Amino acid dipepetide frequency for Paenalcaligenes hominis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.509AlaAla: 11.509 ± 0.179
1.071AlaCys: 1.071 ± 0.047
5.299AlaAsp: 5.299 ± 0.095
5.997AlaGlu: 5.997 ± 0.114
3.834AlaPhe: 3.834 ± 0.083
7.209AlaGly: 7.209 ± 0.128
2.463AlaHis: 2.463 ± 0.073
5.928AlaIle: 5.928 ± 0.122
4.024AlaLys: 4.024 ± 0.102
12.886AlaLeu: 12.886 ± 0.183
2.773AlaMet: 2.773 ± 0.066
3.153AlaAsn: 3.153 ± 0.083
4.254AlaPro: 4.254 ± 0.106
6.634AlaGln: 6.634 ± 0.137
5.345AlaArg: 5.345 ± 0.101
5.408AlaSer: 5.408 ± 0.103
5.444AlaThr: 5.444 ± 0.103
7.298AlaVal: 7.298 ± 0.119
1.501AlaTrp: 1.501 ± 0.046
2.72AlaTyr: 2.72 ± 0.063
0.0AlaXaa: 0.0 ± 0.0
Cys
0.98CysAla: 0.98 ± 0.04
0.104CysCys: 0.104 ± 0.013
0.472CysAsp: 0.472 ± 0.025
0.465CysGlu: 0.465 ± 0.027
0.391CysPhe: 0.391 ± 0.027
0.791CysGly: 0.791 ± 0.037
0.286CysHis: 0.286 ± 0.024
0.511CysIle: 0.511 ± 0.029
0.28CysLys: 0.28 ± 0.023
0.955CysLeu: 0.955 ± 0.046
0.187CysMet: 0.187 ± 0.018
0.235CysAsn: 0.235 ± 0.021
0.507CysPro: 0.507 ± 0.031
0.344CysGln: 0.344 ± 0.024
0.387CysArg: 0.387 ± 0.026
0.598CysSer: 0.598 ± 0.033
0.473CysThr: 0.473 ± 0.023
0.69CysVal: 0.69 ± 0.036
0.108CysTrp: 0.108 ± 0.013
0.247CysTyr: 0.247 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
5.125AspAla: 5.125 ± 0.093
0.42AspCys: 0.42 ± 0.029
2.503AspAsp: 2.503 ± 0.072
3.284AspGlu: 3.284 ± 0.093
2.15AspPhe: 2.15 ± 0.056
3.369AspGly: 3.369 ± 0.08
1.324AspHis: 1.324 ± 0.051
2.887AspIle: 2.887 ± 0.067
1.857AspLys: 1.857 ± 0.06
5.615AspLeu: 5.615 ± 0.099
1.271AspMet: 1.271 ± 0.048
1.561AspAsn: 1.561 ± 0.045
2.645AspPro: 2.645 ± 0.065
2.662AspGln: 2.662 ± 0.067
2.45AspArg: 2.45 ± 0.059
2.639AspSer: 2.639 ± 0.059
2.826AspThr: 2.826 ± 0.072
3.686AspVal: 3.686 ± 0.089
0.857AspTrp: 0.857 ± 0.039
1.786AspTyr: 1.786 ± 0.059
0.0AspXaa: 0.0 ± 0.0
Glu
5.883GluAla: 5.883 ± 0.12
0.422GluCys: 0.422 ± 0.025
2.47GluAsp: 2.47 ± 0.068
2.673GluGlu: 2.673 ± 0.078
1.885GluPhe: 1.885 ± 0.066
3.312GluGly: 3.312 ± 0.092
1.743GluHis: 1.743 ± 0.05
3.208GluIle: 3.208 ± 0.087
2.533GluLys: 2.533 ± 0.076
6.58GluLeu: 6.58 ± 0.111
1.351GluMet: 1.351 ± 0.043
1.978GluAsn: 1.978 ± 0.056
2.476GluPro: 2.476 ± 0.073
4.019GluGln: 4.019 ± 0.092
3.774GluArg: 3.774 ± 0.085
2.849GluSer: 2.849 ± 0.068
2.74GluThr: 2.74 ± 0.08
3.953GluVal: 3.953 ± 0.083
0.78GluTrp: 0.78 ± 0.04
1.356GluTyr: 1.356 ± 0.046
0.0GluXaa: 0.0 ± 0.0
Phe
3.582PheAla: 3.582 ± 0.076
0.381PheCys: 0.381 ± 0.025
2.496PheAsp: 2.496 ± 0.071
2.271PheGlu: 2.271 ± 0.063
1.629PhePhe: 1.629 ± 0.063
2.96PheGly: 2.96 ± 0.076
0.783PheHis: 0.783 ± 0.039
2.422PheIle: 2.422 ± 0.074
1.531PheLys: 1.531 ± 0.049
3.473PheLeu: 3.473 ± 0.084
0.952PheMet: 0.952 ± 0.036
1.505PheAsn: 1.505 ± 0.047
1.447PhePro: 1.447 ± 0.049
1.248PheGln: 1.248 ± 0.05
1.367PheArg: 1.367 ± 0.045
2.687PheSer: 2.687 ± 0.073
2.205PheThr: 2.205 ± 0.065
2.66PheVal: 2.66 ± 0.067
0.593PheTrp: 0.593 ± 0.037
1.22PheTyr: 1.22 ± 0.044
0.0PheXaa: 0.0 ± 0.0
Gly
6.641GlyAla: 6.641 ± 0.114
0.778GlyCys: 0.778 ± 0.038
3.152GlyAsp: 3.152 ± 0.076
3.375GlyGlu: 3.375 ± 0.084
3.031GlyPhe: 3.031 ± 0.073
4.84GlyGly: 4.84 ± 0.127
1.642GlyHis: 1.642 ± 0.059
4.257GlyIle: 4.257 ± 0.083
2.994GlyLys: 2.994 ± 0.088
8.303GlyLeu: 8.303 ± 0.122
1.965GlyMet: 1.965 ± 0.061
1.99GlyAsn: 1.99 ± 0.058
2.351GlyPro: 2.351 ± 0.062
3.38GlyGln: 3.38 ± 0.082
3.796GlyArg: 3.796 ± 0.095
4.06GlySer: 4.06 ± 0.085
3.541GlyThr: 3.541 ± 0.079
5.782GlyVal: 5.782 ± 0.089
1.233GlyTrp: 1.233 ± 0.047
2.238GlyTyr: 2.238 ± 0.066
0.0GlyXaa: 0.0 ± 0.0
His
2.62HisAla: 2.62 ± 0.069
0.278HisCys: 0.278 ± 0.022
1.349HisAsp: 1.349 ± 0.052
1.356HisGlu: 1.356 ± 0.053
1.058HisPhe: 1.058 ± 0.043
1.743HisGly: 1.743 ± 0.06
0.985HisHis: 0.985 ± 0.048
1.596HisIle: 1.596 ± 0.047
0.819HisLys: 0.819 ± 0.039
2.786HisLeu: 2.786 ± 0.067
0.52HisMet: 0.52 ± 0.03
0.925HisAsn: 0.925 ± 0.04
1.525HisPro: 1.525 ± 0.057
1.478HisGln: 1.478 ± 0.052
1.243HisArg: 1.243 ± 0.05
1.586HisSer: 1.586 ± 0.053
1.48HisThr: 1.48 ± 0.049
1.814HisVal: 1.814 ± 0.053
0.429HisTrp: 0.429 ± 0.031
1.056HisTyr: 1.056 ± 0.048
0.0HisXaa: 0.0 ± 0.0
Ile
6.456IleAla: 6.456 ± 0.129
0.482IleCys: 0.482 ± 0.028
3.443IleAsp: 3.443 ± 0.076
3.945IleGlu: 3.945 ± 0.08
1.69IlePhe: 1.69 ± 0.061
4.368IleGly: 4.368 ± 0.105
1.387IleHis: 1.387 ± 0.044
2.852IleIle: 2.852 ± 0.071
2.256IleLys: 2.256 ± 0.067
4.736IleLeu: 4.736 ± 0.104
1.28IleMet: 1.28 ± 0.051
2.2IleAsn: 2.2 ± 0.067
2.647IlePro: 2.647 ± 0.07
2.607IleGln: 2.607 ± 0.066
2.834IleArg: 2.834 ± 0.062
3.458IleSer: 3.458 ± 0.08
3.342IleThr: 3.342 ± 0.082
3.976IleVal: 3.976 ± 0.088
0.672IleTrp: 0.672 ± 0.037
1.496IleTyr: 1.496 ± 0.052
0.0IleXaa: 0.0 ± 0.0
Lys
4.339LysAla: 4.339 ± 0.098
0.167LysCys: 0.167 ± 0.016
2.054LysAsp: 2.054 ± 0.066
2.44LysGlu: 2.44 ± 0.07
0.831LysPhe: 0.831 ± 0.041
2.67LysGly: 2.67 ± 0.069
0.992LysHis: 0.992 ± 0.035
1.909LysIle: 1.909 ± 0.061
2.132LysLys: 2.132 ± 0.071
3.322LysLeu: 3.322 ± 0.066
0.995LysMet: 0.995 ± 0.039
1.72LysAsn: 1.72 ± 0.057
2.028LysPro: 2.028 ± 0.061
2.149LysGln: 2.149 ± 0.057
2.405LysArg: 2.405 ± 0.067
2.036LysSer: 2.036 ± 0.065
2.364LysThr: 2.364 ± 0.061
2.504LysVal: 2.504 ± 0.071
0.424LysTrp: 0.424 ± 0.029
0.834LysTyr: 0.834 ± 0.038
0.0LysXaa: 0.0 ± 0.0
Leu
12.304LeuAla: 12.304 ± 0.145
1.092LeuCys: 1.092 ± 0.041
5.721LeuAsp: 5.721 ± 0.104
6.09LeuGlu: 6.09 ± 0.107
4.026LeuPhe: 4.026 ± 0.1
8.046LeuGly: 8.046 ± 0.122
2.844LeuHis: 2.844 ± 0.081
6.164LeuIle: 6.164 ± 0.113
4.087LeuLys: 4.087 ± 0.079
11.259LeuLeu: 11.259 ± 0.195
2.672LeuMet: 2.672 ± 0.069
3.882LeuAsn: 3.882 ± 0.074
5.229LeuPro: 5.229 ± 0.103
5.006LeuGln: 5.006 ± 0.117
6.467LeuArg: 6.467 ± 0.109
7.394LeuSer: 7.394 ± 0.112
6.058LeuThr: 6.058 ± 0.094
7.609LeuVal: 7.609 ± 0.121
1.313LeuTrp: 1.313 ± 0.061
2.614LeuTyr: 2.614 ± 0.076
0.0LeuXaa: 0.0 ± 0.0
Met
2.657MetAla: 2.657 ± 0.056
0.174MetCys: 0.174 ± 0.017
1.164MetAsp: 1.164 ± 0.048
1.069MetGlu: 1.069 ± 0.043
0.765MetPhe: 0.765 ± 0.038
1.683MetGly: 1.683 ± 0.061
0.589MetHis: 0.589 ± 0.033
1.167MetIle: 1.167 ± 0.049
1.013MetLys: 1.013 ± 0.041
2.491MetLeu: 2.491 ± 0.063
0.669MetMet: 0.669 ± 0.036
0.836MetAsn: 0.836 ± 0.035
1.296MetPro: 1.296 ± 0.044
1.372MetGln: 1.372 ± 0.045
1.606MetArg: 1.606 ± 0.054
1.859MetSer: 1.859 ± 0.048
1.606MetThr: 1.606 ± 0.05
1.784MetVal: 1.784 ± 0.056
0.247MetTrp: 0.247 ± 0.021
0.483MetTyr: 0.483 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
3.569AsnAla: 3.569 ± 0.083
0.291AsnCys: 0.291 ± 0.024
1.68AsnAsp: 1.68 ± 0.058
2.011AsnGlu: 2.011 ± 0.062
1.084AsnPhe: 1.084 ± 0.046
2.218AsnGly: 2.218 ± 0.073
0.851AsnHis: 0.851 ± 0.039
1.687AsnIle: 1.687 ± 0.059
1.417AsnLys: 1.417 ± 0.044
3.175AsnLeu: 3.175 ± 0.08
0.8AsnMet: 0.8 ± 0.04
1.192AsnAsn: 1.192 ± 0.052
2.18AsnPro: 2.18 ± 0.057
1.857AsnGln: 1.857 ± 0.063
1.781AsnArg: 1.781 ± 0.056
1.751AsnSer: 1.751 ± 0.057
2.029AsnThr: 2.029 ± 0.055
2.178AsnVal: 2.178 ± 0.07
0.518AsnTrp: 0.518 ± 0.029
1.114AsnTyr: 1.114 ± 0.042
0.0AsnXaa: 0.0 ± 0.0
Pro
4.539ProAla: 4.539 ± 0.095
0.326ProCys: 0.326 ± 0.026
2.763ProAsp: 2.763 ± 0.07
3.402ProGlu: 3.402 ± 0.08
1.776ProPhe: 1.776 ± 0.054
2.653ProGly: 2.653 ± 0.069
1.243ProHis: 1.243 ± 0.048
2.584ProIle: 2.584 ± 0.07
1.796ProLys: 1.796 ± 0.059
4.744ProLeu: 4.744 ± 0.089
1.132ProMet: 1.132 ± 0.037
1.818ProAsn: 1.818 ± 0.059
1.604ProPro: 1.604 ± 0.056
2.061ProGln: 2.061 ± 0.063
1.97ProArg: 1.97 ± 0.067
2.984ProSer: 2.984 ± 0.079
3.009ProThr: 3.009 ± 0.079
3.637ProVal: 3.637 ± 0.077
0.697ProTrp: 0.697 ± 0.038
1.493ProTyr: 1.493 ± 0.05
0.0ProXaa: 0.0 ± 0.0
Gln
6.298GlnAla: 6.298 ± 0.133
0.406GlnCys: 0.406 ± 0.027
2.094GlnAsp: 2.094 ± 0.064
2.264GlnGlu: 2.264 ± 0.069
1.824GlnPhe: 1.824 ± 0.058
3.37GlnGly: 3.37 ± 0.085
1.834GlnHis: 1.834 ± 0.069
2.692GlnIle: 2.692 ± 0.067
1.773GlnLys: 1.773 ± 0.063
6.421GlnLeu: 6.421 ± 0.139
1.111GlnMet: 1.111 ± 0.041
1.564GlnAsn: 1.564 ± 0.053
2.547GlnPro: 2.547 ± 0.071
3.642GlnGln: 3.642 ± 0.132
3.87GlnArg: 3.87 ± 0.09
3.029GlnSer: 3.029 ± 0.077
2.822GlnThr: 2.822 ± 0.075
3.546GlnVal: 3.546 ± 0.079
0.998GlnTrp: 0.998 ± 0.053
1.213GlnTyr: 1.213 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
4.987ArgAla: 4.987 ± 0.092
0.507ArgCys: 0.507 ± 0.028
2.584ArgAsp: 2.584 ± 0.059
2.961ArgGlu: 2.961 ± 0.079
2.442ArgPhe: 2.442 ± 0.066
3.145ArgGly: 3.145 ± 0.079
1.526ArgHis: 1.526 ± 0.051
3.625ArgIle: 3.625 ± 0.072
1.917ArgLys: 1.917 ± 0.057
6.72ArgLeu: 6.72 ± 0.132
1.352ArgMet: 1.352 ± 0.048
1.801ArgAsn: 1.801 ± 0.058
2.329ArgPro: 2.329 ± 0.074
2.93ArgGln: 2.93 ± 0.075
3.339ArgArg: 3.339 ± 0.088
3.018ArgSer: 3.018 ± 0.071
2.769ArgThr: 2.769 ± 0.057
3.89ArgVal: 3.89 ± 0.083
0.849ArgTrp: 0.849 ± 0.033
1.981ArgTyr: 1.981 ± 0.066
0.0ArgXaa: 0.0 ± 0.0
Ser
6.144SerAla: 6.144 ± 0.107
0.487SerCys: 0.487 ± 0.031
2.776SerAsp: 2.776 ± 0.077
2.791SerGlu: 2.791 ± 0.069
2.394SerPhe: 2.394 ± 0.068
4.562SerGly: 4.562 ± 0.093
1.483SerHis: 1.483 ± 0.05
3.412SerIle: 3.412 ± 0.087
2.018SerLys: 2.018 ± 0.064
6.661SerLeu: 6.661 ± 0.131
1.582SerMet: 1.582 ± 0.057
1.819SerAsn: 1.819 ± 0.061
2.688SerPro: 2.688 ± 0.068
2.932SerGln: 2.932 ± 0.084
2.907SerArg: 2.907 ± 0.067
3.89SerSer: 3.89 ± 0.101
3.518SerThr: 3.518 ± 0.086
4.305SerVal: 4.305 ± 0.097
0.876SerTrp: 0.876 ± 0.041
1.678SerTyr: 1.678 ± 0.051
0.0SerXaa: 0.0 ± 0.0
Thr
5.453ThrAla: 5.453 ± 0.11
0.392ThrCys: 0.392 ± 0.026
2.893ThrAsp: 2.893 ± 0.064
3.317ThrGlu: 3.317 ± 0.069
1.761ThrPhe: 1.761 ± 0.057
4.176ThrGly: 4.176 ± 0.088
1.717ThrHis: 1.717 ± 0.06
2.935ThrIle: 2.935 ± 0.085
1.862ThrLys: 1.862 ± 0.05
6.336ThrLeu: 6.336 ± 0.103
1.063ThrMet: 1.063 ± 0.045
1.549ThrAsn: 1.549 ± 0.053
3.413ThrPro: 3.413 ± 0.071
3.238ThrGln: 3.238 ± 0.069
2.743ThrArg: 2.743 ± 0.067
2.869ThrSer: 2.869 ± 0.069
3.165ThrThr: 3.165 ± 0.087
4.408ThrVal: 4.408 ± 0.094
0.694ThrTrp: 0.694 ± 0.035
1.316ThrTyr: 1.316 ± 0.046
0.0ThrXaa: 0.0 ± 0.0
Val
7.591ValAla: 7.591 ± 0.125
0.811ValCys: 0.811 ± 0.035
3.844ValAsp: 3.844 ± 0.102
3.989ValGlu: 3.989 ± 0.099
3.044ValPhe: 3.044 ± 0.07
5.188ValGly: 5.188 ± 0.107
1.794ValHis: 1.794 ± 0.061
4.211ValIle: 4.211 ± 0.097
2.668ValLys: 2.668 ± 0.077
8.305ValLeu: 8.305 ± 0.151
1.96ValMet: 1.96 ± 0.058
2.453ValAsn: 2.453 ± 0.062
3.133ValPro: 3.133 ± 0.08
3.254ValGln: 3.254 ± 0.075
3.837ValArg: 3.837 ± 0.079
4.256ValSer: 4.256 ± 0.082
3.842ValThr: 3.842 ± 0.084
6.007ValVal: 6.007 ± 0.127
0.965ValTrp: 0.965 ± 0.042
1.731ValTyr: 1.731 ± 0.051
0.0ValXaa: 0.0 ± 0.0
Trp
1.265TrpAla: 1.265 ± 0.05
0.141TrpCys: 0.141 ± 0.017
0.627TrpAsp: 0.627 ± 0.026
0.626TrpGlu: 0.626 ± 0.034
0.604TrpPhe: 0.604 ± 0.033
0.843TrpGly: 0.843 ± 0.045
0.465TrpHis: 0.465 ± 0.029
0.697TrpIle: 0.697 ± 0.04
0.369TrpLys: 0.369 ± 0.022
2.17TrpLeu: 2.17 ± 0.07
0.321TrpMet: 0.321 ± 0.024
0.404TrpAsn: 0.404 ± 0.025
0.607TrpPro: 0.607 ± 0.032
1.099TrpGln: 1.099 ± 0.05
1.018TrpArg: 1.018 ± 0.039
0.834TrpSer: 0.834 ± 0.035
0.564TrpThr: 0.564 ± 0.032
1.193TrpVal: 1.193 ± 0.05
0.285TrpTrp: 0.285 ± 0.023
0.381TrpTyr: 0.381 ± 0.027
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.809TyrAla: 2.809 ± 0.066
0.281TyrCys: 0.281 ± 0.019
1.534TyrAsp: 1.534 ± 0.047
1.659TyrGlu: 1.659 ± 0.053
1.192TyrPhe: 1.192 ± 0.044
2.202TyrGly: 2.202 ± 0.059
0.694TyrHis: 0.694 ± 0.038
1.384TyrIle: 1.384 ± 0.049
0.967TyrLys: 0.967 ± 0.043
2.938TyrLeu: 2.938 ± 0.077
0.574TyrMet: 0.574 ± 0.03
0.8TyrAsn: 0.8 ± 0.039
1.324TyrPro: 1.324 ± 0.045
1.407TyrGln: 1.407 ± 0.045
1.534TyrArg: 1.534 ± 0.047
1.718TyrSer: 1.718 ± 0.059
1.503TyrThr: 1.503 ± 0.049
1.962TyrVal: 1.962 ± 0.06
0.477TyrTrp: 0.477 ± 0.03
0.904TyrTyr: 0.904 ± 0.041
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2082 proteins (604123 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski