Amino acid dipepetide frequency for Deinococcus irradiatisoli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.873AlaAla: 17.873 ± 0.251
0.838AlaCys: 0.838 ± 0.031
5.405AlaAsp: 5.405 ± 0.091
7.54AlaGlu: 7.54 ± 0.117
3.865AlaPhe: 3.865 ± 0.072
10.985AlaGly: 10.985 ± 0.131
2.414AlaHis: 2.414 ± 0.053
3.346AlaIle: 3.346 ± 0.076
2.68AlaLys: 2.68 ± 0.077
16.77AlaLeu: 16.77 ± 0.19
2.168AlaMet: 2.168 ± 0.047
2.28AlaAsn: 2.28 ± 0.058
6.454AlaPro: 6.454 ± 0.128
6.396AlaGln: 6.396 ± 0.124
9.065AlaArg: 9.065 ± 0.12
6.281AlaSer: 6.281 ± 0.104
5.046AlaThr: 5.046 ± 0.088
8.556AlaVal: 8.556 ± 0.102
1.665AlaTrp: 1.665 ± 0.052
2.951AlaTyr: 2.951 ± 0.06
0.0AlaXaa: 0.0 ± 0.0
Cys
0.698CysAla: 0.698 ± 0.031
0.062CysCys: 0.062 ± 0.009
0.295CysAsp: 0.295 ± 0.018
0.261CysGlu: 0.261 ± 0.017
0.165CysPhe: 0.165 ± 0.012
0.666CysGly: 0.666 ± 0.029
0.122CysHis: 0.122 ± 0.011
0.184CysIle: 0.184 ± 0.015
0.119CysLys: 0.119 ± 0.011
0.526CysLeu: 0.526 ± 0.025
0.07CysMet: 0.07 ± 0.009
0.133CysAsn: 0.133 ± 0.013
0.356CysPro: 0.356 ± 0.021
0.213CysGln: 0.213 ± 0.014
0.385CysArg: 0.385 ± 0.023
0.323CysSer: 0.323 ± 0.021
0.345CysThr: 0.345 ± 0.022
0.421CysVal: 0.421 ± 0.024
0.088CysTrp: 0.088 ± 0.01
0.115CysTyr: 0.115 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
6.122AspAla: 6.122 ± 0.093
0.186AspCys: 0.186 ± 0.014
2.442AspAsp: 2.442 ± 0.054
2.952AspGlu: 2.952 ± 0.056
1.931AspPhe: 1.931 ± 0.05
3.829AspGly: 3.829 ± 0.077
1.065AspHis: 1.065 ± 0.041
1.951AspIle: 1.951 ± 0.055
1.443AspLys: 1.443 ± 0.05
6.587AspLeu: 6.587 ± 0.102
0.837AspMet: 0.837 ± 0.033
1.123AspAsn: 1.123 ± 0.041
3.22AspPro: 3.22 ± 0.066
1.748AspGln: 1.748 ± 0.044
2.548AspArg: 2.548 ± 0.051
2.029AspSer: 2.029 ± 0.05
2.633AspThr: 2.633 ± 0.059
4.201AspVal: 4.201 ± 0.074
0.754AspTrp: 0.754 ± 0.029
1.273AspTyr: 1.273 ± 0.044
0.0AspXaa: 0.0 ± 0.0
Glu
7.633GluAla: 7.633 ± 0.12
0.229GluCys: 0.229 ± 0.018
2.5GluAsp: 2.5 ± 0.058
3.064GluGlu: 3.064 ± 0.074
1.631GluPhe: 1.631 ± 0.042
4.463GluGly: 4.463 ± 0.079
1.358GluHis: 1.358 ± 0.044
2.165GluIle: 2.165 ± 0.053
1.658GluLys: 1.658 ± 0.045
6.783GluLeu: 6.783 ± 0.104
1.055GluMet: 1.055 ± 0.035
1.274GluAsn: 1.274 ± 0.04
2.243GluPro: 2.243 ± 0.053
2.81GluGln: 2.81 ± 0.061
5.47GluArg: 5.47 ± 0.105
2.329GluSer: 2.329 ± 0.054
2.521GluThr: 2.521 ± 0.055
5.09GluVal: 5.09 ± 0.09
0.785GluTrp: 0.785 ± 0.034
1.273GluTyr: 1.273 ± 0.037
0.0GluXaa: 0.0 ± 0.0
Phe
3.473PheAla: 3.473 ± 0.065
0.18PheCys: 0.18 ± 0.015
1.899PheAsp: 1.899 ± 0.051
1.986PheGlu: 1.986 ± 0.051
1.046PhePhe: 1.046 ± 0.037
3.263PheGly: 3.263 ± 0.065
0.61PheHis: 0.61 ± 0.027
1.151PheIle: 1.151 ± 0.041
1.036PheLys: 1.036 ± 0.035
3.135PheLeu: 3.135 ± 0.065
0.592PheMet: 0.592 ± 0.024
0.909PheAsn: 0.909 ± 0.036
1.631PhePro: 1.631 ± 0.038
1.148PheGln: 1.148 ± 0.04
1.725PheArg: 1.725 ± 0.043
2.257PheSer: 2.257 ± 0.057
2.106PheThr: 2.106 ± 0.051
2.423PheVal: 2.423 ± 0.053
0.475PheTrp: 0.475 ± 0.028
0.851PheTyr: 0.851 ± 0.035
0.0PheXaa: 0.0 ± 0.0
Gly
9.736GlyAla: 9.736 ± 0.133
0.54GlyCys: 0.54 ± 0.023
4.149GlyAsp: 4.149 ± 0.069
5.939GlyGlu: 5.939 ± 0.097
2.978GlyPhe: 2.978 ± 0.057
8.455GlyGly: 8.455 ± 0.121
1.898GlyHis: 1.898 ± 0.057
3.138GlyIle: 3.138 ± 0.069
3.128GlyLys: 3.128 ± 0.064
10.355GlyLeu: 10.355 ± 0.137
1.779GlyMet: 1.779 ± 0.049
2.33GlyAsn: 2.33 ± 0.061
3.679GlyPro: 3.679 ± 0.08
4.463GlyGln: 4.463 ± 0.118
5.944GlyArg: 5.944 ± 0.087
5.142GlySer: 5.142 ± 0.094
4.761GlyThr: 4.761 ± 0.091
7.533GlyVal: 7.533 ± 0.099
1.532GlyTrp: 1.532 ± 0.044
2.337GlyTyr: 2.337 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
2.423HisAla: 2.423 ± 0.06
0.139HisCys: 0.139 ± 0.013
1.148HisAsp: 1.148 ± 0.041
0.989HisGlu: 0.989 ± 0.038
0.803HisPhe: 0.803 ± 0.03
1.779HisGly: 1.779 ± 0.052
0.675HisHis: 0.675 ± 0.034
0.734HisIle: 0.734 ± 0.033
0.434HisLys: 0.434 ± 0.021
2.832HisLeu: 2.832 ± 0.059
0.302HisMet: 0.302 ± 0.022
0.496HisAsn: 0.496 ± 0.024
1.617HisPro: 1.617 ± 0.051
0.793HisGln: 0.793 ± 0.037
1.291HisArg: 1.291 ± 0.043
1.001HisSer: 1.001 ± 0.033
1.152HisThr: 1.152 ± 0.041
1.309HisVal: 1.309 ± 0.037
0.327HisTrp: 0.327 ± 0.017
0.579HisTyr: 0.579 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
3.878IleAla: 3.878 ± 0.07
0.236IleCys: 0.236 ± 0.018
2.037IleAsp: 2.037 ± 0.049
2.428IleGlu: 2.428 ± 0.066
1.149IlePhe: 1.149 ± 0.042
3.629IleGly: 3.629 ± 0.072
0.746IleHis: 0.746 ± 0.027
1.502IleIle: 1.502 ± 0.052
1.245IleLys: 1.245 ± 0.05
3.205IleLeu: 3.205 ± 0.065
0.615IleMet: 0.615 ± 0.028
1.131IleAsn: 1.131 ± 0.041
1.756IlePro: 1.756 ± 0.05
1.312IleGln: 1.312 ± 0.043
2.191IleArg: 2.191 ± 0.053
2.292IleSer: 2.292 ± 0.048
2.359IleThr: 2.359 ± 0.058
2.932IleVal: 2.932 ± 0.064
0.468IleTrp: 0.468 ± 0.019
0.989IleTyr: 0.989 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
3.621LysAla: 3.621 ± 0.081
0.095LysCys: 0.095 ± 0.01
1.448LysAsp: 1.448 ± 0.044
1.221LysGlu: 1.221 ± 0.05
0.847LysPhe: 0.847 ± 0.035
2.002LysGly: 2.002 ± 0.052
0.512LysHis: 0.512 ± 0.021
1.204LysIle: 1.204 ± 0.044
1.158LysLys: 1.158 ± 0.044
3.448LysLeu: 3.448 ± 0.06
0.719LysMet: 0.719 ± 0.03
0.953LysAsn: 0.953 ± 0.042
1.619LysPro: 1.619 ± 0.045
0.974LysGln: 0.974 ± 0.037
1.88LysArg: 1.88 ± 0.05
1.409LysSer: 1.409 ± 0.046
1.746LysThr: 1.746 ± 0.048
2.563LysVal: 2.563 ± 0.064
0.327LysTrp: 0.327 ± 0.02
0.746LysTyr: 0.746 ± 0.029
0.0LysXaa: 0.0 ± 0.0
Leu
13.953LeuAla: 13.953 ± 0.157
0.673LeuCys: 0.673 ± 0.028
6.221LeuAsp: 6.221 ± 0.088
6.691LeuGlu: 6.691 ± 0.124
2.951LeuPhe: 2.951 ± 0.066
11.631LeuGly: 11.631 ± 0.161
2.526LeuHis: 2.526 ± 0.063
4.911LeuIle: 4.911 ± 0.101
3.893LeuLys: 3.893 ± 0.074
13.683LeuLeu: 13.683 ± 0.213
2.025LeuMet: 2.025 ± 0.049
3.289LeuAsn: 3.289 ± 0.061
7.56LeuPro: 7.56 ± 0.118
3.977LeuGln: 3.977 ± 0.093
8.516LeuArg: 8.516 ± 0.104
9.392LeuSer: 9.392 ± 0.153
7.488LeuThr: 7.488 ± 0.111
7.06LeuVal: 7.06 ± 0.107
1.473LeuTrp: 1.473 ± 0.05
2.553LeuTyr: 2.553 ± 0.051
0.0LeuXaa: 0.0 ± 0.0
Met
1.815MetAla: 1.815 ± 0.047
0.072MetCys: 0.072 ± 0.01
0.736MetAsp: 0.736 ± 0.031
0.715MetGlu: 0.715 ± 0.031
0.534MetPhe: 0.534 ± 0.026
1.429MetGly: 1.429 ± 0.046
0.375MetHis: 0.375 ± 0.024
0.755MetIle: 0.755 ± 0.03
0.734MetLys: 0.734 ± 0.028
2.206MetLeu: 2.206 ± 0.057
0.367MetMet: 0.367 ± 0.021
0.787MetAsn: 0.787 ± 0.031
1.186MetPro: 1.186 ± 0.036
0.856MetGln: 0.856 ± 0.032
1.2MetArg: 1.2 ± 0.034
1.16MetSer: 1.16 ± 0.037
1.665MetThr: 1.665 ± 0.04
1.235MetVal: 1.235 ± 0.038
0.169MetTrp: 0.169 ± 0.015
0.407MetTyr: 0.407 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.209AsnAla: 3.209 ± 0.072
0.154AsnCys: 0.154 ± 0.014
1.108AsnAsp: 1.108 ± 0.042
1.027AsnGlu: 1.027 ± 0.034
0.981AsnPhe: 0.981 ± 0.034
2.058AsnGly: 2.058 ± 0.062
0.485AsnHis: 0.485 ± 0.025
1.067AsnIle: 1.067 ± 0.041
0.789AsnLys: 0.789 ± 0.037
3.135AsnLeu: 3.135 ± 0.068
0.47AsnMet: 0.47 ± 0.024
0.72AsnAsn: 0.72 ± 0.035
1.862AsnPro: 1.862 ± 0.052
0.786AsnGln: 0.786 ± 0.03
1.35AsnArg: 1.35 ± 0.037
1.112AsnSer: 1.112 ± 0.036
1.456AsnThr: 1.456 ± 0.045
2.306AsnVal: 2.306 ± 0.055
0.375AsnTrp: 0.375 ± 0.02
0.71AsnTyr: 0.71 ± 0.032
0.0AsnXaa: 0.0 ± 0.0
Pro
7.305ProAla: 7.305 ± 0.124
0.26ProCys: 0.26 ± 0.019
3.777ProAsp: 3.777 ± 0.074
4.253ProGlu: 4.253 ± 0.084
1.673ProPhe: 1.673 ± 0.042
5.364ProGly: 5.364 ± 0.087
1.268ProHis: 1.268 ± 0.043
1.702ProIle: 1.702 ± 0.041
1.366ProLys: 1.366 ± 0.043
6.347ProLeu: 6.347 ± 0.091
1.049ProMet: 1.049 ± 0.033
1.371ProAsn: 1.371 ± 0.041
3.167ProPro: 3.167 ± 0.079
2.747ProGln: 2.747 ± 0.062
3.14ProArg: 3.14 ± 0.069
3.06ProSer: 3.06 ± 0.068
3.019ProThr: 3.019 ± 0.074
4.044ProVal: 4.044 ± 0.077
0.702ProTrp: 0.702 ± 0.031
1.353ProTyr: 1.353 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
6.352GlnAla: 6.352 ± 0.123
0.111GlnCys: 0.111 ± 0.011
2.011GlnAsp: 2.011 ± 0.047
2.047GlnGlu: 2.047 ± 0.051
1.153GlnPhe: 1.153 ± 0.039
3.768GlnGly: 3.768 ± 0.085
0.954GlnHis: 0.954 ± 0.034
1.574GlnIle: 1.574 ± 0.045
1.071GlnLys: 1.071 ± 0.037
4.86GlnLeu: 4.86 ± 0.109
0.799GlnMet: 0.799 ± 0.03
1.095GlnAsn: 1.095 ± 0.039
2.419GlnPro: 2.419 ± 0.053
2.117GlnGln: 2.117 ± 0.062
3.127GlnArg: 3.127 ± 0.072
1.929GlnSer: 1.929 ± 0.052
2.367GlnThr: 2.367 ± 0.059
3.697GlnVal: 3.697 ± 0.064
0.443GlnTrp: 0.443 ± 0.025
0.813GlnTyr: 0.813 ± 0.031
0.0GlnXaa: 0.0 ± 0.0
Arg
8.218ArgAla: 8.218 ± 0.13
0.397ArgCys: 0.397 ± 0.022
3.257ArgAsp: 3.257 ± 0.065
4.666ArgGlu: 4.666 ± 0.085
2.443ArgPhe: 2.443 ± 0.057
5.36ArgGly: 5.36 ± 0.079
1.5ArgHis: 1.5 ± 0.045
2.449ArgIle: 2.449 ± 0.052
1.631ArgLys: 1.631 ± 0.048
8.374ArgLeu: 8.374 ± 0.116
1.345ArgMet: 1.345 ± 0.038
1.439ArgAsn: 1.439 ± 0.039
4.021ArgPro: 4.021 ± 0.081
3.087ArgGln: 3.087 ± 0.074
5.805ArgArg: 5.805 ± 0.103
3.824ArgSer: 3.824 ± 0.066
3.452ArgThr: 3.452 ± 0.066
5.178ArgVal: 5.178 ± 0.098
1.087ArgTrp: 1.087 ± 0.039
1.876ArgTyr: 1.876 ± 0.051
0.0ArgXaa: 0.0 ± 0.0
Ser
7.619SerAla: 7.619 ± 0.132
0.3SerCys: 0.3 ± 0.023
2.743SerAsp: 2.743 ± 0.062
2.992SerGlu: 2.992 ± 0.064
1.851SerPhe: 1.851 ± 0.046
6.938SerGly: 6.938 ± 0.156
0.979SerHis: 0.979 ± 0.034
1.901SerIle: 1.901 ± 0.052
1.462SerLys: 1.462 ± 0.046
6.229SerLeu: 6.229 ± 0.101
1.117SerMet: 1.117 ± 0.035
1.279SerAsn: 1.279 ± 0.044
3.188SerPro: 3.188 ± 0.068
1.909SerGln: 1.909 ± 0.055
3.623SerArg: 3.623 ± 0.072
3.509SerSer: 3.509 ± 0.085
2.743SerThr: 2.743 ± 0.064
4.525SerVal: 4.525 ± 0.071
0.768SerTrp: 0.768 ± 0.031
1.27SerTyr: 1.27 ± 0.04
0.0SerXaa: 0.0 ± 0.0
Thr
6.064ThrAla: 6.064 ± 0.095
0.338ThrCys: 0.338 ± 0.024
2.484ThrAsp: 2.484 ± 0.063
2.365ThrGlu: 2.365 ± 0.054
2.191ThrPhe: 2.191 ± 0.05
4.531ThrGly: 4.531 ± 0.081
1.083ThrHis: 1.083 ± 0.037
1.795ThrIle: 1.795 ± 0.057
1.226ThrLys: 1.226 ± 0.037
8.056ThrLeu: 8.056 ± 0.13
0.785ThrMet: 0.785 ± 0.032
1.213ThrAsn: 1.213 ± 0.045
4.52ThrPro: 4.52 ± 0.091
1.978ThrGln: 1.978 ± 0.049
3.563ThrArg: 3.563 ± 0.065
3.012ThrSer: 3.012 ± 0.062
2.921ThrThr: 2.921 ± 0.083
4.59ThrVal: 4.59 ± 0.083
0.685ThrTrp: 0.685 ± 0.03
1.55ThrTyr: 1.55 ± 0.042
0.0ThrXaa: 0.0 ± 0.0
Val
8.119ValAla: 8.119 ± 0.106
0.474ValCys: 0.474 ± 0.023
3.254ValAsp: 3.254 ± 0.063
3.636ValGlu: 3.636 ± 0.074
2.386ValPhe: 2.386 ± 0.061
6.293ValGly: 6.293 ± 0.104
1.371ValHis: 1.371 ± 0.04
3.399ValIle: 3.399 ± 0.067
2.37ValLys: 2.37 ± 0.056
9.167ValLeu: 9.167 ± 0.124
1.679ValMet: 1.679 ± 0.043
2.197ValAsn: 2.197 ± 0.054
4.257ValPro: 4.257 ± 0.079
3.521ValGln: 3.521 ± 0.071
5.569ValArg: 5.569 ± 0.098
4.762ValSer: 4.762 ± 0.079
4.796ValThr: 4.796 ± 0.09
5.986ValVal: 5.986 ± 0.102
1.134ValTrp: 1.134 ± 0.036
1.881ValTyr: 1.881 ± 0.044
0.0ValXaa: 0.0 ± 0.0
Trp
1.442TrpAla: 1.442 ± 0.038
0.091TrpCys: 0.091 ± 0.01
0.627TrpAsp: 0.627 ± 0.028
0.581TrpGlu: 0.581 ± 0.029
0.401TrpPhe: 0.401 ± 0.021
0.971TrpGly: 0.971 ± 0.037
0.322TrpHis: 0.322 ± 0.019
0.425TrpIle: 0.425 ± 0.025
0.409TrpLys: 0.409 ± 0.022
1.838TrpLeu: 1.838 ± 0.052
0.308TrpMet: 0.308 ± 0.019
0.535TrpAsn: 0.535 ± 0.023
0.848TrpPro: 0.848 ± 0.037
0.856TrpGln: 0.856 ± 0.032
1.088TrpArg: 1.088 ± 0.035
0.788TrpSer: 0.788 ± 0.03
0.876TrpThr: 0.876 ± 0.034
0.962TrpVal: 0.962 ± 0.031
0.273TrpTrp: 0.273 ± 0.021
0.243TrpTyr: 0.243 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.029TyrAla: 3.029 ± 0.062
0.171TyrCys: 0.171 ± 0.017
1.332TyrAsp: 1.332 ± 0.04
0.98TyrGlu: 0.98 ± 0.035
0.913TyrPhe: 0.913 ± 0.037
2.402TyrGly: 2.402 ± 0.052
0.561TyrHis: 0.561 ± 0.025
0.748TyrIle: 0.748 ± 0.029
0.641TyrLys: 0.641 ± 0.027
2.927TyrLeu: 2.927 ± 0.066
0.319TyrMet: 0.319 ± 0.018
0.605TyrAsn: 0.605 ± 0.029
1.366TyrPro: 1.366 ± 0.042
1.017TyrGln: 1.017 ± 0.032
1.931TyrArg: 1.931 ± 0.045
1.332TyrSer: 1.332 ± 0.041
1.498TyrThr: 1.498 ± 0.044
1.64TyrVal: 1.64 ± 0.043
0.358TyrTrp: 0.358 ± 0.02
0.624TyrTyr: 0.624 ± 0.026
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2903 proteins (896936 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski