Amino acid dipepetide frequency for Parabacteroides sp. AF48-14

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.125AlaAla: 6.125 ± 0.101	0.914AlaCys: 0.914 ± 0.032	4.472AlaAsp: 4.472 ± 0.058	4.836AlaGlu: 4.836 ± 0.071	3.3AlaPhe: 3.3 ± 0.057	5.684AlaGly: 5.684 ± 0.08	1.11AlaHis: 1.11 ± 0.027	4.813AlaIle: 4.813 ± 0.07	4.13AlaLys: 4.13 ± 0.061	6.721AlaLeu: 6.721 ± 0.081	1.75AlaMet: 1.75 ± 0.038	3.381AlaAsn: 3.381 ± 0.06	2.404AlaPro: 2.404 ± 0.044	2.415AlaGln: 2.415 ± 0.045	3.021AlaArg: 3.021 ± 0.052	4.387AlaSer: 4.387 ± 0.065	4.051AlaThr: 4.051 ± 0.066	4.844AlaVal: 4.844 ± 0.07	0.841AlaTrp: 0.841 ± 0.027	2.996AlaTyr: 2.996 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.662CysAla: 0.662 ± 0.023	0.206CysCys: 0.206 ± 0.011	0.6CysAsp: 0.6 ± 0.019	0.637CysGlu: 0.637 ± 0.025	0.605CysPhe: 0.605 ± 0.024	0.9CysGly: 0.9 ± 0.03	0.247CysHis: 0.247 ± 0.015	0.788CysIle: 0.788 ± 0.024	0.668CysLys: 0.668 ± 0.026	1.121CysLeu: 1.121 ± 0.031	0.311CysMet: 0.311 ± 0.018	0.517CysAsn: 0.517 ± 0.021	0.514CysPro: 0.514 ± 0.023	0.32CysGln: 0.32 ± 0.015	0.612CysArg: 0.612 ± 0.025	0.737CysSer: 0.737 ± 0.027	0.636CysThr: 0.636 ± 0.022	0.713CysVal: 0.713 ± 0.027	0.158CysTrp: 0.158 ± 0.011	0.545CysTyr: 0.545 ± 0.025	0.0CysXaa: 0.0 ± 0.0
Asp	4.19AspAla: 4.19 ± 0.067	0.616AspCys: 0.616 ± 0.023	2.74AspAsp: 2.74 ± 0.051	3.812AspGlu: 3.812 ± 0.053	2.936AspPhe: 2.936 ± 0.043	4.495AspGly: 4.495 ± 0.068	0.83AspHis: 0.83 ± 0.028	4.189AspIle: 4.189 ± 0.061	4.107AspLys: 4.107 ± 0.058	4.907AspLeu: 4.907 ± 0.049	1.613AspMet: 1.613 ± 0.036	2.897AspAsn: 2.897 ± 0.057	2.087AspPro: 2.087 ± 0.038	1.443AspGln: 1.443 ± 0.034	2.677AspArg: 2.677 ± 0.048	3.135AspSer: 3.135 ± 0.06	2.768AspThr: 2.768 ± 0.057	3.572AspVal: 3.572 ± 0.052	0.877AspTrp: 0.877 ± 0.029	2.879AspTyr: 2.879 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	5.132GluAla: 5.132 ± 0.068	0.615GluCys: 0.615 ± 0.022	3.271GluAsp: 3.271 ± 0.056	5.001GluGlu: 5.001 ± 0.075	2.243GluPhe: 2.243 ± 0.043	4.231GluGly: 4.231 ± 0.059	1.138GluHis: 1.138 ± 0.032	4.663GluIle: 4.663 ± 0.07	5.247GluLys: 5.247 ± 0.073	6.091GluLeu: 6.091 ± 0.075	2.038GluMet: 2.038 ± 0.037	3.512GluAsn: 3.512 ± 0.057	1.899GluPro: 1.899 ± 0.042	2.652GluGln: 2.652 ± 0.052	3.175GluArg: 3.175 ± 0.06	3.19GluSer: 3.19 ± 0.049	3.582GluThr: 3.582 ± 0.055	4.249GluVal: 4.249 ± 0.058	0.812GluTrp: 0.812 ± 0.026	2.698GluTyr: 2.698 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	3.056PheAla: 3.056 ± 0.048	0.618PheCys: 0.618 ± 0.022	2.848PheAsp: 2.848 ± 0.046	2.482PheGlu: 2.482 ± 0.05	2.3PhePhe: 2.3 ± 0.047	3.201PheGly: 3.201 ± 0.053	0.807PheHis: 0.807 ± 0.028	3.158PheIle: 3.158 ± 0.056	2.453PheLys: 2.453 ± 0.045	4.103PheLeu: 4.103 ± 0.071	1.233PheMet: 1.233 ± 0.034	2.359PheAsn: 2.359 ± 0.043	1.779PhePro: 1.779 ± 0.04	1.279PheGln: 1.279 ± 0.029	2.33PheArg: 2.33 ± 0.044	3.454PheSer: 3.454 ± 0.061	2.926PheThr: 2.926 ± 0.054	2.874PheVal: 2.874 ± 0.05	0.57PheTrp: 0.57 ± 0.021	2.064PheTyr: 2.064 ± 0.043	0.0PheXaa: 0.0 ± 0.0
Gly	4.425GlyAla: 4.425 ± 0.069	0.916GlyCys: 0.916 ± 0.029	3.799GlyAsp: 3.799 ± 0.057	4.297GlyGlu: 4.297 ± 0.063	3.153GlyPhe: 3.153 ± 0.049	4.833GlyGly: 4.833 ± 0.086	1.211GlyHis: 1.211 ± 0.029	5.064GlyIle: 5.064 ± 0.072	5.569GlyLys: 5.569 ± 0.07	5.889GlyLeu: 5.889 ± 0.078	2.037GlyMet: 2.037 ± 0.048	3.655GlyAsn: 3.655 ± 0.065	1.337GlyPro: 1.337 ± 0.036	2.196GlyGln: 2.196 ± 0.039	2.946GlyArg: 2.946 ± 0.056	4.132GlySer: 4.132 ± 0.065	4.323GlyThr: 4.323 ± 0.068	4.733GlyVal: 4.733 ± 0.074	1.074GlyTrp: 1.074 ± 0.031	3.421GlyTyr: 3.421 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	1.102HisAla: 1.102 ± 0.028	0.229HisCys: 0.229 ± 0.011	0.845HisAsp: 0.845 ± 0.024	0.942HisGlu: 0.942 ± 0.026	0.973HisPhe: 0.973 ± 0.027	1.047HisGly: 1.047 ± 0.024	0.406HisHis: 0.406 ± 0.021	1.393HisIle: 1.393 ± 0.035	0.939HisLys: 0.939 ± 0.029	1.725HisLeu: 1.725 ± 0.038	0.336HisMet: 0.336 ± 0.017	0.88HisAsn: 0.88 ± 0.027	1.005HisPro: 1.005 ± 0.028	0.551HisGln: 0.551 ± 0.019	0.78HisArg: 0.78 ± 0.028	1.044HisSer: 1.044 ± 0.03	0.962HisThr: 0.962 ± 0.031	1.021HisVal: 1.021 ± 0.025	0.252HisTrp: 0.252 ± 0.012	0.875HisTyr: 0.875 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.235IleAla: 5.235 ± 0.06	0.918IleCys: 0.918 ± 0.027	4.062IleAsp: 4.062 ± 0.059	4.443IleGlu: 4.443 ± 0.063	2.637IlePhe: 2.637 ± 0.052	4.638IleGly: 4.638 ± 0.072	1.249IleHis: 1.249 ± 0.031	4.239IleIle: 4.239 ± 0.078	4.065IleLys: 4.065 ± 0.063	5.932IleLeu: 5.932 ± 0.085	1.463IleMet: 1.463 ± 0.031	3.394IleAsn: 3.394 ± 0.056	3.169IlePro: 3.169 ± 0.05	2.265IleGln: 2.265 ± 0.046	3.602IleArg: 3.602 ± 0.059	4.685IleSer: 4.685 ± 0.074	4.108IleThr: 4.108 ± 0.069	4.279IleVal: 4.279 ± 0.068	0.767IleTrp: 0.767 ± 0.029	2.765IleTyr: 2.765 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	5.023LysAla: 5.023 ± 0.079	0.506LysCys: 0.506 ± 0.022	4.24LysAsp: 4.24 ± 0.062	5.775LysGlu: 5.775 ± 0.064	2.1LysPhe: 2.1 ± 0.043	4.631LysGly: 4.631 ± 0.066	1.125LysHis: 1.125 ± 0.024	4.209LysIle: 4.209 ± 0.077	4.94LysLys: 4.94 ± 0.068	5.256LysLeu: 5.256 ± 0.071	1.971LysMet: 1.971 ± 0.043	3.35LysAsn: 3.35 ± 0.053	2.257LysPro: 2.257 ± 0.04	2.669LysGln: 2.669 ± 0.051	3.054LysArg: 3.054 ± 0.056	3.471LysSer: 3.471 ± 0.057	3.669LysThr: 3.669 ± 0.054	4.259LysVal: 4.259 ± 0.069	0.75LysTrp: 0.75 ± 0.024	2.912LysTyr: 2.912 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	6.41LeuAla: 6.41 ± 0.079	1.21LeuCys: 1.21 ± 0.029	4.916LeuAsp: 4.916 ± 0.064	5.035LeuGlu: 5.035 ± 0.071	4.803LeuPhe: 4.803 ± 0.076	5.39LeuGly: 5.39 ± 0.081	1.628LeuHis: 1.628 ± 0.039	5.656LeuIle: 5.656 ± 0.075	6.339LeuLys: 6.339 ± 0.066	9.443LeuLeu: 9.443 ± 0.128	2.396LeuMet: 2.396 ± 0.042	4.647LeuAsn: 4.647 ± 0.063	3.986LeuPro: 3.986 ± 0.06	3.414LeuGln: 3.414 ± 0.065	4.215LeuArg: 4.215 ± 0.066	6.833LeuSer: 6.833 ± 0.075	5.315LeuThr: 5.315 ± 0.063	5.285LeuVal: 5.285 ± 0.068	0.966LeuTrp: 0.966 ± 0.031	3.845LeuTyr: 3.845 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	1.98MetAla: 1.98 ± 0.039	0.221MetCys: 0.221 ± 0.014	1.531MetAsp: 1.531 ± 0.037	1.865MetGlu: 1.865 ± 0.039	1.003MetPhe: 1.003 ± 0.029	1.722MetGly: 1.722 ± 0.035	0.42MetHis: 0.42 ± 0.016	1.626MetIle: 1.626 ± 0.037	2.359MetLys: 2.359 ± 0.039	2.434MetLeu: 2.434 ± 0.045	0.716MetMet: 0.716 ± 0.028	1.509MetAsn: 1.509 ± 0.032	1.119MetPro: 1.119 ± 0.03	1.11MetGln: 1.11 ± 0.029	1.203MetArg: 1.203 ± 0.031	1.47MetSer: 1.47 ± 0.034	1.408MetThr: 1.408 ± 0.03	1.484MetVal: 1.484 ± 0.036	0.221MetTrp: 0.221 ± 0.012	0.879MetTyr: 0.879 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.466AsnAla: 3.466 ± 0.065	0.514AsnCys: 0.514 ± 0.021	2.605AsnAsp: 2.605 ± 0.045	3.046AsnGlu: 3.046 ± 0.048	2.164AsnPhe: 2.164 ± 0.044	3.94AsnGly: 3.94 ± 0.062	0.866AsnHis: 0.866 ± 0.026	3.711AsnIle: 3.711 ± 0.056	3.225AsnLys: 3.225 ± 0.05	4.305AsnLeu: 4.305 ± 0.059	1.346AsnMet: 1.346 ± 0.032	2.756AsnAsn: 2.756 ± 0.05	2.598AsnPro: 2.598 ± 0.043	1.597AsnGln: 1.597 ± 0.034	2.587AsnArg: 2.587 ± 0.046	2.836AsnSer: 2.836 ± 0.047	2.86AsnThr: 2.86 ± 0.051	3.163AsnVal: 3.163 ± 0.053	0.704AsnTrp: 0.704 ± 0.024	2.346AsnTyr: 2.346 ± 0.047	0.0AsnXaa: 0.0 ± 0.0
Pro	3.139ProAla: 3.139 ± 0.057	0.361ProCys: 0.361 ± 0.017	2.832ProAsp: 2.832 ± 0.053	3.588ProGlu: 3.588 ± 0.048	1.936ProPhe: 1.936 ± 0.043	2.632ProGly: 2.632 ± 0.047	0.642ProHis: 0.642 ± 0.024	2.18ProIle: 2.18 ± 0.043	1.902ProLys: 1.902 ± 0.039	3.268ProLeu: 3.268 ± 0.045	0.88ProMet: 0.88 ± 0.024	1.642ProAsn: 1.642 ± 0.035	0.835ProPro: 0.835 ± 0.03	1.241ProGln: 1.241 ± 0.03	1.258ProArg: 1.258 ± 0.035	2.272ProSer: 2.272 ± 0.041	1.87ProThr: 1.87 ± 0.04	3.364ProVal: 3.364 ± 0.05	0.461ProTrp: 0.461 ± 0.019	1.743ProTyr: 1.743 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	2.584GlnAla: 2.584 ± 0.042	0.266GlnCys: 0.266 ± 0.013	1.662GlnAsp: 1.662 ± 0.038	2.3GlnGlu: 2.3 ± 0.042	1.352GlnPhe: 1.352 ± 0.03	1.983GlnGly: 1.983 ± 0.045	0.552GlnHis: 0.552 ± 0.019	2.348GlnIle: 2.348 ± 0.048	2.384GlnLys: 2.384 ± 0.05	3.297GlnLeu: 3.297 ± 0.055	0.989GlnMet: 0.989 ± 0.025	1.727GlnAsn: 1.727 ± 0.033	1.302GlnPro: 1.302 ± 0.034	1.565GlnGln: 1.565 ± 0.041	1.472GlnArg: 1.472 ± 0.033	1.968GlnSer: 1.968 ± 0.042	2.058GlnThr: 2.058 ± 0.036	2.242GlnVal: 2.242 ± 0.043	0.43GlnTrp: 0.43 ± 0.016	1.536GlnTyr: 1.536 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	2.726ArgAla: 2.726 ± 0.057	0.468ArgCys: 0.468 ± 0.022	2.176ArgAsp: 2.176 ± 0.044	3.171ArgGlu: 3.171 ± 0.062	2.409ArgPhe: 2.409 ± 0.039	2.349ArgGly: 2.349 ± 0.047	0.905ArgHis: 0.905 ± 0.026	3.678ArgIle: 3.678 ± 0.061	3.441ArgLys: 3.441 ± 0.066	4.55ArgLeu: 4.55 ± 0.067	1.508ArgMet: 1.508 ± 0.033	2.474ArgAsn: 2.474 ± 0.046	1.693ArgPro: 1.693 ± 0.04	1.833ArgGln: 1.833 ± 0.036	2.371ArgArg: 2.371 ± 0.055	2.427ArgSer: 2.427 ± 0.044	2.484ArgThr: 2.484 ± 0.043	2.678ArgVal: 2.678 ± 0.039	0.613ArgTrp: 0.613 ± 0.019	2.278ArgTyr: 2.278 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	4.306SerAla: 4.306 ± 0.057	0.799SerCys: 0.799 ± 0.026	3.603SerAsp: 3.603 ± 0.059	3.475SerGlu: 3.475 ± 0.056	3.469SerPhe: 3.469 ± 0.058	4.78SerGly: 4.78 ± 0.071	1.026SerHis: 1.026 ± 0.031	4.169SerIle: 4.169 ± 0.058	3.331SerLys: 3.331 ± 0.053	6.144SerLeu: 6.144 ± 0.076	1.404SerMet: 1.404 ± 0.033	2.7SerAsn: 2.7 ± 0.051	2.424SerPro: 2.424 ± 0.038	1.782SerGln: 1.782 ± 0.033	2.82SerArg: 2.82 ± 0.046	3.856SerSer: 3.856 ± 0.076	3.228SerThr: 3.228 ± 0.06	4.397SerVal: 4.397 ± 0.061	0.821SerTrp: 0.821 ± 0.031	2.86SerTyr: 2.86 ± 0.06	0.0SerXaa: 0.0 ± 0.0
Thr	4.29ThrAla: 4.29 ± 0.073	0.536ThrCys: 0.536 ± 0.022	3.645ThrAsp: 3.645 ± 0.056	3.4ThrGlu: 3.4 ± 0.052	2.856ThrPhe: 2.856 ± 0.057	4.705ThrGly: 4.705 ± 0.068	0.987ThrHis: 0.987 ± 0.031	4.014ThrIle: 4.014 ± 0.062	2.921ThrLys: 2.921 ± 0.052	5.413ThrLeu: 5.413 ± 0.073	1.11ThrMet: 1.11 ± 0.031	2.611ThrAsn: 2.611 ± 0.053	2.748ThrPro: 2.748 ± 0.054	1.668ThrGln: 1.668 ± 0.033	2.172ThrArg: 2.172 ± 0.044	3.321ThrSer: 3.321 ± 0.057	3.212ThrThr: 3.212 ± 0.063	4.32ThrVal: 4.32 ± 0.069	0.663ThrTrp: 0.663 ± 0.025	2.443ThrTyr: 2.443 ± 0.046	0.0ThrXaa: 0.0 ± 0.0
Val	4.691ValAla: 4.691 ± 0.077	0.917ValCys: 0.917 ± 0.029	3.614ValAsp: 3.614 ± 0.058	4.065ValGlu: 4.065 ± 0.059	2.947ValPhe: 2.947 ± 0.049	3.928ValGly: 3.928 ± 0.054	1.022ValHis: 1.022 ± 0.029	4.431ValIle: 4.431 ± 0.072	4.401ValLys: 4.401 ± 0.061	5.827ValLeu: 5.827 ± 0.072	1.63ValMet: 1.63 ± 0.036	3.344ValAsn: 3.344 ± 0.055	2.603ValPro: 2.603 ± 0.054	1.982ValGln: 1.982 ± 0.041	3.09ValArg: 3.09 ± 0.054	4.68ValSer: 4.68 ± 0.059	4.078ValThr: 4.078 ± 0.072	4.574ValVal: 4.574 ± 0.076	0.762ValTrp: 0.762 ± 0.027	2.709ValTyr: 2.709 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.698TrpAla: 0.698 ± 0.025	0.149TrpCys: 0.149 ± 0.01	0.734TrpAsp: 0.734 ± 0.029	0.79TrpGlu: 0.79 ± 0.024	0.567TrpPhe: 0.567 ± 0.023	0.912TrpGly: 0.912 ± 0.031	0.272TrpHis: 0.272 ± 0.015	0.793TrpIle: 0.793 ± 0.029	0.953TrpLys: 0.953 ± 0.031	1.183TrpLeu: 1.183 ± 0.031	0.427TrpMet: 0.427 ± 0.018	0.811TrpAsn: 0.811 ± 0.026	0.312TrpPro: 0.312 ± 0.016	0.514TrpGln: 0.514 ± 0.022	0.547TrpArg: 0.547 ± 0.021	0.696TrpSer: 0.696 ± 0.024	0.713TrpThr: 0.713 ± 0.026	0.734TrpVal: 0.734 ± 0.029	0.199TrpTrp: 0.199 ± 0.012	0.558TrpTyr: 0.558 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.953TyrAla: 2.953 ± 0.054	0.515TyrCys: 0.515 ± 0.019	2.577TyrAsp: 2.577 ± 0.054	2.481TyrGlu: 2.481 ± 0.048	2.14TyrPhe: 2.14 ± 0.041	3.012TyrGly: 3.012 ± 0.058	0.864TyrHis: 0.864 ± 0.029	2.795TyrIle: 2.795 ± 0.047	2.791TyrLys: 2.791 ± 0.052	4.123TyrLeu: 4.123 ± 0.061	1.124TyrMet: 1.124 ± 0.03	2.468TyrAsn: 2.468 ± 0.047	1.974TyrPro: 1.974 ± 0.044	1.523TyrGln: 1.523 ± 0.035	2.298TyrArg: 2.298 ± 0.044	2.798TyrSer: 2.798 ± 0.052	2.782TyrThr: 2.782 ± 0.044	2.512TyrVal: 2.512 ± 0.043	0.621TyrTrp: 0.621 ± 0.021	2.222TyrTyr: 2.222 ± 0.053	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3786 proteins (1319893 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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