Amino acid dipepetide frequency for Aureicoccus marinus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.262AlaAla: 5.262 ± 0.103
0.651AlaCys: 0.651 ± 0.03
3.878AlaAsp: 3.878 ± 0.087
5.19AlaGlu: 5.19 ± 0.088
3.614AlaPhe: 3.614 ± 0.063
5.186AlaGly: 5.186 ± 0.094
1.337AlaHis: 1.337 ± 0.045
4.525AlaIle: 4.525 ± 0.087
4.023AlaLys: 4.023 ± 0.084
8.005AlaLeu: 8.005 ± 0.115
1.66AlaMet: 1.66 ± 0.051
2.892AlaAsn: 2.892 ± 0.071
2.511AlaPro: 2.511 ± 0.065
3.4AlaGln: 3.4 ± 0.069
2.89AlaArg: 2.89 ± 0.06
4.399AlaSer: 4.399 ± 0.077
3.37AlaThr: 3.37 ± 0.088
4.618AlaVal: 4.618 ± 0.091
0.798AlaTrp: 0.798 ± 0.032
2.662AlaTyr: 2.662 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
0.492CysAla: 0.492 ± 0.026
0.095CysCys: 0.095 ± 0.011
0.418CysAsp: 0.418 ± 0.025
0.467CysGlu: 0.467 ± 0.025
0.409CysPhe: 0.409 ± 0.025
0.59CysGly: 0.59 ± 0.03
0.163CysHis: 0.163 ± 0.017
0.473CysIle: 0.473 ± 0.026
0.323CysLys: 0.323 ± 0.021
0.777CysLeu: 0.777 ± 0.033
0.152CysMet: 0.152 ± 0.013
0.281CysAsn: 0.281 ± 0.021
0.334CysPro: 0.334 ± 0.021
0.335CysGln: 0.335 ± 0.023
0.325CysArg: 0.325 ± 0.023
0.61CysSer: 0.61 ± 0.033
0.486CysThr: 0.486 ± 0.031
0.39CysVal: 0.39 ± 0.024
0.077CysTrp: 0.077 ± 0.01
0.264CysTyr: 0.264 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
3.548AspAla: 3.548 ± 0.069
0.401AspCys: 0.401 ± 0.025
2.598AspAsp: 2.598 ± 0.077
3.406AspGlu: 3.406 ± 0.071
3.399AspPhe: 3.399 ± 0.07
4.025AspGly: 4.025 ± 0.116
1.135AspHis: 1.135 ± 0.038
3.496AspIle: 3.496 ± 0.076
3.094AspLys: 3.094 ± 0.068
5.779AspLeu: 5.779 ± 0.102
1.159AspMet: 1.159 ± 0.046
2.446AspAsn: 2.446 ± 0.069
2.456AspPro: 2.456 ± 0.07
2.682AspGln: 2.682 ± 0.062
2.69AspArg: 2.69 ± 0.057
3.465AspSer: 3.465 ± 0.068
2.559AspThr: 2.559 ± 0.064
2.987AspVal: 2.987 ± 0.067
0.886AspTrp: 0.886 ± 0.035
2.692AspTyr: 2.692 ± 0.068
0.0AspXaa: 0.0 ± 0.0
Glu
5.294GluAla: 5.294 ± 0.098
0.366GluCys: 0.366 ± 0.022
3.799GluAsp: 3.799 ± 0.068
6.883GluGlu: 6.883 ± 0.135
2.9GluPhe: 2.9 ± 0.066
4.794GluGly: 4.794 ± 0.074
1.26GluHis: 1.26 ± 0.049
4.784GluIle: 4.784 ± 0.079
4.957GluLys: 4.957 ± 0.1
7.282GluLeu: 7.282 ± 0.104
1.775GluMet: 1.775 ± 0.053
3.502GluAsn: 3.502 ± 0.065
1.947GluPro: 1.947 ± 0.048
3.161GluGln: 3.161 ± 0.072
3.263GluArg: 3.263 ± 0.065
3.755GluSer: 3.755 ± 0.071
3.159GluThr: 3.159 ± 0.065
5.294GluVal: 5.294 ± 0.09
0.843GluTrp: 0.843 ± 0.031
2.394GluTyr: 2.394 ± 0.053
0.0GluXaa: 0.0 ± 0.0
Phe
3.14PheAla: 3.14 ± 0.066
0.419PheCys: 0.419 ± 0.023
3.184PheAsp: 3.184 ± 0.065
3.458PheGlu: 3.458 ± 0.072
2.639PhePhe: 2.639 ± 0.076
3.691PheGly: 3.691 ± 0.075
0.791PheHis: 0.791 ± 0.031
2.9PheIle: 2.9 ± 0.058
2.693PheLys: 2.693 ± 0.065
4.954PheLeu: 4.954 ± 0.088
1.087PheMet: 1.087 ± 0.036
2.415PheAsn: 2.415 ± 0.055
1.871PhePro: 1.871 ± 0.052
1.911PheGln: 1.911 ± 0.054
2.196PheArg: 2.196 ± 0.057
3.689PheSer: 3.689 ± 0.064
2.7PheThr: 2.7 ± 0.079
2.993PheVal: 2.993 ± 0.068
0.681PheTrp: 0.681 ± 0.032
1.997PheTyr: 1.997 ± 0.044
0.0PheXaa: 0.0 ± 0.0
Gly
4.668GlyAla: 4.668 ± 0.089
0.66GlyCys: 0.66 ± 0.046
3.685GlyAsp: 3.685 ± 0.083
4.315GlyGlu: 4.315 ± 0.075
3.836GlyPhe: 3.836 ± 0.079
5.377GlyGly: 5.377 ± 0.13
1.396GlyHis: 1.396 ± 0.045
5.203GlyIle: 5.203 ± 0.09
4.357GlyLys: 4.357 ± 0.083
7.228GlyLeu: 7.228 ± 0.109
1.9GlyMet: 1.9 ± 0.052
3.406GlyAsn: 3.406 ± 0.087
1.898GlyPro: 1.898 ± 0.049
2.926GlyGln: 2.926 ± 0.064
2.951GlyArg: 2.951 ± 0.066
4.633GlySer: 4.633 ± 0.091
4.084GlyThr: 4.084 ± 0.119
4.832GlyVal: 4.832 ± 0.091
0.928GlyTrp: 0.928 ± 0.035
2.928GlyTyr: 2.928 ± 0.056
0.0GlyXaa: 0.0 ± 0.0
His
1.072HisAla: 1.072 ± 0.041
0.203HisCys: 0.203 ± 0.017
0.766HisAsp: 0.766 ± 0.036
0.919HisGlu: 0.919 ± 0.04
1.251HisPhe: 1.251 ± 0.04
1.199HisGly: 1.199 ± 0.04
0.502HisHis: 0.502 ± 0.029
1.233HisIle: 1.233 ± 0.038
0.981HisLys: 0.981 ± 0.038
2.241HisLeu: 2.241 ± 0.059
0.4HisMet: 0.4 ± 0.023
0.731HisAsn: 0.731 ± 0.033
1.089HisPro: 1.089 ± 0.036
0.954HisGln: 0.954 ± 0.037
0.969HisArg: 0.969 ± 0.035
1.081HisSer: 1.081 ± 0.043
0.933HisThr: 0.933 ± 0.037
0.868HisVal: 0.868 ± 0.036
0.324HisTrp: 0.324 ± 0.022
0.918HisTyr: 0.918 ± 0.034
0.0HisXaa: 0.0 ± 0.0
Ile
4.987IleAla: 4.987 ± 0.091
0.502IleCys: 0.502 ± 0.024
3.998IleAsp: 3.998 ± 0.072
4.683IleGlu: 4.683 ± 0.082
2.532IlePhe: 2.532 ± 0.056
4.556IleGly: 4.556 ± 0.085
1.254IleHis: 1.254 ± 0.036
3.579IleIle: 3.579 ± 0.087
3.547IleLys: 3.547 ± 0.084
5.922IleLeu: 5.922 ± 0.11
1.117IleMet: 1.117 ± 0.041
3.115IleAsn: 3.115 ± 0.071
2.988IlePro: 2.988 ± 0.054
2.932IleGln: 2.932 ± 0.061
3.122IleArg: 3.122 ± 0.063
4.498IleSer: 4.498 ± 0.083
3.609IleThr: 3.609 ± 0.078
3.58IleVal: 3.58 ± 0.083
0.694IleTrp: 0.694 ± 0.029
2.252IleTyr: 2.252 ± 0.058
0.0IleXaa: 0.0 ± 0.0
Lys
4.804LysAla: 4.804 ± 0.105
0.216LysCys: 0.216 ± 0.016
3.339LysAsp: 3.339 ± 0.072
5.587LysGlu: 5.587 ± 0.108
1.815LysPhe: 1.815 ± 0.05
4.207LysGly: 4.207 ± 0.08
1.045LysHis: 1.045 ± 0.033
3.643LysIle: 3.643 ± 0.083
5.169LysLys: 5.169 ± 0.105
5.007LysLeu: 5.007 ± 0.1
1.584LysMet: 1.584 ± 0.048
3.187LysAsn: 3.187 ± 0.069
2.115LysPro: 2.115 ± 0.049
2.391LysGln: 2.391 ± 0.064
3.279LysArg: 3.279 ± 0.071
3.784LysSer: 3.784 ± 0.075
3.555LysThr: 3.555 ± 0.067
3.735LysVal: 3.735 ± 0.074
0.736LysTrp: 0.736 ± 0.035
1.986LysTyr: 1.986 ± 0.058
0.0LysXaa: 0.0 ± 0.0
Leu
7.266LeuAla: 7.266 ± 0.109
0.784LeuCys: 0.784 ± 0.029
5.793LeuAsp: 5.793 ± 0.094
7.182LeuGlu: 7.182 ± 0.115
5.21LeuPhe: 5.21 ± 0.095
7.129LeuGly: 7.129 ± 0.123
1.84LeuHis: 1.84 ± 0.05
6.365LeuIle: 6.365 ± 0.093
6.485LeuLys: 6.485 ± 0.108
10.905LeuLeu: 10.905 ± 0.17
2.204LeuMet: 2.204 ± 0.057
4.827LeuAsn: 4.827 ± 0.084
4.359LeuPro: 4.359 ± 0.073
4.233LeuGln: 4.233 ± 0.079
4.524LeuArg: 4.524 ± 0.086
7.133LeuSer: 7.133 ± 0.102
4.94LeuThr: 4.94 ± 0.092
6.474LeuVal: 6.474 ± 0.092
1.119LeuTrp: 1.119 ± 0.039
3.453LeuTyr: 3.453 ± 0.074
0.0LeuXaa: 0.0 ± 0.0
Met
1.902MetAla: 1.902 ± 0.056
0.115MetCys: 0.115 ± 0.012
1.311MetAsp: 1.311 ± 0.038
1.713MetGlu: 1.713 ± 0.04
0.659MetPhe: 0.659 ± 0.033
1.715MetGly: 1.715 ± 0.052
0.414MetHis: 0.414 ± 0.022
1.317MetIle: 1.317 ± 0.04
1.971MetLys: 1.971 ± 0.054
1.972MetLeu: 1.972 ± 0.056
0.565MetMet: 0.565 ± 0.031
1.186MetAsn: 1.186 ± 0.039
0.936MetPro: 0.936 ± 0.032
0.87MetGln: 0.87 ± 0.031
1.093MetArg: 1.093 ± 0.035
1.497MetSer: 1.497 ± 0.043
1.174MetThr: 1.174 ± 0.036
1.392MetVal: 1.392 ± 0.047
0.191MetTrp: 0.191 ± 0.018
0.636MetTyr: 0.636 ± 0.028
0.0MetXaa: 0.0 ± 0.0
Asn
3.227AsnAla: 3.227 ± 0.074
0.421AsnCys: 0.421 ± 0.029
2.307AsnAsp: 2.307 ± 0.068
2.716AsnGlu: 2.716 ± 0.058
2.298AsnPhe: 2.298 ± 0.061
3.595AsnGly: 3.595 ± 0.103
0.891AsnHis: 0.891 ± 0.034
2.828AsnIle: 2.828 ± 0.055
2.589AsnLys: 2.589 ± 0.074
4.376AsnLeu: 4.376 ± 0.088
1.043AsnMet: 1.043 ± 0.037
2.372AsnAsn: 2.372 ± 0.069
2.786AsnPro: 2.786 ± 0.07
2.171AsnGln: 2.171 ± 0.06
2.518AsnArg: 2.518 ± 0.062
3.181AsnSer: 3.181 ± 0.072
2.904AsnThr: 2.904 ± 0.068
2.333AsnVal: 2.333 ± 0.062
0.732AsnTrp: 0.732 ± 0.035
2.073AsnTyr: 2.073 ± 0.055
0.0AsnXaa: 0.0 ± 0.0
Pro
2.741ProAla: 2.741 ± 0.07
0.228ProCys: 0.228 ± 0.016
2.481ProAsp: 2.481 ± 0.059
3.469ProGlu: 3.469 ± 0.065
2.002ProPhe: 2.002 ± 0.047
2.651ProGly: 2.651 ± 0.066
0.755ProHis: 0.755 ± 0.035
2.378ProIle: 2.378 ± 0.054
2.302ProLys: 2.302 ± 0.058
3.967ProLeu: 3.967 ± 0.076
0.892ProMet: 0.892 ± 0.035
2.001ProAsn: 2.001 ± 0.047
1.17ProPro: 1.17 ± 0.042
1.607ProGln: 1.607 ± 0.05
1.311ProArg: 1.311 ± 0.043
2.456ProSer: 2.456 ± 0.062
1.972ProThr: 1.972 ± 0.054
2.79ProVal: 2.79 ± 0.059
0.463ProTrp: 0.463 ± 0.025
1.569ProTyr: 1.569 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
3.193GlnAla: 3.193 ± 0.066
0.246GlnCys: 0.246 ± 0.018
2.136GlnAsp: 2.136 ± 0.051
3.337GlnGlu: 3.337 ± 0.057
1.952GlnPhe: 1.952 ± 0.049
2.988GlnGly: 2.988 ± 0.066
0.73GlnHis: 0.73 ± 0.03
2.7GlnIle: 2.7 ± 0.06
2.909GlnLys: 2.909 ± 0.075
4.536GlnLeu: 4.536 ± 0.084
1.115GlnMet: 1.115 ± 0.037
2.07GlnAsn: 2.07 ± 0.049
1.427GlnPro: 1.427 ± 0.042
1.95GlnGln: 1.95 ± 0.058
1.85GlnArg: 1.85 ± 0.054
2.486GlnSer: 2.486 ± 0.059
2.004GlnThr: 2.004 ± 0.046
2.784GlnVal: 2.784 ± 0.059
0.696GlnTrp: 0.696 ± 0.032
1.489GlnTyr: 1.489 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
2.891ArgAla: 2.891 ± 0.066
0.268ArgCys: 0.268 ± 0.02
2.296ArgAsp: 2.296 ± 0.057
3.088ArgGlu: 3.088 ± 0.064
2.614ArgPhe: 2.614 ± 0.054
2.696ArgGly: 2.696 ± 0.059
0.823ArgHis: 0.823 ± 0.032
3.507ArgIle: 3.507 ± 0.065
3.052ArgLys: 3.052 ± 0.068
5.013ArgLeu: 5.013 ± 0.083
1.224ArgMet: 1.224 ± 0.043
2.154ArgAsn: 2.154 ± 0.054
1.596ArgPro: 1.596 ± 0.045
1.729ArgGln: 1.729 ± 0.052
2.064ArgArg: 2.064 ± 0.056
2.805ArgSer: 2.805 ± 0.057
2.206ArgThr: 2.206 ± 0.043
2.846ArgVal: 2.846 ± 0.064
0.633ArgTrp: 0.633 ± 0.03
2.078ArgTyr: 2.078 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
4.501SerAla: 4.501 ± 0.08
0.658SerCys: 0.658 ± 0.04
3.32SerAsp: 3.32 ± 0.063
4.075SerGlu: 4.075 ± 0.075
3.565SerPhe: 3.565 ± 0.064
5.113SerGly: 5.113 ± 0.111
1.059SerHis: 1.059 ± 0.036
4.257SerIle: 4.257 ± 0.08
3.711SerLys: 3.711 ± 0.078
6.894SerLeu: 6.894 ± 0.09
1.404SerMet: 1.404 ± 0.035
2.912SerAsn: 2.912 ± 0.08
2.696SerPro: 2.696 ± 0.067
2.372SerGln: 2.372 ± 0.057
2.892SerArg: 2.892 ± 0.063
4.546SerSer: 4.546 ± 0.093
3.699SerThr: 3.699 ± 0.079
3.884SerVal: 3.884 ± 0.07
0.849SerTrp: 0.849 ± 0.037
2.507SerTyr: 2.507 ± 0.062
0.0SerXaa: 0.0 ± 0.0
Thr
4.109ThrAla: 4.109 ± 0.109
0.308ThrCys: 0.308 ± 0.022
3.139ThrAsp: 3.139 ± 0.083
3.458ThrGlu: 3.458 ± 0.068
2.456ThrPhe: 2.456 ± 0.068
4.058ThrGly: 4.058 ± 0.085
1.042ThrHis: 1.042 ± 0.04
3.236ThrIle: 3.236 ± 0.074
2.517ThrLys: 2.517 ± 0.057
5.497ThrLeu: 5.497 ± 0.1
0.888ThrMet: 0.888 ± 0.035
2.332ThrAsn: 2.332 ± 0.075
2.46ThrPro: 2.46 ± 0.065
2.112ThrGln: 2.112 ± 0.049
2.134ThrArg: 2.134 ± 0.057
3.263ThrSer: 3.263 ± 0.074
3.101ThrThr: 3.101 ± 0.094
3.593ThrVal: 3.593 ± 0.108
0.553ThrTrp: 0.553 ± 0.029
2.224ThrTyr: 2.224 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
4.285ValAla: 4.285 ± 0.074
0.504ValCys: 0.504 ± 0.025
3.635ValAsp: 3.635 ± 0.084
4.378ValGlu: 4.378 ± 0.07
3.393ValPhe: 3.393 ± 0.073
4.031ValGly: 4.031 ± 0.07
1.179ValHis: 1.179 ± 0.04
4.191ValIle: 4.191 ± 0.086
3.477ValLys: 3.477 ± 0.074
6.734ValLeu: 6.734 ± 0.112
1.391ValMet: 1.391 ± 0.042
2.999ValAsn: 2.999 ± 0.065
2.463ValPro: 2.463 ± 0.049
2.47ValGln: 2.47 ± 0.057
2.742ValArg: 2.742 ± 0.063
4.219ValSer: 4.219 ± 0.085
3.035ValThr: 3.035 ± 0.095
4.726ValVal: 4.726 ± 0.093
0.727ValTrp: 0.727 ± 0.032
2.462ValTyr: 2.462 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
0.868TrpAla: 0.868 ± 0.034
0.086TrpCys: 0.086 ± 0.011
0.684TrpAsp: 0.684 ± 0.03
0.869TrpGlu: 0.869 ± 0.032
0.607TrpPhe: 0.607 ± 0.031
0.909TrpGly: 0.909 ± 0.033
0.248TrpHis: 0.248 ± 0.018
0.813TrpIle: 0.813 ± 0.035
0.892TrpLys: 0.892 ± 0.037
1.129TrpLeu: 1.129 ± 0.039
0.366TrpMet: 0.366 ± 0.021
0.672TrpAsn: 0.672 ± 0.025
0.43TrpPro: 0.43 ± 0.025
0.511TrpGln: 0.511 ± 0.027
0.544TrpArg: 0.544 ± 0.027
0.814TrpSer: 0.814 ± 0.032
0.675TrpThr: 0.675 ± 0.031
0.882TrpVal: 0.882 ± 0.033
0.154TrpTrp: 0.154 ± 0.015
0.493TrpTyr: 0.493 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.621TyrAla: 2.621 ± 0.055
0.33TyrCys: 0.33 ± 0.02
2.139TyrAsp: 2.139 ± 0.057
2.222TyrGlu: 2.222 ± 0.057
2.26TyrPhe: 2.26 ± 0.053
2.699TyrGly: 2.699 ± 0.058
0.767TyrHis: 0.767 ± 0.03
2.042TyrIle: 2.042 ± 0.047
2.136TyrLys: 2.136 ± 0.055
4.006TyrLeu: 4.006 ± 0.078
0.7TyrMet: 0.7 ± 0.029
1.86TyrAsn: 1.86 ± 0.051
1.673TyrPro: 1.673 ± 0.048
1.88TyrGln: 1.88 ± 0.053
2.226TyrArg: 2.226 ± 0.052
2.598TyrSer: 2.598 ± 0.054
2.315TyrThr: 2.315 ± 0.061
2.039TyrVal: 2.039 ± 0.054
0.564TyrTrp: 0.564 ± 0.033
1.697TyrTyr: 1.697 ± 0.045
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2543 proteins (833196 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski