Amino acid dipepetide frequency for Sphingopyxis bauzanensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.486AlaAla: 20.486 ± 0.197	1.033AlaCys: 1.033 ± 0.031	8.166AlaAsp: 8.166 ± 0.095	7.524AlaGlu: 7.524 ± 0.091	4.373AlaPhe: 4.373 ± 0.063	11.059AlaGly: 11.059 ± 0.105	2.386AlaHis: 2.386 ± 0.053	7.035AlaIle: 7.035 ± 0.081	4.591AlaLys: 4.591 ± 0.072	13.7AlaLeu: 13.7 ± 0.14	4.05AlaMet: 4.05 ± 0.071	3.393AlaAsn: 3.393 ± 0.053	6.362AlaPro: 6.362 ± 0.084	4.252AlaGln: 4.252 ± 0.06	9.292AlaArg: 9.292 ± 0.105	6.849AlaSer: 6.849 ± 0.082	6.83AlaThr: 6.83 ± 0.09	8.72AlaVal: 8.72 ± 0.076	1.655AlaTrp: 1.655 ± 0.039	2.561AlaTyr: 2.561 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.004CysAla: 1.004 ± 0.03	0.1CysCys: 0.1 ± 0.009	0.548CysAsp: 0.548 ± 0.021	0.406CysGlu: 0.406 ± 0.021	0.282CysPhe: 0.282 ± 0.016	0.826CysGly: 0.826 ± 0.029	0.214CysHis: 0.214 ± 0.017	0.385CysIle: 0.385 ± 0.019	0.182CysLys: 0.182 ± 0.013	0.678CysLeu: 0.678 ± 0.019	0.142CysMet: 0.142 ± 0.012	0.219CysAsn: 0.219 ± 0.014	0.435CysPro: 0.435 ± 0.022	0.227CysGln: 0.227 ± 0.013	0.605CysArg: 0.605 ± 0.022	0.475CysSer: 0.475 ± 0.018	0.373CysThr: 0.373 ± 0.017	0.516CysVal: 0.516 ± 0.023	0.123CysTrp: 0.123 ± 0.01	0.168CysTyr: 0.168 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.292AspAla: 8.292 ± 0.097	0.522AspCys: 0.522 ± 0.024	3.704AspAsp: 3.704 ± 0.068	3.51AspGlu: 3.51 ± 0.056	2.276AspPhe: 2.276 ± 0.045	5.832AspGly: 5.832 ± 0.07	1.354AspHis: 1.354 ± 0.03	3.193AspIle: 3.193 ± 0.051	1.898AspLys: 1.898 ± 0.042	5.675AspLeu: 5.675 ± 0.067	1.493AspMet: 1.493 ± 0.037	1.503AspAsn: 1.503 ± 0.033	3.75AspPro: 3.75 ± 0.054	1.819AspGln: 1.819 ± 0.038	4.979AspArg: 4.979 ± 0.065	2.533AspSer: 2.533 ± 0.047	2.719AspThr: 2.719 ± 0.053	4.199AspVal: 4.199 ± 0.058	1.139AspTrp: 1.139 ± 0.033	1.714AspTyr: 1.714 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	7.543GluAla: 7.543 ± 0.093	0.315GluCys: 0.315 ± 0.017	2.601GluAsp: 2.601 ± 0.053	2.624GluGlu: 2.624 ± 0.056	1.586GluPhe: 1.586 ± 0.037	4.148GluGly: 4.148 ± 0.066	1.036GluHis: 1.036 ± 0.029	3.125GluIle: 3.125 ± 0.05	1.997GluLys: 1.997 ± 0.045	5.173GluLeu: 5.173 ± 0.074	1.475GluMet: 1.475 ± 0.037	1.393GluAsn: 1.393 ± 0.034	2.471GluPro: 2.471 ± 0.055	2.01GluGln: 2.01 ± 0.047	4.833GluArg: 4.833 ± 0.078	2.192GluSer: 2.192 ± 0.044	3.1GluThr: 3.1 ± 0.059	3.459GluVal: 3.459 ± 0.058	0.764GluTrp: 0.764 ± 0.023	1.018GluTyr: 1.018 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	5.103PheAla: 5.103 ± 0.062	0.32PheCys: 0.32 ± 0.017	2.831PheAsp: 2.831 ± 0.056	2.014PheGlu: 2.014 ± 0.039	1.302PhePhe: 1.302 ± 0.033	3.763PheGly: 3.763 ± 0.057	0.692PheHis: 0.692 ± 0.027	1.572PheIle: 1.572 ± 0.04	0.899PheLys: 0.899 ± 0.028	3.103PheLeu: 3.103 ± 0.056	0.705PheMet: 0.705 ± 0.024	1.051PheAsn: 1.051 ± 0.032	1.51PhePro: 1.51 ± 0.035	0.929PheGln: 0.929 ± 0.026	2.205PheArg: 2.205 ± 0.048	2.066PheSer: 2.066 ± 0.042	1.913PheThr: 1.913 ± 0.035	2.638PheVal: 2.638 ± 0.047	0.551PheTrp: 0.551 ± 0.022	0.887PheTyr: 0.887 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	9.873GlyAla: 9.873 ± 0.098	0.803GlyCys: 0.803 ± 0.027	5.341GlyAsp: 5.341 ± 0.066	4.812GlyGlu: 4.812 ± 0.063	3.639GlyPhe: 3.639 ± 0.063	8.136GlyGly: 8.136 ± 0.125	1.844GlyHis: 1.844 ± 0.045	4.558GlyIle: 4.558 ± 0.068	3.367GlyLys: 3.367 ± 0.061	8.426GlyLeu: 8.426 ± 0.094	2.246GlyMet: 2.246 ± 0.041	2.4GlyAsn: 2.4 ± 0.056	3.431GlyPro: 3.431 ± 0.058	2.991GlyGln: 2.991 ± 0.056	6.181GlyArg: 6.181 ± 0.085	4.956GlySer: 4.956 ± 0.07	4.771GlyThr: 4.771 ± 0.098	6.104GlyVal: 6.104 ± 0.078	1.65GlyTrp: 1.65 ± 0.045	2.251GlyTyr: 2.251 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.352HisAla: 2.352 ± 0.048	0.229HisCys: 0.229 ± 0.014	1.264HisAsp: 1.264 ± 0.031	0.912HisGlu: 0.912 ± 0.029	0.876HisPhe: 0.876 ± 0.031	1.984HisGly: 1.984 ± 0.046	0.565HisHis: 0.565 ± 0.028	1.022HisIle: 1.022 ± 0.031	0.484HisLys: 0.484 ± 0.019	1.847HisLeu: 1.847 ± 0.039	0.458HisMet: 0.458 ± 0.017	0.481HisAsn: 0.481 ± 0.022	1.246HisPro: 1.246 ± 0.033	0.578HisGln: 0.578 ± 0.021	1.523HisArg: 1.523 ± 0.037	1.026HisSer: 1.026 ± 0.028	0.65HisThr: 0.65 ± 0.024	1.424HisVal: 1.424 ± 0.039	0.403HisTrp: 0.403 ± 0.019	0.545HisTyr: 0.545 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	8.127IleAla: 8.127 ± 0.09	0.447IleCys: 0.447 ± 0.019	4.308IleAsp: 4.308 ± 0.065	3.517IleGlu: 3.517 ± 0.053	1.827IlePhe: 1.827 ± 0.038	5.147IleGly: 5.147 ± 0.067	0.91IleHis: 0.91 ± 0.028	2.362IleIle: 2.362 ± 0.051	1.371IleLys: 1.371 ± 0.035	4.274IleLeu: 4.274 ± 0.063	0.919IleMet: 0.919 ± 0.025	1.386IleAsn: 1.386 ± 0.037	2.334IlePro: 2.334 ± 0.045	1.121IleGln: 1.121 ± 0.029	3.204IleArg: 3.204 ± 0.051	2.7IleSer: 2.7 ± 0.056	2.538IleThr: 2.538 ± 0.053	4.158IleVal: 4.158 ± 0.064	0.677IleTrp: 0.677 ± 0.026	1.026IleTyr: 1.026 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.216LysAla: 4.216 ± 0.063	0.173LysCys: 0.173 ± 0.014	1.747LysAsp: 1.747 ± 0.042	1.342LysGlu: 1.342 ± 0.038	0.933LysPhe: 0.933 ± 0.029	2.642LysGly: 2.642 ± 0.04	0.614LysHis: 0.614 ± 0.021	1.609LysIle: 1.609 ± 0.039	1.161LysLys: 1.161 ± 0.04	3.355LysLeu: 3.355 ± 0.058	0.816LysMet: 0.816 ± 0.027	0.763LysAsn: 0.763 ± 0.026	1.976LysPro: 1.976 ± 0.041	0.971LysGln: 0.971 ± 0.027	2.268LysArg: 2.268 ± 0.046	1.761LysSer: 1.761 ± 0.038	1.728LysThr: 1.728 ± 0.036	2.227LysVal: 2.227 ± 0.049	0.432LysTrp: 0.432 ± 0.021	0.647LysTyr: 0.647 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	14.323LeuAla: 14.323 ± 0.138	0.771LeuCys: 0.771 ± 0.025	5.945LeuAsp: 5.945 ± 0.069	4.404LeuGlu: 4.404 ± 0.076	3.717LeuPhe: 3.717 ± 0.064	8.14LeuGly: 8.14 ± 0.088	1.833LeuHis: 1.833 ± 0.048	5.076LeuIle: 5.076 ± 0.072	3.007LeuLys: 3.007 ± 0.063	9.523LeuLeu: 9.523 ± 0.12	2.124LeuMet: 2.124 ± 0.04	2.469LeuAsn: 2.469 ± 0.053	5.383LeuPro: 5.383 ± 0.076	2.405LeuGln: 2.405 ± 0.045	6.645LeuArg: 6.645 ± 0.077	5.836LeuSer: 5.836 ± 0.057	5.745LeuThr: 5.745 ± 0.065	7.09LeuVal: 7.09 ± 0.077	1.318LeuTrp: 1.318 ± 0.038	2.008LeuTyr: 2.008 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	3.285MetAla: 3.285 ± 0.052	0.145MetCys: 0.145 ± 0.01	1.116MetAsp: 1.116 ± 0.034	1.068MetGlu: 1.068 ± 0.031	0.76MetPhe: 0.76 ± 0.027	1.883MetGly: 1.883 ± 0.035	0.417MetHis: 0.417 ± 0.018	1.406MetIle: 1.406 ± 0.036	0.928MetLys: 0.928 ± 0.028	2.686MetLeu: 2.686 ± 0.056	0.677MetMet: 0.677 ± 0.028	0.664MetAsn: 0.664 ± 0.021	1.443MetPro: 1.443 ± 0.033	0.731MetGln: 0.731 ± 0.023	1.855MetArg: 1.855 ± 0.037	1.422MetSer: 1.422 ± 0.033	1.943MetThr: 1.943 ± 0.036	1.597MetVal: 1.597 ± 0.038	0.241MetTrp: 0.241 ± 0.014	0.252MetTyr: 0.252 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.242AsnAla: 3.242 ± 0.067	0.257AsnCys: 0.257 ± 0.014	1.531AsnAsp: 1.531 ± 0.038	1.189AsnGlu: 1.189 ± 0.031	1.051AsnPhe: 1.051 ± 0.03	2.424AsnGly: 2.424 ± 0.055	0.499AsnHis: 0.499 ± 0.018	1.481AsnIle: 1.481 ± 0.04	0.697AsnLys: 0.697 ± 0.026	2.517AsnLeu: 2.517 ± 0.05	0.588AsnMet: 0.588 ± 0.023	0.727AsnAsn: 0.727 ± 0.029	1.784AsnPro: 1.784 ± 0.042	0.764AsnGln: 0.764 ± 0.021	1.944AsnArg: 1.944 ± 0.042	1.372AsnSer: 1.372 ± 0.039	1.067AsnThr: 1.067 ± 0.031	1.801AsnVal: 1.801 ± 0.045	0.461AsnTrp: 0.461 ± 0.021	0.72AsnTyr: 0.72 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	6.894ProAla: 6.894 ± 0.095	0.331ProCys: 0.331 ± 0.02	3.783ProAsp: 3.783 ± 0.055	3.198ProGlu: 3.198 ± 0.054	1.905ProPhe: 1.905 ± 0.039	4.604ProGly: 4.604 ± 0.069	1.026ProHis: 1.026 ± 0.028	2.459ProIle: 2.459 ± 0.041	1.593ProLys: 1.593 ± 0.04	4.849ProLeu: 4.849 ± 0.069	1.197ProMet: 1.197 ± 0.031	1.278ProAsn: 1.278 ± 0.033	2.767ProPro: 2.767 ± 0.068	1.625ProGln: 1.625 ± 0.036	3.071ProArg: 3.071 ± 0.065	2.633ProSer: 2.633 ± 0.051	2.773ProThr: 2.773 ± 0.053	4.21ProVal: 4.21 ± 0.066	0.668ProTrp: 0.668 ± 0.027	1.045ProTyr: 1.045 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.961GlnAla: 3.961 ± 0.064	0.227GlnCys: 0.227 ± 0.014	1.427GlnAsp: 1.427 ± 0.037	1.199GlnGlu: 1.199 ± 0.032	1.123GlnPhe: 1.123 ± 0.032	2.344GlnGly: 2.344 ± 0.041	0.593GlnHis: 0.593 ± 0.022	1.78GlnIle: 1.78 ± 0.037	0.952GlnLys: 0.952 ± 0.026	3.31GlnLeu: 3.31 ± 0.057	0.822GlnMet: 0.822 ± 0.027	0.791GlnAsn: 0.791 ± 0.026	1.765GlnPro: 1.765 ± 0.036	1.3GlnGln: 1.3 ± 0.04	2.579GlnArg: 2.579 ± 0.048	1.775GlnSer: 1.775 ± 0.046	1.574GlnThr: 1.574 ± 0.042	2.116GlnVal: 2.116 ± 0.04	0.469GlnTrp: 0.469 ± 0.017	0.646GlnTyr: 0.646 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	8.606ArgAla: 8.606 ± 0.107	0.535ArgCys: 0.535 ± 0.022	4.451ArgAsp: 4.451 ± 0.063	4.039ArgGlu: 4.039 ± 0.061	2.95ArgPhe: 2.95 ± 0.048	5.197ArgGly: 5.197 ± 0.067	1.709ArgHis: 1.709 ± 0.04	4.235ArgIle: 4.235 ± 0.063	2.182ArgLys: 2.182 ± 0.043	7.793ArgLeu: 7.793 ± 0.094	1.883ArgMet: 1.883 ± 0.039	1.819ArgAsn: 1.819 ± 0.044	3.589ArgPro: 3.589 ± 0.062	2.553ArgGln: 2.553 ± 0.044	5.564ArgArg: 5.564 ± 0.084	3.773ArgSer: 3.773 ± 0.063	3.471ArgThr: 3.471 ± 0.048	4.648ArgVal: 4.648 ± 0.058	1.238ArgTrp: 1.238 ± 0.034	1.818ArgTyr: 1.818 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	6.503SerAla: 6.503 ± 0.078	0.435SerCys: 0.435 ± 0.021	3.423SerAsp: 3.423 ± 0.05	2.725SerGlu: 2.725 ± 0.046	2.234SerPhe: 2.234 ± 0.045	5.459SerGly: 5.459 ± 0.081	1.005SerHis: 1.005 ± 0.03	2.713SerIle: 2.713 ± 0.05	1.483SerLys: 1.483 ± 0.043	5.265SerLeu: 5.265 ± 0.073	1.228SerMet: 1.228 ± 0.032	1.441SerAsn: 1.441 ± 0.038	2.79SerPro: 2.79 ± 0.05	1.573SerGln: 1.573 ± 0.035	3.524SerArg: 3.524 ± 0.053	2.818SerSer: 2.818 ± 0.058	2.49SerThr: 2.49 ± 0.046	3.777SerVal: 3.777 ± 0.066	0.828SerTrp: 0.828 ± 0.028	1.336SerTyr: 1.336 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	6.686ThrAla: 6.686 ± 0.083	0.376ThrCys: 0.376 ± 0.018	3.129ThrAsp: 3.129 ± 0.049	2.348ThrGlu: 2.348 ± 0.049	1.69ThrPhe: 1.69 ± 0.039	5.288ThrGly: 5.288 ± 0.082	1.006ThrHis: 1.006 ± 0.031	3.05ThrIle: 3.05 ± 0.057	1.435ThrLys: 1.435 ± 0.035	5.671ThrLeu: 5.671 ± 0.078	1.264ThrMet: 1.264 ± 0.031	1.357ThrAsn: 1.357 ± 0.038	3.368ThrPro: 3.368 ± 0.059	1.442ThrGln: 1.442 ± 0.037	3.406ThrArg: 3.406 ± 0.05	2.793ThrSer: 2.793 ± 0.05	2.745ThrThr: 2.745 ± 0.064	3.879ThrVal: 3.879 ± 0.066	0.612ThrTrp: 0.612 ± 0.021	1.067ThrTyr: 1.067 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	9.759ValAla: 9.759 ± 0.097	0.519ValCys: 0.519 ± 0.02	4.422ValAsp: 4.422 ± 0.066	4.325ValGlu: 4.325 ± 0.06	2.088ValPhe: 2.088 ± 0.044	5.869ValGly: 5.869 ± 0.076	1.354ValHis: 1.354 ± 0.039	3.692ValIle: 3.692 ± 0.063	2.083ValLys: 2.083 ± 0.043	6.008ValLeu: 6.008 ± 0.085	1.658ValMet: 1.658 ± 0.038	1.934ValAsn: 1.934 ± 0.05	3.775ValPro: 3.775 ± 0.053	2.072ValGln: 2.072 ± 0.04	5.055ValArg: 5.055 ± 0.073	3.896ValSer: 3.896 ± 0.052	4.325ValThr: 4.325 ± 0.072	5.038ValVal: 5.038 ± 0.071	0.797ValTrp: 0.797 ± 0.025	1.332ValTyr: 1.332 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.426TrpAla: 1.426 ± 0.042	0.144TrpCys: 0.144 ± 0.009	0.784TrpAsp: 0.784 ± 0.029	0.596TrpGlu: 0.596 ± 0.02	0.584TrpPhe: 0.584 ± 0.023	0.943TrpGly: 0.943 ± 0.029	0.32TrpHis: 0.32 ± 0.017	0.719TrpIle: 0.719 ± 0.024	0.481TrpLys: 0.481 ± 0.024	1.834TrpLeu: 1.834 ± 0.043	0.377TrpMet: 0.377 ± 0.018	0.431TrpAsn: 0.431 ± 0.019	0.733TrpPro: 0.733 ± 0.027	0.66TrpGln: 0.66 ± 0.021	1.38TrpArg: 1.38 ± 0.038	0.927TrpSer: 0.927 ± 0.027	0.879TrpThr: 0.879 ± 0.025	0.877TrpVal: 0.877 ± 0.033	0.248TrpTrp: 0.248 ± 0.014	0.304TrpTyr: 0.304 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.637TyrAla: 2.637 ± 0.05	0.226TyrCys: 0.226 ± 0.013	1.582TyrAsp: 1.582 ± 0.033	1.113TyrGlu: 1.113 ± 0.03	0.858TyrPhe: 0.858 ± 0.027	2.091TyrGly: 2.091 ± 0.049	0.493TyrHis: 0.493 ± 0.019	0.881TyrIle: 0.881 ± 0.023	0.593TyrLys: 0.593 ± 0.023	2.072TyrLeu: 2.072 ± 0.039	0.398TyrMet: 0.398 ± 0.018	0.617TyrAsn: 0.617 ± 0.024	0.996TyrPro: 0.996 ± 0.027	0.73TyrGln: 0.73 ± 0.025	1.942TyrArg: 1.942 ± 0.043	1.247TyrSer: 1.247 ± 0.032	0.976TyrThr: 0.976 ± 0.033	1.525TyrVal: 1.525 ± 0.034	0.37TyrTrp: 0.37 ± 0.018	0.605TyrTyr: 0.605 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3927 proteins (1240143 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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