Amino acid dipepetide frequency for Microviridae Fen7940_21

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.111AlaAla: 11.111 ± 4.528
0.741AlaCys: 0.741 ± 0.704
6.667AlaAsp: 6.667 ± 2.528
3.704AlaGlu: 3.704 ± 2.437
2.963AlaPhe: 2.963 ± 1.339
6.667AlaGly: 6.667 ± 1.793
1.481AlaHis: 1.481 ± 0.726
1.481AlaIle: 1.481 ± 0.966
2.222AlaLys: 2.222 ± 0.783
10.37AlaLeu: 10.37 ± 2.143
2.963AlaMet: 2.963 ± 0.822
7.407AlaAsn: 7.407 ± 2.033
7.407AlaPro: 7.407 ± 2.769
2.963AlaGln: 2.963 ± 0.768
11.111AlaArg: 11.111 ± 2.898
11.111AlaSer: 11.111 ± 2.364
5.185AlaThr: 5.185 ± 1.039
6.667AlaVal: 6.667 ± 1.964
2.963AlaTrp: 2.963 ± 1.215
2.222AlaTyr: 2.222 ± 0.783
0.0AlaXaa: 0.0 ± 0.0
Cys
0.741CysAla: 0.741 ± 0.476
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.741CysGly: 0.741 ± 0.704
0.741CysHis: 0.741 ± 0.704
0.741CysIle: 0.741 ± 0.75
0.741CysLys: 0.741 ± 0.476
1.481CysLeu: 1.481 ± 0.966
0.741CysMet: 0.741 ± 0.697
0.0CysAsn: 0.0 ± 0.0
0.741CysPro: 0.741 ± 0.704
0.741CysGln: 0.741 ± 0.704
1.481CysArg: 1.481 ± 0.966
0.0CysSer: 0.0 ± 0.0
0.0CysThr: 0.0 ± 0.0
1.481CysVal: 1.481 ± 0.726
0.0CysTrp: 0.0 ± 0.0
0.741CysTyr: 0.741 ± 0.704
0.0CysXaa: 0.0 ± 0.0
Asp
5.185AspAla: 5.185 ± 0.964
0.0AspCys: 0.0 ± 0.0
2.963AspAsp: 2.963 ± 0.821
4.444AspGlu: 4.444 ± 1.834
1.481AspPhe: 1.481 ± 1.646
3.704AspGly: 3.704 ± 1.52
0.741AspHis: 0.741 ± 0.476
2.222AspIle: 2.222 ± 1.307
2.222AspLys: 2.222 ± 1.472
2.222AspLeu: 2.222 ± 0.832
0.0AspMet: 0.0 ± 0.0
2.222AspAsn: 2.222 ± 1.307
6.667AspPro: 6.667 ± 4.723
2.222AspGln: 2.222 ± 1.349
2.222AspArg: 2.222 ± 1.428
1.481AspSer: 1.481 ± 0.952
5.185AspThr: 5.185 ± 1.738
3.704AspVal: 3.704 ± 1.455
0.0AspTrp: 0.0 ± 0.0
1.481AspTyr: 1.481 ± 0.952
0.0AspXaa: 0.0 ± 0.0
Glu
7.407GluAla: 7.407 ± 2.801
0.741GluCys: 0.741 ± 0.704
2.963GluAsp: 2.963 ± 1.603
1.481GluGlu: 1.481 ± 0.726
2.963GluPhe: 2.963 ± 0.89
1.481GluGly: 1.481 ± 0.726
0.741GluHis: 0.741 ± 0.476
0.741GluIle: 0.741 ± 0.823
1.481GluLys: 1.481 ± 0.726
4.444GluLeu: 4.444 ± 2.04
0.741GluMet: 0.741 ± 0.823
2.963GluAsn: 2.963 ± 0.821
1.481GluPro: 1.481 ± 0.934
2.222GluGln: 2.222 ± 1.349
2.222GluArg: 2.222 ± 2.249
1.481GluSer: 1.481 ± 0.631
2.222GluThr: 2.222 ± 0.832
2.222GluVal: 2.222 ± 0.726
0.0GluTrp: 0.0 ± 0.0
2.963GluTyr: 2.963 ± 1.396
0.0GluXaa: 0.0 ± 0.0
Phe
6.667PheAla: 6.667 ± 1.666
0.0PheCys: 0.0 ± 0.0
3.704PheAsp: 3.704 ± 4.114
1.481PheGlu: 1.481 ± 0.952
2.222PhePhe: 2.222 ± 0.726
3.704PheGly: 3.704 ± 1.23
1.481PheHis: 1.481 ± 0.755
0.741PheIle: 0.741 ± 0.476
0.0PheLys: 0.0 ± 0.0
0.0PheLeu: 0.0 ± 0.0
0.741PheMet: 0.741 ± 0.432
2.963PheAsn: 2.963 ± 1.215
0.0PhePro: 0.0 ± 0.0
1.481PheGln: 1.481 ± 0.755
2.222PheArg: 2.222 ± 0.726
5.926PheSer: 5.926 ± 2.793
2.963PheThr: 2.963 ± 1.339
2.222PheVal: 2.222 ± 0.71
0.0PheTrp: 0.0 ± 0.0
0.741PheTyr: 0.741 ± 0.476
0.0PheXaa: 0.0 ± 0.0
Gly
6.667GlyAla: 6.667 ± 2.278
1.481GlyCys: 1.481 ± 1.116
2.222GlyAsp: 2.222 ± 1.005
2.222GlyGlu: 2.222 ± 1.472
1.481GlyPhe: 1.481 ± 0.726
9.63GlyGly: 9.63 ± 2.444
2.222GlyHis: 2.222 ± 0.726
4.444GlyIle: 4.444 ± 1.204
0.741GlyLys: 0.741 ± 0.476
8.148GlyLeu: 8.148 ± 2.54
1.481GlyMet: 1.481 ± 0.631
2.222GlyAsn: 2.222 ± 0.992
2.222GlyPro: 2.222 ± 0.898
5.926GlyGln: 5.926 ± 1.628
3.704GlyArg: 3.704 ± 1.947
7.407GlySer: 7.407 ± 3.938
5.185GlyThr: 5.185 ± 3.333
3.704GlyVal: 3.704 ± 1.253
0.741GlyTrp: 0.741 ± 0.476
2.222GlyTyr: 2.222 ± 1.005
0.0GlyXaa: 0.0 ± 0.0
His
2.222HisAla: 2.222 ± 1.349
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.0HisGlu: 0.0 ± 0.0
0.0HisPhe: 0.0 ± 0.0
2.963HisGly: 2.963 ± 1.452
1.481HisHis: 1.481 ± 0.726
0.741HisIle: 0.741 ± 0.476
0.0HisLys: 0.0 ± 0.0
2.222HisLeu: 2.222 ± 1.016
0.0HisMet: 0.0 ± 0.0
1.481HisAsn: 1.481 ± 0.845
1.481HisPro: 1.481 ± 0.952
0.0HisGln: 0.0 ± 0.0
2.222HisArg: 2.222 ± 1.434
2.222HisSer: 2.222 ± 1.005
0.741HisThr: 0.741 ± 0.823
0.741HisVal: 0.741 ± 0.704
0.741HisTrp: 0.741 ± 0.476
1.481HisTyr: 1.481 ± 0.726
0.0HisXaa: 0.0 ± 0.0
Ile
4.444IleAla: 4.444 ± 1.319
0.0IleCys: 0.0 ± 0.0
1.481IleAsp: 1.481 ± 1.509
0.741IleGlu: 0.741 ± 0.704
3.704IlePhe: 3.704 ± 1.23
3.704IleGly: 3.704 ± 0.493
0.0IleHis: 0.0 ± 0.0
0.741IleIle: 0.741 ± 0.476
1.481IleLys: 1.481 ± 1.116
0.741IleLeu: 0.741 ± 0.823
0.0IleMet: 0.0 ± 0.0
3.704IleAsn: 3.704 ± 1.389
2.222IlePro: 2.222 ± 1.812
3.704IleGln: 3.704 ± 1.821
1.481IleArg: 1.481 ± 0.726
3.704IleSer: 3.704 ± 2.028
2.222IleThr: 2.222 ± 1.428
0.741IleVal: 0.741 ± 0.476
0.741IleTrp: 0.741 ± 0.476
0.741IleTyr: 0.741 ± 0.75
0.0IleXaa: 0.0 ± 0.0
Lys
1.481LysAla: 1.481 ± 0.845
0.0LysCys: 0.0 ± 0.0
0.741LysAsp: 0.741 ± 0.476
2.222LysGlu: 2.222 ± 1.016
2.963LysPhe: 2.963 ± 1.285
1.481LysGly: 1.481 ± 0.755
0.741LysHis: 0.741 ± 0.75
2.222LysIle: 2.222 ± 1.145
0.741LysLys: 0.741 ± 0.704
1.481LysLeu: 1.481 ± 0.755
2.222LysMet: 2.222 ± 0.726
0.741LysAsn: 0.741 ± 0.476
0.741LysPro: 0.741 ± 0.755
0.0LysGln: 0.0 ± 0.0
4.444LysArg: 4.444 ± 1.641
1.481LysSer: 1.481 ± 1.001
2.222LysThr: 2.222 ± 1.016
1.481LysVal: 1.481 ± 0.845
0.0LysTrp: 0.0 ± 0.0
0.741LysTyr: 0.741 ± 0.75
0.0LysXaa: 0.0 ± 0.0
Leu
5.926LeuAla: 5.926 ± 0.565
0.0LeuCys: 0.0 ± 0.0
3.704LeuAsp: 3.704 ± 0.698
4.444LeuGlu: 4.444 ± 2.185
0.741LeuPhe: 0.741 ± 0.75
9.63LeuGly: 9.63 ± 2.855
0.0LeuHis: 0.0 ± 0.0
2.963LeuIle: 2.963 ± 0.822
2.222LeuLys: 2.222 ± 1.076
4.444LeuLeu: 4.444 ± 1.442
3.704LeuMet: 3.704 ± 1.342
2.963LeuAsn: 2.963 ± 1.014
3.704LeuPro: 3.704 ± 0.698
6.667LeuGln: 6.667 ± 1.632
5.926LeuArg: 5.926 ± 3.073
11.111LeuSer: 11.111 ± 3.451
5.185LeuThr: 5.185 ± 1.094
3.704LeuVal: 3.704 ± 1.063
1.481LeuTrp: 1.481 ± 0.966
1.481LeuTyr: 1.481 ± 0.631
0.0LeuXaa: 0.0 ± 0.0
Met
0.0MetAla: 0.0 ± 0.0
0.741MetCys: 0.741 ± 0.704
0.741MetAsp: 0.741 ± 0.476
0.741MetGlu: 0.741 ± 0.823
0.741MetPhe: 0.741 ± 0.75
3.704MetGly: 3.704 ± 1.092
0.741MetHis: 0.741 ± 0.476
0.741MetIle: 0.741 ± 0.823
0.741MetLys: 0.741 ± 0.476
0.741MetLeu: 0.741 ± 0.704
0.0MetMet: 0.0 ± 0.0
0.741MetAsn: 0.741 ± 0.755
2.222MetPro: 2.222 ± 0.98
1.481MetGln: 1.481 ± 0.631
1.481MetArg: 1.481 ± 0.726
3.704MetSer: 3.704 ± 1.167
2.222MetThr: 2.222 ± 1.005
3.704MetVal: 3.704 ± 0.833
0.0MetTrp: 0.0 ± 0.0
0.741MetTyr: 0.741 ± 0.476
0.0MetXaa: 0.0 ± 0.0
Asn
6.667AsnAla: 6.667 ± 3.368
0.0AsnCys: 0.0 ± 0.0
0.741AsnAsp: 0.741 ± 0.75
0.741AsnGlu: 0.741 ± 0.476
1.481AsnPhe: 1.481 ± 0.631
2.222AsnGly: 2.222 ± 1.02
1.481AsnHis: 1.481 ± 0.726
2.222AsnIle: 2.222 ± 0.71
2.222AsnLys: 2.222 ± 1.434
4.444AsnLeu: 4.444 ± 1.78
0.741AsnMet: 0.741 ± 0.755
0.741AsnAsn: 0.741 ± 0.755
3.704AsnPro: 3.704 ± 2.169
0.0AsnGln: 0.0 ± 0.0
4.444AsnArg: 4.444 ± 1.009
4.444AsnSer: 4.444 ± 2.614
1.481AsnThr: 1.481 ± 0.631
2.963AsnVal: 2.963 ± 1.904
1.481AsnTrp: 1.481 ± 0.952
0.741AsnTyr: 0.741 ± 0.476
0.0AsnXaa: 0.0 ± 0.0
Pro
9.63ProAla: 9.63 ± 2.768
1.481ProCys: 1.481 ± 0.845
5.185ProAsp: 5.185 ± 2.856
2.222ProGlu: 2.222 ± 0.726
0.741ProPhe: 0.741 ± 0.823
2.222ProGly: 2.222 ± 0.71
1.481ProHis: 1.481 ± 0.966
1.481ProIle: 1.481 ± 0.795
1.481ProLys: 1.481 ± 0.755
6.667ProLeu: 6.667 ± 3.194
0.741ProMet: 0.741 ± 0.631
0.741ProAsn: 0.741 ± 0.476
2.222ProPro: 2.222 ± 1.812
0.741ProGln: 0.741 ± 0.704
1.481ProArg: 1.481 ± 0.934
2.963ProSer: 2.963 ± 1.339
5.926ProThr: 5.926 ± 1.638
5.926ProVal: 5.926 ± 2.061
0.741ProTrp: 0.741 ± 0.476
1.481ProTyr: 1.481 ± 1.118
0.0ProXaa: 0.0 ± 0.0
Gln
6.667GlnAla: 6.667 ± 3.041
1.481GlnCys: 1.481 ± 1.409
2.963GlnAsp: 2.963 ± 1.379
0.741GlnGlu: 0.741 ± 0.476
2.222GlnPhe: 2.222 ± 1.428
0.0GlnGly: 0.0 ± 0.0
0.741GlnHis: 0.741 ± 0.476
1.481GlnIle: 1.481 ± 0.952
0.741GlnLys: 0.741 ± 0.476
2.963GlnLeu: 2.963 ± 0.612
0.741GlnMet: 0.741 ± 0.704
1.481GlnAsn: 1.481 ± 0.631
0.741GlnPro: 0.741 ± 0.704
3.704GlnGln: 3.704 ± 1.092
7.407GlnArg: 7.407 ± 1.619
2.222GlnSer: 2.222 ± 1.472
4.444GlnThr: 4.444 ± 0.751
2.222GlnVal: 2.222 ± 1.3
0.0GlnTrp: 0.0 ± 0.0
0.741GlnTyr: 0.741 ± 0.704
0.0GlnXaa: 0.0 ± 0.0
Arg
8.148ArgAla: 8.148 ± 2.521
1.481ArgCys: 1.481 ± 0.726
2.222ArgAsp: 2.222 ± 1.428
5.185ArgGlu: 5.185 ± 1.208
7.407ArgPhe: 7.407 ± 1.774
2.222ArgGly: 2.222 ± 0.832
2.963ArgHis: 2.963 ± 1.215
2.963ArgIle: 2.963 ± 0.904
2.222ArgLys: 2.222 ± 1.076
8.889ArgLeu: 8.889 ± 3.034
4.444ArgMet: 4.444 ± 1.246
2.963ArgAsn: 2.963 ± 0.612
6.667ArgPro: 6.667 ± 1.448
1.481ArgGln: 1.481 ± 1.499
9.63ArgArg: 9.63 ± 4.525
5.926ArgSer: 5.926 ± 1.684
1.481ArgThr: 1.481 ± 1.409
2.222ArgVal: 2.222 ± 1.434
0.741ArgTrp: 0.741 ± 0.476
5.185ArgTyr: 5.185 ± 1.889
0.0ArgXaa: 0.0 ± 0.0
Ser
10.37SerAla: 10.37 ± 3.222
1.481SerCys: 1.481 ± 0.726
5.185SerAsp: 5.185 ± 1.365
2.963SerGlu: 2.963 ± 1.487
2.222SerPhe: 2.222 ± 1.434
6.667SerGly: 6.667 ± 1.476
0.741SerHis: 0.741 ± 0.476
4.444SerIle: 4.444 ± 1.447
2.963SerLys: 2.963 ± 1.511
8.148SerLeu: 8.148 ± 2.353
1.481SerMet: 1.481 ± 0.631
4.444SerAsn: 4.444 ± 1.893
3.704SerPro: 3.704 ± 1.733
2.222SerGln: 2.222 ± 1.307
6.667SerArg: 6.667 ± 2.172
5.926SerSer: 5.926 ± 1.772
6.667SerThr: 6.667 ± 2.304
7.407SerVal: 7.407 ± 2.204
1.481SerTrp: 1.481 ± 0.631
1.481SerTyr: 1.481 ± 0.726
0.0SerXaa: 0.0 ± 0.0
Thr
7.407ThrAla: 7.407 ± 2.566
0.741ThrCys: 0.741 ± 0.476
3.704ThrAsp: 3.704 ± 1.187
1.481ThrGlu: 1.481 ± 0.934
2.963ThrPhe: 2.963 ± 0.904
5.926ThrGly: 5.926 ± 1.814
0.0ThrHis: 0.0 ± 0.0
2.963ThrIle: 2.963 ± 1.396
0.741ThrLys: 0.741 ± 0.476
4.444ThrLeu: 4.444 ± 1.396
1.481ThrMet: 1.481 ± 0.952
2.222ThrAsn: 2.222 ± 0.783
2.963ThrPro: 2.963 ± 0.951
5.185ThrGln: 5.185 ± 3.652
2.222ThrArg: 2.222 ± 0.783
7.407ThrSer: 7.407 ± 3.26
4.444ThrThr: 4.444 ± 2.267
4.444ThrVal: 4.444 ± 1.341
2.222ThrTrp: 2.222 ± 1.349
2.222ThrTyr: 2.222 ± 0.98
0.0ThrXaa: 0.0 ± 0.0
Val
3.704ValAla: 3.704 ± 1.222
0.0ValCys: 0.0 ± 0.0
2.222ValAsp: 2.222 ± 1.02
2.963ValGlu: 2.963 ± 0.821
2.222ValPhe: 2.222 ± 1.547
4.444ValGly: 4.444 ± 1.355
1.481ValHis: 1.481 ± 0.726
1.481ValIle: 1.481 ± 0.755
2.963ValLys: 2.963 ± 1.474
2.222ValLeu: 2.222 ± 1.016
2.963ValMet: 2.963 ± 1.628
2.963ValAsn: 2.963 ± 1.339
5.926ValPro: 5.926 ± 1.478
0.741ValGln: 0.741 ± 0.823
10.37ValArg: 10.37 ± 1.365
6.667ValSer: 6.667 ± 2.172
3.704ValThr: 3.704 ± 1.23
3.704ValVal: 3.704 ± 1.144
0.0ValTrp: 0.0 ± 0.0
0.741ValTyr: 0.741 ± 0.704
0.0ValXaa: 0.0 ± 0.0
Trp
0.741TrpAla: 0.741 ± 0.704
0.741TrpCys: 0.741 ± 0.823
0.741TrpAsp: 0.741 ± 0.704
2.222TrpGlu: 2.222 ± 1.428
0.741TrpPhe: 0.741 ± 0.476
0.741TrpGly: 0.741 ± 0.704
0.741TrpHis: 0.741 ± 0.476
0.741TrpIle: 0.741 ± 0.75
0.0TrpLys: 0.0 ± 0.0
1.481TrpLeu: 1.481 ± 0.934
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.741TrpPro: 0.741 ± 0.476
1.481TrpGln: 1.481 ± 0.952
0.741TrpArg: 0.741 ± 0.476
0.0TrpSer: 0.0 ± 0.0
0.741TrpThr: 0.741 ± 0.476
0.741TrpVal: 0.741 ± 0.704
0.741TrpTrp: 0.741 ± 0.476
0.741TrpTyr: 0.741 ± 0.476
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.222TyrAla: 2.222 ± 1.005
0.0TyrCys: 0.0 ± 0.0
2.222TyrAsp: 2.222 ± 1.307
2.963TyrGlu: 2.963 ± 0.951
0.0TyrPhe: 0.0 ± 0.0
2.222TyrGly: 2.222 ± 0.71
0.741TyrHis: 0.741 ± 0.704
0.741TyrIle: 0.741 ± 0.704
2.222TyrLys: 2.222 ± 1.428
4.444TyrLeu: 4.444 ± 2.011
0.0TyrMet: 0.0 ± 0.0
0.0TyrAsn: 0.0 ± 0.0
0.0TyrPro: 0.0 ± 0.0
0.741TyrGln: 0.741 ± 0.476
2.963TyrArg: 2.963 ± 1.396
1.481TyrSer: 1.481 ± 0.631
2.963TyrThr: 2.963 ± 1.397
2.222TyrVal: 2.222 ± 1.005
0.741TyrTrp: 0.741 ± 0.476
0.0TyrTyr: 0.0 ± 0.0
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1351 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski