Amino acid dipepetide frequency for Ovis aries (Sheep)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.54AlaAla: 6.54 ± 0.048	1.458AlaCys: 1.458 ± 0.013	2.875AlaAsp: 2.875 ± 0.017	4.708AlaGlu: 4.708 ± 0.03	2.674AlaPhe: 2.674 ± 0.02	4.844AlaGly: 4.844 ± 0.033	1.603AlaHis: 1.603 ± 0.015	2.757AlaIle: 2.757 ± 0.017	3.375AlaLys: 3.375 ± 0.023	7.254AlaLeu: 7.254 ± 0.04	1.438AlaMet: 1.438 ± 0.013	1.948AlaAsn: 1.948 ± 0.014	4.414AlaPro: 4.414 ± 0.031	3.197AlaGln: 3.197 ± 0.025	3.734AlaArg: 3.734 ± 0.025	5.807AlaSer: 5.807 ± 0.031	3.467AlaThr: 3.467 ± 0.023	4.814AlaVal: 4.814 ± 0.025	0.85AlaTrp: 0.85 ± 0.011	1.533AlaTyr: 1.533 ± 0.014	0.01AlaXaa: 0.01 ± 0.001
Cys	1.351CysAla: 1.351 ± 0.015	0.671CysCys: 0.671 ± 0.012	1.029CysAsp: 1.029 ± 0.013	1.272CysGlu: 1.272 ± 0.017	0.887CysPhe: 0.887 ± 0.01	1.714CysGly: 1.714 ± 0.023	0.663CysHis: 0.663 ± 0.008	0.962CysIle: 0.962 ± 0.011	1.124CysLys: 1.124 ± 0.012	2.272CysLeu: 2.272 ± 0.015	0.411CysMet: 0.411 ± 0.007	0.783CysAsn: 0.783 ± 0.011	1.477CysPro: 1.477 ± 0.016	1.074CysGln: 1.074 ± 0.014	1.339CysArg: 1.339 ± 0.012	2.067CysSer: 2.067 ± 0.018	1.098CysThr: 1.098 ± 0.012	1.408CysVal: 1.408 ± 0.02	0.314CysTrp: 0.314 ± 0.006	0.599CysTyr: 0.599 ± 0.008	0.001CysXaa: 0.001 ± 0.0
Asp	2.822AspAla: 2.822 ± 0.017	1.043AspCys: 1.043 ± 0.013	2.521AspAsp: 2.521 ± 0.022	3.335AspGlu: 3.335 ± 0.023	2.119AspPhe: 2.119 ± 0.015	3.211AspGly: 3.211 ± 0.022	1.136AspHis: 1.136 ± 0.012	2.539AspIle: 2.539 ± 0.018	2.445AspLys: 2.445 ± 0.018	4.939AspLeu: 4.939 ± 0.024	1.056AspMet: 1.056 ± 0.011	1.599AspAsn: 1.599 ± 0.013	2.91AspPro: 2.91 ± 0.021	1.818AspGln: 1.818 ± 0.014	2.425AspArg: 2.425 ± 0.019	4.117AspSer: 4.117 ± 0.025	2.453AspThr: 2.453 ± 0.019	3.028AspVal: 3.028 ± 0.028	0.645AspTrp: 0.645 ± 0.008	1.424AspTyr: 1.424 ± 0.012	0.002AspXaa: 0.002 ± 0.0
Glu	5.257GluAla: 5.257 ± 0.033	1.357GluCys: 1.357 ± 0.022	4.33GluAsp: 4.33 ± 0.024	7.739GluGlu: 7.739 ± 0.061	2.056GluPhe: 2.056 ± 0.014	4.237GluGly: 4.237 ± 0.029	1.465GluHis: 1.465 ± 0.014	3.064GluIle: 3.064 ± 0.023	5.288GluLys: 5.288 ± 0.045	6.324GluLeu: 6.324 ± 0.035	1.617GluMet: 1.617 ± 0.014	3.046GluAsn: 3.046 ± 0.02	3.283GluPro: 3.283 ± 0.027	3.045GluGln: 3.045 ± 0.023	3.901GluArg: 3.901 ± 0.03	4.335GluSer: 4.335 ± 0.027	3.425GluThr: 3.425 ± 0.02	4.182GluVal: 4.182 ± 0.028	0.697GluTrp: 0.697 ± 0.008	1.531GluTyr: 1.531 ± 0.015	0.004GluXaa: 0.004 ± 0.001
Phe	1.957PheAla: 1.957 ± 0.015	1.005PheCys: 1.005 ± 0.011	1.649PheAsp: 1.649 ± 0.014	1.963PheGlu: 1.963 ± 0.015	1.715PhePhe: 1.715 ± 0.017	2.237PheGly: 2.237 ± 0.018	1.039PheHis: 1.039 ± 0.01	1.893PheIle: 1.893 ± 0.015	1.772PheLys: 1.772 ± 0.016	4.371PheLeu: 4.371 ± 0.027	0.754PheMet: 0.754 ± 0.008	1.336PheAsn: 1.336 ± 0.012	2.076PhePro: 2.076 ± 0.017	1.821PheGln: 1.821 ± 0.012	1.991PheArg: 1.991 ± 0.017	3.518PheSer: 3.518 ± 0.019	2.074PheThr: 2.074 ± 0.015	2.211PheVal: 2.211 ± 0.019	0.517PheTrp: 0.517 ± 0.008	1.245PheTyr: 1.245 ± 0.012	0.001PheXaa: 0.001 ± 0.0
Gly	4.654GlyAla: 4.654 ± 0.032	1.357GlyCys: 1.357 ± 0.014	3.079GlyAsp: 3.079 ± 0.022	4.074GlyGlu: 4.074 ± 0.033	2.451GlyPhe: 2.451 ± 0.019	5.192GlyGly: 5.192 ± 0.04	1.702GlyHis: 1.702 ± 0.015	2.761GlyIle: 2.761 ± 0.018	3.745GlyLys: 3.745 ± 0.024	6.065GlyLeu: 6.065 ± 0.035	1.254GlyMet: 1.254 ± 0.013	2.353GlyAsn: 2.353 ± 0.017	4.491GlyPro: 4.491 ± 0.058	2.806GlyGln: 2.806 ± 0.021	3.924GlyArg: 3.924 ± 0.025	5.803GlySer: 5.803 ± 0.033	3.573GlyThr: 3.573 ± 0.021	3.633GlyVal: 3.633 ± 0.023	0.843GlyTrp: 0.843 ± 0.009	1.707GlyTyr: 1.707 ± 0.018	0.011GlyXaa: 0.011 ± 0.001
His	1.34HisAla: 1.34 ± 0.012	0.717HisCys: 0.717 ± 0.01	0.868HisAsp: 0.868 ± 0.009	1.25HisGlu: 1.25 ± 0.012	1.116HisPhe: 1.116 ± 0.011	1.543HisGly: 1.543 ± 0.016	0.871HisHis: 0.871 ± 0.011	1.22HisIle: 1.22 ± 0.01	1.199HisLys: 1.199 ± 0.012	2.958HisLeu: 2.958 ± 0.018	0.567HisMet: 0.567 ± 0.008	0.816HisAsn: 0.816 ± 0.008	1.694HisPro: 1.694 ± 0.014	1.331HisGln: 1.331 ± 0.018	1.607HisArg: 1.607 ± 0.013	2.284HisSer: 2.284 ± 0.017	1.549HisThr: 1.549 ± 0.022	1.514HisVal: 1.514 ± 0.013	0.356HisTrp: 0.356 ± 0.006	0.799HisTyr: 0.799 ± 0.009	0.002HisXaa: 0.002 ± 0.0
Ile	2.528IleAla: 2.528 ± 0.019	1.112IleCys: 1.112 ± 0.012	1.93IleAsp: 1.93 ± 0.018	2.473IleGlu: 2.473 ± 0.019	1.978IlePhe: 1.978 ± 0.017	2.157IleGly: 2.157 ± 0.018	1.341IleHis: 1.341 ± 0.013	2.374IleIle: 2.374 ± 0.02	2.574IleLys: 2.574 ± 0.022	4.71IleLeu: 4.71 ± 0.027	0.972IleMet: 0.972 ± 0.009	1.792IleAsn: 1.792 ± 0.014	2.613IlePro: 2.613 ± 0.019	2.277IleGln: 2.277 ± 0.016	2.344IleArg: 2.344 ± 0.017	3.751IleSer: 3.751 ± 0.02	2.575IleThr: 2.575 ± 0.022	2.485IleVal: 2.485 ± 0.018	0.535IleTrp: 0.535 ± 0.008	1.429IleTyr: 1.429 ± 0.013	0.001IleXaa: 0.001 ± 0.0
Lys	4.023LysAla: 4.023 ± 0.028	1.108LysCys: 1.108 ± 0.014	3.075LysAsp: 3.075 ± 0.022	5.047LysGlu: 5.047 ± 0.036	1.716LysPhe: 1.716 ± 0.014	3.28LysGly: 3.28 ± 0.036	1.37LysHis: 1.37 ± 0.013	2.757LysIle: 2.757 ± 0.022	4.693LysLys: 4.693 ± 0.033	5.102LysLeu: 5.102 ± 0.029	1.425LysMet: 1.425 ± 0.015	2.345LysAsn: 2.345 ± 0.017	3.065LysPro: 3.065 ± 0.024	2.533LysGln: 2.533 ± 0.022	3.257LysArg: 3.257 ± 0.019	3.842LysSer: 3.842 ± 0.025	3.102LysThr: 3.102 ± 0.021	3.449LysVal: 3.449 ± 0.023	0.616LysTrp: 0.616 ± 0.008	1.54LysTyr: 1.54 ± 0.013	0.003LysXaa: 0.003 ± 0.0
Leu	6.886LeuAla: 6.886 ± 0.037	2.315LeuCys: 2.315 ± 0.02	4.681LeuAsp: 4.681 ± 0.024	7.093LeuGlu: 7.093 ± 0.038	3.521LeuPhe: 3.521 ± 0.025	6.147LeuGly: 6.147 ± 0.032	2.727LeuHis: 2.727 ± 0.018	3.989LeuIle: 3.989 ± 0.027	5.791LeuLys: 5.791 ± 0.03	11.064LeuLeu: 11.064 ± 0.056	1.972LeuMet: 1.972 ± 0.016	3.504LeuAsn: 3.504 ± 0.02	6.134LeuPro: 6.134 ± 0.037	5.736LeuGln: 5.736 ± 0.036	5.997LeuArg: 5.997 ± 0.035	8.178LeuSer: 8.178 ± 0.038	5.232LeuThr: 5.232 ± 0.023	5.679LeuVal: 5.679 ± 0.031	1.208LeuTrp: 1.208 ± 0.011	2.584LeuTyr: 2.584 ± 0.016	0.005LeuXaa: 0.005 ± 0.001
Met	1.818MetAla: 1.818 ± 0.013	0.397MetCys: 0.397 ± 0.007	1.201MetAsp: 1.201 ± 0.012	1.74MetGlu: 1.74 ± 0.012	0.729MetPhe: 0.729 ± 0.01	1.27MetGly: 1.27 ± 0.012	0.433MetHis: 0.433 ± 0.006	0.847MetIle: 0.847 ± 0.009	1.425MetLys: 1.425 ± 0.012	1.957MetLeu: 1.957 ± 0.015	0.533MetMet: 0.533 ± 0.009	0.856MetAsn: 0.856 ± 0.01	1.05MetPro: 1.05 ± 0.014	0.88MetGln: 0.88 ± 0.01	1.013MetArg: 1.013 ± 0.009	1.505MetSer: 1.505 ± 0.013	1.099MetThr: 1.099 ± 0.011	1.367MetVal: 1.367 ± 0.011	0.235MetTrp: 0.235 ± 0.004	0.598MetTyr: 0.598 ± 0.008	0.001MetXaa: 0.001 ± 0.0
Asn	1.986AsnAla: 1.986 ± 0.016	0.84AsnCys: 0.84 ± 0.009	1.447AsnAsp: 1.447 ± 0.012	2.133AsnGlu: 2.133 ± 0.017	1.489AsnPhe: 1.489 ± 0.013	2.291AsnGly: 2.291 ± 0.02	0.934AsnHis: 0.934 ± 0.009	2.076AsnIle: 2.076 ± 0.015	2.158AsnLys: 2.158 ± 0.018	3.705AsnLeu: 3.705 ± 0.024	0.861AsnMet: 0.861 ± 0.009	1.454AsnAsn: 1.454 ± 0.014	2.174AsnPro: 2.174 ± 0.016	1.601AsnGln: 1.601 ± 0.014	1.795AsnArg: 1.795 ± 0.014	3.023AsnSer: 3.023 ± 0.02	1.913AsnThr: 1.913 ± 0.015	2.132AsnVal: 2.132 ± 0.015	0.459AsnTrp: 0.459 ± 0.006	1.098AsnTyr: 1.098 ± 0.012	0.001AsnXaa: 0.001 ± 0.0
Pro	4.965ProAla: 4.965 ± 0.035	1.214ProCys: 1.214 ± 0.013	2.762ProAsp: 2.762 ± 0.02	4.548ProGlu: 4.548 ± 0.029	1.955ProPhe: 1.955 ± 0.015	5.484ProGly: 5.484 ± 0.074	1.478ProHis: 1.478 ± 0.013	1.836ProIle: 1.836 ± 0.017	2.856ProLys: 2.856 ± 0.03	5.43ProLeu: 5.43 ± 0.03	1.059ProMet: 1.059 ± 0.012	1.75ProAsn: 1.75 ± 0.013	6.267ProPro: 6.267 ± 0.06	2.871ProGln: 2.871 ± 0.022	3.617ProArg: 3.617 ± 0.028	5.79ProSer: 5.79 ± 0.035	3.09ProThr: 3.09 ± 0.023	3.87ProVal: 3.87 ± 0.025	0.768ProTrp: 0.768 ± 0.01	1.459ProTyr: 1.459 ± 0.017	0.015ProXaa: 0.015 ± 0.001
Gln	3.517GlnAla: 3.517 ± 0.029	0.927GlnCys: 0.927 ± 0.013	2.307GlnAsp: 2.307 ± 0.015	3.899GlnGlu: 3.899 ± 0.031	1.343GlnPhe: 1.343 ± 0.011	2.91GlnGly: 2.91 ± 0.024	1.243GlnHis: 1.243 ± 0.015	1.96GlnIle: 1.96 ± 0.015	2.932GlnLys: 2.932 ± 0.021	4.693GlnLeu: 4.693 ± 0.033	1.072GlnMet: 1.072 ± 0.01	1.807GlnAsn: 1.807 ± 0.014	2.744GlnPro: 2.744 ± 0.022	2.798GlnGln: 2.798 ± 0.032	2.967GlnArg: 2.967 ± 0.025	3.084GlnSer: 3.084 ± 0.022	2.314GlnThr: 2.314 ± 0.02	2.855GlnVal: 2.855 ± 0.016	0.538GlnTrp: 0.538 ± 0.008	1.107GlnTyr: 1.107 ± 0.009	0.005GlnXaa: 0.005 ± 0.001
Arg	4.017ArgAla: 4.017 ± 0.025	1.257ArgCys: 1.257 ± 0.014	2.727ArgAsp: 2.727 ± 0.018	3.993ArgGlu: 3.993 ± 0.029	1.867ArgPhe: 1.867 ± 0.015	3.821ArgGly: 3.821 ± 0.029	1.525ArgHis: 1.525 ± 0.014	2.395ArgIle: 2.395 ± 0.016	3.703ArgLys: 3.703 ± 0.023	5.452ArgLeu: 5.452 ± 0.026	1.15ArgMet: 1.15 ± 0.01	2.095ArgAsn: 2.095 ± 0.015	3.388ArgPro: 3.388 ± 0.023	2.587ArgGln: 2.587 ± 0.022	4.338ArgArg: 4.338 ± 0.031	4.2ArgSer: 4.2 ± 0.031	2.779ArgThr: 2.779 ± 0.019	3.208ArgVal: 3.208 ± 0.023	0.729ArgTrp: 0.729 ± 0.009	1.483ArgTyr: 1.483 ± 0.011	0.007ArgXaa: 0.007 ± 0.001
Ser	5.348SerAla: 5.348 ± 0.022	1.921SerCys: 1.921 ± 0.018	3.816SerAsp: 3.816 ± 0.029	5.182SerGlu: 5.182 ± 0.029	3.142SerPhe: 3.142 ± 0.019	5.646SerGly: 5.646 ± 0.034	2.126SerHis: 2.126 ± 0.016	3.244SerIle: 3.244 ± 0.018	4.013SerLys: 4.013 ± 0.023	8.392SerLeu: 8.392 ± 0.037	1.518SerMet: 1.518 ± 0.012	2.583SerAsn: 2.583 ± 0.019	6.058SerPro: 6.058 ± 0.042	3.864SerGln: 3.864 ± 0.023	4.557SerArg: 4.557 ± 0.03	9.076SerSer: 9.076 ± 0.055	4.374SerThr: 4.374 ± 0.03	4.998SerVal: 4.998 ± 0.027	1.128SerTrp: 1.128 ± 0.012	2.094SerTyr: 2.094 ± 0.014	0.006SerXaa: 0.006 ± 0.001
Thr	3.764ThrAla: 3.764 ± 0.021	1.34ThrCys: 1.34 ± 0.015	2.454ThrAsp: 2.454 ± 0.017	3.469ThrGlu: 3.469 ± 0.021	2.125ThrPhe: 2.125 ± 0.015	3.541ThrGly: 3.541 ± 0.024	1.35ThrHis: 1.35 ± 0.019	2.357ThrIle: 2.357 ± 0.019	2.585ThrLys: 2.585 ± 0.018	5.382ThrLeu: 5.382 ± 0.021	1.079ThrMet: 1.079 ± 0.009	1.659ThrAsn: 1.659 ± 0.015	3.621ThrPro: 3.621 ± 0.028	2.288ThrGln: 2.288 ± 0.016	2.494ThrArg: 2.494 ± 0.017	4.574ThrSer: 4.574 ± 0.028	2.952ThrThr: 2.952 ± 0.041	3.952ThrVal: 3.952 ± 0.024	0.719ThrTrp: 0.719 ± 0.009	1.42ThrTyr: 1.42 ± 0.012	0.004ThrXaa: 0.004 ± 0.001
Val	4.272ValAla: 4.272 ± 0.024	1.546ValCys: 1.546 ± 0.018	2.905ValAsp: 2.905 ± 0.023	3.786ValGlu: 3.786 ± 0.024	2.493ValPhe: 2.493 ± 0.015	3.469ValGly: 3.469 ± 0.023	1.549ValHis: 1.549 ± 0.011	2.97ValIle: 2.97 ± 0.02	3.388ValLys: 3.388 ± 0.025	6.421ValLeu: 6.421 ± 0.031	1.317ValMet: 1.317 ± 0.011	2.238ValAsn: 2.238 ± 0.017	3.725ValPro: 3.725 ± 0.033	2.721ValGln: 2.721 ± 0.018	3.065ValArg: 3.065 ± 0.018	5.035ValSer: 5.035 ± 0.029	3.848ValThr: 3.848 ± 0.031	4.041ValVal: 4.041 ± 0.026	0.756ValTrp: 0.756 ± 0.01	1.654ValTyr: 1.654 ± 0.014	0.004ValXaa: 0.004 ± 0.001
Trp	0.852TrpAla: 0.852 ± 0.009	0.254TrpCys: 0.254 ± 0.005	0.667TrpAsp: 0.667 ± 0.009	0.832TrpGlu: 0.832 ± 0.01	0.475TrpPhe: 0.475 ± 0.008	0.824TrpGly: 0.824 ± 0.011	0.305TrpHis: 0.305 ± 0.006	0.569TrpIle: 0.569 ± 0.008	0.827TrpLys: 0.827 ± 0.009	1.244TrpLeu: 1.244 ± 0.012	0.31TrpMet: 0.31 ± 0.005	0.534TrpAsn: 0.534 ± 0.007	0.569TrpPro: 0.569 ± 0.006	0.54TrpGln: 0.54 ± 0.008	0.765TrpArg: 0.765 ± 0.011	0.904TrpSer: 0.904 ± 0.01	0.701TrpThr: 0.701 ± 0.011	0.758TrpVal: 0.758 ± 0.008	0.209TrpTrp: 0.209 ± 0.006	0.347TrpTyr: 0.347 ± 0.007	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.392TyrAla: 1.392 ± 0.012	0.677TyrCys: 0.677 ± 0.008	1.264TyrAsp: 1.264 ± 0.013	1.643TyrGlu: 1.643 ± 0.016	1.291TyrPhe: 1.291 ± 0.012	1.643TyrGly: 1.643 ± 0.015	0.737TyrHis: 0.737 ± 0.009	1.382TyrIle: 1.382 ± 0.014	1.454TyrLys: 1.454 ± 0.019	2.701TyrLeu: 2.701 ± 0.017	0.588TyrMet: 0.588 ± 0.008	1.071TyrAsn: 1.071 ± 0.01	1.316TyrPro: 1.316 ± 0.012	1.232TyrGln: 1.232 ± 0.013	1.58TyrArg: 1.58 ± 0.013	2.189TyrSer: 2.189 ± 0.019	1.507TyrThr: 1.507 ± 0.014	1.615TyrVal: 1.615 ± 0.016	0.368TyrTrp: 0.368 ± 0.007	0.939TyrTyr: 0.939 ± 0.011	0.001TyrXaa: 0.001 ± 0.0
Xaa	0.011XaaAla: 0.011 ± 0.001	0.002XaaCys: 0.002 ± 0.0	0.002XaaAsp: 0.002 ± 0.0	0.004XaaGlu: 0.004 ± 0.001	0.002XaaPhe: 0.002 ± 0.0	0.013XaaGly: 0.013 ± 0.001	0.002XaaHis: 0.002 ± 0.0	0.001XaaIle: 0.001 ± 0.0	0.002XaaLys: 0.002 ± 0.0	0.007XaaLeu: 0.007 ± 0.001	0.001XaaMet: 0.001 ± 0.0	0.001XaaAsn: 0.001 ± 0.0	0.013XaaPro: 0.013 ± 0.001	0.002XaaGln: 0.002 ± 0.0	0.01XaaArg: 0.01 ± 0.001	0.006XaaSer: 0.006 ± 0.001	0.003XaaThr: 0.003 ± 0.0	0.003XaaVal: 0.003 ± 0.0	0.001XaaTrp: 0.001 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.512XaaXaa: 0.512 ± 0.046

Statistics based on 23135 proteins (12233952 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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