Amino acid dipepetide frequency for Muribaculaceae bacterium Isolate-114 (HZI)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.913AlaAla: 6.913 ± 0.121	0.904AlaCys: 0.904 ± 0.027	4.992AlaAsp: 4.992 ± 0.087	5.116AlaGlu: 5.116 ± 0.084	3.073AlaPhe: 3.073 ± 0.061	5.853AlaGly: 5.853 ± 0.082	1.186AlaHis: 1.186 ± 0.037	4.929AlaIle: 4.929 ± 0.077	4.24AlaLys: 4.24 ± 0.085	6.761AlaLeu: 6.761 ± 0.094	2.228AlaMet: 2.228 ± 0.05	3.167AlaAsn: 3.167 ± 0.058	2.625AlaPro: 2.625 ± 0.055	2.17AlaGln: 2.17 ± 0.049	3.69AlaArg: 3.69 ± 0.067	5.092AlaSer: 5.092 ± 0.071	4.066AlaThr: 4.066 ± 0.067	5.497AlaVal: 5.497 ± 0.088	0.89AlaTrp: 0.89 ± 0.033	2.722AlaTyr: 2.722 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	0.879CysAla: 0.879 ± 0.033	0.194CysCys: 0.194 ± 0.016	0.774CysAsp: 0.774 ± 0.028	0.7CysGlu: 0.7 ± 0.026	0.611CysPhe: 0.611 ± 0.026	1.144CysGly: 1.144 ± 0.036	0.313CysHis: 0.313 ± 0.02	0.727CysIle: 0.727 ± 0.031	0.603CysLys: 0.603 ± 0.022	1.03CysLeu: 1.03 ± 0.033	0.319CysMet: 0.319 ± 0.017	0.55CysAsn: 0.55 ± 0.024	0.481CysPro: 0.481 ± 0.02	0.29CysGln: 0.29 ± 0.016	0.81CysArg: 0.81 ± 0.031	0.833CysSer: 0.833 ± 0.03	0.525CysThr: 0.525 ± 0.024	0.893CysVal: 0.893 ± 0.028	0.154CysTrp: 0.154 ± 0.011	0.488CysTyr: 0.488 ± 0.027	0.0CysXaa: 0.0 ± 0.0
Asp	4.522AspAla: 4.522 ± 0.068	0.72AspCys: 0.72 ± 0.029	3.033AspAsp: 3.033 ± 0.071	3.773AspGlu: 3.773 ± 0.07	3.336AspPhe: 3.336 ± 0.061	4.672AspGly: 4.672 ± 0.084	0.872AspHis: 0.872 ± 0.029	4.714AspIle: 4.714 ± 0.083	3.814AspLys: 3.814 ± 0.058	4.768AspLeu: 4.768 ± 0.072	1.928AspMet: 1.928 ± 0.048	3.269AspAsn: 3.269 ± 0.069	2.294AspPro: 2.294 ± 0.056	1.099AspGln: 1.099 ± 0.033	3.162AspArg: 3.162 ± 0.061	4.056AspSer: 4.056 ± 0.068	3.048AspThr: 3.048 ± 0.061	3.772AspVal: 3.772 ± 0.062	0.888AspTrp: 0.888 ± 0.033	2.95AspTyr: 2.95 ± 0.068	0.0AspXaa: 0.0 ± 0.0
Glu	4.828GluAla: 4.828 ± 0.083	0.725GluCys: 0.725 ± 0.034	3.587GluAsp: 3.587 ± 0.061	4.655GluGlu: 4.655 ± 0.095	2.601GluPhe: 2.601 ± 0.053	4.2GluGly: 4.2 ± 0.08	1.085GluHis: 1.085 ± 0.031	5.079GluIle: 5.079 ± 0.077	4.748GluLys: 4.748 ± 0.081	5.614GluLeu: 5.614 ± 0.098	1.976GluMet: 1.976 ± 0.043	3.625GluAsn: 3.625 ± 0.05	1.894GluPro: 1.894 ± 0.043	1.917GluGln: 1.917 ± 0.047	3.415GluArg: 3.415 ± 0.07	3.673GluSer: 3.673 ± 0.056	3.441GluThr: 3.441 ± 0.07	3.93GluVal: 3.93 ± 0.061	0.913GluTrp: 0.913 ± 0.03	2.71GluTyr: 2.71 ± 0.055	0.0GluXaa: 0.0 ± 0.0
Phe	3.148PheAla: 3.148 ± 0.059	0.631PheCys: 0.631 ± 0.026	3.015PheAsp: 3.015 ± 0.051	2.432PheGlu: 2.432 ± 0.045	1.932PhePhe: 1.932 ± 0.046	3.386PheGly: 3.386 ± 0.064	0.814PheHis: 0.814 ± 0.026	2.934PheIle: 2.934 ± 0.057	2.362PheLys: 2.362 ± 0.052	3.585PheLeu: 3.585 ± 0.059	1.298PheMet: 1.298 ± 0.036	2.538PheAsn: 2.538 ± 0.056	1.766PhePro: 1.766 ± 0.043	0.992PheGln: 0.992 ± 0.034	2.436PheArg: 2.436 ± 0.05	3.386PheSer: 3.386 ± 0.066	2.651PheThr: 2.651 ± 0.06	2.605PheVal: 2.605 ± 0.047	0.555PheTrp: 0.555 ± 0.025	1.63PheTyr: 1.63 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	4.99GlyAla: 4.99 ± 0.072	1.041GlyCys: 1.041 ± 0.034	4.057GlyAsp: 4.057 ± 0.079	4.494GlyGlu: 4.494 ± 0.07	3.397GlyPhe: 3.397 ± 0.065	5.016GlyGly: 5.016 ± 0.097	1.322GlyHis: 1.322 ± 0.042	5.486GlyIle: 5.486 ± 0.084	5.184GlyLys: 5.184 ± 0.078	5.426GlyLeu: 5.426 ± 0.093	2.17GlyMet: 2.17 ± 0.054	3.93GlyAsn: 3.93 ± 0.075	1.411GlyPro: 1.411 ± 0.04	1.76GlyGln: 1.76 ± 0.045	3.372GlyArg: 3.372 ± 0.066	4.479GlySer: 4.479 ± 0.084	4.107GlyThr: 4.107 ± 0.076	4.997GlyVal: 4.997 ± 0.076	1.098GlyTrp: 1.098 ± 0.034	3.451GlyTyr: 3.451 ± 0.066	0.0GlyXaa: 0.0 ± 0.0
His	1.191HisAla: 1.191 ± 0.036	0.257HisCys: 0.257 ± 0.017	1.121HisAsp: 1.121 ± 0.03	1.008HisGlu: 1.008 ± 0.038	0.845HisPhe: 0.845 ± 0.032	1.25HisGly: 1.25 ± 0.038	0.446HisHis: 0.446 ± 0.023	1.345HisIle: 1.345 ± 0.042	0.998HisLys: 0.998 ± 0.037	1.598HisLeu: 1.598 ± 0.041	0.352HisMet: 0.352 ± 0.017	0.948HisAsn: 0.948 ± 0.034	0.981HisPro: 0.981 ± 0.038	0.441HisGln: 0.441 ± 0.021	1.018HisArg: 1.018 ± 0.035	1.161HisSer: 1.161 ± 0.034	0.977HisThr: 0.977 ± 0.034	0.991HisVal: 0.991 ± 0.031	0.231HisTrp: 0.231 ± 0.017	0.765HisTyr: 0.765 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.415IleAla: 5.415 ± 0.08	0.963IleCys: 0.963 ± 0.03	4.526IleAsp: 4.526 ± 0.074	4.594IleGlu: 4.594 ± 0.082	2.824IlePhe: 2.824 ± 0.051	4.763IleGly: 4.763 ± 0.078	1.137IleHis: 1.137 ± 0.04	4.513IleIle: 4.513 ± 0.077	3.929IleLys: 3.929 ± 0.061	5.471IleLeu: 5.471 ± 0.084	1.62IleMet: 1.62 ± 0.039	3.234IleAsn: 3.234 ± 0.058	3.275IlePro: 3.275 ± 0.061	1.567IleGln: 1.567 ± 0.045	3.708IleArg: 3.708 ± 0.063	5.006IleSer: 5.006 ± 0.073	3.79IleThr: 3.79 ± 0.066	4.361IleVal: 4.361 ± 0.077	0.722IleTrp: 0.722 ± 0.028	2.583IleTyr: 2.583 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	4.612LysAla: 4.612 ± 0.068	0.582LysCys: 0.582 ± 0.025	3.744LysAsp: 3.744 ± 0.069	4.787LysGlu: 4.787 ± 0.094	2.304LysPhe: 2.304 ± 0.049	4.358LysGly: 4.358 ± 0.062	0.996LysHis: 0.996 ± 0.03	4.221LysIle: 4.221 ± 0.07	4.343LysLys: 4.343 ± 0.083	4.641LysLeu: 4.641 ± 0.076	1.911LysMet: 1.911 ± 0.046	3.113LysAsn: 3.113 ± 0.052	2.203LysPro: 2.203 ± 0.054	1.623LysGln: 1.623 ± 0.046	3.027LysArg: 3.027 ± 0.055	3.617LysSer: 3.617 ± 0.058	3.498LysThr: 3.498 ± 0.061	3.979LysVal: 3.979 ± 0.064	0.823LysTrp: 0.823 ± 0.028	2.616LysTyr: 2.616 ± 0.057	0.0LysXaa: 0.0 ± 0.0
Leu	6.549LeuAla: 6.549 ± 0.096	1.213LeuCys: 1.213 ± 0.037	5.025LeuAsp: 5.025 ± 0.077	4.856LeuGlu: 4.856 ± 0.07	3.66LeuPhe: 3.66 ± 0.063	5.559LeuGly: 5.559 ± 0.081	1.586LeuHis: 1.586 ± 0.04	5.04LeuIle: 5.04 ± 0.082	5.424LeuLys: 5.424 ± 0.084	7.351LeuLeu: 7.351 ± 0.114	2.389LeuMet: 2.389 ± 0.048	4.215LeuAsn: 4.215 ± 0.071	4.094LeuPro: 4.094 ± 0.075	2.475LeuGln: 2.475 ± 0.052	5.01LeuArg: 5.01 ± 0.076	6.631LeuSer: 6.631 ± 0.094	5.158LeuThr: 5.158 ± 0.077	4.893LeuVal: 4.893 ± 0.077	0.937LeuTrp: 0.937 ± 0.029	3.211LeuTyr: 3.211 ± 0.064	0.0LeuXaa: 0.0 ± 0.0
Met	2.378MetAla: 2.378 ± 0.049	0.292MetCys: 0.292 ± 0.016	1.37MetAsp: 1.37 ± 0.038	1.795MetGlu: 1.795 ± 0.039	0.994MetPhe: 0.994 ± 0.037	1.728MetGly: 1.728 ± 0.042	0.515MetHis: 0.515 ± 0.021	1.74MetIle: 1.74 ± 0.042	2.271MetLys: 2.271 ± 0.049	2.562MetLeu: 2.562 ± 0.056	0.839MetMet: 0.839 ± 0.031	1.434MetAsn: 1.434 ± 0.044	1.342MetPro: 1.342 ± 0.04	0.939MetGln: 0.939 ± 0.031	1.583MetArg: 1.583 ± 0.036	1.9MetSer: 1.9 ± 0.045	1.801MetThr: 1.801 ± 0.039	1.61MetVal: 1.61 ± 0.043	0.306MetTrp: 0.306 ± 0.017	0.737MetTyr: 0.737 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	3.868AsnAla: 3.868 ± 0.071	0.532AsnCys: 0.532 ± 0.032	2.736AsnAsp: 2.736 ± 0.052	2.832AsnGlu: 2.832 ± 0.059	2.115AsnPhe: 2.115 ± 0.052	4.073AsnGly: 4.073 ± 0.073	0.916AsnHis: 0.916 ± 0.033	3.692AsnIle: 3.692 ± 0.07	2.631AsnLys: 2.631 ± 0.053	4.198AsnLeu: 4.198 ± 0.071	1.295AsnMet: 1.295 ± 0.037	2.523AsnAsn: 2.523 ± 0.057	2.968AsnPro: 2.968 ± 0.048	1.255AsnGln: 1.255 ± 0.039	2.687AsnArg: 2.687 ± 0.056	3.022AsnSer: 3.022 ± 0.063	2.549AsnThr: 2.549 ± 0.051	3.289AsnVal: 3.289 ± 0.063	0.65AsnTrp: 0.65 ± 0.027	2.151AsnTyr: 2.151 ± 0.058	0.0AsnXaa: 0.0 ± 0.0
Pro	3.407ProAla: 3.407 ± 0.065	0.354ProCys: 0.354 ± 0.021	3.207ProAsp: 3.207 ± 0.057	3.693ProGlu: 3.693 ± 0.063	1.786ProPhe: 1.786 ± 0.038	2.849ProGly: 2.849 ± 0.056	0.734ProHis: 0.734 ± 0.03	1.968ProIle: 1.968 ± 0.049	1.941ProLys: 1.941 ± 0.05	3.345ProLeu: 3.345 ± 0.065	1.048ProMet: 1.048 ± 0.033	1.496ProAsn: 1.496 ± 0.038	0.933ProPro: 0.933 ± 0.034	1.361ProGln: 1.361 ± 0.038	1.656ProArg: 1.656 ± 0.043	2.612ProSer: 2.612 ± 0.051	1.943ProThr: 1.943 ± 0.041	3.299ProVal: 3.299 ± 0.061	0.5ProTrp: 0.5 ± 0.026	1.678ProTyr: 1.678 ± 0.044	0.0ProXaa: 0.0 ± 0.0
Gln	1.874GlnAla: 1.874 ± 0.046	0.273GlnCys: 0.273 ± 0.015	1.31GlnAsp: 1.31 ± 0.034	1.701GlnGlu: 1.701 ± 0.044	1.101GlnPhe: 1.101 ± 0.034	1.757GlnGly: 1.757 ± 0.045	0.444GlnHis: 0.444 ± 0.022	1.881GlnIle: 1.881 ± 0.041	1.824GlnLys: 1.824 ± 0.05	2.542GlnLeu: 2.542 ± 0.055	0.897GlnMet: 0.897 ± 0.026	1.516GlnAsn: 1.516 ± 0.042	1.066GlnPro: 1.066 ± 0.038	1.07GlnGln: 1.07 ± 0.047	1.514GlnArg: 1.514 ± 0.038	1.719GlnSer: 1.719 ± 0.044	1.68GlnThr: 1.68 ± 0.046	1.575GlnVal: 1.575 ± 0.04	0.448GlnTrp: 0.448 ± 0.023	1.165GlnTyr: 1.165 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	3.194ArgAla: 3.194 ± 0.065	0.597ArgCys: 0.597 ± 0.026	2.892ArgAsp: 2.892 ± 0.061	3.533ArgGlu: 3.533 ± 0.064	2.64ArgPhe: 2.64 ± 0.055	2.854ArgGly: 2.854 ± 0.054	1.356ArgHis: 1.356 ± 0.037	4.042ArgIle: 4.042 ± 0.063	3.714ArgLys: 3.714 ± 0.067	5.183ArgLeu: 5.183 ± 0.077	1.664ArgMet: 1.664 ± 0.043	2.901ArgAsn: 2.901 ± 0.058	1.884ArgPro: 1.884 ± 0.047	1.877ArgGln: 1.877 ± 0.049	3.252ArgArg: 3.252 ± 0.069	2.775ArgSer: 2.775 ± 0.056	2.5ArgThr: 2.5 ± 0.052	2.979ArgVal: 2.979 ± 0.059	0.742ArgTrp: 0.742 ± 0.029	2.292ArgTyr: 2.292 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	5.01SerAla: 5.01 ± 0.079	0.822SerCys: 0.822 ± 0.027	4.26SerAsp: 4.26 ± 0.076	4.065SerGlu: 4.065 ± 0.071	3.216SerPhe: 3.216 ± 0.061	5.376SerGly: 5.376 ± 0.083	1.282SerHis: 1.282 ± 0.035	4.115SerIle: 4.115 ± 0.063	3.413SerLys: 3.413 ± 0.059	6.285SerLeu: 6.285 ± 0.1	1.71SerMet: 1.71 ± 0.041	2.847SerAsn: 2.847 ± 0.069	2.781SerPro: 2.781 ± 0.061	1.925SerGln: 1.925 ± 0.045	3.602SerArg: 3.602 ± 0.06	4.179SerSer: 4.179 ± 0.08	3.343SerThr: 3.343 ± 0.066	4.689SerVal: 4.689 ± 0.076	0.852SerTrp: 0.852 ± 0.032	2.681SerTyr: 2.681 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	4.474ThrAla: 4.474 ± 0.064	0.558ThrCys: 0.558 ± 0.025	3.643ThrAsp: 3.643 ± 0.068	3.29ThrGlu: 3.29 ± 0.056	2.447ThrPhe: 2.447 ± 0.052	4.551ThrGly: 4.551 ± 0.077	0.954ThrHis: 0.954 ± 0.034	3.638ThrIle: 3.638 ± 0.063	2.475ThrLys: 2.475 ± 0.052	5.251ThrLeu: 5.251 ± 0.068	1.256ThrMet: 1.256 ± 0.035	2.087ThrAsn: 2.087 ± 0.045	3.048ThrPro: 3.048 ± 0.057	1.517ThrGln: 1.517 ± 0.042	2.534ThrArg: 2.534 ± 0.054	3.406ThrSer: 3.406 ± 0.055	2.843ThrThr: 2.843 ± 0.057	4.218ThrVal: 4.218 ± 0.07	0.664ThrTrp: 0.664 ± 0.028	2.127ThrTyr: 2.127 ± 0.059	0.0ThrXaa: 0.0 ± 0.0
Val	5.261ValAla: 5.261 ± 0.08	0.873ValCys: 0.873 ± 0.031	3.888ValAsp: 3.888 ± 0.067	4.199ValGlu: 4.199 ± 0.079	2.758ValPhe: 2.758 ± 0.06	3.927ValGly: 3.927 ± 0.063	0.885ValHis: 0.885 ± 0.035	4.491ValIle: 4.491 ± 0.069	4.179ValLys: 4.179 ± 0.075	5.093ValLeu: 5.093 ± 0.083	1.861ValMet: 1.861 ± 0.051	3.449ValAsn: 3.449 ± 0.064	2.66ValPro: 2.66 ± 0.061	1.412ValGln: 1.412 ± 0.042	3.331ValArg: 3.331 ± 0.054	5.208ValSer: 5.208 ± 0.084	4.116ValThr: 4.116 ± 0.071	4.541ValVal: 4.541 ± 0.079	0.805ValTrp: 0.805 ± 0.03	2.499ValTyr: 2.499 ± 0.06	0.0ValXaa: 0.0 ± 0.0
Trp	0.741TrpAla: 0.741 ± 0.029	0.19TrpCys: 0.19 ± 0.013	0.762TrpAsp: 0.762 ± 0.032	0.81TrpGlu: 0.81 ± 0.034	0.533TrpPhe: 0.533 ± 0.022	0.994TrpGly: 0.994 ± 0.039	0.286TrpHis: 0.286 ± 0.016	0.839TrpIle: 0.839 ± 0.032	0.826TrpLys: 0.826 ± 0.025	1.213TrpLeu: 1.213 ± 0.039	0.391TrpMet: 0.391 ± 0.021	0.876TrpAsn: 0.876 ± 0.027	0.284TrpPro: 0.284 ± 0.019	0.521TrpGln: 0.521 ± 0.025	0.738TrpArg: 0.738 ± 0.028	0.814TrpSer: 0.814 ± 0.032	0.685TrpThr: 0.685 ± 0.028	0.722TrpVal: 0.722 ± 0.027	0.242TrpTrp: 0.242 ± 0.017	0.494TrpTyr: 0.494 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.859TyrAla: 2.859 ± 0.051	0.593TyrCys: 0.593 ± 0.026	2.747TyrAsp: 2.747 ± 0.055	2.283TyrGlu: 2.283 ± 0.049	1.925TyrPhe: 1.925 ± 0.051	2.878TyrGly: 2.878 ± 0.057	0.796TyrHis: 0.796 ± 0.03	2.609TyrIle: 2.609 ± 0.063	2.078TyrLys: 2.078 ± 0.05	3.361TyrLeu: 3.361 ± 0.061	0.98TyrMet: 0.98 ± 0.032	2.264TyrAsn: 2.264 ± 0.056	1.82TyrPro: 1.82 ± 0.046	1.147TyrGln: 1.147 ± 0.034	2.326TyrArg: 2.326 ± 0.052	2.884TyrSer: 2.884 ± 0.066	2.264TyrThr: 2.264 ± 0.059	2.598TyrVal: 2.598 ± 0.052	0.539TyrTrp: 0.539 ± 0.025	1.85TyrTyr: 1.85 ± 0.044	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2793 proteins (1002792 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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