Amino acid dipepetide frequency for Cellulophaga tyrosinoxydans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.605AlaAla: 4.605 ± 0.092	0.547AlaCys: 0.547 ± 0.025	3.395AlaAsp: 3.395 ± 0.06	4.104AlaGlu: 4.104 ± 0.069	3.297AlaPhe: 3.297 ± 0.053	4.114AlaGly: 4.114 ± 0.085	1.03AlaHis: 1.03 ± 0.032	6.082AlaIle: 6.082 ± 0.075	4.959AlaLys: 4.959 ± 0.086	6.566AlaLeu: 6.566 ± 0.099	1.564AlaMet: 1.564 ± 0.041	3.904AlaAsn: 3.904 ± 0.069	2.019AlaPro: 2.019 ± 0.052	2.374AlaGln: 2.374 ± 0.043	1.861AlaArg: 1.861 ± 0.041	4.292AlaSer: 4.292 ± 0.064	4.01AlaThr: 4.01 ± 0.088	4.112AlaVal: 4.112 ± 0.07	0.605AlaTrp: 0.605 ± 0.024	2.628AlaTyr: 2.628 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.447CysAla: 0.447 ± 0.02	0.085CysCys: 0.085 ± 0.009	0.435CysAsp: 0.435 ± 0.022	0.45CysGlu: 0.45 ± 0.022	0.398CysPhe: 0.398 ± 0.019	0.597CysGly: 0.597 ± 0.025	0.172CysHis: 0.172 ± 0.014	0.583CysIle: 0.583 ± 0.024	0.458CysLys: 0.458 ± 0.02	0.644CysLeu: 0.644 ± 0.022	0.135CysMet: 0.135 ± 0.011	0.444CysAsn: 0.444 ± 0.021	0.314CysPro: 0.314 ± 0.02	0.22CysGln: 0.22 ± 0.015	0.158CysArg: 0.158 ± 0.013	0.544CysSer: 0.544 ± 0.028	0.456CysThr: 0.456 ± 0.031	0.395CysVal: 0.395 ± 0.021	0.056CysTrp: 0.056 ± 0.007	0.297CysTyr: 0.297 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	4.004AspAla: 4.004 ± 0.079	0.403AspCys: 0.403 ± 0.022	2.892AspAsp: 2.892 ± 0.063	3.535AspGlu: 3.535 ± 0.065	3.615AspPhe: 3.615 ± 0.061	3.893AspGly: 3.893 ± 0.09	0.883AspHis: 0.883 ± 0.03	4.351AspIle: 4.351 ± 0.059	4.204AspLys: 4.204 ± 0.066	5.168AspLeu: 5.168 ± 0.08	1.049AspMet: 1.049 ± 0.032	3.196AspAsn: 3.196 ± 0.057	1.63AspPro: 1.63 ± 0.046	1.468AspGln: 1.468 ± 0.037	1.757AspArg: 1.757 ± 0.043	3.19AspSer: 3.19 ± 0.066	2.942AspThr: 2.942 ± 0.065	3.524AspVal: 3.524 ± 0.06	0.745AspTrp: 0.745 ± 0.025	2.741AspTyr: 2.741 ± 0.058	0.0AspXaa: 0.0 ± 0.0
Glu	4.187GluAla: 4.187 ± 0.073	0.326GluCys: 0.326 ± 0.018	3.508GluAsp: 3.508 ± 0.06	4.663GluGlu: 4.663 ± 0.081	2.979GluPhe: 2.979 ± 0.052	3.531GluGly: 3.531 ± 0.064	1.098GluHis: 1.098 ± 0.033	5.655GluIle: 5.655 ± 0.08	5.998GluLys: 5.998 ± 0.098	6.253GluLeu: 6.253 ± 0.098	1.49GluMet: 1.49 ± 0.039	4.929GluAsn: 4.929 ± 0.075	1.556GluPro: 1.556 ± 0.038	2.211GluGln: 2.211 ± 0.056	2.324GluArg: 2.324 ± 0.057	3.257GluSer: 3.257 ± 0.055	3.517GluThr: 3.517 ± 0.064	4.262GluVal: 4.262 ± 0.069	0.605GluTrp: 0.605 ± 0.023	2.413GluTyr: 2.413 ± 0.052	0.0GluXaa: 0.0 ± 0.0
Phe	2.976PheAla: 2.976 ± 0.055	0.423PheCys: 0.423 ± 0.022	3.239PheAsp: 3.239 ± 0.058	3.397PheGlu: 3.397 ± 0.061	2.713PhePhe: 2.713 ± 0.061	3.622PheGly: 3.622 ± 0.063	0.785PheHis: 0.785 ± 0.028	4.039PheIle: 4.039 ± 0.066	3.941PheLys: 3.941 ± 0.071	4.787PheLeu: 4.787 ± 0.086	1.144PheMet: 1.144 ± 0.037	3.409PheAsn: 3.409 ± 0.062	1.672PhePro: 1.672 ± 0.042	1.526PheGln: 1.526 ± 0.039	1.555PheArg: 1.555 ± 0.038	4.085PheSer: 4.085 ± 0.073	3.215PheThr: 3.215 ± 0.065	2.969PheVal: 2.969 ± 0.057	0.554PheTrp: 0.554 ± 0.024	2.227PheTyr: 2.227 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	4.333GlyAla: 4.333 ± 0.091	0.602GlyCys: 0.602 ± 0.04	3.493GlyAsp: 3.493 ± 0.063	3.624GlyGlu: 3.624 ± 0.066	3.635GlyPhe: 3.635 ± 0.068	4.557GlyGly: 4.557 ± 0.096	1.091GlyHis: 1.091 ± 0.032	5.777GlyIle: 5.777 ± 0.077	4.85GlyLys: 4.85 ± 0.083	5.759GlyLeu: 5.759 ± 0.079	1.522GlyMet: 1.522 ± 0.042	3.601GlyAsn: 3.601 ± 0.09	1.323GlyPro: 1.323 ± 0.045	1.834GlyGln: 1.834 ± 0.05	1.988GlyArg: 1.988 ± 0.048	3.997GlySer: 3.997 ± 0.074	4.093GlyThr: 4.093 ± 0.103	4.39GlyVal: 4.39 ± 0.078	0.781GlyTrp: 0.781 ± 0.03	2.787GlyTyr: 2.787 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	0.919HisAla: 0.919 ± 0.033	0.162HisCys: 0.162 ± 0.013	0.767HisAsp: 0.767 ± 0.027	0.944HisGlu: 0.944 ± 0.033	1.0HisPhe: 1.0 ± 0.028	1.042HisGly: 1.042 ± 0.037	0.444HisHis: 0.444 ± 0.025	1.355HisIle: 1.355 ± 0.04	1.236HisLys: 1.236 ± 0.033	1.71HisLeu: 1.71 ± 0.05	0.339HisMet: 0.339 ± 0.018	0.852HisAsn: 0.852 ± 0.026	0.805HisPro: 0.805 ± 0.029	0.658HisGln: 0.658 ± 0.023	0.585HisArg: 0.585 ± 0.025	1.061HisSer: 1.061 ± 0.031	0.933HisThr: 0.933 ± 0.03	0.923HisVal: 0.923 ± 0.032	0.21HisTrp: 0.21 ± 0.012	0.743HisTyr: 0.743 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.234IleAla: 6.234 ± 0.08	0.619IleCys: 0.619 ± 0.026	4.821IleAsp: 4.821 ± 0.074	5.241IleGlu: 5.241 ± 0.076	3.813IlePhe: 3.813 ± 0.076	5.334IleGly: 5.334 ± 0.086	1.321IleHis: 1.321 ± 0.045	6.204IleIle: 6.204 ± 0.086	5.963IleLys: 5.963 ± 0.096	7.572IleLeu: 7.572 ± 0.098	1.361IleMet: 1.361 ± 0.037	4.925IleAsn: 4.925 ± 0.074	3.28IlePro: 3.28 ± 0.062	2.526IleGln: 2.526 ± 0.052	2.527IleArg: 2.527 ± 0.054	5.809IleSer: 5.809 ± 0.09	5.256IleThr: 5.256 ± 0.115	4.847IleVal: 4.847 ± 0.061	0.746IleTrp: 0.746 ± 0.027	2.802IleTyr: 2.802 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	5.081LysAla: 5.081 ± 0.088	0.373LysCys: 0.373 ± 0.023	4.417LysAsp: 4.417 ± 0.08	6.199LysGlu: 6.199 ± 0.106	3.091LysPhe: 3.091 ± 0.054	4.493LysGly: 4.493 ± 0.071	1.266LysHis: 1.266 ± 0.039	6.429LysIle: 6.429 ± 0.088	7.244LysLys: 7.244 ± 0.105	6.946LysLeu: 6.946 ± 0.099	1.99LysMet: 1.99 ± 0.047	5.747LysAsn: 5.747 ± 0.089	2.364LysPro: 2.364 ± 0.053	2.583LysGln: 2.583 ± 0.053	2.609LysArg: 2.609 ± 0.053	4.886LysSer: 4.886 ± 0.072	4.76LysThr: 4.76 ± 0.07	4.74LysVal: 4.74 ± 0.078	0.788LysTrp: 0.788 ± 0.031	3.025LysTyr: 3.025 ± 0.06	0.0LysXaa: 0.0 ± 0.0
Leu	6.231LeuAla: 6.231 ± 0.088	0.658LeuCys: 0.658 ± 0.023	5.158LeuAsp: 5.158 ± 0.077	6.384LeuGlu: 6.384 ± 0.092	5.058LeuPhe: 5.058 ± 0.09	5.961LeuGly: 5.961 ± 0.081	1.578LeuHis: 1.578 ± 0.043	7.045LeuIle: 7.045 ± 0.104	8.134LeuLys: 8.134 ± 0.102	9.039LeuLeu: 9.039 ± 0.117	2.062LeuMet: 2.062 ± 0.052	5.976LeuAsn: 5.976 ± 0.078	3.505LeuPro: 3.505 ± 0.058	3.204LeuGln: 3.204 ± 0.063	2.951LeuArg: 2.951 ± 0.062	6.421LeuSer: 6.421 ± 0.085	5.041LeuThr: 5.041 ± 0.072	5.714LeuVal: 5.714 ± 0.087	0.8LeuTrp: 0.8 ± 0.026	3.193LeuTyr: 3.193 ± 0.059	0.0LeuXaa: 0.0 ± 0.0
Met	1.592MetAla: 1.592 ± 0.044	0.143MetCys: 0.143 ± 0.012	1.088MetAsp: 1.088 ± 0.034	1.334MetGlu: 1.334 ± 0.039	0.92MetPhe: 0.92 ± 0.051	1.434MetGly: 1.434 ± 0.039	0.399MetHis: 0.399 ± 0.019	1.43MetIle: 1.43 ± 0.043	2.077MetLys: 2.077 ± 0.041	1.954MetLeu: 1.954 ± 0.048	0.554MetMet: 0.554 ± 0.026	1.31MetAsn: 1.31 ± 0.037	0.864MetPro: 0.864 ± 0.032	0.882MetGln: 0.882 ± 0.031	0.778MetArg: 0.778 ± 0.028	1.286MetSer: 1.286 ± 0.037	1.068MetThr: 1.068 ± 0.032	1.419MetVal: 1.419 ± 0.039	0.159MetTrp: 0.159 ± 0.014	0.695MetTyr: 0.695 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	4.177AsnAla: 4.177 ± 0.068	0.469AsnCys: 0.469 ± 0.028	3.373AsnAsp: 3.373 ± 0.059	3.741AsnGlu: 3.741 ± 0.062	3.352AsnPhe: 3.352 ± 0.067	4.305AsnGly: 4.305 ± 0.085	1.001AsnHis: 1.001 ± 0.036	4.768AsnIle: 4.768 ± 0.076	4.568AsnLys: 4.568 ± 0.074	5.738AsnLeu: 5.738 ± 0.07	1.321AsnMet: 1.321 ± 0.044	4.089AsnAsn: 4.089 ± 0.09	2.727AsnPro: 2.727 ± 0.057	2.228AsnGln: 2.228 ± 0.052	2.056AsnArg: 2.056 ± 0.046	4.272AsnSer: 4.272 ± 0.068	4.134AsnThr: 4.134 ± 0.078	3.581AsnVal: 3.581 ± 0.072	0.814AsnTrp: 0.814 ± 0.036	2.984AsnTyr: 2.984 ± 0.064	0.0AsnXaa: 0.0 ± 0.0
Pro	1.863ProAla: 1.863 ± 0.049	0.188ProCys: 0.188 ± 0.013	1.964ProAsp: 1.964 ± 0.042	2.786ProGlu: 2.786 ± 0.05	1.873ProPhe: 1.873 ± 0.046	1.867ProGly: 1.867 ± 0.047	0.539ProHis: 0.539 ± 0.024	2.894ProIle: 2.894 ± 0.048	2.589ProLys: 2.589 ± 0.053	2.986ProLeu: 2.986 ± 0.06	0.689ProMet: 0.689 ± 0.027	2.413ProAsn: 2.413 ± 0.055	0.798ProPro: 0.798 ± 0.035	1.021ProGln: 1.021 ± 0.033	0.872ProArg: 0.872 ± 0.027	2.169ProSer: 2.169 ± 0.048	2.014ProThr: 2.014 ± 0.058	2.165ProVal: 2.165 ± 0.045	0.322ProTrp: 0.322 ± 0.016	1.324ProTyr: 1.324 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	1.92GlnAla: 1.92 ± 0.046	0.158GlnCys: 0.158 ± 0.012	1.607GlnAsp: 1.607 ± 0.041	2.407GlnGlu: 2.407 ± 0.057	1.601GlnPhe: 1.601 ± 0.041	1.713GlnGly: 1.713 ± 0.039	0.574GlnHis: 0.574 ± 0.022	2.661GlnIle: 2.661 ± 0.051	2.886GlnLys: 2.886 ± 0.059	3.437GlnLeu: 3.437 ± 0.055	0.774GlnMet: 0.774 ± 0.028	2.18GlnAsn: 2.18 ± 0.05	1.028GlnPro: 1.028 ± 0.032	1.309GlnGln: 1.309 ± 0.036	1.221GlnArg: 1.221 ± 0.036	1.815GlnSer: 1.815 ± 0.048	1.754GlnThr: 1.754 ± 0.043	1.858GlnVal: 1.858 ± 0.043	0.391GlnTrp: 0.391 ± 0.019	1.291GlnTyr: 1.291 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	1.964ArgAla: 1.964 ± 0.05	0.185ArgCys: 0.185 ± 0.013	1.642ArgAsp: 1.642 ± 0.038	1.98ArgGlu: 1.98 ± 0.048	1.731ArgPhe: 1.731 ± 0.043	1.859ArgGly: 1.859 ± 0.046	0.539ArgHis: 0.539 ± 0.025	2.775ArgIle: 2.775 ± 0.058	2.699ArgLys: 2.699 ± 0.057	3.017ArgLeu: 3.017 ± 0.049	0.83ArgMet: 0.83 ± 0.028	1.97ArgAsn: 1.97 ± 0.042	1.034ArgPro: 1.034 ± 0.034	1.016ArgGln: 1.016 ± 0.03	1.148ArgArg: 1.148 ± 0.039	1.796ArgSer: 1.796 ± 0.047	1.788ArgThr: 1.788 ± 0.047	1.985ArgVal: 1.985 ± 0.046	0.366ArgTrp: 0.366 ± 0.019	1.428ArgTyr: 1.428 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	3.982SerAla: 3.982 ± 0.067	0.67SerCys: 0.67 ± 0.027	3.569SerAsp: 3.569 ± 0.063	4.025SerGlu: 4.025 ± 0.066	3.745SerPhe: 3.745 ± 0.071	4.553SerGly: 4.553 ± 0.09	1.028SerHis: 1.028 ± 0.034	5.411SerIle: 5.411 ± 0.073	5.105SerLys: 5.105 ± 0.086	6.079SerLeu: 6.079 ± 0.093	1.213SerMet: 1.213 ± 0.039	3.946SerAsn: 3.946 ± 0.073	2.005SerPro: 2.005 ± 0.045	1.991SerGln: 1.991 ± 0.042	2.023SerArg: 2.023 ± 0.051	4.296SerSer: 4.296 ± 0.081	3.778SerThr: 3.778 ± 0.081	3.847SerVal: 3.847 ± 0.065	0.693SerTrp: 0.693 ± 0.032	2.786SerTyr: 2.786 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	3.998ThrAla: 3.998 ± 0.084	0.391ThrCys: 0.391 ± 0.031	3.328ThrAsp: 3.328 ± 0.075	3.376ThrGlu: 3.376 ± 0.063	3.096ThrPhe: 3.096 ± 0.057	3.992ThrGly: 3.992 ± 0.096	0.936ThrHis: 0.936 ± 0.031	5.347ThrIle: 5.347 ± 0.1	4.05ThrLys: 4.05 ± 0.077	5.358ThrLeu: 5.358 ± 0.077	1.028ThrMet: 1.028 ± 0.034	3.803ThrAsn: 3.803 ± 0.087	2.537ThrPro: 2.537 ± 0.063	1.781ThrGln: 1.781 ± 0.039	1.625ThrArg: 1.625 ± 0.045	3.99ThrSer: 3.99 ± 0.077	3.922ThrThr: 3.922 ± 0.106	3.791ThrVal: 3.791 ± 0.096	0.572ThrTrp: 0.572 ± 0.024	2.518ThrTyr: 2.518 ± 0.062	0.0ThrXaa: 0.0 ± 0.0
Val	4.401ValAla: 4.401 ± 0.071	0.469ValCys: 0.469 ± 0.021	3.509ValAsp: 3.509 ± 0.058	3.655ValGlu: 3.655 ± 0.057	3.357ValPhe: 3.357 ± 0.07	3.85ValGly: 3.85 ± 0.066	1.006ValHis: 1.006 ± 0.03	4.873ValIle: 4.873 ± 0.066	4.243ValLys: 4.243 ± 0.069	6.335ValLeu: 6.335 ± 0.081	1.272ValMet: 1.272 ± 0.038	3.572ValAsn: 3.572 ± 0.059	2.146ValPro: 2.146 ± 0.045	1.77ValGln: 1.77 ± 0.045	1.864ValArg: 1.864 ± 0.05	4.305ValSer: 4.305 ± 0.076	3.672ValThr: 3.672 ± 0.093	4.226ValVal: 4.226 ± 0.076	0.552ValTrp: 0.552 ± 0.023	2.401ValTyr: 2.401 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.587TrpAla: 0.587 ± 0.025	0.09TrpCys: 0.09 ± 0.009	0.654TrpAsp: 0.654 ± 0.029	0.692TrpGlu: 0.692 ± 0.024	0.54TrpPhe: 0.54 ± 0.024	0.67TrpGly: 0.67 ± 0.026	0.224TrpHis: 0.224 ± 0.014	0.727TrpIle: 0.727 ± 0.026	0.784TrpLys: 0.784 ± 0.031	0.973TrpLeu: 0.973 ± 0.033	0.311TrpMet: 0.311 ± 0.02	0.738TrpAsn: 0.738 ± 0.036	0.253TrpPro: 0.253 ± 0.018	0.407TrpGln: 0.407 ± 0.02	0.374TrpArg: 0.374 ± 0.018	0.644TrpSer: 0.644 ± 0.027	0.535TrpThr: 0.535 ± 0.025	0.6TrpVal: 0.6 ± 0.024	0.15TrpTrp: 0.15 ± 0.013	0.435TrpTyr: 0.435 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.57TyrAla: 2.57 ± 0.051	0.329TyrCys: 0.329 ± 0.017	2.33TyrAsp: 2.33 ± 0.051	2.225TyrGlu: 2.225 ± 0.052	2.464TyrPhe: 2.464 ± 0.053	2.65TyrGly: 2.65 ± 0.055	0.776TyrHis: 0.776 ± 0.027	2.795TyrIle: 2.795 ± 0.053	3.042TyrLys: 3.042 ± 0.059	3.791TyrLeu: 3.791 ± 0.065	0.738TyrMet: 0.738 ± 0.028	2.694TyrAsn: 2.694 ± 0.056	1.475TyrPro: 1.475 ± 0.043	1.575TyrGln: 1.575 ± 0.04	1.477TyrArg: 1.477 ± 0.043	2.628TyrSer: 2.628 ± 0.058	2.551TyrThr: 2.551 ± 0.068	2.13TyrVal: 2.13 ± 0.045	0.478TyrTrp: 0.478 ± 0.021	1.808TyrTyr: 1.808 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3140 proteins (1080595 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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