Amino acid dipepetide frequency for Aminobacterium colombiense (strain DSM 12261 / ALA-1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.729AlaAla: 7.729 ± 0.161
1.04AlaCys: 1.04 ± 0.045
3.425AlaAsp: 3.425 ± 0.099
5.109AlaGlu: 5.109 ± 0.103
3.802AlaPhe: 3.802 ± 0.1
6.64AlaGly: 6.64 ± 0.127
1.543AlaHis: 1.543 ± 0.053
5.944AlaIle: 5.944 ± 0.11
4.0AlaLys: 4.0 ± 0.097
10.139AlaLeu: 10.139 ± 0.149
2.551AlaMet: 2.551 ± 0.07
2.045AlaAsn: 2.045 ± 0.06
2.836AlaPro: 2.836 ± 0.084
2.596AlaGln: 2.596 ± 0.071
4.257AlaArg: 4.257 ± 0.086
5.208AlaSer: 5.208 ± 0.111
3.401AlaThr: 3.401 ± 0.068
6.454AlaVal: 6.454 ± 0.126
0.985AlaTrp: 0.985 ± 0.04
2.336AlaTyr: 2.336 ± 0.062
0.0AlaXaa: 0.0 ± 0.0
Cys
0.817CysAla: 0.817 ± 0.04
0.208CysCys: 0.208 ± 0.018
0.617CysAsp: 0.617 ± 0.029
0.711CysGlu: 0.711 ± 0.037
0.512CysPhe: 0.512 ± 0.028
1.28CysGly: 1.28 ± 0.045
0.34CysHis: 0.34 ± 0.023
0.74CysIle: 0.74 ± 0.037
0.512CysLys: 0.512 ± 0.034
1.26CysLeu: 1.26 ± 0.047
0.268CysMet: 0.268 ± 0.022
0.403CysAsn: 0.403 ± 0.029
0.772CysPro: 0.772 ± 0.044
0.354CysGln: 0.354 ± 0.022
0.693CysArg: 0.693 ± 0.034
0.849CysSer: 0.849 ± 0.036
0.592CysThr: 0.592 ± 0.029
0.82CysVal: 0.82 ± 0.039
0.158CysTrp: 0.158 ± 0.017
0.369CysTyr: 0.369 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
3.474AspAla: 3.474 ± 0.077
0.485AspCys: 0.485 ± 0.028
2.026AspAsp: 2.026 ± 0.062
3.658AspGlu: 3.658 ± 0.075
2.242AspPhe: 2.242 ± 0.066
3.472AspGly: 3.472 ± 0.088
1.021AspHis: 1.021 ± 0.042
4.02AspIle: 4.02 ± 0.086
2.387AspLys: 2.387 ± 0.063
5.282AspLeu: 5.282 ± 0.103
1.387AspMet: 1.387 ± 0.057
1.464AspAsn: 1.464 ± 0.052
2.335AspPro: 2.335 ± 0.061
1.236AspGln: 1.236 ± 0.047
2.499AspArg: 2.499 ± 0.069
2.576AspSer: 2.576 ± 0.075
2.026AspThr: 2.026 ± 0.062
3.977AspVal: 3.977 ± 0.085
0.553AspTrp: 0.553 ± 0.034
1.506AspTyr: 1.506 ± 0.05
0.0AspXaa: 0.0 ± 0.0
Glu
6.026GluAla: 6.026 ± 0.119
0.627GluCys: 0.627 ± 0.033
3.366GluAsp: 3.366 ± 0.081
7.096GluGlu: 7.096 ± 0.147
2.088GluPhe: 2.088 ± 0.06
5.404GluGly: 5.404 ± 0.113
1.196GluHis: 1.196 ± 0.045
5.34GluIle: 5.34 ± 0.109
6.323GluLys: 6.323 ± 0.114
6.031GluLeu: 6.031 ± 0.109
2.247GluMet: 2.247 ± 0.066
2.865GluAsn: 2.865 ± 0.067
2.023GluPro: 2.023 ± 0.07
2.145GluGln: 2.145 ± 0.056
4.401GluArg: 4.401 ± 0.101
3.363GluSer: 3.363 ± 0.075
3.427GluThr: 3.427 ± 0.082
4.783GluVal: 4.783 ± 0.093
0.817GluTrp: 0.817 ± 0.038
1.848GluTyr: 1.848 ± 0.056
0.0GluXaa: 0.0 ± 0.0
Phe
3.348PheAla: 3.348 ± 0.078
0.674PheCys: 0.674 ± 0.032
2.169PheAsp: 2.169 ± 0.056
2.264PheGlu: 2.264 ± 0.059
2.41PhePhe: 2.41 ± 0.087
2.997PheGly: 2.997 ± 0.075
0.943PheHis: 0.943 ± 0.038
3.059PheIle: 3.059 ± 0.084
1.912PheLys: 1.912 ± 0.059
4.817PheLeu: 4.817 ± 0.112
1.119PheMet: 1.119 ± 0.047
1.419PheAsn: 1.419 ± 0.047
2.083PhePro: 2.083 ± 0.061
1.214PheGln: 1.214 ± 0.047
1.904PheArg: 1.904 ± 0.053
3.452PheSer: 3.452 ± 0.076
2.04PheThr: 2.04 ± 0.061
3.229PheVal: 3.229 ± 0.076
0.616PheTrp: 0.616 ± 0.033
1.328PheTyr: 1.328 ± 0.05
0.0PheXaa: 0.0 ± 0.0
Gly
6.466GlyAla: 6.466 ± 0.124
1.182GlyCys: 1.182 ± 0.048
3.458GlyAsp: 3.458 ± 0.08
4.913GlyGlu: 4.913 ± 0.095
3.4GlyPhe: 3.4 ± 0.085
6.154GlyGly: 6.154 ± 0.12
1.577GlyHis: 1.577 ± 0.048
6.231GlyIle: 6.231 ± 0.107
4.934GlyLys: 4.934 ± 0.102
7.626GlyLeu: 7.626 ± 0.127
2.466GlyMet: 2.466 ± 0.066
2.538GlyAsn: 2.538 ± 0.067
2.336GlyPro: 2.336 ± 0.07
2.237GlyGln: 2.237 ± 0.059
4.196GlyArg: 4.196 ± 0.09
4.48GlySer: 4.48 ± 0.075
4.406GlyThr: 4.406 ± 0.09
6.14GlyVal: 6.14 ± 0.116
1.02GlyTrp: 1.02 ± 0.042
2.613GlyTyr: 2.613 ± 0.069
0.0GlyXaa: 0.0 ± 0.0
His
1.308HisAla: 1.308 ± 0.059
0.315HisCys: 0.315 ± 0.022
0.919HisAsp: 0.919 ± 0.033
1.159HisGlu: 1.159 ± 0.04
0.973HisPhe: 0.973 ± 0.045
1.499HisGly: 1.499 ± 0.051
0.468HisHis: 0.468 ± 0.031
1.515HisIle: 1.515 ± 0.054
0.879HisLys: 0.879 ± 0.04
2.028HisLeu: 2.028 ± 0.066
0.557HisMet: 0.557 ± 0.03
0.681HisAsn: 0.681 ± 0.035
1.201HisPro: 1.201 ± 0.049
0.538HisGln: 0.538 ± 0.031
1.037HisArg: 1.037 ± 0.045
1.13HisSer: 1.13 ± 0.044
0.867HisThr: 0.867 ± 0.038
1.414HisVal: 1.414 ± 0.051
0.242HisTrp: 0.242 ± 0.021
0.604HisTyr: 0.604 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
6.273IleAla: 6.273 ± 0.104
0.959IleCys: 0.959 ± 0.04
3.916IleAsp: 3.916 ± 0.081
5.017IleGlu: 5.017 ± 0.1
2.881IlePhe: 2.881 ± 0.077
5.171IleGly: 5.171 ± 0.106
1.365IleHis: 1.365 ± 0.058
4.671IleIle: 4.671 ± 0.098
3.354IleLys: 3.354 ± 0.077
7.356IleLeu: 7.356 ± 0.11
1.739IleMet: 1.739 ± 0.058
2.284IleAsn: 2.284 ± 0.067
3.754IlePro: 3.754 ± 0.079
2.014IleGln: 2.014 ± 0.06
3.827IleArg: 3.827 ± 0.089
4.718IleSer: 4.718 ± 0.095
3.673IleThr: 3.673 ± 0.085
5.325IleVal: 5.325 ± 0.093
0.834IleTrp: 0.834 ± 0.036
1.956IleTyr: 1.956 ± 0.062
0.0IleXaa: 0.0 ± 0.0
Lys
4.738LysAla: 4.738 ± 0.086
0.463LysCys: 0.463 ± 0.027
3.165LysAsp: 3.165 ± 0.072
5.555LysGlu: 5.555 ± 0.103
1.426LysPhe: 1.426 ± 0.05
5.017LysGly: 5.017 ± 0.1
0.887LysHis: 0.887 ± 0.033
3.96LysIle: 3.96 ± 0.086
4.755LysLys: 4.755 ± 0.109
4.49LysLeu: 4.49 ± 0.086
1.655LysMet: 1.655 ± 0.057
2.61LysAsn: 2.61 ± 0.075
1.847LysPro: 1.847 ± 0.065
1.55LysGln: 1.55 ± 0.052
3.158LysArg: 3.158 ± 0.07
2.689LysSer: 2.689 ± 0.061
3.011LysThr: 3.011 ± 0.075
4.002LysVal: 4.002 ± 0.092
0.642LysTrp: 0.642 ± 0.031
1.603LysTyr: 1.603 ± 0.054
0.0LysXaa: 0.0 ± 0.0
Leu
9.067LeuAla: 9.067 ± 0.153
1.389LeuCys: 1.389 ± 0.056
4.886LeuAsp: 4.886 ± 0.093
7.034LeuGlu: 7.034 ± 0.122
4.949LeuPhe: 4.949 ± 0.106
7.781LeuGly: 7.781 ± 0.123
2.033LeuHis: 2.033 ± 0.062
6.191LeuIle: 6.191 ± 0.119
6.004LeuLys: 6.004 ± 0.109
10.961LeuLeu: 10.961 ± 0.171
2.591LeuMet: 2.591 ± 0.066
3.299LeuAsn: 3.299 ± 0.081
5.139LeuPro: 5.139 ± 0.107
3.111LeuGln: 3.111 ± 0.082
5.587LeuArg: 5.587 ± 0.106
8.0LeuSer: 8.0 ± 0.139
4.835LeuThr: 4.835 ± 0.104
6.957LeuVal: 6.957 ± 0.121
1.441LeuTrp: 1.441 ± 0.06
2.831LeuTyr: 2.831 ± 0.068
0.0LeuXaa: 0.0 ± 0.0
Met
2.95MetAla: 2.95 ± 0.067
0.226MetCys: 0.226 ± 0.02
1.298MetAsp: 1.298 ± 0.042
2.043MetGlu: 2.043 ± 0.067
0.85MetPhe: 0.85 ± 0.038
2.558MetGly: 2.558 ± 0.072
0.347MetHis: 0.347 ± 0.022
1.744MetIle: 1.744 ± 0.051
2.011MetLys: 2.011 ± 0.05
2.457MetLeu: 2.457 ± 0.082
0.674MetMet: 0.674 ± 0.033
1.169MetAsn: 1.169 ± 0.041
1.28MetPro: 1.28 ± 0.049
0.629MetGln: 0.629 ± 0.038
1.352MetArg: 1.352 ± 0.044
1.726MetSer: 1.726 ± 0.056
1.516MetThr: 1.516 ± 0.048
2.078MetVal: 2.078 ± 0.059
0.236MetTrp: 0.236 ± 0.024
0.557MetTyr: 0.557 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
2.425AsnAla: 2.425 ± 0.064
0.381AsnCys: 0.381 ± 0.023
1.424AsnAsp: 1.424 ± 0.054
2.068AsnGlu: 2.068 ± 0.06
1.399AsnPhe: 1.399 ± 0.045
2.318AsnGly: 2.318 ± 0.072
0.624AsnHis: 0.624 ± 0.034
2.88AsnIle: 2.88 ± 0.081
1.786AsnLys: 1.786 ± 0.052
3.653AsnLeu: 3.653 ± 0.079
1.045AsnMet: 1.045 ± 0.042
1.186AsnAsn: 1.186 ± 0.048
1.972AsnPro: 1.972 ± 0.063
0.835AsnGln: 0.835 ± 0.037
1.87AsnArg: 1.87 ± 0.063
1.734AsnSer: 1.734 ± 0.056
1.481AsnThr: 1.481 ± 0.049
2.638AsnVal: 2.638 ± 0.063
0.456AsnTrp: 0.456 ± 0.027
1.033AsnTyr: 1.033 ± 0.04
0.0AsnXaa: 0.0 ± 0.0
Pro
3.103ProAla: 3.103 ± 0.082
0.523ProCys: 0.523 ± 0.026
2.296ProAsp: 2.296 ± 0.06
3.725ProGlu: 3.725 ± 0.079
2.268ProPhe: 2.268 ± 0.063
3.417ProGly: 3.417 ± 0.089
0.983ProHis: 0.983 ± 0.044
2.67ProIle: 2.67 ± 0.069
1.723ProLys: 1.723 ± 0.055
4.778ProLeu: 4.778 ± 0.105
1.047ProMet: 1.047 ± 0.043
1.134ProAsn: 1.134 ± 0.047
1.583ProPro: 1.583 ± 0.054
1.491ProGln: 1.491 ± 0.053
1.85ProArg: 1.85 ± 0.066
2.853ProSer: 2.853 ± 0.072
1.956ProThr: 1.956 ± 0.057
3.569ProVal: 3.569 ± 0.077
0.631ProTrp: 0.631 ± 0.034
1.473ProTyr: 1.473 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
2.474GlnAla: 2.474 ± 0.063
0.305GlnCys: 0.305 ± 0.024
1.229GlnAsp: 1.229 ± 0.047
2.305GlnGlu: 2.305 ± 0.068
0.897GlnPhe: 0.897 ± 0.039
2.17GlnGly: 2.17 ± 0.06
0.552GlnHis: 0.552 ± 0.033
2.185GlnIle: 2.185 ± 0.053
2.397GlnLys: 2.397 ± 0.066
2.611GlnLeu: 2.611 ± 0.077
0.812GlnMet: 0.812 ± 0.041
1.256GlnAsn: 1.256 ± 0.047
0.973GlnPro: 0.973 ± 0.042
0.996GlnGln: 0.996 ± 0.042
1.855GlnArg: 1.855 ± 0.06
1.6GlnSer: 1.6 ± 0.055
1.39GlnThr: 1.39 ± 0.048
2.045GlnVal: 2.045 ± 0.065
0.478GlnTrp: 0.478 ± 0.032
0.867GlnTyr: 0.867 ± 0.042
0.0GlnXaa: 0.0 ± 0.0
Arg
3.703ArgAla: 3.703 ± 0.085
0.678ArgCys: 0.678 ± 0.032
2.598ArgAsp: 2.598 ± 0.058
4.245ArgGlu: 4.245 ± 0.094
2.348ArgPhe: 2.348 ± 0.063
3.822ArgGly: 3.822 ± 0.084
1.068ArgHis: 1.068 ± 0.049
3.957ArgIle: 3.957 ± 0.088
3.343ArgLys: 3.343 ± 0.078
5.382ArgLeu: 5.382 ± 0.1
1.516ArgMet: 1.516 ± 0.053
1.934ArgAsn: 1.934 ± 0.052
1.981ArgPro: 1.981 ± 0.068
1.912ArgGln: 1.912 ± 0.06
3.133ArgArg: 3.133 ± 0.092
3.042ArgSer: 3.042 ± 0.078
2.397ArgThr: 2.397 ± 0.065
3.621ArgVal: 3.621 ± 0.075
0.738ArgTrp: 0.738 ± 0.039
1.833ArgTyr: 1.833 ± 0.063
0.0ArgXaa: 0.0 ± 0.0
Ser
4.535SerAla: 4.535 ± 0.085
0.783SerCys: 0.783 ± 0.037
2.699SerAsp: 2.699 ± 0.069
3.569SerGlu: 3.569 ± 0.078
3.291SerPhe: 3.291 ± 0.091
5.171SerGly: 5.171 ± 0.091
1.243SerHis: 1.243 ± 0.042
4.534SerIle: 4.534 ± 0.087
2.878SerLys: 2.878 ± 0.069
7.744SerLeu: 7.744 ± 0.155
1.785SerMet: 1.785 ± 0.053
1.731SerAsn: 1.731 ± 0.052
2.9SerPro: 2.9 ± 0.074
1.991SerGln: 1.991 ± 0.067
3.435SerArg: 3.435 ± 0.073
4.409SerSer: 4.409 ± 0.099
2.68SerThr: 2.68 ± 0.071
4.383SerVal: 4.383 ± 0.091
0.87SerTrp: 0.87 ± 0.038
1.865SerTyr: 1.865 ± 0.059
0.0SerXaa: 0.0 ± 0.0
Thr
4.005ThrAla: 4.005 ± 0.089
0.52ThrCys: 0.52 ± 0.032
2.078ThrAsp: 2.078 ± 0.059
2.957ThrGlu: 2.957 ± 0.073
2.102ThrPhe: 2.102 ± 0.057
4.299ThrGly: 4.299 ± 0.089
0.931ThrHis: 0.931 ± 0.038
3.413ThrIle: 3.413 ± 0.079
1.977ThrLys: 1.977 ± 0.06
5.61ThrLeu: 5.61 ± 0.111
1.187ThrMet: 1.187 ± 0.052
1.337ThrAsn: 1.337 ± 0.044
2.704ThrPro: 2.704 ± 0.08
1.253ThrGln: 1.253 ± 0.048
2.15ThrArg: 2.15 ± 0.065
2.974ThrSer: 2.974 ± 0.067
2.511ThrThr: 2.511 ± 0.073
3.913ThrVal: 3.913 ± 0.082
0.639ThrTrp: 0.639 ± 0.034
1.432ThrTyr: 1.432 ± 0.051
0.0ThrXaa: 0.0 ± 0.0
Val
6.509ValAla: 6.509 ± 0.118
0.929ValCys: 0.929 ± 0.039
3.844ValAsp: 3.844 ± 0.088
5.137ValGlu: 5.137 ± 0.09
3.329ValPhe: 3.329 ± 0.082
5.26ValGly: 5.26 ± 0.101
1.348ValHis: 1.348 ± 0.047
5.307ValIle: 5.307 ± 0.109
3.846ValLys: 3.846 ± 0.082
7.715ValLeu: 7.715 ± 0.132
1.974ValMet: 1.974 ± 0.062
2.293ValAsn: 2.293 ± 0.065
3.442ValPro: 3.442 ± 0.091
1.977ValGln: 1.977 ± 0.057
3.742ValArg: 3.742 ± 0.091
4.956ValSer: 4.956 ± 0.098
3.898ValThr: 3.898 ± 0.087
6.224ValVal: 6.224 ± 0.118
0.787ValTrp: 0.787 ± 0.034
1.951ValTyr: 1.951 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
0.973TrpAla: 0.973 ± 0.04
0.139TrpCys: 0.139 ± 0.018
0.584TrpAsp: 0.584 ± 0.033
0.845TrpGlu: 0.845 ± 0.041
0.465TrpPhe: 0.465 ± 0.03
1.285TrpGly: 1.285 ± 0.052
0.294TrpHis: 0.294 ± 0.023
0.829TrpIle: 0.829 ± 0.038
0.859TrpLys: 0.859 ± 0.042
1.307TrpLeu: 1.307 ± 0.052
0.339TrpMet: 0.339 ± 0.023
0.565TrpAsn: 0.565 ± 0.03
0.481TrpPro: 0.481 ± 0.027
0.532TrpGln: 0.532 ± 0.029
0.704TrpArg: 0.704 ± 0.038
0.699TrpSer: 0.699 ± 0.032
0.491TrpThr: 0.491 ± 0.027
0.852TrpVal: 0.852 ± 0.041
0.242TrpTrp: 0.242 ± 0.019
0.292TrpTyr: 0.292 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.117TyrAla: 2.117 ± 0.066
0.444TyrCys: 0.444 ± 0.024
1.629TyrAsp: 1.629 ± 0.06
2.008TyrGlu: 2.008 ± 0.059
1.364TyrPhe: 1.364 ± 0.058
2.66TyrGly: 2.66 ± 0.066
0.57TyrHis: 0.57 ± 0.032
1.9TyrIle: 1.9 ± 0.064
1.343TyrLys: 1.343 ± 0.048
2.84TyrLeu: 2.84 ± 0.08
0.741TyrMet: 0.741 ± 0.035
0.998TyrAsn: 0.998 ± 0.038
1.431TyrPro: 1.431 ± 0.052
0.785TyrGln: 0.785 ± 0.036
1.602TyrArg: 1.602 ± 0.057
2.036TyrSer: 2.036 ± 0.053
1.394TyrThr: 1.394 ± 0.051
2.045TyrVal: 2.045 ± 0.056
0.392TyrTrp: 0.392 ± 0.026
0.882TyrTyr: 0.882 ± 0.043
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1872 proteins (596225 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski