Amino acid dipepetide frequency for Blastopirellula marina DSM 3645

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.852AlaAla: 13.852 ± 0.147	1.072AlaCys: 1.072 ± 0.023	6.562AlaAsp: 6.562 ± 0.067	7.198AlaGlu: 7.198 ± 0.069	3.273AlaPhe: 3.273 ± 0.042	7.701AlaGly: 7.701 ± 0.076	1.708AlaHis: 1.708 ± 0.032	6.289AlaIle: 6.289 ± 0.061	4.473AlaLys: 4.473 ± 0.059	8.972AlaLeu: 8.972 ± 0.088	2.613AlaMet: 2.613 ± 0.04	3.261AlaAsn: 3.261 ± 0.054	4.726AlaPro: 4.726 ± 0.057	4.016AlaGln: 4.016 ± 0.053	5.249AlaArg: 5.249 ± 0.062	6.058AlaSer: 6.058 ± 0.062	5.668AlaThr: 5.668 ± 0.077	6.799AlaVal: 6.799 ± 0.076	1.482AlaTrp: 1.482 ± 0.027	2.333AlaTyr: 2.333 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	0.903CysAla: 0.903 ± 0.027	0.245CysCys: 0.245 ± 0.013	0.719CysAsp: 0.719 ± 0.021	0.687CysGlu: 0.687 ± 0.021	0.447CysPhe: 0.447 ± 0.015	1.106CysGly: 1.106 ± 0.029	0.38CysHis: 0.38 ± 0.018	0.469CysIle: 0.469 ± 0.016	0.331CysLys: 0.331 ± 0.017	1.04CysLeu: 1.04 ± 0.027	0.204CysMet: 0.204 ± 0.011	0.324CysAsn: 0.324 ± 0.014	0.582CysPro: 0.582 ± 0.022	0.426CysGln: 0.426 ± 0.016	0.793CysArg: 0.793 ± 0.022	0.685CysSer: 0.685 ± 0.02	0.53CysThr: 0.53 ± 0.018	0.743CysVal: 0.743 ± 0.02	0.189CysTrp: 0.189 ± 0.011	0.32CysTyr: 0.32 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.301AspAla: 6.301 ± 0.074	0.575AspCys: 0.575 ± 0.02	3.743AspAsp: 3.743 ± 0.059	4.086AspGlu: 4.086 ± 0.052	2.51AspPhe: 2.51 ± 0.044	5.076AspGly: 5.076 ± 0.074	1.304AspHis: 1.304 ± 0.03	2.59AspIle: 2.59 ± 0.043	2.067AspLys: 2.067 ± 0.043	5.863AspLeu: 5.863 ± 0.06	1.128AspMet: 1.128 ± 0.026	1.687AspAsn: 1.687 ± 0.037	3.449AspPro: 3.449 ± 0.053	2.755AspGln: 2.755 ± 0.041	3.9AspArg: 3.9 ± 0.042	3.371AspSer: 3.371 ± 0.056	2.224AspThr: 2.224 ± 0.044	4.123AspVal: 4.123 ± 0.049	1.094AspTrp: 1.094 ± 0.028	1.742AspTyr: 1.742 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	6.147GluAla: 6.147 ± 0.054	0.477GluCys: 0.477 ± 0.016	2.896GluAsp: 2.896 ± 0.047	4.07GluGlu: 4.07 ± 0.064	2.3GluPhe: 2.3 ± 0.041	3.588GluGly: 3.588 ± 0.045	1.309GluHis: 1.309 ± 0.032	4.02GluIle: 4.02 ± 0.044	3.17GluLys: 3.17 ± 0.053	6.793GluLeu: 6.793 ± 0.058	1.857GluMet: 1.857 ± 0.029	2.147GluAsn: 2.147 ± 0.036	2.75GluPro: 2.75 ± 0.042	3.098GluGln: 3.098 ± 0.046	3.937GluArg: 3.937 ± 0.05	3.862GluSer: 3.862 ± 0.041	3.974GluThr: 3.974 ± 0.044	4.289GluVal: 4.289 ± 0.051	0.717GluTrp: 0.717 ± 0.021	1.54GluTyr: 1.54 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.046PheAla: 4.046 ± 0.046	0.529PheCys: 0.529 ± 0.017	2.727PheAsp: 2.727 ± 0.045	2.226PheGlu: 2.226 ± 0.036	1.498PhePhe: 1.498 ± 0.032	3.239PheGly: 3.239 ± 0.048	0.865PheHis: 0.865 ± 0.022	1.479PheIle: 1.479 ± 0.03	0.915PheLys: 0.915 ± 0.024	3.598PheLeu: 3.598 ± 0.044	0.686PheMet: 0.686 ± 0.021	1.198PheAsn: 1.198 ± 0.028	1.805PhePro: 1.805 ± 0.029	1.505PheGln: 1.505 ± 0.028	2.378PheArg: 2.378 ± 0.038	2.441PheSer: 2.441 ± 0.035	2.035PheThr: 2.035 ± 0.039	2.842PheVal: 2.842 ± 0.043	0.563PheTrp: 0.563 ± 0.019	1.043PheTyr: 1.043 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	6.844GlyAla: 6.844 ± 0.063	1.021GlyCys: 1.021 ± 0.028	4.802GlyAsp: 4.802 ± 0.067	4.948GlyGlu: 4.948 ± 0.049	2.986GlyPhe: 2.986 ± 0.048	6.451GlyGly: 6.451 ± 0.096	1.519GlyHis: 1.519 ± 0.031	3.601GlyIle: 3.601 ± 0.047	3.649GlyLys: 3.649 ± 0.053	6.628GlyLeu: 6.628 ± 0.064	1.926GlyMet: 1.926 ± 0.037	2.413GlyAsn: 2.413 ± 0.053	3.062GlyPro: 3.062 ± 0.047	3.011GlyGln: 3.011 ± 0.043	4.634GlyArg: 4.634 ± 0.057	4.684GlySer: 4.684 ± 0.064	3.634GlyThr: 3.634 ± 0.063	5.869GlyVal: 5.869 ± 0.059	1.251GlyTrp: 1.251 ± 0.031	2.247GlyTyr: 2.247 ± 0.04	0.0GlyXaa: 0.0 ± 0.0
His	2.005HisAla: 2.005 ± 0.032	0.297HisCys: 0.297 ± 0.012	1.424HisAsp: 1.424 ± 0.031	1.287HisGlu: 1.287 ± 0.027	0.978HisPhe: 0.978 ± 0.026	1.73HisGly: 1.73 ± 0.037	0.624HisHis: 0.624 ± 0.019	0.809HisIle: 0.809 ± 0.021	0.543HisLys: 0.543 ± 0.02	2.134HisLeu: 2.134 ± 0.035	0.366HisMet: 0.366 ± 0.013	0.672HisAsn: 0.672 ± 0.018	1.326HisPro: 1.326 ± 0.026	0.899HisGln: 0.899 ± 0.024	1.478HisArg: 1.478 ± 0.029	1.199HisSer: 1.199 ± 0.026	0.797HisThr: 0.797 ± 0.021	1.417HisVal: 1.417 ± 0.027	0.424HisTrp: 0.424 ± 0.018	0.617HisTyr: 0.617 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.598IleAla: 6.598 ± 0.074	0.736IleCys: 0.736 ± 0.021	4.077IleAsp: 4.077 ± 0.048	3.93IleGlu: 3.93 ± 0.051	1.803IlePhe: 1.803 ± 0.029	4.44IleGly: 4.44 ± 0.056	1.091IleHis: 1.091 ± 0.023	2.097IleIle: 2.097 ± 0.036	1.487IleLys: 1.487 ± 0.03	4.315IleLeu: 4.315 ± 0.049	0.823IleMet: 0.823 ± 0.021	1.639IleAsn: 1.639 ± 0.034	2.455IlePro: 2.455 ± 0.037	1.897IleGln: 1.897 ± 0.029	3.429IleArg: 3.429 ± 0.045	3.293IleSer: 3.293 ± 0.045	2.737IleThr: 2.737 ± 0.043	4.127IleVal: 4.127 ± 0.053	0.678IleTrp: 0.678 ± 0.021	1.395IleTyr: 1.395 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.33LysAla: 3.33 ± 0.048	0.333LysCys: 0.333 ± 0.012	1.683LysAsp: 1.683 ± 0.034	2.187LysGlu: 2.187 ± 0.041	1.466LysPhe: 1.466 ± 0.027	2.094LysGly: 2.094 ± 0.041	0.749LysHis: 0.749 ± 0.02	2.351LysIle: 2.351 ± 0.041	2.026LysLys: 2.026 ± 0.046	4.261LysLeu: 4.261 ± 0.055	1.145LysMet: 1.145 ± 0.028	1.281LysAsn: 1.281 ± 0.028	2.261LysPro: 2.261 ± 0.039	1.845LysGln: 1.845 ± 0.035	2.454LysArg: 2.454 ± 0.036	2.718LysSer: 2.718 ± 0.039	2.263LysThr: 2.263 ± 0.04	2.41LysVal: 2.41 ± 0.043	0.497LysTrp: 0.497 ± 0.018	1.079LysTyr: 1.079 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	11.47LeuAla: 11.47 ± 0.098	1.055LeuCys: 1.055 ± 0.029	5.678LeuAsp: 5.678 ± 0.067	6.063LeuGlu: 6.063 ± 0.06	3.499LeuPhe: 3.499 ± 0.051	7.081LeuGly: 7.081 ± 0.058	2.105LeuHis: 2.105 ± 0.039	5.082LeuIle: 5.082 ± 0.056	3.777LeuLys: 3.777 ± 0.05	10.303LeuLeu: 10.303 ± 0.103	2.014LeuMet: 2.014 ± 0.033	2.898LeuAsn: 2.898 ± 0.044	5.426LeuPro: 5.426 ± 0.06	4.117LeuGln: 4.117 ± 0.05	6.207LeuArg: 6.207 ± 0.067	6.219LeuSer: 6.219 ± 0.07	5.872LeuThr: 5.872 ± 0.07	6.669LeuVal: 6.669 ± 0.074	1.177LeuTrp: 1.177 ± 0.026	2.124LeuTyr: 2.124 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	2.223MetAla: 2.223 ± 0.038	0.191MetCys: 0.191 ± 0.01	0.967MetAsp: 0.967 ± 0.029	1.159MetGlu: 1.159 ± 0.026	0.853MetPhe: 0.853 ± 0.021	1.465MetGly: 1.465 ± 0.03	0.484MetHis: 0.484 ± 0.017	1.4MetIle: 1.4 ± 0.027	1.065MetLys: 1.065 ± 0.021	2.482MetLeu: 2.482 ± 0.035	0.621MetMet: 0.621 ± 0.018	0.87MetAsn: 0.87 ± 0.023	1.366MetPro: 1.366 ± 0.028	1.109MetGln: 1.109 ± 0.023	1.427MetArg: 1.427 ± 0.029	1.63MetSer: 1.63 ± 0.03	1.527MetThr: 1.527 ± 0.027	1.464MetVal: 1.464 ± 0.029	0.227MetTrp: 0.227 ± 0.01	0.408MetTyr: 0.408 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.985AsnAla: 2.985 ± 0.046	0.424AsnCys: 0.424 ± 0.016	1.989AsnAsp: 1.989 ± 0.044	1.807AsnGlu: 1.807 ± 0.029	1.329AsnPhe: 1.329 ± 0.034	2.669AsnGly: 2.669 ± 0.052	0.677AsnHis: 0.677 ± 0.018	1.443AsnIle: 1.443 ± 0.026	0.898AsnLys: 0.898 ± 0.02	3.186AsnLeu: 3.186 ± 0.043	0.674AsnMet: 0.674 ± 0.019	1.162AsnAsn: 1.162 ± 0.032	2.015AsnPro: 2.015 ± 0.035	1.423AsnGln: 1.423 ± 0.029	2.167AsnArg: 2.167 ± 0.038	2.044AsnSer: 2.044 ± 0.038	1.487AsnThr: 1.487 ± 0.031	2.249AsnVal: 2.249 ± 0.033	0.559AsnTrp: 0.559 ± 0.019	1.098AsnTyr: 1.098 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	5.39ProAla: 5.39 ± 0.066	0.408ProCys: 0.408 ± 0.017	2.957ProAsp: 2.957 ± 0.046	3.711ProGlu: 3.711 ± 0.04	1.833ProPhe: 1.833 ± 0.034	3.789ProGly: 3.789 ± 0.051	1.155ProHis: 1.155 ± 0.028	2.81ProIle: 2.81 ± 0.036	1.927ProLys: 1.927 ± 0.033	4.884ProLeu: 4.884 ± 0.062	1.07ProMet: 1.07 ± 0.031	1.803ProAsn: 1.803 ± 0.029	2.948ProPro: 2.948 ± 0.056	2.504ProGln: 2.504 ± 0.04	2.613ProArg: 2.613 ± 0.044	3.277ProSer: 3.277 ± 0.046	3.162ProThr: 3.162 ± 0.047	3.414ProVal: 3.414 ± 0.049	0.695ProTrp: 0.695 ± 0.02	1.232ProTyr: 1.232 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	4.338GlnAla: 4.338 ± 0.048	0.409GlnCys: 0.409 ± 0.014	1.729GlnAsp: 1.729 ± 0.032	2.212GlnGlu: 2.212 ± 0.042	1.74GlnPhe: 1.74 ± 0.034	2.642GlnGly: 2.642 ± 0.045	0.909GlnHis: 0.909 ± 0.02	2.582GlnIle: 2.582 ± 0.039	1.597GlnLys: 1.597 ± 0.033	5.076GlnLeu: 5.076 ± 0.06	1.083GlnMet: 1.083 ± 0.025	1.296GlnAsn: 1.296 ± 0.025	2.376GlnPro: 2.376 ± 0.047	2.672GlnGln: 2.672 ± 0.069	3.014GlnArg: 3.014 ± 0.049	2.609GlnSer: 2.609 ± 0.036	2.366GlnThr: 2.366 ± 0.04	2.804GlnVal: 2.804 ± 0.036	0.666GlnTrp: 0.666 ± 0.018	1.096GlnTyr: 1.096 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	4.647ArgAla: 4.647 ± 0.062	0.719ArgCys: 0.719 ± 0.021	3.655ArgAsp: 3.655 ± 0.049	3.979ArgGlu: 3.979 ± 0.055	2.701ArgPhe: 2.701 ± 0.04	3.98ArgGly: 3.98 ± 0.052	1.385ArgHis: 1.385 ± 0.027	3.625ArgIle: 3.625 ± 0.049	2.557ArgLys: 2.557 ± 0.042	6.833ArgLeu: 6.833 ± 0.073	1.783ArgMet: 1.783 ± 0.029	2.163ArgAsn: 2.163 ± 0.035	2.95ArgPro: 2.95 ± 0.045	3.031ArgGln: 3.031 ± 0.046	5.346ArgArg: 5.346 ± 0.083	3.806ArgSer: 3.806 ± 0.047	3.103ArgThr: 3.103 ± 0.041	3.932ArgVal: 3.932 ± 0.049	1.098ArgTrp: 1.098 ± 0.027	1.838ArgTyr: 1.838 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	5.893SerAla: 5.893 ± 0.08	0.664SerCys: 0.664 ± 0.021	3.747SerAsp: 3.747 ± 0.055	3.579SerGlu: 3.579 ± 0.049	2.311SerPhe: 2.311 ± 0.036	5.54SerGly: 5.54 ± 0.067	1.298SerHis: 1.298 ± 0.022	3.238SerIle: 3.238 ± 0.045	2.107SerLys: 2.107 ± 0.034	6.302SerLeu: 6.302 ± 0.061	1.382SerMet: 1.382 ± 0.027	2.071SerAsn: 2.071 ± 0.037	3.702SerPro: 3.702 ± 0.041	2.677SerGln: 2.677 ± 0.039	3.782SerArg: 3.782 ± 0.051	4.233SerSer: 4.233 ± 0.076	3.344SerThr: 3.344 ± 0.054	3.963SerVal: 3.963 ± 0.05	0.917SerTrp: 0.917 ± 0.023	1.617SerTyr: 1.617 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	5.549ThrAla: 5.549 ± 0.078	0.567ThrCys: 0.567 ± 0.02	3.046ThrAsp: 3.046 ± 0.048	2.801ThrGlu: 2.801 ± 0.04	2.083ThrPhe: 2.083 ± 0.041	4.318ThrGly: 4.318 ± 0.055	1.08ThrHis: 1.08 ± 0.024	3.393ThrIle: 3.393 ± 0.053	1.93ThrLys: 1.93 ± 0.036	5.558ThrLeu: 5.558 ± 0.059	1.163ThrMet: 1.163 ± 0.023	1.8ThrAsn: 1.8 ± 0.036	3.549ThrPro: 3.549 ± 0.049	1.918ThrGln: 1.918 ± 0.035	2.751ThrArg: 2.751 ± 0.044	3.455ThrSer: 3.455 ± 0.058	3.174ThrThr: 3.174 ± 0.053	3.554ThrVal: 3.554 ± 0.061	0.763ThrTrp: 0.763 ± 0.02	1.445ThrTyr: 1.445 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	7.265ValAla: 7.265 ± 0.061	0.861ValCys: 0.861 ± 0.027	4.542ValAsp: 4.542 ± 0.047	4.676ValGlu: 4.676 ± 0.052	2.264ValPhe: 2.264 ± 0.037	5.111ValGly: 5.111 ± 0.057	1.354ValHis: 1.354 ± 0.027	3.937ValIle: 3.937 ± 0.04	2.474ValLys: 2.474 ± 0.04	6.258ValLeu: 6.258 ± 0.063	1.55ValMet: 1.55 ± 0.032	2.154ValAsn: 2.154 ± 0.044	2.963ValPro: 2.963 ± 0.043	2.457ValGln: 2.457 ± 0.04	4.418ValArg: 4.418 ± 0.051	4.243ValSer: 4.243 ± 0.059	4.115ValThr: 4.115 ± 0.059	5.393ValVal: 5.393 ± 0.067	0.967ValTrp: 0.967 ± 0.024	1.658ValTyr: 1.658 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.128TrpAla: 1.128 ± 0.029	0.173TrpCys: 0.173 ± 0.009	0.787TrpAsp: 0.787 ± 0.021	0.738TrpGlu: 0.738 ± 0.02	0.537TrpPhe: 0.537 ± 0.018	1.041TrpGly: 1.041 ± 0.026	0.329TrpHis: 0.329 ± 0.013	0.902TrpIle: 0.902 ± 0.023	0.734TrpLys: 0.734 ± 0.023	1.597TrpLeu: 1.597 ± 0.038	0.409TrpMet: 0.409 ± 0.015	0.622TrpAsn: 0.622 ± 0.018	0.645TrpPro: 0.645 ± 0.022	0.594TrpGln: 0.594 ± 0.018	1.231TrpArg: 1.231 ± 0.026	1.005TrpSer: 1.005 ± 0.024	0.853TrpThr: 0.853 ± 0.023	0.78TrpVal: 0.78 ± 0.022	0.25TrpTrp: 0.25 ± 0.011	0.351TrpTyr: 0.351 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.392TyrAla: 2.392 ± 0.042	0.368TyrCys: 0.368 ± 0.015	1.858TyrAsp: 1.858 ± 0.047	1.595TyrGlu: 1.595 ± 0.032	1.207TyrPhe: 1.207 ± 0.023	2.12TyrGly: 2.12 ± 0.039	0.703TyrHis: 0.703 ± 0.02	0.93TyrIle: 0.93 ± 0.027	0.704TyrLys: 0.704 ± 0.022	2.756TyrLeu: 2.756 ± 0.048	0.441TyrMet: 0.441 ± 0.015	0.821TyrAsn: 0.821 ± 0.027	1.225TyrPro: 1.225 ± 0.028	1.261TyrGln: 1.261 ± 0.026	1.925TyrArg: 1.925 ± 0.036	1.537TyrSer: 1.537 ± 0.035	1.034TyrThr: 1.034 ± 0.028	1.816TyrVal: 1.816 ± 0.027	0.491TyrTrp: 0.491 ± 0.018	0.937TyrTyr: 0.937 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6010 proteins (1930168 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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