.907
3.532SerPhe: 3.532 ± 1.346
3.886SerGly: 3.886 ± 1.078
1.766SerHis: 1.766 ± 0.947
4.239SerIle: 4.239 ± 2.612
4.945SerLys: 4.945 ± 1.561
7.418SerLeu: 7.418 ± 4.047
1.413SerMet: 1.413 ± 0.757
3.532SerAsn: 3.532 ± 0.762
2.826SerPro: 2.826 ± 1.053
2.119SerGln: 2.119 ± 0.935
4.239SerArg: 4.239 ± 0.678
6.358SerSer: 6.358 ± 2.211
5.298SerThr: 5.298 ± 0.895
3.532SerVal: 3.532 ± 1.537
0.0SerTrp: 0.0 ± 0.0
1.413SerTyr: 1.413 ± 0.863
0.0SerXaa: 0.0 ± 0.0
Thr
2.826ThrAla: 2.826 ± 1.896
1.413ThrCys: 1.413 ± 1.121
1.06ThrAsp: 1.06 ± 1.159
2.826ThrGlu: 2.826 ± 0.657
5.652ThrPhe: 5.652 ± 0.984
4.239ThrGly: 4.239 ± 1.039
1.413ThrHis: 1.413 ± 0.757
1.766ThrIle: 1.766 ± 0.563
2.826ThrLys: 2.826 ± 1.119
3.179ThrLeu: 3.179 ± 1.422
1.413ThrMet: 1.413 ± 0.757
1.766ThrAsn: 1.766 ± 0.563
2.119ThrPro: 2.119 ± 2.286
1.06ThrGln: 1.06 ± 0.987
2.473ThrArg: 2.473 ± 2.037
4.592ThrSer: 4.592 ± 1.889
1.413ThrThr: 1.413 ± 1.121
2.119ThrVal: 2.119 ± 1.088
0.706ThrTrp: 0.706 ± 0.379
2.473ThrTyr: 2.473 ± 0.896
0.0ThrXaa: 0.0 ± 0.0
Val
2.826ValAla: 2.826 ± 1.295
3.179ValCys: 3.179 ± 0.556
3.886ValAsp: 3.886 ± 0.865
3.886ValGlu: 3.886 ± 1.612
2.473ValPhe: 2.473 ± 1.648
2.826ValGly: 2.826 ± 1.53
1.06ValHis: 1.06 ± 0.685
4.945ValIle: 4.945 ± 1.13
2.826ValLys: 2.826 ± 1.515
8.478ValLeu: 8.478 ± 2.441
1.06ValMet: 1.06 ± 0.568
1.766ValAsn: 1.766 ± 0.947
4.592ValPro: 4.592 ± 1.203
2.119ValGln: 2.119 ± 0.778
2.473ValArg: 2.473 ± 1.325
4.945ValSer: 4.945 ± 0.81
3.532ValThr: 3.532 ± 1.45
3.179ValVal: 3.179 ± 0.998
0.706ValTrp: 0.706 ± 1.143
2.826ValTyr: 2.826 ± 1.04
0.0ValXaa: 0.0 ± 0.0
Trp
1.06TrpAla: 1.06 ± 0.568
0.353TrpCys: 0.353 ± 0.189
0.0TrpAsp: 0.0 ± 0.0
0.353TrpGlu: 0.353 ± 0.189
1.06TrpPhe: 1.06 ± 0.685
0.353TrpGly: 0.353 ± 0.818
0.706TrpHis: 0.706 ± 0.379
0.0TrpIle: 0.0 ± 0.0
0.0TrpLys: 0.0 ± 0.0
2.119TrpLeu: 2.119 ± 1.136
0.353TrpMet: 0.353 ± 0.189
1.413TrpAsn: 1.413 ± 0.482
0.353TrpPro: 0.353 ± 0.818
0.0TrpGln: 0.0 ± 0.0
0.706TrpArg: 0.706 ± 0.529
1.413TrpSer: 1.413 ± 0.482
0.0TrpThr: 0.0 ± 0.0
0.353TrpVal: 0.353 ± 0.189
0.0TrpTrp: 0.0 ± 0.0
0.353TrpTyr: 0.353 ± 0.189
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.239TyrAla: 4.239 ± 2.465
1.06TyrCys: 1.06 ± 0.469
1.413TyrAsp: 1.413 ± 0.757
1.766TyrGlu: 1.766 ± 0.947
0.353TyrPhe: 0.353 ± 0.811
1.766TyrGly: 1.766 ± 0.753
0.353TyrHis: 0.353 ± 0.189
2.826TyrIle: 2.826 ± 0.491
3.532TyrLys: 3.532 ± 0.949
4.592TyrLeu: 4.592 ± 1.878
0.706TyrMet: 0.706 ± 0.529
1.766TyrAsn: 1.766 ± 0.517
2.473TyrPro: 2.473 ± 0.922
1.06TyrGln: 1.06 ± 0.469
1.413TyrArg: 1.413 ± 1.121
1.413TyrSer: 1.413 ± 0.648
2.473TyrThr: 2.473 ± 0.977
1.413TyrVal: 1.413 ± 0.482
0.353TyrTrp: 0.353 ± 0.189
2.119TyrTyr: 2.119 ± 0.992
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6 proteins (2832 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski