Amino acid dipepetide frequency for Alteromonas phage vB_AmaP_AD45-P1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.589AlaAla: 7.589 ± 0.681
0.912AlaCys: 0.912 ± 0.187
5.582AlaAsp: 5.582 ± 0.562
6.969AlaGlu: 6.969 ± 0.767
2.554AlaPhe: 2.554 ± 0.288
4.706AlaGly: 4.706 ± 0.535
1.423AlaHis: 1.423 ± 0.193
4.67AlaIle: 4.67 ± 0.455
6.02AlaLys: 6.02 ± 0.505
6.75AlaLeu: 6.75 ± 0.491
1.897AlaMet: 1.897 ± 0.324
4.706AlaAsn: 4.706 ± 0.56
2.371AlaPro: 2.371 ± 0.369
3.357AlaGln: 3.357 ± 0.451
3.466AlaArg: 3.466 ± 0.337
5.436AlaSer: 5.436 ± 0.512
4.962AlaThr: 4.962 ± 0.564
5.947AlaVal: 5.947 ± 0.468
0.839AlaTrp: 0.839 ± 0.165
2.663AlaTyr: 2.663 ± 0.373
0.0AlaXaa: 0.0 ± 0.0
Cys
0.584CysAla: 0.584 ± 0.154
0.109CysCys: 0.109 ± 0.053
0.401CysAsp: 0.401 ± 0.131
0.401CysGlu: 0.401 ± 0.139
0.584CysPhe: 0.584 ± 0.152
0.328CysGly: 0.328 ± 0.102
0.182CysHis: 0.182 ± 0.08
0.365CysIle: 0.365 ± 0.118
0.657CysLys: 0.657 ± 0.142
0.62CysLeu: 0.62 ± 0.162
0.109CysMet: 0.109 ± 0.056
0.511CysAsn: 0.511 ± 0.146
0.438CysPro: 0.438 ± 0.114
0.401CysGln: 0.401 ± 0.116
0.657CysArg: 0.657 ± 0.182
0.328CysSer: 0.328 ± 0.094
0.62CysThr: 0.62 ± 0.138
0.511CysVal: 0.511 ± 0.122
0.109CysTrp: 0.109 ± 0.067
0.255CysTyr: 0.255 ± 0.094
0.0CysXaa: 0.0 ± 0.0
Asp
5.144AspAla: 5.144 ± 0.457
0.657AspCys: 0.657 ± 0.221
4.196AspAsp: 4.196 ± 0.488
4.962AspGlu: 4.962 ± 0.602
2.189AspPhe: 2.189 ± 0.3
4.706AspGly: 4.706 ± 0.567
1.058AspHis: 1.058 ± 0.204
4.159AspIle: 4.159 ± 0.375
3.867AspLys: 3.867 ± 0.304
5.874AspLeu: 5.874 ± 0.457
1.897AspMet: 1.897 ± 0.264
4.159AspAsn: 4.159 ± 0.573
2.517AspPro: 2.517 ± 0.356
1.934AspGln: 1.934 ± 0.309
2.7AspArg: 2.7 ± 0.498
4.67AspSer: 4.67 ± 0.485
3.575AspThr: 3.575 ± 0.315
4.743AspVal: 4.743 ± 0.456
0.62AspTrp: 0.62 ± 0.114
2.481AspTyr: 2.481 ± 0.298
0.0AspXaa: 0.0 ± 0.0
Glu
7.37GluAla: 7.37 ± 0.697
0.365GluCys: 0.365 ± 0.132
4.378GluAsp: 4.378 ± 0.527
6.129GluGlu: 6.129 ± 0.609
2.955GluPhe: 2.955 ± 0.345
3.575GluGly: 3.575 ± 0.384
1.313GluHis: 1.313 ± 0.274
4.013GluIle: 4.013 ± 0.412
4.706GluLys: 4.706 ± 0.526
6.713GluLeu: 6.713 ± 0.612
2.189GluMet: 2.189 ± 0.381
3.794GluAsn: 3.794 ± 0.273
1.715GluPro: 1.715 ± 0.233
3.612GluGln: 3.612 ± 0.553
2.809GluArg: 2.809 ± 0.357
3.721GluSer: 3.721 ± 0.387
3.648GluThr: 3.648 ± 0.351
5.436GluVal: 5.436 ± 0.442
0.73GluTrp: 0.73 ± 0.149
2.882GluTyr: 2.882 ± 0.385
0.0GluXaa: 0.0 ± 0.0
Phe
2.335PheAla: 2.335 ± 0.3
0.511PheCys: 0.511 ± 0.163
2.444PheAsp: 2.444 ± 0.289
2.116PheGlu: 2.116 ± 0.309
1.423PhePhe: 1.423 ± 0.264
1.605PheGly: 1.605 ± 0.257
0.62PheHis: 0.62 ± 0.136
2.554PheIle: 2.554 ± 0.407
2.919PheLys: 2.919 ± 0.326
2.262PheLeu: 2.262 ± 0.256
1.24PheMet: 1.24 ± 0.245
2.59PheAsn: 2.59 ± 0.262
1.095PhePro: 1.095 ± 0.213
0.766PheGln: 0.766 ± 0.222
1.824PheArg: 1.824 ± 0.289
2.299PheSer: 2.299 ± 0.367
2.517PheThr: 2.517 ± 0.361
2.992PheVal: 2.992 ± 0.341
0.401PheTrp: 0.401 ± 0.098
1.459PheTyr: 1.459 ± 0.227
0.0PheXaa: 0.0 ± 0.0
Gly
4.123GlyAla: 4.123 ± 0.545
0.219GlyCys: 0.219 ± 0.065
3.721GlyAsp: 3.721 ± 0.44
3.101GlyGlu: 3.101 ± 0.35
2.153GlyPhe: 2.153 ± 0.252
4.159GlyGly: 4.159 ± 0.593
1.167GlyHis: 1.167 ± 0.186
3.539GlyIle: 3.539 ± 0.336
4.889GlyLys: 4.889 ± 0.425
4.451GlyLeu: 4.451 ± 0.409
1.313GlyMet: 1.313 ± 0.242
4.05GlyAsn: 4.05 ± 0.814
1.313GlyPro: 1.313 ± 0.305
1.934GlyGln: 1.934 ± 0.345
2.444GlyArg: 2.444 ± 0.474
5.619GlySer: 5.619 ± 0.695
4.998GlyThr: 4.998 ± 0.435
4.086GlyVal: 4.086 ± 0.413
0.985GlyTrp: 0.985 ± 0.236
2.335GlyTyr: 2.335 ± 0.247
0.0GlyXaa: 0.0 ± 0.0
His
1.386HisAla: 1.386 ± 0.256
0.219HisCys: 0.219 ± 0.121
1.167HisAsp: 1.167 ± 0.171
1.131HisGlu: 1.131 ± 0.19
0.985HisPhe: 0.985 ± 0.201
0.985HisGly: 0.985 ± 0.196
0.328HisHis: 0.328 ± 0.123
1.386HisIle: 1.386 ± 0.248
1.131HisLys: 1.131 ± 0.195
1.861HisLeu: 1.861 ± 0.315
0.438HisMet: 0.438 ± 0.126
0.912HisAsn: 0.912 ± 0.203
0.912HisPro: 0.912 ± 0.195
0.511HisGln: 0.511 ± 0.156
1.204HisArg: 1.204 ± 0.209
1.095HisSer: 1.095 ± 0.236
1.022HisThr: 1.022 ± 0.203
1.24HisVal: 1.24 ± 0.207
0.255HisTrp: 0.255 ± 0.104
1.095HisTyr: 1.095 ± 0.236
0.0HisXaa: 0.0 ± 0.0
Ile
5.363IleAla: 5.363 ± 0.559
0.328IleCys: 0.328 ± 0.113
4.925IleAsp: 4.925 ± 0.584
4.779IleGlu: 4.779 ± 0.418
1.532IlePhe: 1.532 ± 0.261
3.43IleGly: 3.43 ± 0.298
0.912IleHis: 0.912 ± 0.162
2.955IleIle: 2.955 ± 0.375
4.159IleLys: 4.159 ± 0.45
4.196IleLeu: 4.196 ± 0.35
0.985IleMet: 0.985 ± 0.192
3.794IleAsn: 3.794 ± 0.366
1.715IlePro: 1.715 ± 0.233
1.861IleGln: 1.861 ± 0.254
2.736IleArg: 2.736 ± 0.275
3.612IleSer: 3.612 ± 0.355
3.357IleThr: 3.357 ± 0.307
3.612IleVal: 3.612 ± 0.325
0.584IleTrp: 0.584 ± 0.173
2.043IleTyr: 2.043 ± 0.265
0.0IleXaa: 0.0 ± 0.0
Lys
6.093LysAla: 6.093 ± 0.626
0.292LysCys: 0.292 ± 0.124
4.451LysAsp: 4.451 ± 0.392
6.604LysGlu: 6.604 ± 0.625
2.663LysPhe: 2.663 ± 0.348
4.415LysGly: 4.415 ± 0.416
1.277LysHis: 1.277 ± 0.242
3.685LysIle: 3.685 ± 0.344
5.035LysLys: 5.035 ± 0.548
5.363LysLeu: 5.363 ± 0.605
1.751LysMet: 1.751 ± 0.265
3.393LysAsn: 3.393 ± 0.405
2.335LysPro: 2.335 ± 0.314
3.211LysGln: 3.211 ± 0.429
4.123LysArg: 4.123 ± 0.412
3.758LysSer: 3.758 ± 0.297
4.378LysThr: 4.378 ± 0.363
4.925LysVal: 4.925 ± 0.395
0.657LysTrp: 0.657 ± 0.137
2.663LysTyr: 2.663 ± 0.265
0.0LysXaa: 0.0 ± 0.0
Leu
7.37LeuAla: 7.37 ± 0.595
0.73LeuCys: 0.73 ± 0.17
5.254LeuAsp: 5.254 ± 0.509
5.837LeuGlu: 5.837 ± 0.562
2.554LeuPhe: 2.554 ± 0.342
4.889LeuGly: 4.889 ± 0.472
1.934LeuHis: 1.934 ± 0.324
4.05LeuIle: 4.05 ± 0.338
5.837LeuLys: 5.837 ± 0.436
5.144LeuLeu: 5.144 ± 0.507
1.97LeuMet: 1.97 ± 0.339
4.232LeuAsn: 4.232 ± 0.42
3.211LeuPro: 3.211 ± 0.316
3.174LeuGln: 3.174 ± 0.4
3.466LeuArg: 3.466 ± 0.41
5.473LeuSer: 5.473 ± 0.441
4.561LeuThr: 4.561 ± 0.376
5.91LeuVal: 5.91 ± 0.52
0.912LeuTrp: 0.912 ± 0.192
2.846LeuTyr: 2.846 ± 0.313
0.0LeuXaa: 0.0 ± 0.0
Met
1.605MetAla: 1.605 ± 0.262
0.109MetCys: 0.109 ± 0.058
1.532MetAsp: 1.532 ± 0.238
1.678MetGlu: 1.678 ± 0.292
0.766MetPhe: 0.766 ± 0.17
1.131MetGly: 1.131 ± 0.18
0.584MetHis: 0.584 ± 0.141
1.277MetIle: 1.277 ± 0.242
2.007MetLys: 2.007 ± 0.271
2.08MetLeu: 2.08 ± 0.304
0.474MetMet: 0.474 ± 0.145
1.277MetAsn: 1.277 ± 0.239
0.985MetPro: 0.985 ± 0.19
0.912MetGln: 0.912 ± 0.22
1.095MetArg: 1.095 ± 0.209
2.262MetSer: 2.262 ± 0.287
1.496MetThr: 1.496 ± 0.225
0.73MetVal: 0.73 ± 0.171
0.109MetTrp: 0.109 ± 0.071
0.876MetTyr: 0.876 ± 0.192
0.0MetXaa: 0.0 ± 0.0
Asn
4.597AsnAla: 4.597 ± 0.453
0.547AsnCys: 0.547 ± 0.141
3.794AsnAsp: 3.794 ± 0.306
3.502AsnGlu: 3.502 ± 0.42
2.08AsnPhe: 2.08 ± 0.317
4.415AsnGly: 4.415 ± 0.702
0.912AsnHis: 0.912 ± 0.215
3.43AsnIle: 3.43 ± 0.488
3.575AsnLys: 3.575 ± 0.412
4.415AsnLeu: 4.415 ± 0.533
1.022AsnMet: 1.022 ± 0.25
3.612AsnAsn: 3.612 ± 0.405
2.809AsnPro: 2.809 ± 0.386
1.605AsnGln: 1.605 ± 0.256
2.517AsnArg: 2.517 ± 0.361
3.831AsnSer: 3.831 ± 0.538
3.977AsnThr: 3.977 ± 0.578
4.488AsnVal: 4.488 ± 0.635
0.839AsnTrp: 0.839 ± 0.179
2.189AsnTyr: 2.189 ± 0.294
0.0AsnXaa: 0.0 ± 0.0
Pro
2.554ProAla: 2.554 ± 0.403
0.255ProCys: 0.255 ± 0.099
2.955ProAsp: 2.955 ± 0.34
3.028ProGlu: 3.028 ± 0.316
1.131ProPhe: 1.131 ± 0.19
1.642ProGly: 1.642 ± 0.342
0.693ProHis: 0.693 ± 0.147
1.715ProIle: 1.715 ± 0.263
2.59ProLys: 2.59 ± 0.362
2.517ProLeu: 2.517 ± 0.291
0.62ProMet: 0.62 ± 0.173
1.678ProAsn: 1.678 ± 0.256
0.839ProPro: 0.839 ± 0.187
1.167ProGln: 1.167 ± 0.2
0.839ProArg: 0.839 ± 0.162
2.554ProSer: 2.554 ± 0.365
2.7ProThr: 2.7 ± 0.365
2.517ProVal: 2.517 ± 0.249
0.547ProTrp: 0.547 ± 0.144
1.496ProTyr: 1.496 ± 0.247
0.0ProXaa: 0.0 ± 0.0
Gln
2.809GlnAla: 2.809 ± 0.412
0.182GlnCys: 0.182 ± 0.086
2.007GlnAsp: 2.007 ± 0.3
2.736GlnGlu: 2.736 ± 0.379
1.496GlnPhe: 1.496 ± 0.202
2.007GlnGly: 2.007 ± 0.261
1.095GlnHis: 1.095 ± 0.224
1.861GlnIle: 1.861 ± 0.305
3.211GlnLys: 3.211 ± 0.363
3.612GlnLeu: 3.612 ± 0.541
0.912GlnMet: 0.912 ± 0.218
2.335GlnAsn: 2.335 ± 0.21
1.022GlnPro: 1.022 ± 0.185
1.861GlnGln: 1.861 ± 0.332
1.532GlnArg: 1.532 ± 0.193
1.824GlnSer: 1.824 ± 0.274
1.897GlnThr: 1.897 ± 0.295
2.007GlnVal: 2.007 ± 0.197
0.365GlnTrp: 0.365 ± 0.131
1.167GlnTyr: 1.167 ± 0.203
0.0GlnXaa: 0.0 ± 0.0
Arg
3.247ArgAla: 3.247 ± 0.403
0.474ArgCys: 0.474 ± 0.149
2.517ArgAsp: 2.517 ± 0.263
2.809ArgGlu: 2.809 ± 0.344
1.934ArgPhe: 1.934 ± 0.358
1.897ArgGly: 1.897 ± 0.281
1.058ArgHis: 1.058 ± 0.193
2.846ArgIle: 2.846 ± 0.327
3.539ArgLys: 3.539 ± 0.501
4.415ArgLeu: 4.415 ± 0.461
1.167ArgMet: 1.167 ± 0.192
2.663ArgAsn: 2.663 ± 0.308
1.313ArgPro: 1.313 ± 0.216
1.897ArgGln: 1.897 ± 0.229
2.335ArgArg: 2.335 ± 0.352
2.627ArgSer: 2.627 ± 0.273
2.189ArgThr: 2.189 ± 0.276
3.721ArgVal: 3.721 ± 0.45
0.365ArgTrp: 0.365 ± 0.11
2.262ArgTyr: 2.262 ± 0.321
0.0ArgXaa: 0.0 ± 0.0
Ser
5.254SerAla: 5.254 ± 0.409
0.511SerCys: 0.511 ± 0.118
4.305SerAsp: 4.305 ± 0.551
4.05SerGlu: 4.05 ± 0.42
2.444SerPhe: 2.444 ± 0.269
5.327SerGly: 5.327 ± 0.728
1.131SerHis: 1.131 ± 0.21
4.524SerIle: 4.524 ± 0.882
4.196SerLys: 4.196 ± 0.392
5.728SerLeu: 5.728 ± 0.48
1.569SerMet: 1.569 ± 0.3
3.284SerAsn: 3.284 ± 0.487
2.189SerPro: 2.189 ± 0.26
1.678SerGln: 1.678 ± 0.23
3.138SerArg: 3.138 ± 0.365
5.363SerSer: 5.363 ± 0.614
3.831SerThr: 3.831 ± 0.47
5.181SerVal: 5.181 ± 0.577
1.022SerTrp: 1.022 ± 0.251
2.554SerTyr: 2.554 ± 0.303
0.0SerXaa: 0.0 ± 0.0
Thr
6.02ThrAla: 6.02 ± 0.603
0.584ThrCys: 0.584 ± 0.161
4.159ThrAsp: 4.159 ± 0.442
4.159ThrGlu: 4.159 ± 0.414
2.043ThrPhe: 2.043 ± 0.259
4.67ThrGly: 4.67 ± 0.621
1.24ThrHis: 1.24 ± 0.253
3.284ThrIle: 3.284 ± 0.336
3.539ThrLys: 3.539 ± 0.389
4.561ThrLeu: 4.561 ± 0.353
0.839ThrMet: 0.839 ± 0.163
3.575ThrAsn: 3.575 ± 0.416
3.028ThrPro: 3.028 ± 0.354
2.116ThrGln: 2.116 ± 0.289
2.663ThrArg: 2.663 ± 0.327
4.05ThrSer: 4.05 ± 0.47
4.67ThrThr: 4.67 ± 0.661
4.05ThrVal: 4.05 ± 0.546
0.73ThrTrp: 0.73 ± 0.155
2.919ThrTyr: 2.919 ± 0.427
0.0ThrXaa: 0.0 ± 0.0
Val
5.509ValAla: 5.509 ± 0.757
0.73ValCys: 0.73 ± 0.175
4.852ValAsp: 4.852 ± 0.495
4.634ValGlu: 4.634 ± 0.473
2.299ValPhe: 2.299 ± 0.287
3.43ValGly: 3.43 ± 0.462
1.277ValHis: 1.277 ± 0.254
4.123ValIle: 4.123 ± 0.41
5.29ValLys: 5.29 ± 0.452
4.305ValLeu: 4.305 ± 0.383
1.569ValMet: 1.569 ± 0.182
4.561ValAsn: 4.561 ± 0.63
2.992ValPro: 2.992 ± 0.328
2.444ValGln: 2.444 ± 0.287
3.174ValArg: 3.174 ± 0.318
5.436ValSer: 5.436 ± 0.7
5.509ValThr: 5.509 ± 0.465
4.816ValVal: 4.816 ± 0.454
0.803ValTrp: 0.803 ± 0.138
2.444ValTyr: 2.444 ± 0.296
0.0ValXaa: 0.0 ± 0.0
Trp
0.584TrpAla: 0.584 ± 0.147
0.146TrpCys: 0.146 ± 0.077
0.876TrpAsp: 0.876 ± 0.211
0.73TrpGlu: 0.73 ± 0.158
0.401TrpPhe: 0.401 ± 0.111
0.912TrpGly: 0.912 ± 0.174
0.219TrpHis: 0.219 ± 0.084
0.511TrpIle: 0.511 ± 0.158
1.167TrpLys: 1.167 ± 0.177
0.73TrpLeu: 0.73 ± 0.165
0.182TrpMet: 0.182 ± 0.066
0.584TrpAsn: 0.584 ± 0.139
0.219TrpPro: 0.219 ± 0.08
0.584TrpGln: 0.584 ± 0.15
0.255TrpArg: 0.255 ± 0.091
0.876TrpSer: 0.876 ± 0.25
0.584TrpThr: 0.584 ± 0.17
1.095TrpVal: 1.095 ± 0.23
0.182TrpTrp: 0.182 ± 0.081
0.912TrpTyr: 0.912 ± 0.227
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.284TyrAla: 3.284 ± 0.32
0.292TyrCys: 0.292 ± 0.108
2.59TyrAsp: 2.59 ± 0.312
2.7TyrGlu: 2.7 ± 0.336
1.788TyrPhe: 1.788 ± 0.309
2.371TyrGly: 2.371 ± 0.345
0.839TyrHis: 0.839 ± 0.177
1.934TyrIle: 1.934 ± 0.235
2.736TyrLys: 2.736 ± 0.358
3.758TyrLeu: 3.758 ± 0.4
0.803TyrMet: 0.803 ± 0.178
2.444TyrAsn: 2.444 ± 0.254
1.058TyrPro: 1.058 ± 0.238
0.912TyrGln: 0.912 ± 0.153
2.299TyrArg: 2.299 ± 0.329
2.444TyrSer: 2.444 ± 0.353
2.408TyrThr: 2.408 ± 0.406
2.189TyrVal: 2.189 ± 0.368
0.693TyrTrp: 0.693 ± 0.156
1.642TyrTyr: 1.642 ± 0.254
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 120 proteins (27410 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski