Amino acid dipepetide frequency for Paenibacillus pini JCM 16418

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.624AlaAla: 6.624 ± 0.099	0.628AlaCys: 0.628 ± 0.024	3.794AlaAsp: 3.794 ± 0.064	4.951AlaGlu: 4.951 ± 0.074	3.036AlaPhe: 3.036 ± 0.05	5.73AlaGly: 5.73 ± 0.082	1.287AlaHis: 1.287 ± 0.031	5.166AlaIle: 5.166 ± 0.073	4.342AlaLys: 4.342 ± 0.062	7.269AlaLeu: 7.269 ± 0.075	2.217AlaMet: 2.217 ± 0.036	2.705AlaAsn: 2.705 ± 0.047	2.327AlaPro: 2.327 ± 0.05	2.597AlaGln: 2.597 ± 0.051	2.869AlaArg: 2.869 ± 0.047	4.998AlaSer: 4.998 ± 0.068	3.626AlaThr: 3.626 ± 0.072	5.599AlaVal: 5.599 ± 0.077	0.799AlaTrp: 0.799 ± 0.022	2.436AlaTyr: 2.436 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.502CysAla: 0.502 ± 0.021	0.12CysCys: 0.12 ± 0.011	0.412CysAsp: 0.412 ± 0.017	0.437CysGlu: 0.437 ± 0.017	0.314CysPhe: 0.314 ± 0.015	0.765CysGly: 0.765 ± 0.024	0.191CysHis: 0.191 ± 0.011	0.581CysIle: 0.581 ± 0.021	0.363CysLys: 0.363 ± 0.017	0.729CysLeu: 0.729 ± 0.022	0.234CysMet: 0.234 ± 0.013	0.307CysAsn: 0.307 ± 0.017	0.343CysPro: 0.343 ± 0.017	0.254CysGln: 0.254 ± 0.013	0.382CysArg: 0.382 ± 0.018	0.587CysSer: 0.587 ± 0.023	0.416CysThr: 0.416 ± 0.02	0.451CysVal: 0.451 ± 0.021	0.089CysTrp: 0.089 ± 0.008	0.277CysTyr: 0.277 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.644AspAla: 3.644 ± 0.06	0.404AspCys: 0.404 ± 0.018	2.491AspAsp: 2.491 ± 0.048	3.899AspGlu: 3.899 ± 0.06	2.148AspPhe: 2.148 ± 0.038	3.671AspGly: 3.671 ± 0.067	1.252AspHis: 1.252 ± 0.029	4.066AspIle: 4.066 ± 0.066	3.104AspLys: 3.104 ± 0.051	5.059AspLeu: 5.059 ± 0.056	1.561AspMet: 1.561 ± 0.033	1.992AspAsn: 1.992 ± 0.042	2.22AspPro: 2.22 ± 0.037	2.225AspGln: 2.225 ± 0.043	2.376AspArg: 2.376 ± 0.04	2.911AspSer: 2.911 ± 0.049	2.794AspThr: 2.794 ± 0.041	3.721AspVal: 3.721 ± 0.049	0.721AspTrp: 0.721 ± 0.027	2.077AspTyr: 2.077 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	5.269GluAla: 5.269 ± 0.066	0.425GluCys: 0.425 ± 0.019	3.409GluAsp: 3.409 ± 0.055	5.322GluGlu: 5.322 ± 0.08	2.23GluPhe: 2.23 ± 0.047	4.229GluGly: 4.229 ± 0.059	1.68GluHis: 1.68 ± 0.036	4.746GluIle: 4.746 ± 0.065	4.197GluLys: 4.197 ± 0.064	6.997GluLeu: 6.997 ± 0.093	2.218GluMet: 2.218 ± 0.038	2.639GluAsn: 2.639 ± 0.042	2.064GluPro: 2.064 ± 0.04	3.795GluGln: 3.795 ± 0.07	3.504GluArg: 3.504 ± 0.058	3.729GluSer: 3.729 ± 0.051	3.155GluThr: 3.155 ± 0.049	4.63GluVal: 4.63 ± 0.067	0.905GluTrp: 0.905 ± 0.027	2.077GluTyr: 2.077 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	2.956PheAla: 2.956 ± 0.05	0.391PheCys: 0.391 ± 0.017	2.296PheAsp: 2.296 ± 0.042	2.453PheGlu: 2.453 ± 0.05	1.748PhePhe: 1.748 ± 0.042	3.004PheGly: 3.004 ± 0.051	0.881PheHis: 0.881 ± 0.023	3.142PheIle: 3.142 ± 0.059	2.207PheLys: 2.207 ± 0.04	3.701PheLeu: 3.701 ± 0.067	1.249PheMet: 1.249 ± 0.03	1.849PheAsn: 1.849 ± 0.045	1.487PhePro: 1.487 ± 0.035	1.384PheGln: 1.384 ± 0.029	1.712PheArg: 1.712 ± 0.037	2.816PheSer: 2.816 ± 0.047	2.439PheThr: 2.439 ± 0.043	2.886PheVal: 2.886 ± 0.041	0.482PheTrp: 0.482 ± 0.02	1.443PheTyr: 1.443 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	4.893GlyAla: 4.893 ± 0.074	0.653GlyCys: 0.653 ± 0.022	3.454GlyAsp: 3.454 ± 0.059	4.188GlyGlu: 4.188 ± 0.056	3.051GlyPhe: 3.051 ± 0.052	5.118GlyGly: 5.118 ± 0.078	1.428GlyHis: 1.428 ± 0.028	5.831GlyIle: 5.831 ± 0.075	4.603GlyLys: 4.603 ± 0.06	6.658GlyLeu: 6.658 ± 0.077	2.361GlyMet: 2.361 ± 0.045	2.879GlyAsn: 2.879 ± 0.061	1.716GlyPro: 1.716 ± 0.036	2.617GlyGln: 2.617 ± 0.047	3.018GlyArg: 3.018 ± 0.042	4.853GlySer: 4.853 ± 0.076	4.308GlyThr: 4.308 ± 0.078	5.008GlyVal: 5.008 ± 0.068	0.907GlyTrp: 0.907 ± 0.025	2.859GlyTyr: 2.859 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.48HisAla: 1.48 ± 0.036	0.208HisCys: 0.208 ± 0.012	0.989HisAsp: 0.989 ± 0.027	1.432HisGlu: 1.432 ± 0.033	1.004HisPhe: 1.004 ± 0.026	1.524HisGly: 1.524 ± 0.034	0.65HisHis: 0.65 ± 0.025	1.665HisIle: 1.665 ± 0.033	1.017HisLys: 1.017 ± 0.03	2.173HisLeu: 2.173 ± 0.049	0.693HisMet: 0.693 ± 0.024	0.814HisAsn: 0.814 ± 0.027	1.201HisPro: 1.201 ± 0.033	0.858HisGln: 0.858 ± 0.028	0.994HisArg: 0.994 ± 0.03	1.371HisSer: 1.371 ± 0.031	1.14HisThr: 1.14 ± 0.028	1.54HisVal: 1.54 ± 0.038	0.298HisTrp: 0.298 ± 0.016	0.843HisTyr: 0.843 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.66IleAla: 5.66 ± 0.071	0.678IleCys: 0.678 ± 0.025	3.783IleAsp: 3.783 ± 0.045	4.797IleGlu: 4.797 ± 0.07	2.75IlePhe: 2.75 ± 0.049	5.358IleGly: 5.358 ± 0.073	1.801IleHis: 1.801 ± 0.042	5.187IleIle: 5.187 ± 0.078	3.606IleLys: 3.606 ± 0.065	6.606IleLeu: 6.606 ± 0.081	1.892IleMet: 1.892 ± 0.039	2.908IleAsn: 2.908 ± 0.048	3.439IlePro: 3.439 ± 0.053	3.099IleGln: 3.099 ± 0.044	3.637IleArg: 3.637 ± 0.055	5.424IleSer: 5.424 ± 0.067	4.398IleThr: 4.398 ± 0.067	5.328IleVal: 5.328 ± 0.069	0.748IleTrp: 0.748 ± 0.025	2.282IleTyr: 2.282 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.182LysAla: 4.182 ± 0.061	0.303LysCys: 0.303 ± 0.015	3.489LysAsp: 3.489 ± 0.051	4.725LysGlu: 4.725 ± 0.078	1.737LysPhe: 1.737 ± 0.036	3.904LysGly: 3.904 ± 0.058	1.298LysHis: 1.298 ± 0.033	3.734LysIle: 3.734 ± 0.069	3.875LysLys: 3.875 ± 0.061	5.744LysLeu: 5.744 ± 0.065	1.834LysMet: 1.834 ± 0.041	2.594LysAsn: 2.594 ± 0.055	2.26LysPro: 2.26 ± 0.04	2.904LysGln: 2.904 ± 0.054	2.827LysArg: 2.827 ± 0.049	3.586LysSer: 3.586 ± 0.052	3.127LysThr: 3.127 ± 0.051	4.135LysVal: 4.135 ± 0.065	0.764LysTrp: 0.764 ± 0.025	2.022LysTyr: 2.022 ± 0.046	0.0LysXaa: 0.0 ± 0.0
Leu	7.129LeuAla: 7.129 ± 0.077	0.807LeuCys: 0.807 ± 0.024	5.029LeuAsp: 5.029 ± 0.068	6.179LeuGlu: 6.179 ± 0.072	4.216LeuPhe: 4.216 ± 0.061	6.378LeuGly: 6.378 ± 0.079	2.197LeuHis: 2.197 ± 0.044	7.005LeuIle: 7.005 ± 0.086	5.757LeuLys: 5.757 ± 0.068	10.007LeuLeu: 10.007 ± 0.101	2.85LeuMet: 2.85 ± 0.046	4.365LeuAsn: 4.365 ± 0.059	4.188LeuPro: 4.188 ± 0.065	4.137LeuGln: 4.137 ± 0.065	4.419LeuArg: 4.419 ± 0.06	7.256LeuSer: 7.256 ± 0.074	5.638LeuThr: 5.638 ± 0.067	5.997LeuVal: 5.997 ± 0.073	0.958LeuTrp: 0.958 ± 0.022	3.171LeuTyr: 3.171 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.107MetAla: 2.107 ± 0.043	0.186MetCys: 0.186 ± 0.011	1.785MetAsp: 1.785 ± 0.034	1.98MetGlu: 1.98 ± 0.043	1.081MetPhe: 1.081 ± 0.032	1.935MetGly: 1.935 ± 0.037	0.54MetHis: 0.54 ± 0.019	2.334MetIle: 2.334 ± 0.042	2.299MetLys: 2.299 ± 0.042	3.054MetLeu: 3.054 ± 0.049	1.071MetMet: 1.071 ± 0.03	1.79MetAsn: 1.79 ± 0.034	1.098MetPro: 1.098 ± 0.032	1.158MetGln: 1.158 ± 0.029	1.284MetArg: 1.284 ± 0.03	2.069MetSer: 2.069 ± 0.036	1.695MetThr: 1.695 ± 0.034	1.941MetVal: 1.941 ± 0.036	0.229MetTrp: 0.229 ± 0.013	0.818MetTyr: 0.818 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.9AsnAla: 2.9 ± 0.051	0.288AsnCys: 0.288 ± 0.014	2.205AsnAsp: 2.205 ± 0.039	2.856AsnGlu: 2.856 ± 0.05	1.505AsnPhe: 1.505 ± 0.038	3.278AsnGly: 3.278 ± 0.073	1.004AsnHis: 1.004 ± 0.028	3.116AsnIle: 3.116 ± 0.05	2.624AsnLys: 2.624 ± 0.055	3.674AsnLeu: 3.674 ± 0.065	1.293AsnMet: 1.293 ± 0.033	2.034AsnAsn: 2.034 ± 0.046	2.141AsnPro: 2.141 ± 0.041	1.804AsnGln: 1.804 ± 0.035	2.036AsnArg: 2.036 ± 0.037	2.604AsnSer: 2.604 ± 0.06	2.482AsnThr: 2.482 ± 0.054	2.936AsnVal: 2.936 ± 0.051	0.572AsnTrp: 0.572 ± 0.02	1.527AsnTyr: 1.527 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	2.763ProAla: 2.763 ± 0.055	0.252ProCys: 0.252 ± 0.013	2.341ProAsp: 2.341 ± 0.041	3.12ProGlu: 3.12 ± 0.052	1.818ProPhe: 1.818 ± 0.034	2.443ProGly: 2.443 ± 0.051	0.829ProHis: 0.829 ± 0.025	2.569ProIle: 2.569 ± 0.045	1.957ProLys: 1.957 ± 0.04	3.73ProLeu: 3.73 ± 0.053	1.021ProMet: 1.021 ± 0.031	1.695ProAsn: 1.695 ± 0.043	1.046ProPro: 1.046 ± 0.032	1.467ProGln: 1.467 ± 0.034	1.25ProArg: 1.25 ± 0.03	2.696ProSer: 2.696 ± 0.053	2.082ProThr: 2.082 ± 0.05	3.012ProVal: 3.012 ± 0.044	0.477ProTrp: 0.477 ± 0.02	1.465ProTyr: 1.465 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	3.115GlnAla: 3.115 ± 0.05	0.217GlnCys: 0.217 ± 0.013	1.97GlnAsp: 1.97 ± 0.039	2.917GlnGlu: 2.917 ± 0.06	1.563GlnPhe: 1.563 ± 0.036	2.712GlnGly: 2.712 ± 0.05	0.984GlnHis: 0.984 ± 0.026	2.868GlnIle: 2.868 ± 0.044	2.304GlnLys: 2.304 ± 0.047	4.295GlnLeu: 4.295 ± 0.064	1.306GlnMet: 1.306 ± 0.031	1.56GlnAsn: 1.56 ± 0.039	1.424GlnPro: 1.424 ± 0.036	2.174GlnGln: 2.174 ± 0.046	1.872GlnArg: 1.872 ± 0.042	2.639GlnSer: 2.639 ± 0.046	2.09GlnThr: 2.09 ± 0.036	2.8GlnVal: 2.8 ± 0.05	0.557GlnTrp: 0.557 ± 0.02	1.399GlnTyr: 1.399 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.734ArgAla: 2.734 ± 0.049	0.339ArgCys: 0.339 ± 0.016	2.28ArgAsp: 2.28 ± 0.037	3.23ArgGlu: 3.23 ± 0.053	1.971ArgPhe: 1.971 ± 0.039	2.665ArgGly: 2.665 ± 0.044	0.918ArgHis: 0.918 ± 0.027	3.555ArgIle: 3.555 ± 0.055	2.946ArgLys: 2.946 ± 0.046	4.482ArgLeu: 4.482 ± 0.062	1.569ArgMet: 1.569 ± 0.035	2.072ArgAsn: 2.072 ± 0.037	1.48ArgPro: 1.48 ± 0.031	1.72ArgGln: 1.72 ± 0.039	2.233ArgArg: 2.233 ± 0.045	2.933ArgSer: 2.933 ± 0.045	2.45ArgThr: 2.45 ± 0.045	2.839ArgVal: 2.839 ± 0.051	0.561ArgTrp: 0.561 ± 0.022	1.75ArgTyr: 1.75 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	4.614SerAla: 4.614 ± 0.068	0.463SerCys: 0.463 ± 0.021	3.325SerAsp: 3.325 ± 0.052	4.102SerGlu: 4.102 ± 0.059	3.086SerPhe: 3.086 ± 0.054	5.343SerGly: 5.343 ± 0.071	1.344SerHis: 1.344 ± 0.031	5.137SerIle: 5.137 ± 0.073	4.026SerLys: 4.026 ± 0.059	6.663SerLeu: 6.663 ± 0.07	2.015SerMet: 2.015 ± 0.036	2.869SerAsn: 2.869 ± 0.054	2.428SerPro: 2.428 ± 0.048	2.3SerGln: 2.3 ± 0.041	2.876SerArg: 2.876 ± 0.045	5.098SerSer: 5.098 ± 0.093	3.738SerThr: 3.738 ± 0.066	4.654SerVal: 4.654 ± 0.071	0.833SerTrp: 0.833 ± 0.023	2.52SerTyr: 2.52 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	4.349ThrAla: 4.349 ± 0.075	0.376ThrCys: 0.376 ± 0.018	2.944ThrAsp: 2.944 ± 0.048	3.311ThrGlu: 3.311 ± 0.052	2.459ThrPhe: 2.459 ± 0.043	4.532ThrGly: 4.532 ± 0.078	1.138ThrHis: 1.138 ± 0.031	4.055ThrIle: 4.055 ± 0.058	2.866ThrLys: 2.866 ± 0.046	5.569ThrLeu: 5.569 ± 0.07	1.451ThrMet: 1.451 ± 0.035	2.379ThrAsn: 2.379 ± 0.052	2.586ThrPro: 2.586 ± 0.044	1.741ThrGln: 1.741 ± 0.036	2.161ThrArg: 2.161 ± 0.034	3.885ThrSer: 3.885 ± 0.06	3.19ThrThr: 3.19 ± 0.055	4.284ThrVal: 4.284 ± 0.067	0.643ThrTrp: 0.643 ± 0.021	1.942ThrTyr: 1.942 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	4.996ValAla: 4.996 ± 0.068	0.594ValCys: 0.594 ± 0.024	3.719ValAsp: 3.719 ± 0.059	4.363ValGlu: 4.363 ± 0.058	2.719ValPhe: 2.719 ± 0.05	4.484ValGly: 4.484 ± 0.06	1.498ValHis: 1.498 ± 0.035	5.333ValIle: 5.333 ± 0.084	4.209ValLys: 4.209 ± 0.058	6.817ValLeu: 6.817 ± 0.078	2.118ValMet: 2.118 ± 0.041	3.222ValAsn: 3.222 ± 0.061	2.818ValPro: 2.818 ± 0.046	2.717ValGln: 2.717 ± 0.046	2.952ValArg: 2.952 ± 0.05	4.829ValSer: 4.829 ± 0.072	4.444ValThr: 4.444 ± 0.078	5.058ValVal: 5.058 ± 0.072	0.757ValTrp: 0.757 ± 0.023	2.277ValTyr: 2.277 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.7TrpAla: 0.7 ± 0.026	0.099TrpCys: 0.099 ± 0.008	0.667TrpAsp: 0.667 ± 0.023	0.698TrpGlu: 0.698 ± 0.024	0.524TrpPhe: 0.524 ± 0.021	0.747TrpGly: 0.747 ± 0.026	0.214TrpHis: 0.214 ± 0.012	0.947TrpIle: 0.947 ± 0.027	0.826TrpLys: 0.826 ± 0.026	1.277TrpLeu: 1.277 ± 0.031	0.448TrpMet: 0.448 ± 0.017	0.71TrpAsn: 0.71 ± 0.024	0.286TrpPro: 0.286 ± 0.015	0.431TrpGln: 0.431 ± 0.02	0.49TrpArg: 0.49 ± 0.021	0.866TrpSer: 0.866 ± 0.027	0.64TrpThr: 0.64 ± 0.022	0.774TrpVal: 0.774 ± 0.028	0.158TrpTrp: 0.158 ± 0.012	0.353TrpTyr: 0.353 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.38TyrAla: 2.38 ± 0.042	0.324TyrCys: 0.324 ± 0.017	1.956TyrAsp: 1.956 ± 0.043	2.26TyrGlu: 2.26 ± 0.043	1.561TyrPhe: 1.561 ± 0.038	2.582TyrGly: 2.582 ± 0.045	0.761TyrHis: 0.761 ± 0.025	2.343TyrIle: 2.343 ± 0.044	1.919TyrLys: 1.919 ± 0.039	3.182TyrLeu: 3.182 ± 0.048	1.049TyrMet: 1.049 ± 0.027	1.498TyrAsn: 1.498 ± 0.037	1.48TyrPro: 1.48 ± 0.035	1.383TyrGln: 1.383 ± 0.029	1.835TyrArg: 1.835 ± 0.036	2.283TyrSer: 2.283 ± 0.04	2.01TyrThr: 2.01 ± 0.045	2.332TyrVal: 2.332 ± 0.046	0.396TyrTrp: 0.396 ± 0.016	1.29TyrTyr: 1.29 ± 0.035	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4874 proteins (1403787 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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