Amino acid dipepetide frequency for Sphingorhabdus sp. SMR4y

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.269AlaAla: 14.269 ± 0.155
0.968AlaCys: 0.968 ± 0.04
7.055AlaAsp: 7.055 ± 0.108
7.362AlaGlu: 7.362 ± 0.095
3.969AlaPhe: 3.969 ± 0.062
9.691AlaGly: 9.691 ± 0.125
1.927AlaHis: 1.927 ± 0.047
6.954AlaIle: 6.954 ± 0.085
4.808AlaLys: 4.808 ± 0.086
11.488AlaLeu: 11.488 ± 0.147
3.592AlaMet: 3.592 ± 0.071
3.285AlaAsn: 3.285 ± 0.068
4.681AlaPro: 4.681 ± 0.07
4.036AlaGln: 4.036 ± 0.073
6.916AlaArg: 6.916 ± 0.093
6.6AlaSer: 6.6 ± 0.103
5.529AlaThr: 5.529 ± 0.096
7.458AlaVal: 7.458 ± 0.1
1.206AlaTrp: 1.206 ± 0.038
2.443AlaTyr: 2.443 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
0.906CysAla: 0.906 ± 0.032
0.109CysCys: 0.109 ± 0.011
0.625CysAsp: 0.625 ± 0.028
0.495CysGlu: 0.495 ± 0.024
0.332CysPhe: 0.332 ± 0.021
0.876CysGly: 0.876 ± 0.031
0.258CysHis: 0.258 ± 0.022
0.42CysIle: 0.42 ± 0.019
0.25CysLys: 0.25 ± 0.015
0.738CysLeu: 0.738 ± 0.024
0.181CysMet: 0.181 ± 0.013
0.29CysAsn: 0.29 ± 0.017
0.432CysPro: 0.432 ± 0.022
0.262CysGln: 0.262 ± 0.018
0.512CysArg: 0.512 ± 0.025
0.542CysSer: 0.542 ± 0.023
0.386CysThr: 0.386 ± 0.019
0.54CysVal: 0.54 ± 0.024
0.09CysTrp: 0.09 ± 0.01
0.205CysTyr: 0.205 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
6.544AspAla: 6.544 ± 0.101
0.55AspCys: 0.55 ± 0.021
3.934AspAsp: 3.934 ± 0.082
3.962AspGlu: 3.962 ± 0.068
2.478AspPhe: 2.478 ± 0.048
5.895AspGly: 5.895 ± 0.102
1.506AspHis: 1.506 ± 0.041
4.019AspIle: 4.019 ± 0.073
2.399AspLys: 2.399 ± 0.049
5.857AspLeu: 5.857 ± 0.077
1.769AspMet: 1.769 ± 0.044
1.94AspAsn: 1.94 ± 0.053
3.473AspPro: 3.473 ± 0.055
2.296AspGln: 2.296 ± 0.047
4.427AspArg: 4.427 ± 0.078
3.219AspSer: 3.219 ± 0.066
2.512AspThr: 2.512 ± 0.06
3.961AspVal: 3.961 ± 0.069
1.104AspTrp: 1.104 ± 0.031
1.781AspTyr: 1.781 ± 0.043
0.0AspXaa: 0.0 ± 0.0
Glu
7.29GluAla: 7.29 ± 0.092
0.357GluCys: 0.357 ± 0.021
3.389GluAsp: 3.389 ± 0.057
3.831GluGlu: 3.831 ± 0.075
1.971GluPhe: 1.971 ± 0.038
4.318GluGly: 4.318 ± 0.063
1.191GluHis: 1.191 ± 0.032
3.974GluIle: 3.974 ± 0.069
3.159GluLys: 3.159 ± 0.059
5.395GluLeu: 5.395 ± 0.077
1.844GluMet: 1.844 ± 0.047
2.169GluAsn: 2.169 ± 0.054
2.59GluPro: 2.59 ± 0.06
2.643GluGln: 2.643 ± 0.049
4.301GluArg: 4.301 ± 0.074
2.972GluSer: 2.972 ± 0.052
3.545GluThr: 3.545 ± 0.065
3.378GluVal: 3.378 ± 0.075
0.754GluTrp: 0.754 ± 0.029
1.397GluTyr: 1.397 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
4.606PheAla: 4.606 ± 0.058
0.347PheCys: 0.347 ± 0.018
2.917PheAsp: 2.917 ± 0.054
2.289PheGlu: 2.289 ± 0.046
1.492PhePhe: 1.492 ± 0.044
3.768PheGly: 3.768 ± 0.062
0.707PheHis: 0.707 ± 0.027
1.902PheIle: 1.902 ± 0.041
1.179PheLys: 1.179 ± 0.036
3.399PheLeu: 3.399 ± 0.061
0.857PheMet: 0.857 ± 0.029
1.23PheAsn: 1.23 ± 0.041
1.56PhePro: 1.56 ± 0.041
1.076PheGln: 1.076 ± 0.033
2.077PheArg: 2.077 ± 0.056
2.455PheSer: 2.455 ± 0.057
2.022PheThr: 2.022 ± 0.049
2.602PheVal: 2.602 ± 0.049
0.576PheTrp: 0.576 ± 0.026
1.036PheTyr: 1.036 ± 0.033
0.0PheXaa: 0.0 ± 0.0
Gly
8.317GlyAla: 8.317 ± 0.12
0.818GlyCys: 0.818 ± 0.027
5.096GlyAsp: 5.096 ± 0.099
5.042GlyGlu: 5.042 ± 0.069
3.663GlyPhe: 3.663 ± 0.063
7.436GlyGly: 7.436 ± 0.159
1.719GlyHis: 1.719 ± 0.041
4.765GlyIle: 4.765 ± 0.076
3.984GlyLys: 3.984 ± 0.066
8.276GlyLeu: 8.276 ± 0.099
2.399GlyMet: 2.399 ± 0.047
2.633GlyAsn: 2.633 ± 0.076
3.387GlyPro: 3.387 ± 0.062
3.142GlyGln: 3.142 ± 0.051
5.102GlyArg: 5.102 ± 0.073
5.172GlySer: 5.172 ± 0.096
4.548GlyThr: 4.548 ± 0.099
5.382GlyVal: 5.382 ± 0.08
1.462GlyTrp: 1.462 ± 0.041
2.385GlyTyr: 2.385 ± 0.053
0.0GlyXaa: 0.0 ± 0.0
His
1.869HisAla: 1.869 ± 0.049
0.276HisCys: 0.276 ± 0.018
1.209HisAsp: 1.209 ± 0.032
1.064HisGlu: 1.064 ± 0.035
0.893HisPhe: 0.893 ± 0.03
1.778HisGly: 1.778 ± 0.045
0.564HisHis: 0.564 ± 0.023
1.208HisIle: 1.208 ± 0.034
0.699HisLys: 0.699 ± 0.025
1.805HisLeu: 1.805 ± 0.046
0.499HisMet: 0.499 ± 0.025
0.561HisAsn: 0.561 ± 0.024
1.21HisPro: 1.21 ± 0.038
0.631HisGln: 0.631 ± 0.025
1.242HisArg: 1.242 ± 0.04
1.09HisSer: 1.09 ± 0.034
0.597HisThr: 0.597 ± 0.025
1.327HisVal: 1.327 ± 0.04
0.382HisTrp: 0.382 ± 0.024
0.547HisTyr: 0.547 ± 0.025
0.0HisXaa: 0.0 ± 0.0
Ile
7.855IleAla: 7.855 ± 0.099
0.62IleCys: 0.62 ± 0.027
4.29IleAsp: 4.29 ± 0.063
3.851IleGlu: 3.851 ± 0.061
2.33IlePhe: 2.33 ± 0.051
5.419IleGly: 5.419 ± 0.08
0.974IleHis: 0.974 ± 0.036
3.283IleIle: 3.283 ± 0.063
1.867IleLys: 1.867 ± 0.044
5.181IleLeu: 5.181 ± 0.076
1.32IleMet: 1.32 ± 0.037
1.927IleAsn: 1.927 ± 0.051
2.62IlePro: 2.62 ± 0.051
1.363IleGln: 1.363 ± 0.038
3.244IleArg: 3.244 ± 0.054
3.745IleSer: 3.745 ± 0.062
3.08IleThr: 3.08 ± 0.073
4.045IleVal: 4.045 ± 0.062
0.801IleTrp: 0.801 ± 0.026
1.298IleTyr: 1.298 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
4.733LysAla: 4.733 ± 0.081
0.259LysCys: 0.259 ± 0.015
2.084LysAsp: 2.084 ± 0.047
1.933LysGlu: 1.933 ± 0.044
1.302LysPhe: 1.302 ± 0.036
2.881LysGly: 2.881 ± 0.055
0.732LysHis: 0.732 ± 0.023
2.555LysIle: 2.555 ± 0.059
1.939LysLys: 1.939 ± 0.055
3.941LysLeu: 3.941 ± 0.067
1.221LysMet: 1.221 ± 0.037
1.293LysAsn: 1.293 ± 0.034
2.411LysPro: 2.411 ± 0.058
1.429LysGln: 1.429 ± 0.037
2.574LysArg: 2.574 ± 0.048
2.493LysSer: 2.493 ± 0.054
2.277LysThr: 2.277 ± 0.049
2.442LysVal: 2.442 ± 0.056
0.525LysTrp: 0.525 ± 0.021
0.898LysTyr: 0.898 ± 0.027
0.0LysXaa: 0.0 ± 0.0
Leu
11.801LeuAla: 11.801 ± 0.137
0.795LeuCys: 0.795 ± 0.027
6.148LeuAsp: 6.148 ± 0.091
5.521LeuGlu: 5.521 ± 0.07
3.758LeuPhe: 3.758 ± 0.066
7.632LeuGly: 7.632 ± 0.093
1.704LeuHis: 1.704 ± 0.038
5.23LeuIle: 5.23 ± 0.072
3.725LeuLys: 3.725 ± 0.069
9.088LeuLeu: 9.088 ± 0.127
2.202LeuMet: 2.202 ± 0.049
2.778LeuAsn: 2.778 ± 0.055
4.928LeuPro: 4.928 ± 0.067
2.94LeuGln: 2.94 ± 0.056
5.453LeuArg: 5.453 ± 0.078
6.429LeuSer: 6.429 ± 0.078
5.443LeuThr: 5.443 ± 0.086
6.684LeuVal: 6.684 ± 0.095
1.143LeuTrp: 1.143 ± 0.037
2.002LeuTyr: 2.002 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
3.247MetAla: 3.247 ± 0.068
0.184MetCys: 0.184 ± 0.014
1.424MetAsp: 1.424 ± 0.041
1.435MetGlu: 1.435 ± 0.041
0.788MetPhe: 0.788 ± 0.025
2.025MetGly: 2.025 ± 0.048
0.503MetHis: 0.503 ± 0.021
1.668MetIle: 1.668 ± 0.048
1.233MetLys: 1.233 ± 0.037
2.648MetLeu: 2.648 ± 0.054
0.782MetMet: 0.782 ± 0.03
0.903MetAsn: 0.903 ± 0.031
1.456MetPro: 1.456 ± 0.038
0.939MetGln: 0.939 ± 0.031
1.654MetArg: 1.654 ± 0.04
1.578MetSer: 1.578 ± 0.037
1.998MetThr: 1.998 ± 0.044
1.814MetVal: 1.814 ± 0.041
0.227MetTrp: 0.227 ± 0.016
0.299MetTyr: 0.299 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
3.364AsnAla: 3.364 ± 0.085
0.325AsnCys: 0.325 ± 0.016
1.855AsnAsp: 1.855 ± 0.046
1.516AsnGlu: 1.516 ± 0.041
1.276AsnPhe: 1.276 ± 0.041
2.923AsnGly: 2.923 ± 0.078
0.574AsnHis: 0.574 ± 0.024
2.187AsnIle: 2.187 ± 0.058
0.992AsnLys: 0.992 ± 0.034
2.975AsnLeu: 2.975 ± 0.062
0.869AsnMet: 0.869 ± 0.029
0.973AsnAsn: 0.973 ± 0.045
2.006AsnPro: 2.006 ± 0.047
0.994AsnGln: 0.994 ± 0.03
2.148AsnArg: 2.148 ± 0.046
1.802AsnSer: 1.802 ± 0.048
1.226AsnThr: 1.226 ± 0.038
2.076AsnVal: 2.076 ± 0.051
0.496AsnTrp: 0.496 ± 0.023
0.884AsnTyr: 0.884 ± 0.03
0.0AsnXaa: 0.0 ± 0.0
Pro
5.489ProAla: 5.489 ± 0.083
0.304ProCys: 0.304 ± 0.019
4.045ProAsp: 4.045 ± 0.068
3.906ProGlu: 3.906 ± 0.067
1.91ProPhe: 1.91 ± 0.04
3.989ProGly: 3.989 ± 0.066
0.907ProHis: 0.907 ± 0.032
2.424ProIle: 2.424 ± 0.052
1.874ProLys: 1.874 ± 0.046
4.424ProLeu: 4.424 ± 0.072
1.229ProMet: 1.229 ± 0.037
1.351ProAsn: 1.351 ± 0.033
2.139ProPro: 2.139 ± 0.059
1.565ProGln: 1.565 ± 0.042
2.285ProArg: 2.285 ± 0.057
2.596ProSer: 2.596 ± 0.049
2.149ProThr: 2.149 ± 0.041
4.108ProVal: 4.108 ± 0.067
0.584ProTrp: 0.584 ± 0.025
1.087ProTyr: 1.087 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
3.993GlnAla: 3.993 ± 0.076
0.287GlnCys: 0.287 ± 0.017
1.783GlnAsp: 1.783 ± 0.041
1.73GlnGlu: 1.73 ± 0.044
1.312GlnPhe: 1.312 ± 0.036
2.441GlnGly: 2.441 ± 0.053
0.642GlnHis: 0.642 ± 0.026
2.213GlnIle: 2.213 ± 0.045
1.436GlnLys: 1.436 ± 0.042
3.231GlnLeu: 3.231 ± 0.052
0.973GlnMet: 0.973 ± 0.035
1.203GlnAsn: 1.203 ± 0.037
1.751GlnPro: 1.751 ± 0.044
1.478GlnGln: 1.478 ± 0.037
2.262GlnArg: 2.262 ± 0.048
2.231GlnSer: 2.231 ± 0.05
1.769GlnThr: 1.769 ± 0.047
2.021GlnVal: 2.021 ± 0.045
0.51GlnTrp: 0.51 ± 0.026
0.854GlnTyr: 0.854 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
6.187ArgAla: 6.187 ± 0.092
0.45ArgCys: 0.45 ± 0.022
3.864ArgAsp: 3.864 ± 0.061
3.728ArgGlu: 3.728 ± 0.067
2.76ArgPhe: 2.76 ± 0.057
4.028ArgGly: 4.028 ± 0.071
1.303ArgHis: 1.303 ± 0.042
3.805ArgIle: 3.805 ± 0.066
2.793ArgLys: 2.793 ± 0.058
6.646ArgLeu: 6.646 ± 0.094
1.711ArgMet: 1.711 ± 0.043
2.215ArgAsn: 2.215 ± 0.053
2.867ArgPro: 2.867 ± 0.058
2.395ArgGln: 2.395 ± 0.051
3.904ArgArg: 3.904 ± 0.071
3.606ArgSer: 3.606 ± 0.069
2.927ArgThr: 2.927 ± 0.052
3.799ArgVal: 3.799 ± 0.063
0.892ArgTrp: 0.892 ± 0.029
1.762ArgTyr: 1.762 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
6.489SerAla: 6.489 ± 0.094
0.508SerCys: 0.508 ± 0.024
3.956SerAsp: 3.956 ± 0.068
3.478SerGlu: 3.478 ± 0.056
2.394SerPhe: 2.394 ± 0.045
6.159SerGly: 6.159 ± 0.094
1.09SerHis: 1.09 ± 0.032
3.395SerIle: 3.395 ± 0.07
2.153SerLys: 2.153 ± 0.05
5.755SerLeu: 5.755 ± 0.079
1.485SerMet: 1.485 ± 0.039
1.778SerAsn: 1.778 ± 0.049
2.889SerPro: 2.889 ± 0.055
1.868SerGln: 1.868 ± 0.046
3.562SerArg: 3.562 ± 0.057
3.462SerSer: 3.462 ± 0.063
2.659SerThr: 2.659 ± 0.056
3.927SerVal: 3.927 ± 0.058
0.819SerTrp: 0.819 ± 0.03
1.633SerTyr: 1.633 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
5.859ThrAla: 5.859 ± 0.088
0.389ThrCys: 0.389 ± 0.02
3.204ThrAsp: 3.204 ± 0.074
2.828ThrGlu: 2.828 ± 0.053
1.751ThrPhe: 1.751 ± 0.043
5.244ThrGly: 5.244 ± 0.087
0.95ThrHis: 0.95 ± 0.031
3.266ThrIle: 3.266 ± 0.073
1.643ThrLys: 1.643 ± 0.044
5.084ThrLeu: 5.084 ± 0.084
1.21ThrMet: 1.21 ± 0.039
1.548ThrAsn: 1.548 ± 0.042
2.914ThrPro: 2.914 ± 0.056
1.426ThrGln: 1.426 ± 0.04
3.045ThrArg: 3.045 ± 0.057
2.822ThrSer: 2.822 ± 0.055
2.527ThrThr: 2.527 ± 0.063
3.888ThrVal: 3.888 ± 0.071
0.489ThrTrp: 0.489 ± 0.023
1.095ThrTyr: 1.095 ± 0.038
0.0ThrXaa: 0.0 ± 0.0
Val
7.745ValAla: 7.745 ± 0.085
0.5ValCys: 0.5 ± 0.023
4.307ValAsp: 4.307 ± 0.07
4.548ValGlu: 4.548 ± 0.073
2.074ValPhe: 2.074 ± 0.043
5.106ValGly: 5.106 ± 0.072
1.306ValHis: 1.306 ± 0.032
3.923ValIle: 3.923 ± 0.066
2.447ValLys: 2.447 ± 0.053
5.559ValLeu: 5.559 ± 0.092
1.744ValMet: 1.744 ± 0.049
2.169ValAsn: 2.169 ± 0.057
3.332ValPro: 3.332 ± 0.058
2.095ValGln: 2.095 ± 0.041
4.165ValArg: 4.165 ± 0.066
4.236ValSer: 4.236 ± 0.065
4.18ValThr: 4.18 ± 0.081
4.343ValVal: 4.343 ± 0.067
0.785ValTrp: 0.785 ± 0.029
1.439ValTyr: 1.439 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
1.185TrpAla: 1.185 ± 0.036
0.125TrpCys: 0.125 ± 0.012
0.767TrpAsp: 0.767 ± 0.027
0.613TrpGlu: 0.613 ± 0.028
0.558TrpPhe: 0.558 ± 0.025
0.899TrpGly: 0.899 ± 0.032
0.319TrpHis: 0.319 ± 0.02
0.75TrpIle: 0.75 ± 0.03
0.585TrpLys: 0.585 ± 0.026
1.598TrpLeu: 1.598 ± 0.049
0.388TrpMet: 0.388 ± 0.019
0.49TrpAsn: 0.49 ± 0.023
0.631TrpPro: 0.631 ± 0.025
0.667TrpGln: 0.667 ± 0.03
0.962TrpArg: 0.962 ± 0.033
0.897TrpSer: 0.897 ± 0.033
0.78TrpThr: 0.78 ± 0.031
0.748TrpVal: 0.748 ± 0.028
0.2TrpTrp: 0.2 ± 0.015
0.289TrpTyr: 0.289 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.493TyrAla: 2.493 ± 0.051
0.278TyrCys: 0.278 ± 0.018
1.67TyrAsp: 1.67 ± 0.042
1.339TyrGlu: 1.339 ± 0.039
1.087TyrPhe: 1.087 ± 0.035
2.218TyrGly: 2.218 ± 0.054
0.576TyrHis: 0.576 ± 0.023
1.171TyrIle: 1.171 ± 0.036
0.759TyrLys: 0.759 ± 0.028
2.314TyrLeu: 2.314 ± 0.046
0.532TyrMet: 0.532 ± 0.023
0.724TyrAsn: 0.724 ± 0.027
1.09TyrPro: 1.09 ± 0.033
0.873TyrGln: 0.873 ± 0.026
1.808TyrArg: 1.808 ± 0.045
1.509TyrSer: 1.509 ± 0.038
1.029TyrThr: 1.029 ± 0.04
1.461TyrVal: 1.461 ± 0.042
0.404TyrTrp: 0.404 ± 0.021
0.679TyrTyr: 0.679 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3323 proteins (1041894 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski