Amino acid dipepetide frequency for Fructobacillus durionis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.292AlaAla: 9.292 ± 0.26
0.284AlaCys: 0.284 ± 0.03
6.009AlaAsp: 6.009 ± 0.143
5.421AlaGlu: 5.421 ± 0.165
4.024AlaPhe: 4.024 ± 0.124
7.076AlaGly: 7.076 ± 0.151
1.582AlaHis: 1.582 ± 0.069
6.394AlaIle: 6.394 ± 0.144
6.846AlaLys: 6.846 ± 0.179
9.467AlaLeu: 9.467 ± 0.189
2.639AlaMet: 2.639 ± 0.084
3.879AlaAsn: 3.879 ± 0.099
2.35AlaPro: 2.35 ± 0.079
3.676AlaGln: 3.676 ± 0.104
3.207AlaArg: 3.207 ± 0.083
4.929AlaSer: 4.929 ± 0.138
4.82AlaThr: 4.82 ± 0.138
6.947AlaVal: 6.947 ± 0.134
0.92AlaTrp: 0.92 ± 0.053
2.972AlaTyr: 2.972 ± 0.082
0.0AlaXaa: 0.0 ± 0.0
Cys
0.152CysAla: 0.152 ± 0.019
0.013CysCys: 0.013 ± 0.006
0.134CysAsp: 0.134 ± 0.017
0.119CysGlu: 0.119 ± 0.016
0.172CysPhe: 0.172 ± 0.023
0.238CysGly: 0.238 ± 0.028
0.091CysHis: 0.091 ± 0.017
0.099CysIle: 0.099 ± 0.016
0.041CysLys: 0.041 ± 0.009
0.35CysLeu: 0.35 ± 0.037
0.051CysMet: 0.051 ± 0.012
0.076CysAsn: 0.076 ± 0.014
0.15CysPro: 0.15 ± 0.027
0.145CysGln: 0.145 ± 0.024
0.127CysArg: 0.127 ± 0.018
0.165CysSer: 0.165 ± 0.022
0.106CysThr: 0.106 ± 0.018
0.119CysVal: 0.119 ± 0.015
0.035CysTrp: 0.035 ± 0.01
0.096CysTyr: 0.096 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
4.926AspAla: 4.926 ± 0.183
0.177AspCys: 0.177 ± 0.024
3.778AspAsp: 3.778 ± 0.139
4.424AspGlu: 4.424 ± 0.146
3.329AspPhe: 3.329 ± 0.089
4.437AspGly: 4.437 ± 0.143
1.141AspHis: 1.141 ± 0.054
3.408AspIle: 3.408 ± 0.105
3.91AspLys: 3.91 ± 0.126
6.425AspLeu: 6.425 ± 0.148
1.562AspMet: 1.562 ± 0.057
2.647AspAsn: 2.647 ± 0.094
2.082AspPro: 2.082 ± 0.075
3.093AspGln: 3.093 ± 0.101
2.586AspArg: 2.586 ± 0.089
3.423AspSer: 3.423 ± 0.102
2.754AspThr: 2.754 ± 0.101
4.077AspVal: 4.077 ± 0.117
0.806AspTrp: 0.806 ± 0.05
2.563AspTyr: 2.563 ± 0.088
0.0AspXaa: 0.0 ± 0.0
Glu
5.781GluAla: 5.781 ± 0.136
0.106GluCys: 0.106 ± 0.017
3.55GluAsp: 3.55 ± 0.103
4.901GluGlu: 4.901 ± 0.138
1.757GluPhe: 1.757 ± 0.067
3.365GluGly: 3.365 ± 0.099
1.171GluHis: 1.171 ± 0.059
3.479GluIle: 3.479 ± 0.097
5.489GluLys: 5.489 ± 0.15
5.826GluLeu: 5.826 ± 0.149
1.737GluMet: 1.737 ± 0.065
3.167GluAsn: 3.167 ± 0.103
1.706GluPro: 1.706 ± 0.08
3.06GluGln: 3.06 ± 0.104
2.685GluArg: 2.685 ± 0.091
3.174GluSer: 3.174 ± 0.098
3.045GluThr: 3.045 ± 0.093
4.039GluVal: 4.039 ± 0.118
0.515GluTrp: 0.515 ± 0.033
1.643GluTyr: 1.643 ± 0.066
0.0GluXaa: 0.0 ± 0.0
Phe
3.813PheAla: 3.813 ± 0.109
0.137PheCys: 0.137 ± 0.017
3.098PheAsp: 3.098 ± 0.096
2.424PheGlu: 2.424 ± 0.084
2.264PhePhe: 2.264 ± 0.099
3.377PheGly: 3.377 ± 0.106
0.715PheHis: 0.715 ± 0.041
2.726PheIle: 2.726 ± 0.11
2.208PheLys: 2.208 ± 0.08
4.285PheLeu: 4.285 ± 0.142
1.057PheMet: 1.057 ± 0.063
1.907PheAsn: 1.907 ± 0.075
1.291PhePro: 1.291 ± 0.063
1.511PheGln: 1.511 ± 0.059
1.23PheArg: 1.23 ± 0.053
2.984PheSer: 2.984 ± 0.109
2.366PheThr: 2.366 ± 0.079
3.078PheVal: 3.078 ± 0.099
0.581PheTrp: 0.581 ± 0.044
1.592PheTyr: 1.592 ± 0.074
0.0PheXaa: 0.0 ± 0.0
Gly
5.444GlyAla: 5.444 ± 0.148
0.203GlyCys: 0.203 ± 0.024
3.768GlyAsp: 3.768 ± 0.104
3.58GlyGlu: 3.58 ± 0.112
3.159GlyPhe: 3.159 ± 0.113
4.336GlyGly: 4.336 ± 0.131
1.534GlyHis: 1.534 ± 0.07
4.876GlyIle: 4.876 ± 0.128
4.632GlyLys: 4.632 ± 0.133
7.114GlyLeu: 7.114 ± 0.144
2.158GlyMet: 2.158 ± 0.074
2.837GlyAsn: 2.837 ± 0.096
1.823GlyPro: 1.823 ± 0.071
3.925GlyGln: 3.925 ± 0.092
3.086GlyArg: 3.086 ± 0.099
4.295GlySer: 4.295 ± 0.122
4.024GlyThr: 4.024 ± 0.112
4.868GlyVal: 4.868 ± 0.126
0.832GlyTrp: 0.832 ± 0.058
2.677GlyTyr: 2.677 ± 0.077
0.0GlyXaa: 0.0 ± 0.0
His
1.247HisAla: 1.247 ± 0.055
0.058HisCys: 0.058 ± 0.012
1.121HisAsp: 1.121 ± 0.054
1.057HisGlu: 1.057 ± 0.052
1.098HisPhe: 1.098 ± 0.062
1.417HisGly: 1.417 ± 0.069
0.474HisHis: 0.474 ± 0.034
1.022HisIle: 1.022 ± 0.052
0.849HisLys: 0.849 ± 0.046
1.897HisLeu: 1.897 ± 0.085
0.408HisMet: 0.408 ± 0.033
0.74HisAsn: 0.74 ± 0.049
0.903HisPro: 0.903 ± 0.053
0.986HisGln: 0.986 ± 0.049
0.829HisArg: 0.829 ± 0.046
0.991HisSer: 0.991 ± 0.053
0.824HisThr: 0.824 ± 0.043
1.225HisVal: 1.225 ± 0.055
0.266HisTrp: 0.266 ± 0.028
0.834HisTyr: 0.834 ± 0.045
0.0HisXaa: 0.0 ± 0.0
Ile
5.936IleAla: 5.936 ± 0.147
0.208IleCys: 0.208 ± 0.023
4.275IleAsp: 4.275 ± 0.108
3.859IleGlu: 3.859 ± 0.11
2.748IlePhe: 2.748 ± 0.106
4.571IleGly: 4.571 ± 0.13
1.154IleHis: 1.154 ± 0.052
4.158IleIle: 4.158 ± 0.108
3.689IleLys: 3.689 ± 0.099
5.961IleLeu: 5.961 ± 0.161
1.453IleMet: 1.453 ± 0.056
2.786IleAsn: 2.786 ± 0.082
2.35IlePro: 2.35 ± 0.073
2.644IleGln: 2.644 ± 0.104
2.358IleArg: 2.358 ± 0.084
3.735IleSer: 3.735 ± 0.106
3.522IleThr: 3.522 ± 0.1
4.703IleVal: 4.703 ± 0.11
0.735IleTrp: 0.735 ± 0.044
1.843IleTyr: 1.843 ± 0.077
0.0IleXaa: 0.0 ± 0.0
Lys
6.146LysAla: 6.146 ± 0.172
0.058LysCys: 0.058 ± 0.012
4.214LysAsp: 4.214 ± 0.113
5.094LysGlu: 5.094 ± 0.139
1.638LysPhe: 1.638 ± 0.067
3.692LysGly: 3.692 ± 0.107
1.133LysHis: 1.133 ± 0.061
3.808LysIle: 3.808 ± 0.109
6.085LysLys: 6.085 ± 0.164
5.084LysLeu: 5.084 ± 0.117
2.262LysMet: 2.262 ± 0.067
3.545LysAsn: 3.545 ± 0.104
2.33LysPro: 2.33 ± 0.074
3.504LysGln: 3.504 ± 0.124
2.921LysArg: 2.921 ± 0.092
3.902LysSer: 3.902 ± 0.11
4.275LysThr: 4.275 ± 0.118
5.134LysVal: 5.134 ± 0.126
0.568LysTrp: 0.568 ± 0.042
1.869LysTyr: 1.869 ± 0.08
0.0LysXaa: 0.0 ± 0.0
Leu
10.568LeuAla: 10.568 ± 0.216
0.223LeuCys: 0.223 ± 0.027
5.598LeuAsp: 5.598 ± 0.144
4.931LeuGlu: 4.931 ± 0.134
4.011LeuPhe: 4.011 ± 0.125
6.531LeuGly: 6.531 ± 0.154
1.623LeuHis: 1.623 ± 0.073
6.24LeuIle: 6.24 ± 0.133
6.237LeuLys: 6.237 ± 0.153
9.434LeuLeu: 9.434 ± 0.254
2.32LeuMet: 2.32 ± 0.084
4.107LeuAsn: 4.107 ± 0.101
4.511LeuPro: 4.511 ± 0.13
3.633LeuGln: 3.633 ± 0.106
3.121LeuArg: 3.121 ± 0.097
7.249LeuSer: 7.249 ± 0.158
6.744LeuThr: 6.744 ± 0.144
7.254LeuVal: 7.254 ± 0.15
0.791LeuTrp: 0.791 ± 0.05
2.683LeuTyr: 2.683 ± 0.09
0.0LeuXaa: 0.0 ± 0.0
Met
3.065MetAla: 3.065 ± 0.088
0.043MetCys: 0.043 ± 0.011
1.478MetAsp: 1.478 ± 0.07
1.161MetGlu: 1.161 ± 0.057
0.773MetPhe: 0.773 ± 0.06
1.886MetGly: 1.886 ± 0.085
0.36MetHis: 0.36 ± 0.03
1.775MetIle: 1.775 ± 0.069
1.965MetLys: 1.965 ± 0.059
2.135MetLeu: 2.135 ± 0.083
0.852MetMet: 0.852 ± 0.052
1.306MetAsn: 1.306 ± 0.058
1.103MetPro: 1.103 ± 0.053
0.979MetGln: 0.979 ± 0.054
0.88MetArg: 0.88 ± 0.038
1.504MetSer: 1.504 ± 0.066
2.145MetThr: 2.145 ± 0.082
2.241MetVal: 2.241 ± 0.083
0.139MetTrp: 0.139 ± 0.018
0.545MetTyr: 0.545 ± 0.037
0.0MetXaa: 0.0 ± 0.0
Asn
3.643AsnAla: 3.643 ± 0.115
0.134AsnCys: 0.134 ± 0.019
2.698AsnAsp: 2.698 ± 0.087
2.472AsnGlu: 2.472 ± 0.068
1.752AsnPhe: 1.752 ± 0.062
3.692AsnGly: 3.692 ± 0.136
0.956AsnHis: 0.956 ± 0.048
2.614AsnIle: 2.614 ± 0.092
2.85AsnLys: 2.85 ± 0.102
4.151AsnLeu: 4.151 ± 0.098
1.194AsnMet: 1.194 ± 0.056
2.018AsnAsn: 2.018 ± 0.096
2.175AsnPro: 2.175 ± 0.078
2.52AsnGln: 2.52 ± 0.096
1.922AsnArg: 1.922 ± 0.067
2.282AsnSer: 2.282 ± 0.101
2.211AsnThr: 2.211 ± 0.088
2.781AsnVal: 2.781 ± 0.09
0.672AsnTrp: 0.672 ± 0.044
1.62AsnTyr: 1.62 ± 0.069
0.0AsnXaa: 0.0 ± 0.0
Pro
3.514ProAla: 3.514 ± 0.099
0.043ProCys: 0.043 ± 0.01
2.553ProAsp: 2.553 ± 0.086
2.875ProGlu: 2.875 ± 0.099
1.582ProPhe: 1.582 ± 0.07
2.348ProGly: 2.348 ± 0.09
0.588ProHis: 0.588 ± 0.037
2.173ProIle: 2.173 ± 0.067
2.363ProLys: 2.363 ± 0.075
2.999ProLeu: 2.999 ± 0.089
0.86ProMet: 0.86 ± 0.045
1.623ProAsn: 1.623 ± 0.075
0.434ProPro: 0.434 ± 0.034
1.09ProGln: 1.09 ± 0.048
1.034ProArg: 1.034 ± 0.05
2.206ProSer: 2.206 ± 0.077
2.066ProThr: 2.066 ± 0.08
3.154ProVal: 3.154 ± 0.093
0.355ProTrp: 0.355 ± 0.03
1.212ProTyr: 1.212 ± 0.056
0.0ProXaa: 0.0 ± 0.0
Gln
4.881GlnAla: 4.881 ± 0.141
0.061GlnCys: 0.061 ± 0.014
2.444GlnAsp: 2.444 ± 0.079
3.159GlnGlu: 3.159 ± 0.127
1.311GlnPhe: 1.311 ± 0.051
2.698GlnGly: 2.698 ± 0.089
0.735GlnHis: 0.735 ± 0.044
2.617GlnIle: 2.617 ± 0.075
3.42GlnLys: 3.42 ± 0.102
4.168GlnLeu: 4.168 ± 0.125
1.263GlnMet: 1.263 ± 0.068
2.132GlnAsn: 2.132 ± 0.077
1.744GlnPro: 1.744 ± 0.079
2.115GlnGln: 2.115 ± 0.091
1.615GlnArg: 1.615 ± 0.063
2.842GlnSer: 2.842 ± 0.089
2.632GlnThr: 2.632 ± 0.085
3.707GlnVal: 3.707 ± 0.108
0.332GlnTrp: 0.332 ± 0.027
1.298GlnTyr: 1.298 ± 0.054
0.0GlnXaa: 0.0 ± 0.0
Arg
3.078ArgAla: 3.078 ± 0.098
0.094ArgCys: 0.094 ± 0.015
2.16ArgAsp: 2.16 ± 0.079
2.307ArgGlu: 2.307 ± 0.088
1.858ArgPhe: 1.858 ± 0.071
2.401ArgGly: 2.401 ± 0.086
0.829ArgHis: 0.829 ± 0.05
2.34ArgIle: 2.34 ± 0.095
2.312ArgLys: 2.312 ± 0.08
4.282ArgLeu: 4.282 ± 0.135
1.009ArgMet: 1.009 ± 0.05
1.433ArgAsn: 1.433 ± 0.066
1.529ArgPro: 1.529 ± 0.074
1.97ArgGln: 1.97 ± 0.086
1.99ArgArg: 1.99 ± 0.088
2.14ArgSer: 2.14 ± 0.073
1.912ArgThr: 1.912 ± 0.069
3.017ArgVal: 3.017 ± 0.093
0.319ArgTrp: 0.319 ± 0.031
1.575ArgTyr: 1.575 ± 0.066
0.0ArgXaa: 0.0 ± 0.0
Ser
5.416SerAla: 5.416 ± 0.129
0.129SerCys: 0.129 ± 0.019
3.897SerAsp: 3.897 ± 0.113
3.372SerGlu: 3.372 ± 0.097
3.002SerPhe: 3.002 ± 0.096
4.617SerGly: 4.617 ± 0.131
1.062SerHis: 1.062 ± 0.053
3.6SerIle: 3.6 ± 0.098
3.998SerLys: 3.998 ± 0.111
5.961SerLeu: 5.961 ± 0.165
1.422SerMet: 1.422 ± 0.066
2.619SerAsn: 2.619 ± 0.102
1.711SerPro: 1.711 ± 0.068
2.738SerGln: 2.738 ± 0.078
2.279SerArg: 2.279 ± 0.084
4.151SerSer: 4.151 ± 0.205
3.448SerThr: 3.448 ± 0.118
4.118SerVal: 4.118 ± 0.102
0.75SerTrp: 0.75 ± 0.045
2.17SerTyr: 2.17 ± 0.071
0.0SerXaa: 0.0 ± 0.0
Thr
5.499ThrAla: 5.499 ± 0.11
0.127ThrCys: 0.127 ± 0.023
3.423ThrAsp: 3.423 ± 0.095
2.804ThrGlu: 2.804 ± 0.08
2.835ThrPhe: 2.835 ± 0.084
4.528ThrGly: 4.528 ± 0.124
0.996ThrHis: 0.996 ± 0.049
4.026ThrIle: 4.026 ± 0.095
3.56ThrLys: 3.56 ± 0.11
5.743ThrLeu: 5.743 ± 0.131
1.311ThrMet: 1.311 ± 0.058
2.444ThrAsn: 2.444 ± 0.101
2.373ThrPro: 2.373 ± 0.103
1.777ThrGln: 1.777 ± 0.071
1.902ThrArg: 1.902 ± 0.067
3.159ThrSer: 3.159 ± 0.106
3.562ThrThr: 3.562 ± 0.108
5.005ThrVal: 5.005 ± 0.115
0.581ThrTrp: 0.581 ± 0.037
1.909ThrTyr: 1.909 ± 0.071
0.0ThrXaa: 0.0 ± 0.0
Val
7.074ValAla: 7.074 ± 0.156
0.221ValCys: 0.221 ± 0.025
4.855ValAsp: 4.855 ± 0.126
4.003ValGlu: 4.003 ± 0.11
3.043ValPhe: 3.043 ± 0.112
4.947ValGly: 4.947 ± 0.115
1.116ValHis: 1.116 ± 0.053
5.005ValIle: 5.005 ± 0.119
4.627ValLys: 4.627 ± 0.13
7.475ValLeu: 7.475 ± 0.139
1.846ValMet: 1.846 ± 0.077
3.278ValAsn: 3.278 ± 0.093
2.751ValPro: 2.751 ± 0.083
3.043ValGln: 3.043 ± 0.089
2.698ValArg: 2.698 ± 0.089
4.693ValSer: 4.693 ± 0.11
4.797ValThr: 4.797 ± 0.127
6.001ValVal: 6.001 ± 0.132
0.649ValTrp: 0.649 ± 0.051
2.074ValTyr: 2.074 ± 0.078
0.0ValXaa: 0.0 ± 0.0
Trp
0.844TrpAla: 0.844 ± 0.049
0.023TrpCys: 0.023 ± 0.008
0.474TrpAsp: 0.474 ± 0.032
0.416TrpGlu: 0.416 ± 0.029
0.601TrpPhe: 0.601 ± 0.046
0.707TrpGly: 0.707 ± 0.046
0.248TrpHis: 0.248 ± 0.024
0.649TrpIle: 0.649 ± 0.039
0.446TrpLys: 0.446 ± 0.034
1.258TrpLeu: 1.258 ± 0.066
0.236TrpMet: 0.236 ± 0.023
0.423TrpAsn: 0.423 ± 0.035
0.403TrpPro: 0.403 ± 0.031
0.596TrpGln: 0.596 ± 0.043
0.497TrpArg: 0.497 ± 0.037
0.756TrpSer: 0.756 ± 0.051
0.619TrpThr: 0.619 ± 0.039
0.7TrpVal: 0.7 ± 0.042
0.18TrpTrp: 0.18 ± 0.023
0.406TrpTyr: 0.406 ± 0.036
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.416TyrAla: 2.416 ± 0.074
0.137TyrCys: 0.137 ± 0.021
2.023TyrAsp: 2.023 ± 0.078
1.815TyrGlu: 1.815 ± 0.063
1.686TyrPhe: 1.686 ± 0.08
2.305TyrGly: 2.305 ± 0.079
0.738TyrHis: 0.738 ± 0.043
1.681TyrIle: 1.681 ± 0.062
1.732TyrLys: 1.732 ± 0.074
3.796TyrLeu: 3.796 ± 0.109
0.695TyrMet: 0.695 ± 0.048
1.389TyrAsn: 1.389 ± 0.057
1.354TyrPro: 1.354 ± 0.063
2.168TyrGln: 2.168 ± 0.08
1.59TyrArg: 1.59 ± 0.068
1.884TyrSer: 1.884 ± 0.066
1.694TyrThr: 1.694 ± 0.075
2.026TyrVal: 2.026 ± 0.077
0.454TyrTrp: 0.454 ± 0.039
1.433TyrTyr: 1.433 ± 0.089
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1250 proteins (394407 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski