Amino acid dipepetide frequency for Wenzhou yanvirus-like virus 1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.745AlaAla: 8.745 ± 1.466
1.874AlaCys: 1.874 ± 1.011
2.498AlaAsp: 2.498 ± 1.348
2.498AlaGlu: 2.498 ± 0.713
2.498AlaPhe: 2.498 ± 0.317
10.618AlaGly: 10.618 ± 3.546
3.748AlaHis: 3.748 ± 2.022
4.372AlaIle: 4.372 ± 0.733
3.123AlaLys: 3.123 ± 1.685
8.745AlaLeu: 8.745 ± 2.496
0.625AlaMet: 0.625 ± 0.337
1.874AlaAsn: 1.874 ± 0.02
3.748AlaPro: 3.748 ± 2.1
1.874AlaGln: 1.874 ± 1.05
3.123AlaArg: 3.123 ± 0.376
7.495AlaSer: 7.495 ± 4.2
8.12AlaThr: 8.12 ± 2.833
8.12AlaVal: 8.12 ± 2.833
2.498AlaTrp: 2.498 ± 1.348
5.621AlaTyr: 5.621 ± 0.059
0.0AlaXaa: 0.0 ± 0.0
Cys
1.249CysAla: 1.249 ± 0.674
0.0CysCys: 0.0 ± 0.0
0.625CysAsp: 0.625 ± 0.337
0.625CysGlu: 0.625 ± 0.337
0.625CysPhe: 0.625 ± 0.337
1.249CysGly: 1.249 ± 0.674
0.0CysHis: 0.0 ± 0.0
0.625CysIle: 0.625 ± 0.337
1.249CysLys: 1.249 ± 0.674
1.874CysLeu: 1.874 ± 1.011
0.625CysMet: 0.625 ± 0.337
0.0CysAsn: 0.0 ± 0.0
1.874CysPro: 1.874 ± 1.05
0.0CysGln: 0.0 ± 0.0
4.997CysArg: 4.997 ± 2.696
3.748CysSer: 3.748 ± 0.991
2.498CysThr: 2.498 ± 0.713
0.625CysVal: 0.625 ± 0.337
0.0CysTrp: 0.0 ± 0.0
0.625CysTyr: 0.625 ± 0.337
0.0CysXaa: 0.0 ± 0.0
Asp
1.249AspAla: 1.249 ± 0.674
0.625AspCys: 0.625 ± 0.694
0.625AspAsp: 0.625 ± 0.337
0.625AspGlu: 0.625 ± 0.337
1.874AspPhe: 1.874 ± 0.02
3.123AspGly: 3.123 ± 0.654
1.249AspHis: 1.249 ± 0.674
5.621AspIle: 5.621 ± 3.033
1.249AspLys: 1.249 ± 0.674
1.249AspLeu: 1.249 ± 1.387
0.0AspMet: 0.0 ± 0.0
1.874AspAsn: 1.874 ± 1.05
2.498AspPro: 2.498 ± 0.317
0.625AspGln: 0.625 ± 0.337
2.498AspArg: 2.498 ± 1.348
1.874AspSer: 1.874 ± 1.011
0.625AspThr: 0.625 ± 0.337
3.748AspVal: 3.748 ± 0.991
1.249AspTrp: 1.249 ± 0.357
3.748AspTyr: 3.748 ± 0.991
0.0AspXaa: 0.0 ± 0.0
Glu
1.249GluAla: 1.249 ± 0.674
1.249GluCys: 1.249 ± 0.674
0.0GluAsp: 0.0 ± 0.0
1.249GluGlu: 1.249 ± 0.674
6.871GluPhe: 6.871 ± 0.615
1.249GluGly: 1.249 ± 0.674
1.249GluHis: 1.249 ± 0.357
1.249GluIle: 1.249 ± 0.674
1.874GluLys: 1.874 ± 1.05
3.748GluLeu: 3.748 ± 2.022
0.0GluMet: 0.0 ± 0.267
0.625GluAsn: 0.625 ± 0.694
1.249GluPro: 1.249 ± 0.674
1.249GluGln: 1.249 ± 0.674
2.498GluArg: 2.498 ± 1.744
1.249GluSer: 1.249 ± 0.357
4.372GluThr: 4.372 ± 1.763
1.874GluVal: 1.874 ± 1.011
2.498GluTrp: 2.498 ± 1.348
2.498GluTyr: 2.498 ± 1.348
0.0GluXaa: 0.0 ± 0.0
Phe
3.123PheAla: 3.123 ± 0.376
2.498PheCys: 2.498 ± 1.348
1.249PheAsp: 1.249 ± 0.674
3.123PheGlu: 3.123 ± 0.376
3.748PhePhe: 3.748 ± 1.07
1.249PheGly: 1.249 ± 0.674
0.0PheHis: 0.0 ± 0.0
1.874PheIle: 1.874 ± 1.011
0.625PheLys: 0.625 ± 0.337
4.997PheLeu: 4.997 ± 1.665
3.123PheMet: 3.123 ± 1.685
1.874PheAsn: 1.874 ± 1.05
5.621PhePro: 5.621 ± 2.12
0.0PheGln: 0.0 ± 0.0
1.249PheArg: 1.249 ± 1.387
1.874PheSer: 1.874 ± 1.011
3.748PheThr: 3.748 ± 0.991
3.123PheVal: 3.123 ± 0.654
2.498PheTrp: 2.498 ± 0.713
1.874PheTyr: 1.874 ± 1.011
0.0PheXaa: 0.0 ± 0.0
Gly
5.621GlyAla: 5.621 ± 1.089
1.874GlyCys: 1.874 ± 0.02
1.249GlyAsp: 1.249 ± 0.674
1.874GlyGlu: 1.874 ± 1.011
2.498GlyPhe: 2.498 ± 1.744
4.372GlyGly: 4.372 ± 0.298
0.0GlyHis: 0.0 ± 0.0
2.498GlyIle: 2.498 ± 0.317
3.123GlyLys: 3.123 ± 0.376
8.12GlyLeu: 8.12 ± 0.772
1.874GlyMet: 1.874 ± 0.02
4.372GlyAsn: 4.372 ± 2.794
4.997GlyPro: 4.997 ± 1.665
1.874GlyGln: 1.874 ± 0.02
5.621GlyArg: 5.621 ± 0.972
4.372GlySer: 4.372 ± 0.298
4.372GlyThr: 4.372 ± 1.763
5.621GlyVal: 5.621 ± 0.972
0.625GlyTrp: 0.625 ± 0.337
0.0GlyTyr: 0.0 ± 0.0
0.0GlyXaa: 0.0 ± 0.0
His
0.625HisAla: 0.625 ± 0.337
0.625HisCys: 0.625 ± 0.337
0.625HisAsp: 0.625 ± 0.337
1.874HisGlu: 1.874 ± 0.02
0.625HisPhe: 0.625 ± 0.337
0.625HisGly: 0.625 ± 0.337
0.0HisHis: 0.0 ± 0.0
1.249HisIle: 1.249 ± 0.357
1.249HisLys: 1.249 ± 0.357
1.249HisLeu: 1.249 ± 0.674
0.625HisMet: 0.625 ± 0.337
0.0HisAsn: 0.0 ± 0.0
2.498HisPro: 2.498 ± 0.713
2.498HisGln: 2.498 ± 0.317
0.0HisArg: 0.0 ± 0.0
1.874HisSer: 1.874 ± 1.011
0.625HisThr: 0.625 ± 0.337
3.748HisVal: 3.748 ± 2.022
0.625HisTrp: 0.625 ± 0.337
1.874HisTyr: 1.874 ± 1.011
0.0HisXaa: 0.0 ± 0.0
Ile
6.871IleAla: 6.871 ± 1.446
1.249IleCys: 1.249 ± 0.674
2.498IleAsp: 2.498 ± 0.317
2.498IleGlu: 2.498 ± 0.317
0.625IlePhe: 0.625 ± 0.337
3.123IleGly: 3.123 ± 0.654
0.625IleHis: 0.625 ± 0.337
0.625IleIle: 0.625 ± 0.337
0.0IleLys: 0.0 ± 0.0
2.498IleLeu: 2.498 ± 1.744
1.249IleMet: 1.249 ± 0.674
2.498IleAsn: 2.498 ± 1.744
3.748IlePro: 3.748 ± 0.039
3.123IleGln: 3.123 ± 0.654
1.874IleArg: 1.874 ± 0.02
6.871IleSer: 6.871 ± 2.676
1.874IleThr: 1.874 ± 1.011
3.123IleVal: 3.123 ± 0.654
1.249IleTrp: 1.249 ± 0.674
4.372IleTyr: 4.372 ± 1.328
0.0IleXaa: 0.0 ± 0.0
Lys
4.372LysAla: 4.372 ± 0.733
0.625LysCys: 0.625 ± 0.337
0.625LysAsp: 0.625 ± 0.337
1.249LysGlu: 1.249 ± 0.674
1.249LysPhe: 1.249 ± 0.674
3.748LysGly: 3.748 ± 0.039
0.625LysHis: 0.625 ± 0.337
0.625LysIle: 0.625 ± 0.337
3.123LysLys: 3.123 ± 3.468
3.748LysLeu: 3.748 ± 2.022
1.249LysMet: 1.249 ± 0.207
0.0LysAsn: 0.0 ± 0.0
2.498LysPro: 2.498 ± 1.744
0.625LysGln: 0.625 ± 0.337
2.498LysArg: 2.498 ± 0.317
3.748LysSer: 3.748 ± 0.039
1.249LysThr: 1.249 ± 0.357
1.249LysVal: 1.249 ± 0.357
0.0LysTrp: 0.0 ± 0.0
0.625LysTyr: 0.625 ± 0.337
0.0LysXaa: 0.0 ± 0.0
Leu
9.369LeuAla: 9.369 ± 2.159
1.874LeuCys: 1.874 ± 0.02
3.123LeuAsp: 3.123 ± 1.407
3.123LeuGlu: 3.123 ± 1.407
3.748LeuPhe: 3.748 ± 0.991
3.748LeuGly: 3.748 ± 1.07
1.249LeuHis: 1.249 ± 1.387
1.874LeuIle: 1.874 ± 1.011
0.625LeuLys: 0.625 ± 0.337
5.621LeuLeu: 5.621 ± 2.002
1.874LeuMet: 1.874 ± 0.02
4.997LeuAsn: 4.997 ± 0.635
8.12LeuPro: 8.12 ± 2.833
1.249LeuGln: 1.249 ± 0.674
4.997LeuArg: 4.997 ± 2.696
8.12LeuSer: 8.12 ± 0.258
1.874LeuThr: 1.874 ± 0.02
5.621LeuVal: 5.621 ± 0.059
0.0LeuTrp: 0.0 ± 0.0
4.372LeuTyr: 4.372 ± 0.298
0.0LeuXaa: 0.0 ± 0.0
Met
1.874MetAla: 1.874 ± 1.011
0.0MetCys: 0.0 ± 0.0
0.625MetAsp: 0.625 ± 0.337
0.625MetGlu: 0.625 ± 0.337
2.498MetPhe: 2.498 ± 0.317
2.498MetGly: 2.498 ± 0.713
0.0MetHis: 0.0 ± 0.0
1.249MetIle: 1.249 ± 0.357
1.249MetLys: 1.249 ± 0.357
1.249MetLeu: 1.249 ± 0.674
0.0MetMet: 0.0 ± 0.0
0.625MetAsn: 0.625 ± 0.337
0.625MetPro: 0.625 ± 0.694
2.498MetGln: 2.498 ± 0.317
5.621MetArg: 5.621 ± 3.033
0.0MetSer: 0.0 ± 0.0
0.625MetThr: 0.625 ± 0.694
2.498MetVal: 2.498 ± 0.317
0.625MetTrp: 0.625 ± 0.337
0.625MetTyr: 0.625 ± 0.694
0.0MetXaa: 0.0 ± 0.0
Asn
3.748AsnAla: 3.748 ± 0.039
0.625AsnCys: 0.625 ± 0.337
2.498AsnAsp: 2.498 ± 1.348
1.874AsnGlu: 1.874 ± 1.011
0.0AsnPhe: 0.0 ± 0.0
3.123AsnGly: 3.123 ± 2.437
1.249AsnHis: 1.249 ± 0.674
2.498AsnIle: 2.498 ± 1.348
3.123AsnLys: 3.123 ± 0.376
0.625AsnLeu: 0.625 ± 0.337
0.625AsnMet: 0.625 ± 0.337
1.249AsnAsn: 1.249 ± 0.357
4.372AsnPro: 4.372 ± 0.733
1.249AsnGln: 1.249 ± 0.357
1.249AsnArg: 1.249 ± 0.674
3.123AsnSer: 3.123 ± 2.437
2.498AsnThr: 2.498 ± 0.713
6.246AsnVal: 6.246 ± 4.874
0.625AsnTrp: 0.625 ± 0.694
0.0AsnTyr: 0.0 ± 0.0
0.0AsnXaa: 0.0 ± 0.0
Pro
8.12ProAla: 8.12 ± 3.864
0.0ProCys: 0.0 ± 0.0
1.249ProAsp: 1.249 ± 0.357
4.997ProGlu: 4.997 ± 0.635
4.372ProPhe: 4.372 ± 0.298
4.372ProGly: 4.372 ± 1.763
1.874ProHis: 1.874 ± 0.02
4.372ProIle: 4.372 ± 0.733
1.249ProLys: 1.249 ± 0.357
4.372ProLeu: 4.372 ± 0.298
1.874ProMet: 1.874 ± 1.011
0.625ProAsn: 0.625 ± 0.337
4.372ProPro: 4.372 ± 0.298
2.498ProGln: 2.498 ± 0.317
4.997ProArg: 4.997 ± 0.635
4.372ProSer: 4.372 ± 2.794
3.123ProThr: 3.123 ± 1.407
5.621ProVal: 5.621 ± 0.059
1.874ProTrp: 1.874 ± 1.05
4.372ProTyr: 4.372 ± 1.328
0.0ProXaa: 0.0 ± 0.0
Gln
3.123GlnAla: 3.123 ± 1.407
1.874GlnCys: 1.874 ± 1.011
0.0GlnAsp: 0.0 ± 0.0
0.625GlnGlu: 0.625 ± 0.337
1.249GlnPhe: 1.249 ± 0.674
0.0GlnGly: 0.0 ± 0.0
1.249GlnHis: 1.249 ± 0.674
1.249GlnIle: 1.249 ± 0.357
1.874GlnLys: 1.874 ± 0.02
3.123GlnLeu: 3.123 ± 1.407
0.0GlnMet: 0.0 ± 0.0
1.249GlnAsn: 1.249 ± 0.674
1.874GlnPro: 1.874 ± 1.011
1.874GlnGln: 1.874 ± 0.02
1.249GlnArg: 1.249 ± 0.674
1.249GlnSer: 1.249 ± 0.674
0.625GlnThr: 0.625 ± 0.694
4.372GlnVal: 4.372 ± 1.763
1.249GlnTrp: 1.249 ± 0.674
0.625GlnTyr: 0.625 ± 0.337
0.0GlnXaa: 0.0 ± 0.0
Arg
1.874ArgAla: 1.874 ± 0.02
1.874ArgCys: 1.874 ± 1.011
3.123ArgAsp: 3.123 ± 1.685
1.249ArgGlu: 1.249 ± 0.674
6.246ArgPhe: 6.246 ± 1.309
4.372ArgGly: 4.372 ± 2.359
2.498ArgHis: 2.498 ± 1.348
4.997ArgIle: 4.997 ± 0.635
1.249ArgLys: 1.249 ± 0.674
3.123ArgLeu: 3.123 ± 0.654
2.498ArgMet: 2.498 ± 0.317
3.123ArgAsn: 3.123 ± 1.685
4.372ArgPro: 4.372 ± 1.328
1.249ArgGln: 1.249 ± 1.387
3.123ArgArg: 3.123 ± 1.685
3.748ArgSer: 3.748 ± 0.991
5.621ArgThr: 5.621 ± 1.089
2.498ArgVal: 2.498 ± 0.713
0.625ArgTrp: 0.625 ± 0.694
3.748ArgTyr: 3.748 ± 0.991
0.0ArgXaa: 0.0 ± 0.0
Ser
9.994SerAla: 9.994 ± 0.239
3.123SerCys: 3.123 ± 1.685
3.748SerAsp: 3.748 ± 2.022
3.123SerGlu: 3.123 ± 0.376
2.498SerPhe: 2.498 ± 0.317
7.495SerGly: 7.495 ± 0.079
0.625SerHis: 0.625 ± 0.337
2.498SerIle: 2.498 ± 0.713
3.123SerLys: 3.123 ± 0.376
4.372SerLeu: 4.372 ± 2.794
2.498SerMet: 2.498 ± 0.317
1.249SerAsn: 1.249 ± 0.357
3.748SerPro: 3.748 ± 0.991
3.123SerGln: 3.123 ± 0.376
4.997SerArg: 4.997 ± 1.665
6.246SerSer: 6.246 ± 1.783
8.745SerThr: 8.745 ± 6.618
5.621SerVal: 5.621 ± 1.089
0.0SerTrp: 0.0 ± 0.0
3.748SerTyr: 3.748 ± 0.039
0.0SerXaa: 0.0 ± 0.0
Thr
7.495ThrAla: 7.495 ± 5.231
1.874ThrCys: 1.874 ± 0.02
1.874ThrAsp: 1.874 ± 0.02
1.874ThrGlu: 1.874 ± 1.011
3.748ThrPhe: 3.748 ± 0.039
2.498ThrGly: 2.498 ± 0.713
1.874ThrHis: 1.874 ± 0.02
3.123ThrIle: 3.123 ± 0.376
0.0ThrLys: 0.0 ± 0.0
5.621ThrLeu: 5.621 ± 3.15
1.249ThrMet: 1.249 ± 0.357
3.123ThrAsn: 3.123 ± 1.407
6.871ThrPro: 6.871 ± 1.446
0.625ThrGln: 0.625 ± 0.337
2.498ThrArg: 2.498 ± 0.713
8.745ThrSer: 8.745 ± 2.496
1.874ThrThr: 1.874 ± 1.05
4.997ThrVal: 4.997 ± 2.457
3.123ThrTrp: 3.123 ± 1.407
3.123ThrTyr: 3.123 ± 0.654
0.0ThrXaa: 0.0 ± 0.0
Val
10.618ValAla: 10.618 ± 1.485
0.625ValCys: 0.625 ± 0.337
4.372ValAsp: 4.372 ± 0.298
1.874ValGlu: 1.874 ± 0.02
0.625ValPhe: 0.625 ± 0.337
4.997ValGly: 4.997 ± 1.665
0.0ValHis: 0.0 ± 0.0
4.372ValIle: 4.372 ± 0.298
3.123ValLys: 3.123 ± 0.376
4.997ValLeu: 4.997 ± 2.457
3.123ValMet: 3.123 ± 1.407
6.246ValAsn: 6.246 ± 1.783
3.748ValPro: 3.748 ± 0.991
1.874ValGln: 1.874 ± 0.02
3.123ValArg: 3.123 ± 0.654
6.871ValSer: 6.871 ± 2.476
7.495ValThr: 7.495 ± 2.14
4.997ValVal: 4.997 ± 1.426
1.874ValTrp: 1.874 ± 1.011
1.249ValTyr: 1.249 ± 0.674
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
1.874TrpAsp: 1.874 ± 1.05
1.249TrpGlu: 1.249 ± 0.674
0.625TrpPhe: 0.625 ± 0.694
1.874TrpGly: 1.874 ± 1.011
3.123TrpHis: 3.123 ± 0.654
1.874TrpIle: 1.874 ± 0.02
0.0TrpLys: 0.0 ± 0.0
1.874TrpLeu: 1.874 ± 1.011
1.249TrpMet: 1.249 ± 0.674
1.249TrpAsn: 1.249 ± 1.387
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
1.874TrpArg: 1.874 ± 0.02
1.249TrpSer: 1.249 ± 0.674
1.874TrpThr: 1.874 ± 0.02
0.625TrpVal: 0.625 ± 0.337
0.0TrpTrp: 0.0 ± 0.0
1.249TrpTyr: 1.249 ± 0.357
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.498TyrAla: 2.498 ± 1.348
0.625TyrCys: 0.625 ± 0.694
3.748TyrAsp: 3.748 ± 0.991
2.498TyrGlu: 2.498 ± 0.317
1.249TyrPhe: 1.249 ± 0.674
0.625TyrGly: 0.625 ± 0.694
1.874TyrHis: 1.874 ± 1.011
3.748TyrIle: 3.748 ± 0.039
2.498TyrLys: 2.498 ± 1.348
4.372TyrLeu: 4.372 ± 2.359
0.625TyrMet: 0.625 ± 0.694
3.748TyrAsn: 3.748 ± 2.022
1.874TyrPro: 1.874 ± 1.05
0.625TyrGln: 0.625 ± 0.337
3.123TyrArg: 3.123 ± 0.654
3.748TyrSer: 3.748 ± 0.039
4.372TyrThr: 4.372 ± 0.298
1.874TyrVal: 1.874 ± 1.011
0.625TyrTrp: 0.625 ± 0.337
1.249TyrTyr: 1.249 ± 0.674
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (1602 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski