Amino acid dipepetide frequency for Parvibaculum lavamentivorans (strain DS-1 / DSM 13023 / NCIMB 13966)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.327AlaAla: 17.327 ± 0.197	1.075AlaCys: 1.075 ± 0.032	6.688AlaAsp: 6.688 ± 0.08	8.407AlaGlu: 8.407 ± 0.114	4.416AlaPhe: 4.416 ± 0.066	10.817AlaGly: 10.817 ± 0.134	2.399AlaHis: 2.399 ± 0.048	5.952AlaIle: 5.952 ± 0.075	4.291AlaLys: 4.291 ± 0.084	13.062AlaLeu: 13.062 ± 0.143	3.426AlaMet: 3.426 ± 0.059	2.877AlaAsn: 2.877 ± 0.051	5.759AlaPro: 5.759 ± 0.095	3.579AlaGln: 3.579 ± 0.059	9.068AlaArg: 9.068 ± 0.104	6.173AlaSer: 6.173 ± 0.079	5.643AlaThr: 5.643 ± 0.081	8.086AlaVal: 8.086 ± 0.09	1.475AlaTrp: 1.475 ± 0.035	2.577AlaTyr: 2.577 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.954CysAla: 0.954 ± 0.03	0.112CysCys: 0.112 ± 0.01	0.536CysAsp: 0.536 ± 0.019	0.471CysGlu: 0.471 ± 0.02	0.364CysPhe: 0.364 ± 0.019	0.837CysGly: 0.837 ± 0.031	0.214CysHis: 0.214 ± 0.013	0.384CysIle: 0.384 ± 0.018	0.203CysLys: 0.203 ± 0.013	0.753CysLeu: 0.753 ± 0.026	0.154CysMet: 0.154 ± 0.011	0.198CysAsn: 0.198 ± 0.015	0.435CysPro: 0.435 ± 0.023	0.203CysGln: 0.203 ± 0.014	0.581CysArg: 0.581 ± 0.021	0.42CysSer: 0.42 ± 0.019	0.391CysThr: 0.391 ± 0.02	0.611CysVal: 0.611 ± 0.024	0.089CysTrp: 0.089 ± 0.008	0.201CysTyr: 0.201 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	6.931AspAla: 6.931 ± 0.076	0.438AspCys: 0.438 ± 0.019	3.076AspAsp: 3.076 ± 0.06	4.171AspGlu: 4.171 ± 0.065	2.302AspPhe: 2.302 ± 0.035	5.091AspGly: 5.091 ± 0.094	1.173AspHis: 1.173 ± 0.034	3.297AspIle: 3.297 ± 0.05	1.903AspLys: 1.903 ± 0.041	5.538AspLeu: 5.538 ± 0.075	1.573AspMet: 1.573 ± 0.037	1.317AspAsn: 1.317 ± 0.04	3.203AspPro: 3.203 ± 0.048	1.373AspGln: 1.373 ± 0.035	3.858AspArg: 3.858 ± 0.059	1.966AspSer: 1.966 ± 0.046	2.703AspThr: 2.703 ± 0.063	4.06AspVal: 4.06 ± 0.059	0.927AspTrp: 0.927 ± 0.026	1.609AspTyr: 1.609 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	8.676GluAla: 8.676 ± 0.107	0.396GluCys: 0.396 ± 0.018	3.258GluAsp: 3.258 ± 0.05	4.53GluGlu: 4.53 ± 0.076	1.878GluPhe: 1.878 ± 0.039	5.281GluGly: 5.281 ± 0.067	1.259GluHis: 1.259 ± 0.037	3.916GluIle: 3.916 ± 0.066	3.089GluLys: 3.089 ± 0.063	5.871GluLeu: 5.871 ± 0.085	1.9GluMet: 1.9 ± 0.044	1.851GluAsn: 1.851 ± 0.038	3.026GluPro: 3.026 ± 0.051	2.083GluGln: 2.083 ± 0.045	5.212GluArg: 5.212 ± 0.07	2.59GluSer: 2.59 ± 0.046	4.08GluThr: 4.08 ± 0.074	4.273GluVal: 4.273 ± 0.063	0.785GluTrp: 0.785 ± 0.029	1.223GluTyr: 1.223 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.487PheAla: 4.487 ± 0.074	0.415PheCys: 0.415 ± 0.02	2.621PheAsp: 2.621 ± 0.047	2.354PheGlu: 2.354 ± 0.046	1.627PhePhe: 1.627 ± 0.046	3.756PheGly: 3.756 ± 0.063	0.795PheHis: 0.795 ± 0.026	1.907PheIle: 1.907 ± 0.044	1.024PheLys: 1.024 ± 0.032	3.578PheLeu: 3.578 ± 0.065	0.926PheMet: 0.926 ± 0.031	1.085PheAsn: 1.085 ± 0.032	1.631PhePro: 1.631 ± 0.041	0.938PheGln: 0.938 ± 0.029	2.366PheArg: 2.366 ± 0.045	2.284PheSer: 2.284 ± 0.051	2.064PheThr: 2.064 ± 0.049	2.75PheVal: 2.75 ± 0.055	0.54PheTrp: 0.54 ± 0.024	1.003PheTyr: 1.003 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	9.469GlyAla: 9.469 ± 0.117	0.771GlyCys: 0.771 ± 0.027	4.58GlyAsp: 4.58 ± 0.076	5.629GlyGlu: 5.629 ± 0.091	3.765GlyPhe: 3.765 ± 0.056	7.803GlyGly: 7.803 ± 0.106	1.924GlyHis: 1.924 ± 0.041	4.854GlyIle: 4.854 ± 0.064	3.595GlyLys: 3.595 ± 0.058	8.712GlyLeu: 8.712 ± 0.107	2.358GlyMet: 2.358 ± 0.045	2.38GlyAsn: 2.38 ± 0.063	3.549GlyPro: 3.549 ± 0.06	2.47GlyGln: 2.47 ± 0.05	5.968GlyArg: 5.968 ± 0.077	4.573GlySer: 4.573 ± 0.081	4.789GlyThr: 4.789 ± 0.107	5.996GlyVal: 5.996 ± 0.074	1.347GlyTrp: 1.347 ± 0.04	2.358GlyTyr: 2.358 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.239HisAla: 2.239 ± 0.04	0.247HisCys: 0.247 ± 0.015	1.161HisAsp: 1.161 ± 0.039	1.313HisGlu: 1.313 ± 0.036	0.871HisPhe: 0.871 ± 0.027	1.912HisGly: 1.912 ± 0.043	0.52HisHis: 0.52 ± 0.024	1.121HisIle: 1.121 ± 0.026	0.566HisLys: 0.566 ± 0.023	2.04HisLeu: 2.04 ± 0.054	0.566HisMet: 0.566 ± 0.022	0.487HisAsn: 0.487 ± 0.02	1.365HisPro: 1.365 ± 0.041	0.513HisGln: 0.513 ± 0.019	1.354HisArg: 1.354 ± 0.035	0.918HisSer: 0.918 ± 0.028	0.854HisThr: 0.854 ± 0.029	1.574HisVal: 1.574 ± 0.035	0.369HisTrp: 0.369 ± 0.019	0.577HisTyr: 0.577 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.112IleAla: 7.112 ± 0.074	0.51IleCys: 0.51 ± 0.026	3.536IleAsp: 3.536 ± 0.056	3.94IleGlu: 3.94 ± 0.062	1.98IlePhe: 1.98 ± 0.043	4.9IleGly: 4.9 ± 0.063	0.939IleHis: 0.939 ± 0.03	2.189IleIle: 2.189 ± 0.051	1.412IleLys: 1.412 ± 0.039	4.241IleLeu: 4.241 ± 0.066	1.034IleMet: 1.034 ± 0.029	1.312IleAsn: 1.312 ± 0.035	2.273IlePro: 2.273 ± 0.047	1.136IleGln: 1.136 ± 0.031	3.301IleArg: 3.301 ± 0.055	2.985IleSer: 2.985 ± 0.058	2.395IleThr: 2.395 ± 0.053	4.435IleVal: 4.435 ± 0.065	0.63IleTrp: 0.63 ± 0.023	1.237IleTyr: 1.237 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.398LysAla: 4.398 ± 0.08	0.175LysCys: 0.175 ± 0.013	1.815LysAsp: 1.815 ± 0.043	2.188LysGlu: 2.188 ± 0.042	1.034LysPhe: 1.034 ± 0.03	3.016LysGly: 3.016 ± 0.062	0.673LysHis: 0.673 ± 0.024	1.81LysIle: 1.81 ± 0.046	1.791LysLys: 1.791 ± 0.058	3.677LysLeu: 3.677 ± 0.057	0.873LysMet: 0.873 ± 0.03	0.998LysAsn: 0.998 ± 0.032	2.273LysPro: 2.273 ± 0.056	1.083LysGln: 1.083 ± 0.036	2.711LysArg: 2.711 ± 0.052	2.058LysSer: 2.058 ± 0.048	2.016LysThr: 2.016 ± 0.048	2.496LysVal: 2.496 ± 0.056	0.423LysTrp: 0.423 ± 0.018	0.744LysTyr: 0.744 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	13.174LeuAla: 13.174 ± 0.134	0.832LeuCys: 0.832 ± 0.029	6.011LeuAsp: 6.011 ± 0.071	5.499LeuGlu: 5.499 ± 0.07	3.658LeuPhe: 3.658 ± 0.071	8.063LeuGly: 8.063 ± 0.091	1.921LeuHis: 1.921 ± 0.039	4.82LeuIle: 4.82 ± 0.066	3.901LeuLys: 3.901 ± 0.076	9.015LeuLeu: 9.015 ± 0.119	2.437LeuMet: 2.437 ± 0.047	2.567LeuAsn: 2.567 ± 0.046	5.516LeuPro: 5.516 ± 0.074	2.517LeuGln: 2.517 ± 0.051	6.558LeuArg: 6.558 ± 0.08	6.082LeuSer: 6.082 ± 0.071	5.469LeuThr: 5.469 ± 0.077	7.244LeuVal: 7.244 ± 0.096	1.214LeuTrp: 1.214 ± 0.035	2.2LeuTyr: 2.2 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.077MetAla: 3.077 ± 0.053	0.169MetCys: 0.169 ± 0.013	1.195MetAsp: 1.195 ± 0.031	1.469MetGlu: 1.469 ± 0.039	0.758MetPhe: 0.758 ± 0.028	1.96MetGly: 1.96 ± 0.044	0.461MetHis: 0.461 ± 0.018	1.228MetIle: 1.228 ± 0.034	1.18MetLys: 1.18 ± 0.035	2.572MetLeu: 2.572 ± 0.048	0.721MetMet: 0.721 ± 0.029	0.839MetAsn: 0.839 ± 0.024	1.642MetPro: 1.642 ± 0.032	0.827MetGln: 0.827 ± 0.025	1.911MetArg: 1.911 ± 0.038	1.848MetSer: 1.848 ± 0.038	1.869MetThr: 1.869 ± 0.048	1.606MetVal: 1.606 ± 0.036	0.25MetTrp: 0.25 ± 0.013	0.357MetTyr: 0.357 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.098AsnAla: 3.098 ± 0.051	0.221AsnCys: 0.221 ± 0.013	1.396AsnAsp: 1.396 ± 0.034	1.58AsnGlu: 1.58 ± 0.036	1.063AsnPhe: 1.063 ± 0.03	2.41AsnGly: 2.41 ± 0.053	0.498AsnHis: 0.498 ± 0.021	1.514AsnIle: 1.514 ± 0.036	0.77AsnLys: 0.77 ± 0.026	2.534AsnLeu: 2.534 ± 0.047	0.692AsnMet: 0.692 ± 0.025	0.697AsnAsn: 0.697 ± 0.028	1.769AsnPro: 1.769 ± 0.041	0.688AsnGln: 0.688 ± 0.026	1.814AsnArg: 1.814 ± 0.044	1.192AsnSer: 1.192 ± 0.035	1.214AsnThr: 1.214 ± 0.036	1.999AsnVal: 1.999 ± 0.043	0.467AsnTrp: 0.467 ± 0.027	0.746AsnTyr: 0.746 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	6.213ProAla: 6.213 ± 0.08	0.346ProCys: 0.346 ± 0.017	3.551ProAsp: 3.551 ± 0.056	4.221ProGlu: 4.221 ± 0.059	2.022ProPhe: 2.022 ± 0.04	4.731ProGly: 4.731 ± 0.06	1.073ProHis: 1.073 ± 0.033	2.059ProIle: 2.059 ± 0.039	1.836ProLys: 1.836 ± 0.041	4.86ProLeu: 4.86 ± 0.069	1.201ProMet: 1.201 ± 0.032	1.266ProAsn: 1.266 ± 0.032	2.365ProPro: 2.365 ± 0.053	1.514ProGln: 1.514 ± 0.04	2.954ProArg: 2.954 ± 0.058	2.621ProSer: 2.621 ± 0.051	2.099ProThr: 2.099 ± 0.046	4.256ProVal: 4.256 ± 0.063	0.701ProTrp: 0.701 ± 0.026	1.227ProTyr: 1.227 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.478GlnAla: 3.478 ± 0.061	0.187GlnCys: 0.187 ± 0.013	1.253GlnAsp: 1.253 ± 0.036	1.523GlnGlu: 1.523 ± 0.038	1.038GlnPhe: 1.038 ± 0.031	2.204GlnGly: 2.204 ± 0.041	0.592GlnHis: 0.592 ± 0.021	1.575GlnIle: 1.575 ± 0.035	1.126GlnLys: 1.126 ± 0.034	2.652GlnLeu: 2.652 ± 0.05	0.833GlnMet: 0.833 ± 0.028	0.79GlnAsn: 0.79 ± 0.028	1.476GlnPro: 1.476 ± 0.035	1.03GlnGln: 1.03 ± 0.039	2.189GlnArg: 2.189 ± 0.053	1.522GlnSer: 1.522 ± 0.037	1.56GlnThr: 1.56 ± 0.039	2.024GlnVal: 2.024 ± 0.046	0.409GlnTrp: 0.409 ± 0.019	0.616GlnTyr: 0.616 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	8.094ArgAla: 8.094 ± 0.094	0.462ArgCys: 0.462 ± 0.022	4.083ArgAsp: 4.083 ± 0.061	4.789ArgGlu: 4.789 ± 0.074	2.925ArgPhe: 2.925 ± 0.059	4.876ArgGly: 4.876 ± 0.077	1.704ArgHis: 1.704 ± 0.042	4.018ArgIle: 4.018 ± 0.058	2.613ArgLys: 2.613 ± 0.046	7.608ArgLeu: 7.608 ± 0.09	1.939ArgMet: 1.939 ± 0.042	1.924ArgAsn: 1.924 ± 0.044	3.277ArgPro: 3.277 ± 0.053	2.292ArgGln: 2.292 ± 0.047	5.632ArgArg: 5.632 ± 0.089	3.285ArgSer: 3.285 ± 0.061	3.192ArgThr: 3.192 ± 0.054	4.792ArgVal: 4.792 ± 0.077	0.932ArgTrp: 0.932 ± 0.038	1.826ArgTyr: 1.826 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.843SerAla: 5.843 ± 0.072	0.398SerCys: 0.398 ± 0.02	2.947SerAsp: 2.947 ± 0.052	3.16SerGlu: 3.16 ± 0.043	2.328SerPhe: 2.328 ± 0.051	5.575SerGly: 5.575 ± 0.095	1.094SerHis: 1.094 ± 0.037	2.658SerIle: 2.658 ± 0.052	1.619SerLys: 1.619 ± 0.037	5.306SerLeu: 5.306 ± 0.07	1.351SerMet: 1.351 ± 0.029	1.32SerAsn: 1.32 ± 0.034	2.784SerPro: 2.784 ± 0.053	1.38SerGln: 1.38 ± 0.037	3.549SerArg: 3.549 ± 0.058	2.894SerSer: 2.894 ± 0.059	2.404SerThr: 2.404 ± 0.047	3.788SerVal: 3.788 ± 0.058	0.713SerTrp: 0.713 ± 0.027	1.379SerTyr: 1.379 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	5.937ThrAla: 5.937 ± 0.1	0.413ThrCys: 0.413 ± 0.017	2.65ThrAsp: 2.65 ± 0.05	2.932ThrGlu: 2.932 ± 0.05	1.91ThrPhe: 1.91 ± 0.042	5.304ThrGly: 5.304 ± 0.097	1.072ThrHis: 1.072 ± 0.03	2.785ThrIle: 2.785 ± 0.057	1.581ThrLys: 1.581 ± 0.043	5.503ThrLeu: 5.503 ± 0.08	1.176ThrMet: 1.176 ± 0.028	1.259ThrAsn: 1.259 ± 0.032	3.144ThrPro: 3.144 ± 0.052	1.372ThrGln: 1.372 ± 0.037	3.39ThrArg: 3.39 ± 0.061	2.728ThrSer: 2.728 ± 0.055	2.549ThrThr: 2.549 ± 0.066	4.024ThrVal: 4.024 ± 0.089	0.673ThrTrp: 0.673 ± 0.027	1.267ThrTyr: 1.267 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	8.725ValAla: 8.725 ± 0.083	0.586ValCys: 0.586 ± 0.023	3.961ValAsp: 3.961 ± 0.063	4.753ValGlu: 4.753 ± 0.065	2.679ValPhe: 2.679 ± 0.052	5.226ValGly: 5.226 ± 0.07	1.405ValHis: 1.405 ± 0.037	3.752ValIle: 3.752 ± 0.057	2.526ValLys: 2.526 ± 0.05	7.163ValLeu: 7.163 ± 0.091	1.865ValMet: 1.865 ± 0.042	2.083ValAsn: 2.083 ± 0.051	3.854ValPro: 3.854 ± 0.056	1.835ValGln: 1.835 ± 0.034	4.737ValArg: 4.737 ± 0.069	4.299ValSer: 4.299 ± 0.06	4.481ValThr: 4.481 ± 0.074	5.413ValVal: 5.413 ± 0.07	0.932ValTrp: 0.932 ± 0.029	1.616ValTyr: 1.616 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.24TrpAla: 1.24 ± 0.034	0.128TrpCys: 0.128 ± 0.01	0.634TrpAsp: 0.634 ± 0.025	0.679TrpGlu: 0.679 ± 0.026	0.513TrpPhe: 0.513 ± 0.024	0.975TrpGly: 0.975 ± 0.029	0.344TrpHis: 0.344 ± 0.019	0.639TrpIle: 0.639 ± 0.021	0.479TrpLys: 0.479 ± 0.021	1.606TrpLeu: 1.606 ± 0.042	0.362TrpMet: 0.362 ± 0.018	0.473TrpAsn: 0.473 ± 0.022	0.72TrpPro: 0.72 ± 0.027	0.61TrpGln: 0.61 ± 0.023	1.184TrpArg: 1.184 ± 0.036	0.821TrpSer: 0.821 ± 0.029	0.748TrpThr: 0.748 ± 0.032	0.811TrpVal: 0.811 ± 0.029	0.25TrpTrp: 0.25 ± 0.017	0.313TrpTyr: 0.313 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.626TyrAla: 2.626 ± 0.046	0.23TyrCys: 0.23 ± 0.014	1.559TyrAsp: 1.559 ± 0.038	1.57TyrGlu: 1.57 ± 0.036	1.017TyrPhe: 1.017 ± 0.029	2.152TyrGly: 2.152 ± 0.051	0.505TyrHis: 0.505 ± 0.023	1.017TyrIle: 1.017 ± 0.031	0.749TyrLys: 0.749 ± 0.028	2.408TyrLeu: 2.408 ± 0.045	0.552TyrMet: 0.552 ± 0.023	0.637TyrAsn: 0.637 ± 0.022	1.057TyrPro: 1.057 ± 0.028	0.638TyrGln: 0.638 ± 0.022	1.926TyrArg: 1.926 ± 0.039	1.228TyrSer: 1.228 ± 0.037	1.148TyrThr: 1.148 ± 0.032	1.654TyrVal: 1.654 ± 0.033	0.402TyrTrp: 0.402 ± 0.019	0.641TyrTyr: 0.641 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3580 proteins (1152854 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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