Amino acid dipepetide frequency for Alistipes dispar

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.9AlaAla: 12.9 ± 0.202
1.323AlaCys: 1.323 ± 0.042
5.879AlaAsp: 5.879 ± 0.092
7.493AlaGlu: 7.493 ± 0.121
3.605AlaPhe: 3.605 ± 0.066
8.639AlaGly: 8.639 ± 0.127
1.365AlaHis: 1.365 ± 0.039
4.015AlaIle: 4.015 ± 0.073
3.317AlaLys: 3.317 ± 0.061
9.047AlaLeu: 9.047 ± 0.138
2.213AlaMet: 2.213 ± 0.049
2.613AlaAsn: 2.613 ± 0.055
3.763AlaPro: 3.763 ± 0.084
2.823AlaGln: 2.823 ± 0.069
6.254AlaArg: 6.254 ± 0.117
5.221AlaSer: 5.221 ± 0.09
4.431AlaThr: 4.431 ± 0.072
7.87AlaVal: 7.87 ± 0.108
1.239AlaTrp: 1.239 ± 0.033
3.086AlaTyr: 3.086 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
1.093CysAla: 1.093 ± 0.04
0.257CysCys: 0.257 ± 0.016
0.873CysAsp: 0.873 ± 0.034
0.722CysGlu: 0.722 ± 0.03
0.529CysPhe: 0.529 ± 0.022
1.342CysGly: 1.342 ± 0.042
0.24CysHis: 0.24 ± 0.017
0.687CysIle: 0.687 ± 0.032
0.364CysLys: 0.364 ± 0.023
0.958CysLeu: 0.958 ± 0.035
0.266CysMet: 0.266 ± 0.015
0.444CysAsn: 0.444 ± 0.02
0.622CysPro: 0.622 ± 0.029
0.227CysGln: 0.227 ± 0.016
1.145CysArg: 1.145 ± 0.036
0.763CysSer: 0.763 ± 0.032
0.737CysThr: 0.737 ± 0.028
0.817CysVal: 0.817 ± 0.035
0.153CysTrp: 0.153 ± 0.015
0.499CysTyr: 0.499 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
5.493AspAla: 5.493 ± 0.081
0.644AspCys: 0.644 ± 0.031
3.267AspAsp: 3.267 ± 0.075
3.996AspGlu: 3.996 ± 0.082
2.991AspPhe: 2.991 ± 0.069
5.339AspGly: 5.339 ± 0.101
0.84AspHis: 0.84 ± 0.033
3.22AspIle: 3.22 ± 0.062
2.43AspLys: 2.43 ± 0.056
4.712AspLeu: 4.712 ± 0.072
1.445AspMet: 1.445 ± 0.041
2.043AspAsn: 2.043 ± 0.054
3.004AspPro: 3.004 ± 0.063
0.965AspGln: 0.965 ± 0.037
4.391AspArg: 4.391 ± 0.078
2.867AspSer: 2.867 ± 0.069
2.931AspThr: 2.931 ± 0.061
3.615AspVal: 3.615 ± 0.066
0.858AspTrp: 0.858 ± 0.03
2.77AspTyr: 2.77 ± 0.064
0.0AspXaa: 0.0 ± 0.0
Glu
6.708GluAla: 6.708 ± 0.102
0.699GluCys: 0.699 ± 0.03
2.793GluAsp: 2.793 ± 0.069
5.067GluGlu: 5.067 ± 0.102
2.563GluPhe: 2.563 ± 0.063
5.198GluGly: 5.198 ± 0.07
1.29GluHis: 1.29 ± 0.04
4.181GluIle: 4.181 ± 0.085
3.431GluLys: 3.431 ± 0.082
6.201GluLeu: 6.201 ± 0.095
1.904GluMet: 1.904 ± 0.045
2.692GluAsn: 2.692 ± 0.067
2.454GluPro: 2.454 ± 0.061
2.326GluGln: 2.326 ± 0.06
5.636GluArg: 5.636 ± 0.102
2.923GluSer: 2.923 ± 0.054
3.663GluThr: 3.663 ± 0.063
4.599GluVal: 4.599 ± 0.075
0.985GluTrp: 0.985 ± 0.032
2.638GluTyr: 2.638 ± 0.059
0.0GluXaa: 0.0 ± 0.0
Phe
3.98PheAla: 3.98 ± 0.066
0.62PheCys: 0.62 ± 0.028
3.239PheAsp: 3.239 ± 0.054
2.479PheGlu: 2.479 ± 0.051
1.813PhePhe: 1.813 ± 0.051
3.814PheGly: 3.814 ± 0.07
0.67PheHis: 0.67 ± 0.03
1.971PheIle: 1.971 ± 0.057
1.318PheLys: 1.318 ± 0.042
3.412PheLeu: 3.412 ± 0.065
0.905PheMet: 0.905 ± 0.03
1.586PheAsn: 1.586 ± 0.047
1.78PhePro: 1.78 ± 0.045
0.812PheGln: 0.812 ± 0.031
3.335PheArg: 3.335 ± 0.068
2.895PheSer: 2.895 ± 0.062
2.524PheThr: 2.524 ± 0.05
2.929PheVal: 2.929 ± 0.059
0.557PheTrp: 0.557 ± 0.028
1.673PheTyr: 1.673 ± 0.043
0.0PheXaa: 0.0 ± 0.0
Gly
6.866GlyAla: 6.866 ± 0.108
1.196GlyCys: 1.196 ± 0.047
4.56GlyAsp: 4.56 ± 0.078
5.608GlyGlu: 5.608 ± 0.085
3.438GlyPhe: 3.438 ± 0.071
6.729GlyGly: 6.729 ± 0.124
1.395GlyHis: 1.395 ± 0.039
4.96GlyIle: 4.96 ± 0.081
3.712GlyLys: 3.712 ± 0.075
6.499GlyLeu: 6.499 ± 0.1
2.192GlyMet: 2.192 ± 0.056
2.979GlyAsn: 2.979 ± 0.064
2.002GlyPro: 2.002 ± 0.053
2.038GlyGln: 2.038 ± 0.042
5.995GlyArg: 5.995 ± 0.095
4.572GlySer: 4.572 ± 0.088
4.704GlyThr: 4.704 ± 0.093
5.807GlyVal: 5.807 ± 0.094
1.273GlyTrp: 1.273 ± 0.049
3.641GlyTyr: 3.641 ± 0.063
0.0GlyXaa: 0.0 ± 0.0
His
1.412HisAla: 1.412 ± 0.04
0.288HisCys: 0.288 ± 0.017
1.008HisAsp: 1.008 ± 0.034
0.968HisGlu: 0.968 ± 0.031
0.818HisPhe: 0.818 ± 0.033
1.322HisGly: 1.322 ± 0.041
0.343HisHis: 0.343 ± 0.024
1.148HisIle: 1.148 ± 0.036
0.643HisLys: 0.643 ± 0.03
1.51HisLeu: 1.51 ± 0.042
0.328HisMet: 0.328 ± 0.021
0.676HisAsn: 0.676 ± 0.029
1.08HisPro: 1.08 ± 0.038
0.347HisGln: 0.347 ± 0.02
1.25HisArg: 1.25 ± 0.036
0.821HisSer: 0.821 ± 0.033
1.043HisThr: 1.043 ± 0.035
1.072HisVal: 1.072 ± 0.039
0.214HisTrp: 0.214 ± 0.016
0.807HisTyr: 0.807 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
5.55IleAla: 5.55 ± 0.084
0.661IleCys: 0.661 ± 0.031
3.91IleAsp: 3.91 ± 0.066
3.638IleGlu: 3.638 ± 0.065
1.936IlePhe: 1.936 ± 0.051
4.38IleGly: 4.38 ± 0.072
0.916IleHis: 0.916 ± 0.03
2.271IleIle: 2.271 ± 0.058
1.848IleLys: 1.848 ± 0.056
4.45IleLeu: 4.45 ± 0.086
0.93IleMet: 0.93 ± 0.037
1.886IleAsn: 1.886 ± 0.054
2.8IlePro: 2.8 ± 0.054
1.122IleGln: 1.122 ± 0.036
4.219IleArg: 4.219 ± 0.068
2.996IleSer: 2.996 ± 0.063
2.854IleThr: 2.854 ± 0.06
4.272IleVal: 4.272 ± 0.071
0.489IleTrp: 0.489 ± 0.026
2.172IleTyr: 2.172 ± 0.054
0.0IleXaa: 0.0 ± 0.0
Lys
3.664LysAla: 3.664 ± 0.077
0.408LysCys: 0.408 ± 0.025
2.069LysAsp: 2.069 ± 0.061
2.94LysGlu: 2.94 ± 0.068
1.423LysPhe: 1.423 ± 0.044
2.965LysGly: 2.965 ± 0.058
0.698LysHis: 0.698 ± 0.029
2.597LysIle: 2.597 ± 0.069
2.215LysLys: 2.215 ± 0.062
3.443LysLeu: 3.443 ± 0.072
1.321LysMet: 1.321 ± 0.04
1.723LysAsn: 1.723 ± 0.051
1.703LysPro: 1.703 ± 0.046
1.275LysGln: 1.275 ± 0.042
2.83LysArg: 2.83 ± 0.061
2.276LysSer: 2.276 ± 0.054
2.436LysThr: 2.436 ± 0.06
2.828LysVal: 2.828 ± 0.075
0.533LysTrp: 0.533 ± 0.028
1.839LysTyr: 1.839 ± 0.044
0.0LysXaa: 0.0 ± 0.0
Leu
8.771LeuAla: 8.771 ± 0.133
1.402LeuCys: 1.402 ± 0.045
5.075LeuAsp: 5.075 ± 0.075
5.201LeuGlu: 5.201 ± 0.084
4.279LeuPhe: 4.279 ± 0.083
6.474LeuGly: 6.474 ± 0.092
1.706LeuHis: 1.706 ± 0.044
3.901LeuIle: 3.901 ± 0.081
3.765LeuLys: 3.765 ± 0.072
9.221LeuLeu: 9.221 ± 0.163
2.09LeuMet: 2.09 ± 0.059
2.988LeuAsn: 2.988 ± 0.06
4.438LeuPro: 4.438 ± 0.088
2.54LeuGln: 2.54 ± 0.057
7.39LeuArg: 7.39 ± 0.117
6.07LeuSer: 6.07 ± 0.092
5.409LeuThr: 5.409 ± 0.089
5.598LeuVal: 5.598 ± 0.107
1.089LeuTrp: 1.089 ± 0.041
3.225LeuTyr: 3.225 ± 0.065
0.0LeuXaa: 0.0 ± 0.0
Met
2.265MetAla: 2.265 ± 0.061
0.246MetCys: 0.246 ± 0.019
1.221MetAsp: 1.221 ± 0.041
1.615MetGlu: 1.615 ± 0.047
0.803MetPhe: 0.803 ± 0.033
1.572MetGly: 1.572 ± 0.044
0.421MetHis: 0.421 ± 0.023
1.336MetIle: 1.336 ± 0.04
1.691MetLys: 1.691 ± 0.042
2.4MetLeu: 2.4 ± 0.059
0.64MetMet: 0.64 ± 0.023
1.154MetAsn: 1.154 ± 0.04
1.258MetPro: 1.258 ± 0.038
0.91MetGln: 0.91 ± 0.036
1.779MetArg: 1.779 ± 0.041
1.339MetSer: 1.339 ± 0.041
1.563MetThr: 1.563 ± 0.045
1.358MetVal: 1.358 ± 0.041
0.289MetTrp: 0.289 ± 0.017
0.661MetTyr: 0.661 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
3.172AsnAla: 3.172 ± 0.064
0.385AsnCys: 0.385 ± 0.022
2.004AsnAsp: 2.004 ± 0.048
1.924AsnGlu: 1.924 ± 0.051
1.506AsnPhe: 1.506 ± 0.051
3.061AsnGly: 3.061 ± 0.074
0.614AsnHis: 0.614 ± 0.031
2.233AsnIle: 2.233 ± 0.055
1.398AsnLys: 1.398 ± 0.047
3.262AsnLeu: 3.262 ± 0.062
0.889AsnMet: 0.889 ± 0.032
1.39AsnAsn: 1.39 ± 0.048
2.171AsnPro: 2.171 ± 0.046
0.826AsnGln: 0.826 ± 0.035
2.581AsnArg: 2.581 ± 0.063
1.782AsnSer: 1.782 ± 0.049
1.976AsnThr: 1.976 ± 0.057
2.454AsnVal: 2.454 ± 0.058
0.459AsnTrp: 0.459 ± 0.025
1.57AsnTyr: 1.57 ± 0.048
0.0AsnXaa: 0.0 ± 0.0
Pro
5.096ProAla: 5.096 ± 0.104
0.439ProCys: 0.439 ± 0.022
3.159ProAsp: 3.159 ± 0.054
4.139ProGlu: 4.139 ± 0.075
1.834ProPhe: 1.834 ± 0.045
3.482ProGly: 3.482 ± 0.065
0.776ProHis: 0.776 ± 0.03
1.714ProIle: 1.714 ± 0.043
1.543ProLys: 1.543 ± 0.049
3.683ProLeu: 3.683 ± 0.072
0.954ProMet: 0.954 ± 0.037
1.273ProAsn: 1.273 ± 0.036
1.137ProPro: 1.137 ± 0.041
1.504ProGln: 1.504 ± 0.044
2.374ProArg: 2.374 ± 0.047
2.481ProSer: 2.481 ± 0.055
1.937ProThr: 1.937 ± 0.049
3.584ProVal: 3.584 ± 0.067
0.55ProTrp: 0.55 ± 0.027
1.773ProTyr: 1.773 ± 0.045
0.0ProXaa: 0.0 ± 0.0
Gln
2.373GlnAla: 2.373 ± 0.059
0.26GlnCys: 0.26 ± 0.016
1.109GlnAsp: 1.109 ± 0.038
1.782GlnGlu: 1.782 ± 0.056
1.028GlnPhe: 1.028 ± 0.034
1.941GlnGly: 1.941 ± 0.045
0.49GlnHis: 0.49 ± 0.023
1.793GlnIle: 1.793 ± 0.043
1.296GlnLys: 1.296 ± 0.04
2.56GlnLeu: 2.56 ± 0.058
0.787GlnMet: 0.787 ± 0.026
1.129GlnAsn: 1.129 ± 0.038
1.272GlnPro: 1.272 ± 0.041
1.098GlnGln: 1.098 ± 0.043
2.0GlnArg: 2.0 ± 0.048
1.55GlnSer: 1.55 ± 0.049
1.76GlnThr: 1.76 ± 0.047
1.607GlnVal: 1.607 ± 0.043
0.384GlnTrp: 0.384 ± 0.02
1.135GlnTyr: 1.135 ± 0.04
0.0GlnXaa: 0.0 ± 0.0
Arg
5.594ArgAla: 5.594 ± 0.087
0.837ArgCys: 0.837 ± 0.032
3.619ArgAsp: 3.619 ± 0.062
5.312ArgGlu: 5.312 ± 0.096
3.463ArgPhe: 3.463 ± 0.065
4.427ArgGly: 4.427 ± 0.079
1.487ArgHis: 1.487 ± 0.044
5.299ArgIle: 5.299 ± 0.079
3.139ArgLys: 3.139 ± 0.074
7.019ArgLeu: 7.019 ± 0.109
2.237ArgMet: 2.237 ± 0.054
2.804ArgAsn: 2.804 ± 0.057
3.046ArgPro: 3.046 ± 0.075
2.353ArgGln: 2.353 ± 0.056
6.22ArgArg: 6.22 ± 0.108
3.657ArgSer: 3.657 ± 0.064
4.38ArgThr: 4.38 ± 0.084
4.064ArgVal: 4.064 ± 0.078
1.018ArgTrp: 1.018 ± 0.032
3.186ArgTyr: 3.186 ± 0.065
0.0ArgXaa: 0.0 ± 0.0
Ser
5.278SerAla: 5.278 ± 0.082
0.74SerCys: 0.74 ± 0.028
3.378SerAsp: 3.378 ± 0.07
3.441SerGlu: 3.441 ± 0.065
2.595SerPhe: 2.595 ± 0.065
5.246SerGly: 5.246 ± 0.102
0.928SerHis: 0.928 ± 0.034
2.736SerIle: 2.736 ± 0.067
2.141SerLys: 2.141 ± 0.054
5.546SerLeu: 5.546 ± 0.092
1.257SerMet: 1.257 ± 0.038
1.722SerAsn: 1.722 ± 0.05
2.505SerPro: 2.505 ± 0.057
1.497SerGln: 1.497 ± 0.048
3.308SerArg: 3.308 ± 0.07
3.133SerSer: 3.133 ± 0.068
2.702SerThr: 2.702 ± 0.057
4.421SerVal: 4.421 ± 0.069
0.784SerTrp: 0.784 ± 0.032
2.475SerTyr: 2.475 ± 0.06
0.0SerXaa: 0.0 ± 0.0
Thr
5.506ThrAla: 5.506 ± 0.095
0.504ThrCys: 0.504 ± 0.024
3.55ThrAsp: 3.55 ± 0.066
3.47ThrGlu: 3.47 ± 0.069
2.463ThrPhe: 2.463 ± 0.061
4.853ThrGly: 4.853 ± 0.077
0.892ThrHis: 0.892 ± 0.036
3.004ThrIle: 3.004 ± 0.054
1.869ThrLys: 1.869 ± 0.048
5.837ThrLeu: 5.837 ± 0.083
1.191ThrMet: 1.191 ± 0.037
1.672ThrAsn: 1.672 ± 0.051
3.171ThrPro: 3.171 ± 0.059
1.446ThrGln: 1.446 ± 0.041
2.972ThrArg: 2.972 ± 0.059
2.91ThrSer: 2.91 ± 0.064
3.215ThrThr: 3.215 ± 0.07
4.738ThrVal: 4.738 ± 0.075
0.69ThrTrp: 0.69 ± 0.031
2.019ThrTyr: 2.019 ± 0.046
0.0ThrXaa: 0.0 ± 0.0
Val
6.748ValAla: 6.748 ± 0.104
1.093ValCys: 1.093 ± 0.04
3.538ValAsp: 3.538 ± 0.062
4.894ValGlu: 4.894 ± 0.076
2.853ValPhe: 2.853 ± 0.07
5.057ValGly: 5.057 ± 0.096
1.07ValHis: 1.07 ± 0.038
3.515ValIle: 3.515 ± 0.072
2.977ValLys: 2.977 ± 0.066
6.18ValLeu: 6.18 ± 0.104
1.684ValMet: 1.684 ± 0.04
2.496ValAsn: 2.496 ± 0.057
3.151ValPro: 3.151 ± 0.067
1.9ValGln: 1.9 ± 0.04
5.592ValArg: 5.592 ± 0.094
4.694ValSer: 4.694 ± 0.079
4.27ValThr: 4.27 ± 0.077
5.652ValVal: 5.652 ± 0.104
0.986ValTrp: 0.986 ± 0.037
2.311ValTyr: 2.311 ± 0.051
0.0ValXaa: 0.0 ± 0.0
Trp
0.901TrpAla: 0.901 ± 0.032
0.218TrpCys: 0.218 ± 0.017
0.754TrpAsp: 0.754 ± 0.029
0.823TrpGlu: 0.823 ± 0.029
0.604TrpPhe: 0.604 ± 0.026
1.035TrpGly: 1.035 ± 0.036
0.279TrpHis: 0.279 ± 0.02
0.772TrpIle: 0.772 ± 0.029
0.597TrpLys: 0.597 ± 0.027
1.25TrpLeu: 1.25 ± 0.04
0.391TrpMet: 0.391 ± 0.024
0.633TrpAsn: 0.633 ± 0.028
0.345TrpPro: 0.345 ± 0.023
0.506TrpGln: 0.506 ± 0.025
0.99TrpArg: 0.99 ± 0.036
0.791TrpSer: 0.791 ± 0.031
0.834TrpThr: 0.834 ± 0.03
0.773TrpVal: 0.773 ± 0.032
0.265TrpTrp: 0.265 ± 0.016
0.523TrpTyr: 0.523 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.724TyrAla: 3.724 ± 0.066
0.519TyrCys: 0.519 ± 0.025
2.819TyrAsp: 2.819 ± 0.063
2.442TyrGlu: 2.442 ± 0.053
1.766TyrPhe: 1.766 ± 0.049
3.292TyrGly: 3.292 ± 0.07
0.677TyrHis: 0.677 ± 0.028
1.944TyrIle: 1.944 ± 0.045
1.492TyrLys: 1.492 ± 0.048
3.443TyrLeu: 3.443 ± 0.069
0.896TyrMet: 0.896 ± 0.034
1.755TyrAsn: 1.755 ± 0.05
1.732TyrPro: 1.732 ± 0.042
0.835TyrGln: 0.835 ± 0.031
2.901TyrArg: 2.901 ± 0.059
2.095TyrSer: 2.095 ± 0.057
2.603TyrThr: 2.603 ± 0.061
2.602TyrVal: 2.602 ± 0.064
0.467TyrTrp: 0.467 ± 0.024
1.82TyrTyr: 1.82 ± 0.057
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2408 proteins (882180 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski