Amino acid dipepetide frequency for Streptococcus satellite phage Javan341

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.575AlaAla: 2.575 ± 1.177
0.515AlaCys: 0.515 ± 0.323
3.605AlaAsp: 3.605 ± 1.007
6.438AlaGlu: 6.438 ± 1.741
2.06AlaPhe: 2.06 ± 0.759
3.605AlaGly: 3.605 ± 0.78
0.515AlaHis: 0.515 ± 0.284
4.378AlaIle: 4.378 ± 1.347
6.181AlaLys: 6.181 ± 1.714
6.438AlaLeu: 6.438 ± 1.134
1.545AlaMet: 1.545 ± 0.736
4.121AlaAsn: 4.121 ± 0.812
0.515AlaPro: 0.515 ± 0.335
3.348AlaGln: 3.348 ± 1.376
4.378AlaArg: 4.378 ± 1.022
3.09AlaSer: 3.09 ± 1.036
3.09AlaThr: 3.09 ± 0.966
3.605AlaVal: 3.605 ± 1.269
1.288AlaTrp: 1.288 ± 0.582
2.06AlaTyr: 2.06 ± 0.87
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
0.0CysAsp: 0.0 ± 0.0
0.258CysGlu: 0.258 ± 0.279
0.0CysPhe: 0.0 ± 0.0
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.515CysIle: 0.515 ± 0.448
0.0CysLys: 0.0 ± 0.0
0.515CysLeu: 0.515 ± 0.323
0.0CysMet: 0.0 ± 0.0
0.258CysAsn: 0.258 ± 0.275
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
0.515CysArg: 0.515 ± 0.332
0.0CysSer: 0.0 ± 0.0
0.258CysThr: 0.258 ± 0.269
0.773CysVal: 0.773 ± 0.419
0.0CysTrp: 0.0 ± 0.0
0.258CysTyr: 0.258 ± 0.271
0.0CysXaa: 0.0 ± 0.0
Asp
2.575AspAla: 2.575 ± 0.954
0.0AspCys: 0.0 ± 0.0
5.408AspAsp: 5.408 ± 1.05
4.893AspGlu: 4.893 ± 1.121
4.378AspPhe: 4.378 ± 1.183
1.803AspGly: 1.803 ± 0.741
0.515AspHis: 0.515 ± 0.41
6.181AspIle: 6.181 ± 1.29
7.468AspLys: 7.468 ± 0.824
6.696AspLeu: 6.696 ± 1.739
2.318AspMet: 2.318 ± 0.796
2.06AspAsn: 2.06 ± 0.758
0.773AspPro: 0.773 ± 0.396
2.318AspGln: 2.318 ± 0.89
4.893AspArg: 4.893 ± 1.658
3.09AspSer: 3.09 ± 0.959
2.575AspThr: 2.575 ± 0.839
3.09AspVal: 3.09 ± 0.769
0.258AspTrp: 0.258 ± 0.289
4.121AspTyr: 4.121 ± 1.259
0.0AspXaa: 0.0 ± 0.0
Glu
5.666GluAla: 5.666 ± 1.106
0.258GluCys: 0.258 ± 0.271
3.09GluAsp: 3.09 ± 0.899
7.211GluGlu: 7.211 ± 2.229
3.348GluPhe: 3.348 ± 0.919
5.408GluGly: 5.408 ± 0.869
1.545GluHis: 1.545 ± 0.646
5.666GluIle: 5.666 ± 1.31
9.786GluLys: 9.786 ± 1.783
12.877GluLeu: 12.877 ± 2.627
2.575GluMet: 2.575 ± 0.844
3.348GluAsn: 3.348 ± 0.694
1.803GluPro: 1.803 ± 0.592
4.636GluGln: 4.636 ± 1.379
4.121GluArg: 4.121 ± 1.041
3.863GluSer: 3.863 ± 0.704
4.636GluThr: 4.636 ± 0.786
5.666GluVal: 5.666 ± 1.742
0.515GluTrp: 0.515 ± 0.332
2.833GluTyr: 2.833 ± 0.709
0.0GluXaa: 0.0 ± 0.0
Phe
2.833PheAla: 2.833 ± 0.859
0.258PheCys: 0.258 ± 0.269
5.408PheAsp: 5.408 ± 0.778
4.378PheGlu: 4.378 ± 1.073
1.803PhePhe: 1.803 ± 0.651
2.318PheGly: 2.318 ± 0.482
0.773PheHis: 0.773 ± 0.47
2.575PheIle: 2.575 ± 0.948
2.833PheLys: 2.833 ± 0.984
4.378PheLeu: 4.378 ± 0.628
0.773PheMet: 0.773 ± 0.577
1.545PheAsn: 1.545 ± 0.694
0.773PhePro: 0.773 ± 0.759
2.833PheGln: 2.833 ± 0.858
0.258PheArg: 0.258 ± 0.231
2.575PheSer: 2.575 ± 0.819
1.288PheThr: 1.288 ± 0.543
2.575PheVal: 2.575 ± 1.03
0.773PheTrp: 0.773 ± 0.407
1.288PheTyr: 1.288 ± 0.502
0.0PheXaa: 0.0 ± 0.0
Gly
1.03GlyAla: 1.03 ± 0.544
0.773GlyCys: 0.773 ± 0.356
3.605GlyAsp: 3.605 ± 0.783
3.863GlyGlu: 3.863 ± 1.136
4.121GlyPhe: 4.121 ± 0.924
3.348GlyGly: 3.348 ± 1.179
0.773GlyHis: 0.773 ± 0.519
4.378GlyIle: 4.378 ± 1.117
2.833GlyLys: 2.833 ± 0.824
5.151GlyLeu: 5.151 ± 1.424
0.773GlyMet: 0.773 ± 0.482
2.833GlyAsn: 2.833 ± 0.83
0.258GlyPro: 0.258 ± 0.253
1.03GlyGln: 1.03 ± 0.475
2.318GlyArg: 2.318 ± 0.779
2.575GlySer: 2.575 ± 1.056
1.545GlyThr: 1.545 ± 0.697
4.636GlyVal: 4.636 ± 1.037
0.515GlyTrp: 0.515 ± 0.551
4.121GlyTyr: 4.121 ± 1.16
0.0GlyXaa: 0.0 ± 0.0
His
0.773HisAla: 0.773 ± 0.502
0.0HisCys: 0.0 ± 0.0
0.773HisAsp: 0.773 ± 0.37
0.515HisGlu: 0.515 ± 0.462
1.03HisPhe: 1.03 ± 0.438
0.258HisGly: 0.258 ± 0.231
0.0HisHis: 0.0 ± 0.0
1.288HisIle: 1.288 ± 0.66
0.258HisLys: 0.258 ± 0.231
1.03HisLeu: 1.03 ± 0.457
0.0HisMet: 0.0 ± 0.0
1.288HisAsn: 1.288 ± 0.556
0.0HisPro: 0.0 ± 0.0
1.03HisGln: 1.03 ± 0.633
0.773HisArg: 0.773 ± 0.471
0.773HisSer: 0.773 ± 0.463
1.03HisThr: 1.03 ± 0.396
0.515HisVal: 0.515 ± 0.284
0.0HisTrp: 0.0 ± 0.0
1.545HisTyr: 1.545 ± 0.55
0.0HisXaa: 0.0 ± 0.0
Ile
5.408IleAla: 5.408 ± 1.465
0.258IleCys: 0.258 ± 0.275
6.696IleAsp: 6.696 ± 1.716
7.211IleGlu: 7.211 ± 1.075
2.318IlePhe: 2.318 ± 0.613
3.09IleGly: 3.09 ± 1.019
1.288IleHis: 1.288 ± 0.801
4.893IleIle: 4.893 ± 1.287
5.666IleLys: 5.666 ± 1.085
5.923IleLeu: 5.923 ± 1.84
2.06IleMet: 2.06 ± 0.665
4.121IleAsn: 4.121 ± 1.293
2.06IlePro: 2.06 ± 0.682
2.318IleGln: 2.318 ± 0.647
3.09IleArg: 3.09 ± 1.201
5.151IleSer: 5.151 ± 1.5
2.06IleThr: 2.06 ± 0.679
3.605IleVal: 3.605 ± 1.08
0.515IleTrp: 0.515 ± 0.301
2.833IleTyr: 2.833 ± 0.932
0.0IleXaa: 0.0 ± 0.0
Lys
9.271LysAla: 9.271 ± 1.758
0.0LysCys: 0.0 ± 0.0
5.923LysAsp: 5.923 ± 1.298
7.984LysGlu: 7.984 ± 1.372
3.605LysPhe: 3.605 ± 0.783
4.893LysGly: 4.893 ± 0.943
1.545LysHis: 1.545 ± 0.659
6.438LysIle: 6.438 ± 1.11
9.014LysLys: 9.014 ± 1.713
6.953LysLeu: 6.953 ± 1.296
1.545LysMet: 1.545 ± 0.653
6.181LysAsn: 6.181 ± 1.006
2.318LysPro: 2.318 ± 0.648
5.151LysGln: 5.151 ± 1.183
6.181LysArg: 6.181 ± 1.192
6.953LysSer: 6.953 ± 1.059
4.893LysThr: 4.893 ± 1.125
3.605LysVal: 3.605 ± 0.752
0.515LysTrp: 0.515 ± 0.376
3.09LysTyr: 3.09 ± 0.995
0.0LysXaa: 0.0 ± 0.0
Leu
7.468LeuAla: 7.468 ± 1.646
0.258LeuCys: 0.258 ± 0.224
8.241LeuAsp: 8.241 ± 1.033
11.847LeuGlu: 11.847 ± 2.266
3.605LeuPhe: 3.605 ± 1.159
5.666LeuGly: 5.666 ± 1.153
1.288LeuHis: 1.288 ± 0.634
4.893LeuIle: 4.893 ± 1.841
8.499LeuLys: 8.499 ± 1.417
10.301LeuLeu: 10.301 ± 1.713
1.545LeuMet: 1.545 ± 0.664
6.181LeuAsn: 6.181 ± 1.125
2.833LeuPro: 2.833 ± 1.402
4.636LeuGln: 4.636 ± 1.202
5.151LeuArg: 5.151 ± 0.917
6.438LeuSer: 6.438 ± 1.042
3.348LeuThr: 3.348 ± 0.752
4.121LeuVal: 4.121 ± 0.912
0.258LeuTrp: 0.258 ± 0.231
4.121LeuTyr: 4.121 ± 1.137
0.0LeuXaa: 0.0 ± 0.0
Met
2.318MetAla: 2.318 ± 1.057
0.0MetCys: 0.0 ± 0.0
1.03MetAsp: 1.03 ± 0.506
2.575MetGlu: 2.575 ± 0.992
0.515MetPhe: 0.515 ± 0.301
1.03MetGly: 1.03 ± 0.562
0.258MetHis: 0.258 ± 0.253
0.515MetIle: 0.515 ± 0.349
2.318MetLys: 2.318 ± 0.672
2.318MetLeu: 2.318 ± 0.769
0.515MetMet: 0.515 ± 0.406
1.545MetAsn: 1.545 ± 0.544
0.515MetPro: 0.515 ± 0.538
1.03MetGln: 1.03 ± 0.581
2.318MetArg: 2.318 ± 0.754
0.0MetSer: 0.0 ± 0.0
1.545MetThr: 1.545 ± 0.595
1.288MetVal: 1.288 ± 0.681
0.0MetTrp: 0.0 ± 0.0
0.515MetTyr: 0.515 ± 0.389
0.0MetXaa: 0.0 ± 0.0
Asn
3.348AsnAla: 3.348 ± 0.972
0.258AsnCys: 0.258 ± 0.279
2.06AsnAsp: 2.06 ± 0.579
2.06AsnGlu: 2.06 ± 0.726
1.545AsnPhe: 1.545 ± 0.582
4.893AsnGly: 4.893 ± 1.281
0.258AsnHis: 0.258 ± 0.297
2.833AsnIle: 2.833 ± 0.921
5.408AsnLys: 5.408 ± 1.375
5.408AsnLeu: 5.408 ± 1.487
1.288AsnMet: 1.288 ± 0.649
3.348AsnAsn: 3.348 ± 0.869
2.833AsnPro: 2.833 ± 1.199
2.06AsnGln: 2.06 ± 0.587
3.348AsnArg: 3.348 ± 0.929
2.06AsnSer: 2.06 ± 1.272
4.636AsnThr: 4.636 ± 1.515
1.545AsnVal: 1.545 ± 0.836
0.773AsnTrp: 0.773 ± 0.642
2.575AsnTyr: 2.575 ± 1.311
0.0AsnXaa: 0.0 ± 0.0
Pro
0.258ProAla: 0.258 ± 0.231
0.0ProCys: 0.0 ± 0.0
2.575ProAsp: 2.575 ± 0.781
2.318ProGlu: 2.318 ± 0.776
2.318ProPhe: 2.318 ± 0.864
0.515ProGly: 0.515 ± 0.506
0.258ProHis: 0.258 ± 0.253
1.288ProIle: 1.288 ± 0.745
1.545ProLys: 1.545 ± 0.769
1.03ProLeu: 1.03 ± 0.662
0.0ProMet: 0.0 ± 0.0
0.773ProAsn: 0.773 ± 0.411
0.0ProPro: 0.0 ± 0.0
1.288ProGln: 1.288 ± 0.771
1.288ProArg: 1.288 ± 0.508
1.288ProSer: 1.288 ± 0.531
2.318ProThr: 2.318 ± 0.626
1.03ProVal: 1.03 ± 0.38
0.0ProTrp: 0.0 ± 0.0
1.03ProTyr: 1.03 ± 0.599
0.0ProXaa: 0.0 ± 0.0
Gln
4.636GlnAla: 4.636 ± 1.581
0.0GlnCys: 0.0 ± 0.0
1.03GlnAsp: 1.03 ± 0.481
5.408GlnGlu: 5.408 ± 0.937
1.288GlnPhe: 1.288 ± 0.517
2.318GlnGly: 2.318 ± 0.86
0.773GlnHis: 0.773 ± 0.373
2.833GlnIle: 2.833 ± 0.739
3.863GlnLys: 3.863 ± 1.046
6.696GlnLeu: 6.696 ± 0.929
1.803GlnMet: 1.803 ± 0.755
1.545GlnAsn: 1.545 ± 0.66
0.515GlnPro: 0.515 ± 0.301
3.09GlnGln: 3.09 ± 1.143
1.545GlnArg: 1.545 ± 0.708
2.318GlnSer: 2.318 ± 0.92
2.575GlnThr: 2.575 ± 0.733
2.833GlnVal: 2.833 ± 0.986
0.515GlnTrp: 0.515 ± 0.416
1.803GlnTyr: 1.803 ± 0.745
0.0GlnXaa: 0.0 ± 0.0
Arg
2.575ArgAla: 2.575 ± 0.836
0.258ArgCys: 0.258 ± 0.224
3.09ArgAsp: 3.09 ± 0.68
5.408ArgGlu: 5.408 ± 1.033
1.288ArgPhe: 1.288 ± 0.455
1.288ArgGly: 1.288 ± 0.62
1.03ArgHis: 1.03 ± 0.451
5.923ArgIle: 5.923 ± 1.26
5.151ArgLys: 5.151 ± 0.991
6.696ArgLeu: 6.696 ± 1.122
1.288ArgMet: 1.288 ± 0.647
2.318ArgAsn: 2.318 ± 0.728
0.515ArgPro: 0.515 ± 0.36
3.863ArgGln: 3.863 ± 0.949
2.06ArgArg: 2.06 ± 0.694
2.06ArgSer: 2.06 ± 0.562
1.803ArgThr: 1.803 ± 0.705
2.06ArgVal: 2.06 ± 1.036
0.515ArgTrp: 0.515 ± 0.335
3.09ArgTyr: 3.09 ± 0.725
0.0ArgXaa: 0.0 ± 0.0
Ser
3.09SerAla: 3.09 ± 0.671
0.258SerCys: 0.258 ± 0.266
3.863SerAsp: 3.863 ± 0.785
4.121SerGlu: 4.121 ± 1.253
3.605SerPhe: 3.605 ± 1.036
4.636SerGly: 4.636 ± 1.222
0.258SerHis: 0.258 ± 0.253
4.636SerIle: 4.636 ± 0.752
5.151SerLys: 5.151 ± 0.857
4.378SerLeu: 4.378 ± 1.257
0.773SerMet: 0.773 ± 0.476
1.803SerAsn: 1.803 ± 0.794
2.318SerPro: 2.318 ± 0.606
3.348SerGln: 3.348 ± 0.821
1.545SerArg: 1.545 ± 0.717
3.605SerSer: 3.605 ± 1.071
3.09SerThr: 3.09 ± 1.251
3.09SerVal: 3.09 ± 0.757
0.515SerTrp: 0.515 ± 0.376
2.575SerTyr: 2.575 ± 0.615
0.0SerXaa: 0.0 ± 0.0
Thr
2.833ThrAla: 2.833 ± 0.992
0.0ThrCys: 0.0 ± 0.0
2.318ThrAsp: 2.318 ± 0.736
2.833ThrGlu: 2.833 ± 0.971
1.03ThrPhe: 1.03 ± 0.466
2.575ThrGly: 2.575 ± 0.612
0.773ThrHis: 0.773 ± 0.401
4.893ThrIle: 4.893 ± 1.162
3.605ThrLys: 3.605 ± 0.891
5.151ThrLeu: 5.151 ± 0.952
1.288ThrMet: 1.288 ± 0.457
1.803ThrAsn: 1.803 ± 0.627
1.545ThrPro: 1.545 ± 0.816
2.06ThrGln: 2.06 ± 0.834
2.06ThrArg: 2.06 ± 0.653
3.348ThrSer: 3.348 ± 0.94
3.605ThrThr: 3.605 ± 0.944
4.893ThrVal: 4.893 ± 1.205
0.0ThrTrp: 0.0 ± 0.0
2.06ThrTyr: 2.06 ± 0.596
0.0ThrXaa: 0.0 ± 0.0
Val
4.121ValAla: 4.121 ± 1.201
0.0ValCys: 0.0 ± 0.0
3.605ValAsp: 3.605 ± 0.985
5.923ValGlu: 5.923 ± 1.792
1.545ValPhe: 1.545 ± 0.609
1.545ValGly: 1.545 ± 0.407
0.515ValHis: 0.515 ± 0.324
3.09ValIle: 3.09 ± 1.023
6.438ValLys: 6.438 ± 1.359
4.636ValLeu: 4.636 ± 1.587
0.773ValMet: 0.773 ± 0.364
4.636ValAsn: 4.636 ± 0.855
0.515ValPro: 0.515 ± 0.283
1.545ValGln: 1.545 ± 0.693
2.575ValArg: 2.575 ± 0.929
4.378ValSer: 4.378 ± 0.87
3.348ValThr: 3.348 ± 0.917
2.833ValVal: 2.833 ± 1.132
0.0ValTrp: 0.0 ± 0.0
2.06ValTyr: 2.06 ± 0.612
0.0ValXaa: 0.0 ± 0.0
Trp
0.773TrpAla: 0.773 ± 0.321
0.0TrpCys: 0.0 ± 0.0
0.773TrpAsp: 0.773 ± 0.546
1.545TrpGlu: 1.545 ± 0.465
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.515TrpIle: 0.515 ± 0.334
1.545TrpLys: 1.545 ± 0.546
0.258TrpLeu: 0.258 ± 0.33
0.0TrpMet: 0.0 ± 0.0
0.258TrpAsn: 0.258 ± 0.271
0.258TrpPro: 0.258 ± 0.289
0.515TrpGln: 0.515 ± 0.376
0.258TrpArg: 0.258 ± 0.268
0.258TrpSer: 0.258 ± 0.231
0.258TrpThr: 0.258 ± 0.224
0.0TrpVal: 0.0 ± 0.0
0.258TrpTrp: 0.258 ± 0.231
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.803TyrAla: 1.803 ± 0.903
0.258TyrCys: 0.258 ± 0.271
2.318TyrAsp: 2.318 ± 0.895
2.06TyrGlu: 2.06 ± 1.045
2.833TyrPhe: 2.833 ± 0.867
1.288TyrGly: 1.288 ± 0.503
0.515TyrHis: 0.515 ± 0.336
2.833TyrIle: 2.833 ± 0.902
8.499TyrLys: 8.499 ± 1.343
3.863TyrLeu: 3.863 ± 0.971
1.03TyrMet: 1.03 ± 0.595
2.575TyrAsn: 2.575 ± 0.726
0.773TyrPro: 0.773 ± 0.416
1.288TyrGln: 1.288 ± 0.543
3.605TyrArg: 3.605 ± 0.952
2.833TyrSer: 2.833 ± 1.029
0.773TyrThr: 0.773 ± 0.443
2.318TyrVal: 2.318 ± 0.833
0.258TyrTrp: 0.258 ± 0.224
2.06TyrTyr: 2.06 ± 0.857
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 24 proteins (3884 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski