Amino acid dipepetide frequency for EBPR podovirus 3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.725AlaAla: 7.725 ± 1.108
0.636AlaCys: 0.636 ± 0.269
3.544AlaAsp: 3.544 ± 0.552
4.09AlaGlu: 4.09 ± 0.672
2.636AlaPhe: 2.636 ± 0.361
5.907AlaGly: 5.907 ± 0.853
1.636AlaHis: 1.636 ± 0.324
6.544AlaIle: 6.544 ± 0.665
5.453AlaLys: 5.453 ± 0.758
7.18AlaLeu: 7.18 ± 0.887
2.454AlaMet: 2.454 ± 0.477
4.272AlaAsn: 4.272 ± 0.602
3.454AlaPro: 3.454 ± 0.687
3.09AlaGln: 3.09 ± 0.513
4.544AlaArg: 4.544 ± 0.742
4.544AlaSer: 4.544 ± 0.678
5.907AlaThr: 5.907 ± 0.958
4.817AlaVal: 4.817 ± 0.671
0.454AlaTrp: 0.454 ± 0.227
3.09AlaTyr: 3.09 ± 0.525
0.0AlaXaa: 0.0 ± 0.0
Cys
0.636CysAla: 0.636 ± 0.246
0.091CysCys: 0.091 ± 0.103
0.545CysAsp: 0.545 ± 0.204
0.454CysGlu: 0.454 ± 0.189
0.454CysPhe: 0.454 ± 0.217
0.636CysGly: 0.636 ± 0.292
0.182CysHis: 0.182 ± 0.154
0.545CysIle: 0.545 ± 0.224
0.636CysLys: 0.636 ± 0.267
0.818CysLeu: 0.818 ± 0.311
0.091CysMet: 0.091 ± 0.093
0.454CysAsn: 0.454 ± 0.237
0.545CysPro: 0.545 ± 0.201
0.273CysGln: 0.273 ± 0.147
0.454CysArg: 0.454 ± 0.198
0.273CysSer: 0.273 ± 0.169
0.364CysThr: 0.364 ± 0.182
0.727CysVal: 0.727 ± 0.332
0.182CysTrp: 0.182 ± 0.115
0.364CysTyr: 0.364 ± 0.194
0.0CysXaa: 0.0 ± 0.0
Asp
4.272AspAla: 4.272 ± 0.599
0.636AspCys: 0.636 ± 0.232
3.635AspAsp: 3.635 ± 0.573
3.817AspGlu: 3.817 ± 0.462
2.454AspPhe: 2.454 ± 0.444
3.454AspGly: 3.454 ± 0.722
1.727AspHis: 1.727 ± 0.489
3.908AspIle: 3.908 ± 0.598
3.908AspLys: 3.908 ± 0.592
5.544AspLeu: 5.544 ± 0.627
0.909AspMet: 0.909 ± 0.24
2.908AspAsn: 2.908 ± 0.5
3.181AspPro: 3.181 ± 0.673
1.272AspGln: 1.272 ± 0.305
2.545AspArg: 2.545 ± 0.418
2.999AspSer: 2.999 ± 0.55
3.272AspThr: 3.272 ± 0.494
3.817AspVal: 3.817 ± 0.668
1.0AspTrp: 1.0 ± 0.268
1.818AspTyr: 1.818 ± 0.447
0.0AspXaa: 0.0 ± 0.0
Glu
5.726GluAla: 5.726 ± 0.74
0.545GluCys: 0.545 ± 0.239
3.454GluAsp: 3.454 ± 0.622
5.18GluGlu: 5.18 ± 0.996
4.181GluPhe: 4.181 ± 0.61
4.09GluGly: 4.09 ± 0.532
1.272GluHis: 1.272 ± 0.327
4.181GluIle: 4.181 ± 0.71
4.09GluLys: 4.09 ± 0.832
7.089GluLeu: 7.089 ± 0.852
2.908GluMet: 2.908 ± 0.461
2.999GluAsn: 2.999 ± 0.435
2.09GluPro: 2.09 ± 0.435
2.363GluGln: 2.363 ± 0.453
2.272GluArg: 2.272 ± 0.47
3.09GluSer: 3.09 ± 0.573
3.635GluThr: 3.635 ± 0.556
3.09GluVal: 3.09 ± 0.442
0.818GluTrp: 0.818 ± 0.315
2.09GluTyr: 2.09 ± 0.387
0.0GluXaa: 0.0 ± 0.0
Phe
2.817PheAla: 2.817 ± 0.464
1.0PheCys: 1.0 ± 0.319
2.817PheAsp: 2.817 ± 0.535
2.181PheGlu: 2.181 ± 0.484
2.09PhePhe: 2.09 ± 0.448
4.09PheGly: 4.09 ± 0.578
0.454PheHis: 0.454 ± 0.199
3.09PheIle: 3.09 ± 0.673
2.09PheLys: 2.09 ± 0.458
3.363PheLeu: 3.363 ± 0.59
1.272PheMet: 1.272 ± 0.256
2.545PheAsn: 2.545 ± 0.396
1.727PhePro: 1.727 ± 0.45
2.454PheGln: 2.454 ± 0.476
1.909PheArg: 1.909 ± 0.393
2.908PheSer: 2.908 ± 0.546
2.09PheThr: 2.09 ± 0.38
1.999PheVal: 1.999 ± 0.374
0.727PheTrp: 0.727 ± 0.244
1.181PheTyr: 1.181 ± 0.384
0.0PheXaa: 0.0 ± 0.0
Gly
4.544GlyAla: 4.544 ± 0.688
0.727GlyCys: 0.727 ± 0.281
3.908GlyAsp: 3.908 ± 0.69
3.635GlyGlu: 3.635 ± 0.534
2.181GlyPhe: 2.181 ± 0.483
3.544GlyGly: 3.544 ± 0.809
0.909GlyHis: 0.909 ± 0.329
5.544GlyIle: 5.544 ± 0.59
5.362GlyLys: 5.362 ± 0.842
4.999GlyLeu: 4.999 ± 0.88
2.545GlyMet: 2.545 ± 0.501
3.272GlyAsn: 3.272 ± 0.388
1.0GlyPro: 1.0 ± 0.278
2.363GlyGln: 2.363 ± 0.475
3.181GlyArg: 3.181 ± 0.718
3.817GlySer: 3.817 ± 0.85
5.998GlyThr: 5.998 ± 1.011
3.454GlyVal: 3.454 ± 0.588
0.909GlyTrp: 0.909 ± 0.289
2.908GlyTyr: 2.908 ± 0.502
0.0GlyXaa: 0.0 ± 0.0
His
1.636HisAla: 1.636 ± 0.348
0.182HisCys: 0.182 ± 0.134
1.0HisAsp: 1.0 ± 0.293
1.181HisGlu: 1.181 ± 0.294
0.545HisPhe: 0.545 ± 0.187
1.818HisGly: 1.818 ± 0.305
0.091HisHis: 0.091 ± 0.072
1.272HisIle: 1.272 ± 0.383
1.0HisLys: 1.0 ± 0.316
2.09HisLeu: 2.09 ± 0.431
0.636HisMet: 0.636 ± 0.213
1.0HisAsn: 1.0 ± 0.342
1.454HisPro: 1.454 ± 0.304
0.818HisGln: 0.818 ± 0.233
0.545HisArg: 0.545 ± 0.193
1.636HisSer: 1.636 ± 0.385
0.818HisThr: 0.818 ± 0.252
0.818HisVal: 0.818 ± 0.355
0.364HisTrp: 0.364 ± 0.164
0.454HisTyr: 0.454 ± 0.172
0.0HisXaa: 0.0 ± 0.0
Ile
5.271IleAla: 5.271 ± 0.861
1.091IleCys: 1.091 ± 0.252
3.544IleAsp: 3.544 ± 0.496
3.726IleGlu: 3.726 ± 0.654
2.817IlePhe: 2.817 ± 0.497
4.635IleGly: 4.635 ± 0.487
1.363IleHis: 1.363 ± 0.336
5.271IleIle: 5.271 ± 1.004
4.181IleLys: 4.181 ± 0.612
6.907IleLeu: 6.907 ± 0.942
1.636IleMet: 1.636 ± 0.354
2.636IleAsn: 2.636 ± 0.487
3.999IlePro: 3.999 ± 0.541
2.999IleGln: 2.999 ± 0.471
3.272IleArg: 3.272 ± 0.561
5.635IleSer: 5.635 ± 0.938
4.817IleThr: 4.817 ± 0.446
3.544IleVal: 3.544 ± 0.682
0.727IleTrp: 0.727 ± 0.23
2.363IleTyr: 2.363 ± 0.37
0.0IleXaa: 0.0 ± 0.0
Lys
5.635LysAla: 5.635 ± 0.939
0.364LysCys: 0.364 ± 0.297
4.362LysAsp: 4.362 ± 0.725
5.362LysGlu: 5.362 ± 0.79
2.09LysPhe: 2.09 ± 0.347
3.635LysGly: 3.635 ± 0.51
1.091LysHis: 1.091 ± 0.277
4.272LysIle: 4.272 ± 0.604
5.453LysLys: 5.453 ± 0.909
5.635LysLeu: 5.635 ± 0.628
1.909LysMet: 1.909 ± 0.412
2.454LysAsn: 2.454 ± 0.462
2.908LysPro: 2.908 ± 0.715
2.363LysGln: 2.363 ± 0.513
2.636LysArg: 2.636 ± 0.625
4.544LysSer: 4.544 ± 0.566
4.635LysThr: 4.635 ± 0.74
3.999LysVal: 3.999 ± 0.808
0.454LysTrp: 0.454 ± 0.225
1.909LysTyr: 1.909 ± 0.402
0.0LysXaa: 0.0 ± 0.0
Leu
8.452LeuAla: 8.452 ± 0.83
0.909LeuCys: 0.909 ± 0.305
5.907LeuAsp: 5.907 ± 0.979
5.635LeuGlu: 5.635 ± 0.801
3.817LeuPhe: 3.817 ± 0.54
4.908LeuGly: 4.908 ± 0.647
2.181LeuHis: 2.181 ± 0.351
4.544LeuIle: 4.544 ± 0.519
6.453LeuLys: 6.453 ± 1.095
7.271LeuLeu: 7.271 ± 1.021
2.454LeuMet: 2.454 ± 0.533
3.908LeuAsn: 3.908 ± 0.485
4.272LeuPro: 4.272 ± 0.6
2.908LeuGln: 2.908 ± 0.449
4.272LeuArg: 4.272 ± 0.6
7.271LeuSer: 7.271 ± 0.854
5.998LeuThr: 5.998 ± 0.861
5.09LeuVal: 5.09 ± 0.751
1.091LeuTrp: 1.091 ± 0.279
2.545LeuTyr: 2.545 ± 0.289
0.0LeuXaa: 0.0 ± 0.0
Met
2.908MetAla: 2.908 ± 0.667
0.091MetCys: 0.091 ± 0.094
1.999MetAsp: 1.999 ± 0.373
3.181MetGlu: 3.181 ± 0.496
0.636MetPhe: 0.636 ± 0.192
1.545MetGly: 1.545 ± 0.344
0.909MetHis: 0.909 ± 0.223
1.454MetIle: 1.454 ± 0.329
2.181MetLys: 2.181 ± 0.47
1.999MetLeu: 1.999 ± 0.344
0.545MetMet: 0.545 ± 0.192
1.818MetAsn: 1.818 ± 0.395
1.091MetPro: 1.091 ± 0.332
1.272MetGln: 1.272 ± 0.556
1.636MetArg: 1.636 ± 0.507
1.181MetSer: 1.181 ± 0.292
1.727MetThr: 1.727 ± 0.352
0.909MetVal: 0.909 ± 0.21
0.182MetTrp: 0.182 ± 0.143
0.818MetTyr: 0.818 ± 0.297
0.0MetXaa: 0.0 ± 0.0
Asn
3.908AsnAla: 3.908 ± 0.467
0.182AsnCys: 0.182 ± 0.118
1.363AsnAsp: 1.363 ± 0.352
2.636AsnGlu: 2.636 ± 0.504
1.999AsnPhe: 1.999 ± 0.47
3.544AsnGly: 3.544 ± 0.676
0.636AsnHis: 0.636 ± 0.219
3.544AsnIle: 3.544 ± 0.609
2.363AsnLys: 2.363 ± 0.378
3.817AsnLeu: 3.817 ± 0.559
0.727AsnMet: 0.727 ± 0.213
1.999AsnAsn: 1.999 ± 0.549
3.908AsnPro: 3.908 ± 0.532
0.636AsnGln: 0.636 ± 0.205
2.545AsnArg: 2.545 ± 0.542
4.272AsnSer: 4.272 ± 0.496
3.09AsnThr: 3.09 ± 0.48
2.727AsnVal: 2.727 ± 0.442
0.636AsnTrp: 0.636 ± 0.249
1.727AsnTyr: 1.727 ± 0.362
0.0AsnXaa: 0.0 ± 0.0
Pro
3.09ProAla: 3.09 ± 0.638
0.273ProCys: 0.273 ± 0.194
3.454ProAsp: 3.454 ± 0.389
3.817ProGlu: 3.817 ± 0.511
2.727ProPhe: 2.727 ± 0.449
3.454ProGly: 3.454 ± 0.648
1.0ProHis: 1.0 ± 0.25
3.454ProIle: 3.454 ± 0.587
2.636ProLys: 2.636 ± 0.496
3.09ProLeu: 3.09 ± 0.455
0.818ProMet: 0.818 ± 0.284
2.181ProAsn: 2.181 ± 0.386
1.636ProPro: 1.636 ± 0.497
2.09ProGln: 2.09 ± 0.476
2.09ProArg: 2.09 ± 0.447
2.636ProSer: 2.636 ± 0.368
2.454ProThr: 2.454 ± 0.393
2.817ProVal: 2.817 ± 0.454
0.273ProTrp: 0.273 ± 0.161
1.545ProTyr: 1.545 ± 0.326
0.0ProXaa: 0.0 ± 0.0
Gln
3.817GlnAla: 3.817 ± 0.58
0.182GlnCys: 0.182 ± 0.134
1.545GlnAsp: 1.545 ± 0.337
2.999GlnGlu: 2.999 ± 0.631
1.727GlnPhe: 1.727 ± 0.321
1.727GlnGly: 1.727 ± 0.377
0.818GlnHis: 0.818 ± 0.23
2.454GlnIle: 2.454 ± 0.373
2.181GlnLys: 2.181 ± 0.712
3.908GlnLeu: 3.908 ± 0.565
0.636GlnMet: 0.636 ± 0.282
1.272GlnAsn: 1.272 ± 0.35
1.0GlnPro: 1.0 ± 0.248
1.999GlnGln: 1.999 ± 0.531
1.818GlnArg: 1.818 ± 0.401
2.636GlnSer: 2.636 ± 0.466
2.181GlnThr: 2.181 ± 0.458
1.454GlnVal: 1.454 ± 0.599
0.182GlnTrp: 0.182 ± 0.159
1.909GlnTyr: 1.909 ± 0.349
0.0GlnXaa: 0.0 ± 0.0
Arg
3.635ArgAla: 3.635 ± 0.627
0.454ArgCys: 0.454 ± 0.235
2.545ArgAsp: 2.545 ± 0.622
3.09ArgGlu: 3.09 ± 0.502
2.545ArgPhe: 2.545 ± 0.465
3.454ArgGly: 3.454 ± 0.812
0.727ArgHis: 0.727 ± 0.251
3.908ArgIle: 3.908 ± 0.725
3.635ArgLys: 3.635 ± 0.889
3.726ArgLeu: 3.726 ± 0.451
1.181ArgMet: 1.181 ± 0.235
2.363ArgAsn: 2.363 ± 0.425
1.545ArgPro: 1.545 ± 0.447
1.999ArgGln: 1.999 ± 0.445
2.363ArgArg: 2.363 ± 0.553
2.09ArgSer: 2.09 ± 0.55
3.181ArgThr: 3.181 ± 0.372
2.999ArgVal: 2.999 ± 0.674
0.091ArgTrp: 0.091 ± 0.113
1.181ArgTyr: 1.181 ± 0.297
0.0ArgXaa: 0.0 ± 0.0
Ser
4.817SerAla: 4.817 ± 0.678
0.364SerCys: 0.364 ± 0.187
2.999SerAsp: 2.999 ± 0.373
3.363SerGlu: 3.363 ± 0.643
2.999SerPhe: 2.999 ± 0.542
3.999SerGly: 3.999 ± 0.771
1.0SerHis: 1.0 ± 0.281
5.726SerIle: 5.726 ± 0.754
3.454SerLys: 3.454 ± 0.437
6.271SerLeu: 6.271 ± 0.708
2.363SerMet: 2.363 ± 0.407
2.908SerAsn: 2.908 ± 0.534
3.272SerPro: 3.272 ± 0.837
2.181SerGln: 2.181 ± 0.382
3.181SerArg: 3.181 ± 0.539
4.453SerSer: 4.453 ± 0.853
3.908SerThr: 3.908 ± 0.566
4.272SerVal: 4.272 ± 0.584
0.454SerTrp: 0.454 ± 0.208
2.181SerTyr: 2.181 ± 0.406
0.0SerXaa: 0.0 ± 0.0
Thr
5.453ThrAla: 5.453 ± 0.768
0.364ThrCys: 0.364 ± 0.208
3.908ThrAsp: 3.908 ± 0.612
4.453ThrGlu: 4.453 ± 0.605
2.727ThrPhe: 2.727 ± 0.475
4.544ThrGly: 4.544 ± 0.577
1.091ThrHis: 1.091 ± 0.266
4.999ThrIle: 4.999 ± 0.778
4.09ThrLys: 4.09 ± 0.716
6.18ThrLeu: 6.18 ± 0.752
2.09ThrMet: 2.09 ± 0.404
2.545ThrAsn: 2.545 ± 0.452
3.726ThrPro: 3.726 ± 0.736
1.545ThrGln: 1.545 ± 0.344
2.272ThrArg: 2.272 ± 0.406
3.817ThrSer: 3.817 ± 0.738
4.908ThrThr: 4.908 ± 1.047
4.362ThrVal: 4.362 ± 0.701
0.545ThrTrp: 0.545 ± 0.188
1.727ThrTyr: 1.727 ± 0.308
0.0ThrXaa: 0.0 ± 0.0
Val
4.362ValAla: 4.362 ± 0.576
0.273ValCys: 0.273 ± 0.193
3.544ValAsp: 3.544 ± 0.511
3.817ValGlu: 3.817 ± 0.559
2.181ValPhe: 2.181 ± 0.505
2.999ValGly: 2.999 ± 0.649
1.272ValHis: 1.272 ± 0.377
3.544ValIle: 3.544 ± 0.505
3.817ValLys: 3.817 ± 0.556
5.362ValLeu: 5.362 ± 0.777
1.545ValMet: 1.545 ± 0.409
2.545ValAsn: 2.545 ± 0.383
2.908ValPro: 2.908 ± 0.434
1.909ValGln: 1.909 ± 0.483
2.09ValArg: 2.09 ± 0.323
4.453ValSer: 4.453 ± 0.502
4.09ValThr: 4.09 ± 0.794
3.363ValVal: 3.363 ± 0.666
0.636ValTrp: 0.636 ± 0.289
2.636ValTyr: 2.636 ± 0.509
0.0ValXaa: 0.0 ± 0.0
Trp
0.545TrpAla: 0.545 ± 0.231
0.182TrpCys: 0.182 ± 0.126
0.727TrpAsp: 0.727 ± 0.275
1.181TrpGlu: 1.181 ± 0.272
0.545TrpPhe: 0.545 ± 0.207
0.273TrpGly: 0.273 ± 0.125
0.454TrpHis: 0.454 ± 0.166
0.273TrpIle: 0.273 ± 0.176
0.636TrpLys: 0.636 ± 0.194
1.091TrpLeu: 1.091 ± 0.272
0.273TrpMet: 0.273 ± 0.164
0.818TrpAsn: 0.818 ± 0.304
0.364TrpPro: 0.364 ± 0.167
0.545TrpGln: 0.545 ± 0.214
0.818TrpArg: 0.818 ± 0.215
0.182TrpSer: 0.182 ± 0.141
0.454TrpThr: 0.454 ± 0.179
0.636TrpVal: 0.636 ± 0.252
0.364TrpTrp: 0.364 ± 0.163
0.182TrpTyr: 0.182 ± 0.103
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.727TyrAla: 2.727 ± 0.54
0.182TyrCys: 0.182 ± 0.135
2.272TyrAsp: 2.272 ± 0.429
1.363TyrGlu: 1.363 ± 0.295
1.454TyrPhe: 1.454 ± 0.444
2.545TyrGly: 2.545 ± 0.488
0.545TyrHis: 0.545 ± 0.217
1.909TyrIle: 1.909 ± 0.495
2.09TyrLys: 2.09 ± 0.381
3.544TyrLeu: 3.544 ± 0.586
1.0TyrMet: 1.0 ± 0.333
1.363TyrAsn: 1.363 ± 0.339
1.454TyrPro: 1.454 ± 0.399
1.454TyrGln: 1.454 ± 0.364
2.272TyrArg: 2.272 ± 0.51
1.727TyrSer: 1.727 ± 0.416
1.818TyrThr: 1.818 ± 0.404
2.454TyrVal: 2.454 ± 0.538
0.454TyrTrp: 0.454 ± 0.202
1.0TyrTyr: 1.0 ± 0.343
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 54 proteins (11004 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski